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List of works by Gema Frühbeck

2014 EASO Position Statement on the Use of Anti-Obesity Drugs

scientific article published in May 2015

2015 Milan Declaration: A Call to Action on Obesity - an EASO Position Statement on the Occasion of the 2015 EXPO.

scientific article published on 30 August 2016

A Lower Olfactory Capacity Is Related to Higher Circulating Concentrations of Endocannabinoid 2-Arachidonoylglycerol and Higher Body Mass Index in Women

scientific article published on 5 February 2016

A Proposal of the European Association for the Study of Obesity to Improve the ICD-11 Diagnostic Criteria for Obesity Based on the Three Dimensions Etiology, Degree of Adiposity and Health Risk

scientific article

A role for adipocyte-derived lipopolysaccharide-binding protein in inflammation- and obesity-associated adipose tissue dysfunction

scientific article published on 21 August 2013

Activation of noncanonical Wnt signaling through WNT5A in visceral adipose tissue of obese subjects is related to inflammation

scientific article published on 19 May 2014

Adiponectin-leptin Ratio is a Functional Biomarker of Adipose Tissue Inflammation

scientific article published on 22 February 2019

Adiponectin-leptin ratio: A promising index to estimate adipose tissue dysfunction. Relation with obesity-associated cardiometabolic risk

scientific article published on 5 December 2017

An EASO position statement on multidisciplinary obesity management in adults

scientific article published on 26 March 2014

Aquaglyceroporins serve as metabolic gateways in adiposity and insulin resistance control ⬇️

scientific article published on May 15, 2011

Aquaporin-11 Contributes to TGF-β1-Induced Endoplasmic Reticulum Stress in Human Visceral Adipocytes: Role in Obesity-Associated Inflammation

scientific article published on 04 June 2020

Aquaporin-7 and glycerol permeability as novel obesity drug-target pathways

scientific article published on 9 June 2006

BAT: a new target for human obesity?

scientific article published in August 2009

Bariatric and metabolic surgery: a shift in eligibility and success criteria

scientific article published on 09 June 2015

Bariatric surgery: many benefits, but emerging risks

scientific article published on 9 January 2018

Beyond BMI--phenotyping the obesities

scientific article published on 23 October 2014

Biliopancreatic diversion induces villi elongation and cholecystokinin and ghrelin increase ⬇️

scientific article published on April 1, 2011

Biophysical assessment of aquaporin-9 as principal facilitative pathway in mouse liver import of glucogenetic glycerol

scientific article published on 23 March 2012

Body adiposity and type 2 diabetes: increased risk with a high body fat percentage even having a normal BMI.

scientific article published on 10 March 2011

Breast cancer 1 (BrCa1) may be behind decreased lipogenesis in adipose tissue from obese subjects

scientific article

COVID Isolation Eating Scale (CIES): Analysis of the impact of confinement in eating disorders and obesity-A collaborative international study

scientific article published on 20 September 2020

Changes in Body Composition in Anorexia Nervosa: Predictors of Recovery and Treatment Outcome

scientific article published on 23 November 2015

Circulating Betatrophin Levels Are Increased in Anorexia and Decreased in Morbidly Obese Women

scientific article published on 14 July 2015

Circulating Concentrations of GDF11 are Positively Associated with TSH Levels in Humans

scientific article published on 19 June 2019

Circulating glucagon is associated with inflammatory mediators in metabolically compromised subjects

scientific article published on 28 July 2011

Circulating markers of inflammation and their link to indices of adiposity

scientific article

Circulating omentin concentration increases after weight loss

scientific article

Circulating pigment epithelium-derived factor levels are associated with insulin resistance and decrease after weight loss

scientific article published on 14 July 2010

Clinical usefulness of abdominal bioimpedance (ViScan) in the determination of visceral fat and its application in the diagnosis and management of obesity and its comorbidities

scientific article published on 28 January 2017

Co-occurrence of non-suicidal self-injury and impulsivity in extreme weight conditions

Complement factor H is expressed in adipose tissue in association with insulin resistance

scientific article

Contributors

Cross-Talk between Autophagy and Apoptosis in Adipose Tissue

scientific article published in 2015

Death of the teaching autopsy: advances in technology have not reduced the value of the autopsy

scientific article published in January 2004

Decision Making Impairment: A Shared Vulnerability in Obesity, Gambling Disorder and Substance Use Disorders?

scientific article

Deletion of inducible nitric-oxide synthase in leptin-deficient mice improves brown adipose tissue function

scientific article

Depot-specific differences in the lipolytic effect of leptin on isolated white adipocytes

scientific article

Differential insulin receptor substrate-1 (IRS1)-related modulation of neuropeptide Y and proopiomelanocortin expression in nondiabetic and diabetic IRS2-/- mice

scientific article

Disruption of the leptin-insulin relationship in obese men 24 hours after laparoscopic adjustable silicone gastric banding

scientific article published in June 2002

Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women

scientific article published on 24 July 2006

Does body adiposity better predict obesity-associated cardiometabolic risk than body mass index?

