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List of works by Cornelis F.M. Sier

5-Aminosalicylic acid inhibits TGF-beta1 signalling in colorectal cancer cells.

scientific article

A method for semi-automated image analysis of HLA class I tumour epithelium expression in rectal cancer.

scientific article

Active TGF-beta1 correlates with myofibroblasts and malignancy in the colorectal adenoma-carcinoma sequence

scientific article published on 01 April 2009

Anti-GD2-IRDye800CW as a targeted probe for fluorescence-guided surgery in neuroblastoma

scientific article published on 19 October 2020

Association of aneuploidy in index adenomas with metachronous colorectal adenoma development and a comparison

scientific article published on 01 October 1992

Beta-glucan enhanced killing of renal cell carcinoma micrometastases by monoclonal antibody G250 directed complement activation.

scientific article published in May 2004

Biomarker expression in rectal cancer tissue before and after neoadjuvant therapy.

scientific article published on 23 March 2018

Bone healing and mannose-binding lectin

scientific article

Circulating bone morphogenetic protein levels and delayed fracture healing.

scientific article published on 28 December 2012

Clinical applications of the urokinase receptor (uPAR) for cancer patients.

scientific article published on January 2011

Clinical evidence for a protective role of lipocalin-2 against MMP-9 autodegradation and the impact for gastric cancer

scientific article published on 02 July 2007

Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer.

scientific article published on 29 August 2006

Clinical prognostic value of combined analysis of Aldh1, Survivin, and EpCAM expression in colorectal cancer

scientific article

Comparative evaluation of carcinoembryonic antigen, secretory component, and mucins in index and metachronous adenomas of the colorectum

scientific article published on 01 October 1991

Correlation Between Preoperative Serum Carcinoembryonic Antigen Levels and Expression on Pancreatic and Rectal Cancer Tissue.

scientific article published on 17 May 2017

Correlation of glutathione S-transferases with overall survival in patients with gastric carcinoma

scientific article published on 01 August 1996

Cytoplasmic Overexpression of HER2: a Key Factor in Colorectal Cancer.

scientific article published on 21 February 2013

Determination of matrilysin activity in gastrointestinal neoplasia

scientific article published on 01 July 2007

Displaced midshaft fractures of the clavicle: non-operative treatment versus plate fixation (Sleutel-TRIAL). A multicentre randomised controlled trial.

scientific article

EGFR and αvβ6 as Promising Targets for Molecular Imaging of Cutaneous and Mucosal Squamous Cell Carcinoma of the Head and Neck Region

scientific article published on 05 June 2020

EMMPRIN-induced MMP-2 activation cascade in human cervical squamous cell carcinoma

scientific article published on 01 June 2006

Efficient degradation-aided selection of protease inhibitors by phage display.

scientific article

Endoglin Expression on Cancer-Associated Fibroblasts Regulates Invasion and Stimulates Colorectal Cancer Metastasis

scientific article published on 26 June 2018

Endoglin targeting inhibits tumor angiogenesis and metastatic spread in breast cancer.

scientific article

Endothelium specific matrilysin (MMP-7) expression in human cancers.

scientific article published on 26 October 2007

Enhanced urinary gelatinase activities (matrix metalloproteinases 2 and 9) are associated with early-stage bladder carcinoma: a comparison with clinically used tumor markers

scientific article published on 01 June 2000

EpCAM as multi-tumour target for near-infrared fluorescence guided surgery.

scientific article

Eradication of Helicobacter pylori infection favourably affects altered gastric mucosal MMP-9 levels

scientific article published on 01 October 2007

Evaluation of EphA2 and EphB4 as Targets for Image-Guided Colorectal Cancer Surgery.

scientific article published on 03 February 2017

Evaluation of EphB4 as Target for Image-Guided Surgery of Breast Cancer

scientific article published on 30 July 2020

Expression of matrix metalloproteinases-2 and -9 in intestinal tissue of patients with inflammatory bowel diseases

scientific article published on 01 August 2005

Expression of uPAR in tumor-associated stromal cells is associated with colorectal cancer patient prognosis: a TMA study

scientific article

Fluorescence- and multispectral optoacoustic imaging for an optimized detection of deeply located tumors in an orthotopic mouse model of pancreatic carcinoma

scientific article

Fluorescence-guided tumor detection with a novel anti-EpCAM targeted antibody fragment: Preclinical validation

scientific article published on 23 October 2018

Gastric mucosal plasminogen activators in Helicobacter pylori infection

scientific article published on 01 August 1996

Glutathione S-transferase pi in colorectal tumors is predictive for overall survival

scientific article published on 01 June 1995

Glutathione S-transferases in liver metastases of colorectal cancer. A comparison with normal liver and primary carcinomas.

scientific article published in October 1994

Glycan-Based Near-infrared Fluorescent (NIRF) Imaging of Gastrointestinal Tumors: a Preclinical Proof-of-Concept In Vivo Study

scientific article published on 11 August 2020

ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer

scientific article published on 04 September 2019

Identification of cell-surface markers for detecting breast cancer cells in ovarian tissue.

scientific article published on 05 March 2016

Implant removal associated complications in children with limb fractures due to trauma.

scientific article published on 17 March 2011

In Search for Optimal Targets for Intraoperative Fluorescence Imaging of Peritoneal Metastasis From Colorectal Cancer.

