List of works - Matthias J Reddehase

'Checks and balances' in cytomegalovirus-host cohabitation

scientific article published on 25 May 2019

A novel transmembrane domain mediating retention of a highly motile herpesvirus glycoprotein in the endoplasmic reticulum

scientific article

Ablation of the regulatory IE1 protein of murine cytomegalovirus alters in vivo pro-inflammatory TNF-alpha production during acute infection

scientific article

Activation of hepatic natural killer cells and control of liver-adapted lymphoma in the murine model of cytomegalovirus infection

scientific article published on 29 February 2008

Adoptive CD8 T cell control of pathogens cannot be improved by combining protective epitope specificities

scientific article published on 01 February 2008

Adverse immunological imprinting by cytomegalovirus sensitizing for allergic airway disease

scientific article published on 10 May 2019

An endocytic YXXΦ (YRRF) cargo sorting motif in the cytoplasmic tail of murine cytomegalovirus AP2 'adapter adapter' protein m04/gp34 antagonizes virus evasion of natural killer cells

scientific article

Antigen presentation under the influence of 'immune evasion' proteins and its modulation by interferon-gamma: implications for immunotherapy of cytomegalovirus infection with antiviral CD8 T cells

scientific article published on 09 September 2012

Antigen-presenting cells of haematopoietic origin prime cytomegalovirus-specific CD8 T-cells but are not sufficient for driving memory inflation during viral latency.

scientific article published in June 2011

Antigens and immunoevasins: opponents in cytomegalovirus immune surveillance

scientific article published on 01 November 2002

CD8 T cells control cytomegalovirus latency by epitope-specific sensing of transcriptional reactivation

scientific article

CD8 T-Cell Immunotherapy of Cytomegalovirus Disease in the Murine Model

CD8 T-cell-based immunotherapy of cytomegalovirus infection: "proof of concept" provided by the murine model

scientific article published on 15 March 2008

Cellular reservoirs of latent cytomegaloviruses

scientific article published on 22 April 2019

Coincident airway exposure to low-potency allergen and cytomegalovirus sensitizes for allergic airway disease by viral activation of migratory dendritic cells

scientific article published on 07 March 2019

Cytomegalovirus encodes a positive regulator of antigen presentation

scientific article

Cytomegalovirus misleads its host by priming of CD8 T cells specific for an epitope not presented in infected tissues

scientific article published on 29 December 2003

Cytomegalovirus-Associated Inhibition of Hematopoiesis Is Preventable by Cytoimmunotherapy With Antiviral CD8 T Cells

scientific article published on 21 April 2020

Dominant-negative FADD rescues the in vivo fitness of a cytomegalovirus lacking an antiapoptotic viral gene

scientific article

Early gene m18, a novel player in the immune response to murine cytomegalovirus

scientific article

Enhancement of Antigen Presentation by Deletion of Viral Immune Evasion Genes Prevents Lethal Cytomegalovirus Disease in Minor Histocompatibility Antigen-Mismatched Hematopoietic Cell Transplantation

scientific article published on 09 June 2020

Enhancerless cytomegalovirus is capable of establishing a low-level maintenance infection in severely immunodeficient host tissues but fails in exponential growth.

scientific article

Epitope-specific in vivo protection against cytomegalovirus disease by CD8 T cells in the murine model of preemptive immunotherapy

scientific article

Evaluating Human T-Cell Therapy of Cytomegalovirus Organ Disease in HLA-Transgenic Mice

scientific article published on 16 July 2015

Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

scientific article published on 15 August 2016

Exogenous introduction of an immunodominant peptide from the non-structural IE1 protein of human cytomegalovirus into the MHC class I presentation pathway by recombinant dense bodies

scientific article published in February 2008

Frequency analysis of cytolytic T cell precursors (CTL-P) generated in vivo during lethal rabies infection of mice. I. Distinction of CTL-P with different interleukin 2 sensitivity ⬇️

scientific article published on June 1, 1982

Frequency analysis of cytolytic T lymphocyte precursors (CTL-P) generated in vivo during lethal rabies infection of mice. II. Rabies virus genus specificity of CTL-P ⬇️

scientific article published on November 1, 1984

Frequent coinfection of cells explains functional in vivo complementation between cytomegalovirus variants in the multiply infected host

scientific article

From basic molecular biology to curative antiviral therapy: the success story of Hepatitis C virology

scientific article published on 01 February 2019

Function of the cargo sorting dileucine motif in a cytomegalovirus immune evasion protein

scientific article published on 19 April 2019

Hematopoietic stem cell deficiency resulting from cytomegalovirus infection of bone marrow stroma

scientific article published on June 1, 1992

Hematopoietic stem cell transplantation with latently infected donors does not transmit virus to immunocompromised recipients in the murine model of cytomegalovirus infection

scientific article published on 26 March 2008

Highly protective in vivo function of cytomegalovirus IE1 epitope-specific memory CD8 T cells purified by T-cell receptor-based cell sorting

scientific article

IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection.

scientific article published on 27 April 2017

Identification of an atypical CD8 T cell epitope encoded by murine cytomegalovirus ORF-M54 gaining dominance after deletion of the immunodominant antiviral CD8 T cell specificities.