scientific article published in February 2015

Effects of diets on adipose tissue

scientific article

Efficiency of autoregulatory homeostatic responses to imposed caloric excess in lean men.

scientific article

Eligibility and Success Criteria for Bariatric/Metabolic Surgery

scientific article

Elucidating the Role of Peripheral Neurotensin in Appetite Control

scientific article published in September 2016

Enduring Changes in Decision Making in Patients with Full Remission from Anorexia Nervosa.

scientific article published on 31 August 2016

Erratum to: Targeting the association of calgranulin B (S100A9) with insulin resistance and type 2 diabetes

scholarly article by Francisco J. Ortega et al published 8 March 2013 in Journal of Molecular Medicine

Evidence for the involvement of resistin in inflammation and cardiovascular disease

scientific article published on August 2005

Evolving discipline finds a forum

scientific article published in Nature

Executive functions profile in extreme eating/weight conditions: from anorexia nervosa to obesity.

scientific article

Expression of S6K1 in human visceral adipose tissue is upregulated in obesity and related to insulin resistance and inflammation.

scientific article

Expression of leptin and adiponectin in the rat oviduct

scientific article published on 12 June 2007

Extracellular fatty acid synthase: a possible surrogate biomarker of insulin resistance ⬇️

scientific article

Fasting plasma ghrelin concentrations 6 months after gastric bypass are not determined by weight loss or changes in insulinemia

scientific article published in October 2004

Functional Relationship between Leptin and Nitric Oxide in Metabolism

scientific article published on 06 September 2019

GLP-1 Limits Adipocyte Inflammation and Its Low Circulating Pre-Operative Concentrations Predict Worse Type 2 Diabetes Remission after Bariatric Surgery in Obese Patients.

scientific article

GLP-1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK.

scientific article published on 10 June 2014

Gene Ablation Prevents Liver Fibrosis in Leptin-Deficient Mice

article

Genetic variations of the bitter taste receptor TAS2R38 are associated with obesity and impact on single immune traits

scientific article published on 27 May 2016

Ghrelin and autophagy

scientific article published on 3 June 2017

HMOX1 as a marker of iron excess-induced adipose tissue dysfunction, affecting glucose uptake and respiratory capacity in human adipocytes.

scientific article

Heme Biosynthetic Pathway is Functionally Linked to Adipogenesis via Mitochondrial Respiratory Activity

scientific article published on 31 August 2017

High Body Adiposity Drives Glucose Intolerance and Increases Cardiovascular Risk in Normoglycemic Subjects

scientific article published on 9 March 2018

IPO8 and FBXL10: new reference genes for gene expression studies in human adipose tissue.

scientific article

Immunocytochemical detection of leptin in non-mammalian vertebrate stomach

scientific article published in September 2002

Impaired adiponectin-AMPK signalling in insulin-sensitive tissues of hypertensive rats

scientific article published on 14 August 2008

Increase of the Adiponectin/Leptin Ratio in Patients with Obesity and Type 2 Diabetes after Roux-en-Y Gastric Bypass

scientific article published on 03 September 2019

Increased Interleukin-32 Levels in Obesity Promote Adipose Tissue Inflammation and Extracellular Matrix Remodeling: Effect of Weight Loss

scientific article published on 14 September 2016

Increased Obesity-Associated Circulating Levels of the Extracellular Matrix Proteins Osteopontin, Chitinase-3 Like-1 and Tenascin C Are Associated with Colon Cancer

scientific article

Increased Small Intestine Expression of Non-Heme Iron Transporters in Morbidly Obese Patients With Newly Diagnosed Type 2 Diabetes

scientific article published on 29 October 2017

Increased adipose tissue heme levels and exportation are associated with altered systemic glucose metabolism

scientific article

Increased cardiometabolic risk factors and inflammation in adipose tissue in obese subjects classified as metabolically healthy

scientific article published on 10 July 2014

Increased circulating and visceral adipose tissue expression levels of YKL-40 in obesity-associated type 2 diabetes are related to inflammation: impact of conventional weight loss and gastric bypass

scientific article published on 13 October 2010

Increased levels of calprotectin in obesity are related to macrophage content: impact on inflammation and effect of weight loss

scientific article published on 5 July 2011

Increased levels of chemerin and its receptor, chemokine-like receptor-1, in obesity are related to inflammation: tumor necrosis factor-α stimulates mRNA levels of chemerin in visceral adipocytes from obese patients

scientific article published on 10 November 2011

Increased serum amyloid A concentrations in morbid obesity decrease after gastric bypass

scientific article published in March 2006

Increased tenascin C and Toll-like receptor 4 levels in visceral adipose tissue as a link between inflammation and extracellular matrix remodeling in obesity

scientific article published on 31 July 2012

Indications for Surgery for Obesity and Weight-Related Diseases: Position Statements from the International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO).