scientific article published on 28 August 2017

Inactive urokinase and increased levels of its inhibitor type 1 in colorectal cancer liver metastasis

article by Cornelis F.M. Sier et al published November 1994 in Gastroenterology

Increased expression of cancer-associated fibroblast markers at the invasive front and its association with tumor-stroma ratio in colorectal cancer

scientific article published on 29 March 2019

Increased mucosal matrix metalloproteinase-1, -2, -3 and -9 activity in patients with inflammatory bowel disease and the relation with Crohn's disease phenotype

scientific article published on 29 June 2007

Increased urokinase receptor levels in human gastrointestinal neoplasia and related liver metastases.

scientific article published in January 1993

Injury pattern, injury severity, and mortality in 33,495 hospital-admitted victims of motorized two-wheeled vehicle crashes in The Netherlands.

scientific article

Introducing fluorescence guided surgery into orthopedic oncology: A systematic review of candidate protein targets for Ewing sarcoma

scientific article published on 13 September 2018

MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients.

scientific article published in April 2012

MMP-9 activity in urine from patients with various tumors, as measured by a novel MMP activity assay using modified urokinase as a substrate

scientific article published on 01 June 1999

Matrix metalloproteinases and their tissue inhibitors as prognostic indicators for diagnostic and surgical recurrence in Crohn's disease.

scientific article published in January 2009

Metabolism of tumour-derived urokinase receptor and receptor fragments in cancer patients and xenografted mice.

scientific article published in February 2004

Molecular imaging of the urokinase plasminogen activator receptor: opportunities beyond cancer

scientific article published on 28 July 2020

Molecular targets for diagnostic and intraoperative imaging of pancreatic ductal adenocarcinoma after neoadjuvant FOLFIRINOX treatment

scientific article published on 01 October 2020

Morphological and phenotypical features of ovarian metastases in breast cancer patients.

scientific article

Novel Molecular Targets for Tumor-Specific Imaging of Epithelial Ovarian Cancer Metastases

scientific article published on 12 June 2020

PAI-1 inhibits urokinase-induced chemotaxis by internalizing the urokinase receptor

scientific article published on 01 September 2001

Plasminogen activators in multiple sclerosis lesions: implications for the inflammatory response and axonal damage.

scientific article published in October 2001

Plasminogen activators in normal tissue and carcinomas of the human oesophagus and stomach

scientific article

Potential targets for tumor-specific imaging of vulvar squamous cell carcinoma: A systematic review of candidate biomarkers

scientific article published on 09 January 2020

Preclinical evaluation of a novel CEA-targeting near-infrared fluorescent tracer delineating colorectal and pancreatic tumors.

scientific article published on 22 June 2015

Preclinical uPAR-targeted multimodal imaging of locoregional oral cancer.

scientific article published on 4 January 2017

Presence of urokinase-type plasminogen activator receptor in urine of cancer patients and its possible clinical relevance

scientific article published on 01 June 1999

Prognostic Impact of Urokinase Plasminogen Activator Receptor Expression in Pancreatic Cancer: Malignant Versus Stromal Cells.

scientific article

Prognostic relevance of plasminogen activators and their inhibitors in colorectal cancer.

scientific article published in August 1994

Prognostic value of plasminogen activators and their inhibitors in colorectal cancer.

scientific article

Prognostic value of the plasminogen activation system in patients with gastric carcinoma

scientific article published on 01 March 1996

Real-time near-infrared fluorescence imaging using cRGD-ZW800-1 for intraoperative visualization of multiple cancer types

scientific article

Reply to the letter to the editor: Could the use of bone morphogenetic proteins in fracture healing do more harm than good to our patients?

scientific article

Selecting Targets for Tumor Imaging: An Overview of Cancer-Associated Membrane Proteins

scientific article

Selecting Tumor-Specific Molecular Targets in Pancreatic Adenocarcinoma: Paving the Way for Image-Guided Pancreatic Surgery

scientific article published on 29 April 2016

Selection of optimal molecular targets for tumor-specific imaging in pancreatic ductal adenocarcinoma.

scientific article published on 26 May 2017

Serum level of soluble urokinase-type plasminogen activator receptor is a strong and independent predictor of survival in human immunodeficiency virus infection.

scientific article published in December 2000

Shedding and cleavage of the urokinase receptor (uPAR): identification and characterisation of uPAR fragments in vitro and in vivo

scientific article published on 01 June 2000

Soluble urokinase receptor levels correlate with number of circulating tumor cells in acute myeloid leukemia and decrease rapidly during chemotherapy

scientific article published on 01 December 2000

Stromal Targets for Fluorescent-Guided Oncologic Surgery

scientific article

Targeting Glycans and Heavily Glycosylated Proteins for Tumor Imaging

scientific article published on 21 December 2020

Targeting endoglin expressing regulatory T cells in the tumor microenvironment enhances the effect of PD1 checkpoint inhibitor immunotherapy

scientific article published on 24 April 2020

Tetranectin expression in human colonic neoplasia

scientific article published on 01 November 1994

The level of urokinase-type plasminogen activator receptor is increased in serum of ovarian cancer patients

scientific article published on 01 May 1998

Tissue level, activation and cellular localisation of TGF-beta1 and association with survival in gastric cancer patients

scientific article published on 17 July 2007

Urokinase receptor and colorectal cancer survival.

scientific article published in August 1994

Use and efficacy of bone morphogenetic proteins in fracture healing.

scientific article published on 23 June 2011

VEGF release by MMP-9 mediated heparan sulphate cleavage induces colorectal cancer angiogenesis.

scientific article published on 6 August 2008

Vitamin D in Head and Neck Cancer: a Systematic Review

scientific article published on 20 November 2020

[The midshaft clavicular fracture]

scientific article published on 01 January 2010

uPAR directed-imaging of head-and-neck cancer.

scientific article published on March 2017

uPAR-targeted multimodal tracer for pre- and intraoperative imaging in cancer surgery

scientific article

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