scientific article published in August 2016

Inflammation is associated with a decrease of lipogenic factors in omental fat in women

scientific article

Inflammatory role of Toll-like receptors in human and murine adipose tissue

scientific article

Influence of morbid obesity and insulin resistance on gene expression levels of AQP7 in visceral adipose tissue and AQP9 in liver

scientific article published on 10 April 2008

Influence of waist circumference on the metabolic risk associated with impaired fasting glucose: effect of weight loss after gastric bypass

scientific article published in May 2007

Insulin resistance modulates iron-related proteins in adipose tissue

scientific article published on 04 February 2014

Insulin- and Leptin-Mediated Control of Aquaglyceroporins in Human Adipocytes and Hepatocytes Is Mediated via the PI3K/Akt/mTOR Signaling Cascade

scientific article published in March 2011

Insulin- and leptin-mediated control of aquaglyceroporins in human adipocytes and hepatocytes is mediated via the PI3K/Akt/mTOR signaling cascade

scientific article published on 2 February 2011

Interaction Between Orexin-A and Sleep Quality in Females in Extreme Weight Conditions.

scientific article

Interdisciplinary European Guidelines on metabolic and bariatric surgery.

scientific article published on 11 October 2013

Intracellular signalling pathways activated by leptin

scientific article

Involvement of serum vascular endothelial growth factor family members in the development of obesity in mice and humans

scientific article

Involvement of the leptin-adiponectin axis in inflammation and oxidative stress in the metabolic syndrome

scientific article published on 26 July 2017

Iron and obesity status-associated insulin resistance influence circulating fibroblast-growth factor-23 concentrations

scientific article

Is hyperleptinemia involved in the development of age-related lens opacities?

scientific article

Is pharmacotherapy enough for urgent weight loss in severely obese patients?

scientific article published on 21 December 2018

Larrad biliopancreatic diversion in Sprague-Dawley rats. Analysis of weight loss related to food intake

scientific article published on 15 October 2008

Leptin administration downregulates the increased expression levels of genes related to oxidative stress and inflammation in the skeletal muscle of ob/ob mice

scientific article

Leptin administration favors muscle mass accretion by decreasing FoxO3a and increasing PGC-1alpha in ob/ob mice

scientific article (publication date: 2009)

Leptin expression in the rat ovary depends on estrous cycle

scientific article published in October 2003

Leptin inhibits angiotensin II-induced intracellular calcium increase and vasoconstriction in the rat aorta

scientific article

Leptin inhibits the proliferation of vascular smooth muscle cells induced by angiotensin II through nitric oxide-dependent mechanisms

scientific article

Leptin reduces the expression and increases the phosphorylation of the negative regulators of GLUT4 traffic TBC1D1 and TBC1D4 in muscle of ob/ob mice

scientific article

Letter by Gomez-Ambrosi et al regarding article, "clinical assessment and management of adult obesity".

scientific article

Lifetime obesity in patients with eating disorders: increasing prevalence, clinical and personality correlates

scientific article

Liver glycerol permeability and aquaporin-9 are dysregulated in a murine model of Non-Alcoholic Fatty Liver Disease

scientific article

Local (gut) and systemic metabolism of rats is altered by consumption of raw bean (Phaseolus vulgaris L var athropurpurea).

scientific article published in March 2003

Loss of control over eating: a description of the eating disorder/obesity spectrum in women.

scientific article published on 12 November 2013

Management of obesity

scientific article

Metabolic Surgery Enters the T2DM Treatment Algorithm

scientific article published on 5 August 2016

Moderate-vigorous physical activity across body mass index in females: moderating effect of endocannabinoids and temperament

scientific article

Modulation of Higher-Order Olfaction Components on Executive Functions in Humans

scientific article published on 17 June 2015

Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Humans

scientific article (publication date: 2013)

NLRP3 Inflammasome: A Possible Link Between Obesity-Associated Low-Grade Chronic Inflammation and Colorectal Cancer Development

article

Need for a paradigm shift in adult overweight and obesity management - an EASO position statement on a pressing public health, clinical and scientific challenge in Europe

scientific article

Normalization of adiponectin concentrations by leptin replacement in ob/ob mice is accompanied by reductions in systemic oxidative stress and inflammation

scientific article published on 5 June 2017

Obesity and Type 2 Diabetes: Two Diseases with a Need for Combined Treatment Strategies - EASO Can Lead the Way.

scientific article published on 12 October 2017

Obesity and the nervous system: more questions.

scientific article published on 12 September 2017

Obesity: a gateway disease with a rising prevalence.

scientific article published on 4 April 2014

Obesity: aquaporin enters the picture

scientific article published in November 2005

Obesity: the gateway to ill health - an EASO position statement on a rising public health, clinical and scientific challenge in Europe

scientific article published on 3 April 2013

Olfaction in eating disorders and abnormal eating behavior: a systematic review

scientific article

Orexin and sleep quality in anorexia nervosa: Clinical relevance and influence on treatment outcome

scientific article published on 21 December 2015

Overview of adipose tissue and its role in obesity and metabolic disorders

scientific article published on January 2008

PRDM16: the interconvertible adipo-myocyte switch

scientific article published on 13 March 2009

Pancreatic Aquaporin-7: A Novel Target for Anti-diabetic Drugs?

scientific article published on 5 April 2018

Peripheral actions of leptin and its involvement in disease

scientific article

Peripheral mononuclear blood cells contribute to the obesity-associated inflammatory state independently of glycemic status: involvement of the novel proinflammatory adipokines chemerin, chitinase-3-like protein 1, lipocalin-2 and osteopontin

scientific article

Peripheral signalling involved in energy homeostasis control

scientific article published on December 2012

Physical exercise remodels visceral adipose tissue and mitochondrial lipid metabolism in rats fed a high-fat diet

scientific article published on 22 November 2016

Precision medicine: diagnosis and management of obesity

scientific article published on 14 September 2017

Proinflammatory cytokines in obesity: impact of type 2 diabetes mellitus and gastric bypass

scientific article published in November 2007

RIP140 gene and protein expression levels are downregulated in visceral adipose tissue in human morbid obesity

scientific article

Rab18 dynamics in adipocytes in relation to lipogenesis, lipolysis and obesity

scientific article

Relationship between eating styles and temperament in an Anorexia Nervosa, Healthy Control, and Morbid Obesity female sample

scientific article published on 27 January 2014

Relevance of Leptin and Other Adipokines in Obesity-Associated Cardiovascular Risk

scientific article published on 05 November 2019

Revisiting the adipocyte: a model for integration of cytokine signaling in the regulation of energy metabolism

scientific article

Role of aquaglyceroporins and caveolins in energy and metabolic homeostasis

scientific article published on 04 July 2014

Role of aquaporin-7 in the pathophysiological control of fat accumulation in mice

scientific article published on 8 August 2006

Role of caveolins in body weight and insulin resistance regulation

scientific article

Serum and urinary concentrations of calprotectin as markers of insulin resistance and type 2 diabetes

scientific article published on 20 July 2012

Sexual Dimorphism of Adipose and Hepatic Aquaglyceroporins in Health and Metabolic Disorders

scientific article

Sleeve gastrectomy induces weight loss in diet-induced obese rats even if high-fat feeding is continued

scientific article published in September 2011

Slow and fast dietary proteins ⬇️

scientific article published on February 26, 1998

Smell-taste dysfunctions in extreme weight/eating conditions: analysis of hormonal and psychological interactions.

scientific article published on 22 July 2015

Study of caveolin-1 gene expression in whole adipose tissue and its subfractions and during differentiation of human adipocytes.

scientific article

Targeting the association of calgranulin B (S100A9) with insulin resistance and type 2 diabetes

scientific article published on 4 December 2012

Targeting the circulating microRNA signature of obesity.

scientific article

The L-α-lysophosphatidylinositol/GPR55 system and its potential role in human obesity

scientific article published on 16 December 2011

The Role Of Diet In The Pathogenesis Of Cholesterol Gallstones

scientific article published on 29 May 2017

The Role and Potential Therapeutic Implications of the Fibroblast Growth Factors in Energy Balance and Type 2 Diabetes

scientific article

The Sir David Cuthbertson Medal Lecture. Hunting for new pieces to the complex puzzle of obesity

scientific article

The dangerous link between childhood and adulthood predictors of obesity and metabolic syndrome

scientific article

The decrease in plasma ghrelin concentrations following bariatric surgery depends on the functional integrity of the fundus

scientific article

The healthy weight debate: does it apply to weight loss in obesity?

scientific article

The inhibitory effect of leptin on angiotensin II-induced vasoconstriction is blunted in spontaneously hypertensive rats

scientific article published on August 2006

The relationship of serum osteocalcin concentration to insulin secretion, sensitivity, and disposal with hypocaloric diet and resistance training

scientific article published on 14 October 2008

Transcriptional analysis of brown adipose tissue in leptin-deficient mice lacking inducible nitric oxide synthase: evidence of the role of Med1 in energy balance

scientific article

Variations in the Prevalence of Obesity Among European Countries, and a Consideration of Possible Causes ⬇️

scientific article published on 11 February 2017

Vasodilator effect of ghrelin in the rat aorta

scientific article

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