scientific article published on 25 March 2015

Immune control in the absence of immunodominant epitopes: implications for immunotherapy of cytomegalovirus infection with antiviral CD8 T cells

scientific article published on 14 September 2012

Immune evasion proteins enhance cytomegalovirus latency in the lungs.

scientific article published on 15 July 2009

Immune evasion proteins of murine cytomegalovirus preferentially affect cell surface display of recently generated peptide presentation complexes

scientific article

Impairment of TGF-beta signaling in T cells increases susceptibility to experimental autoimmune hepatitis in mice

scientific article published on 04 December 2002

In vivo impact of cytomegalovirus evasion of CD8 T-cell immunity: facts and thoughts based on murine models.

scientific article published on 08 October 2010

Insufficient Antigen Presentation Due to Viral Immune Evasion Explains Lethal Cytomegalovirus Organ Disease After Allogeneic Hematopoietic Cell Transplantation

scientific article published on 15 April 2020

Liver sinusoidal endothelial cells are a site of murine cytomegalovirus latency and reactivation

scientific article published on 17 June 2009

Lymphoma cell apoptosis in the liver induced by distant murine cytomegalovirus infection

scientific article

Major histocompatibility complex class I allele-specific cooperative and competitive interactions between immune evasion proteins of cytomegalovirus

scientific article

Margaret Gladys Smith, mother of cytomegalovirus: 60th anniversary of cytomegalovirus isolation

scientific article published on 12 April 2015

Mast cells as rapid innate sensors of cytomegalovirus by TLR3/TRIF signaling-dependent and -independent mechanisms

scientific article

Mast cells expedite control of pulmonary murine cytomegalovirus infection by enhancing the recruitment of protective CD8 T cells to the lungs

scientific article

Mast cells: innate attractors recruiting protective CD8 T cells to sites of cytomegalovirus infection.

scientific article

Mechanism of tumor remission by cytomegalovirus in a murine lymphoma model: evidence for involvement of virally induced cellular interleukin-15.

scientific article published on 25 March 2015

Molecular modeling of an antigenic complex between a viral peptide and a class I major histocompatibility glycoprotein

scientific article published on 01 May 1992

Mouse Model of Cytomegalovirus Disease and Immunotherapy in the Immunocompromised Host: Predictions for Medical Translation that Survived the "Test of Time"

scientific article published on 06 December 2018

Mouse models of cytomegalovirus latency: overview

scientific article

Murine cytomegalovirus immune evasion proteins operative in the MHC class I pathway of antigen processing and presentation: state of knowledge, revisions, and questions

scientific article published on 09 September 2012

Murine cytomegalovirus major immediate-early enhancer region operating as a genetic switch in bidirectional gene pair transcription

scientific article published on 9 May 2007

Murine model of cytomegalovirus latency and reactivation.

scientific article published on January 2008

Mutual Interference between Cytomegalovirus and Reconstitution of Protective Immunity after Hematopoietic Cell Transplantation

scientific article

Non-cognate bystander cytolysis by clonal epitope-specific CTL lines through CD28-CD80 interaction inhibits antibody production: A potential caveat to CD8 T-cell immunotherapy.

scientific article

Non-redundant and redundant roles of cytomegalovirus gH/gL complexes in host organ entry and intra-tissue spread.

scientific article published on 6 February 2015

Noncanonical expression of a murine cytomegalovirus early protein CD8 T-cell epitope as an immediate early epitope based on transcription from an upstream gene.

scientific article published on 14 February 2014

Parameters determining the efficacy of adoptive CD8 T-cell therapy of cytomegalovirus infection.

scientific article published on 13 September 2012

Past, present and future of immunology in Mainz

scientific article

Pediatric roots of cytomegalovirus recurrence and memory inflation in the elderly

scientific article published on 06 May 2019

Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors

scientific article

Polyclonal cytomegalovirus-specific antibodies not only prevent virus dissemination from the portal of entry but also inhibit focal virus spread within target tissues

scientific article published on 26 March 2008

Positive Role of the MHC Class-I Antigen Presentation Regulator m04/gp34 of Murine Cytomegalovirus in Antiviral Protection by CD8 T Cells

scientific article published on 26 August 2020

Principles for studying in vivo attenuation of virus mutants: defining the role of the cytomegalovirus gH/gL/gO complex as a paradigm.

scientific article published on 18 March 2015

Processing and presentation of murine cytomegalovirus pORFm164-derived peptide in fibroblasts in the face of all viral immunosubversive early gene functions

scientific article

Recent advances in CMV tropism, latency, and diagnosis during aging.

scientific article

Reconstitution of CD8 T Cells Protective against Cytomegalovirus in a Mouse Model of Hematopoietic Cell Transplantation: Dynamics and Inessentiality of Epitope Immunodominance.

scientific article published on 14 June 2016

Reconstitution of CD8 T cells is essential for the prevention of multiple-organ cytomegalovirus histopathology after bone marrow transplantation ⬇️

scientific article published on 01 September 1998

Refining human T-cell immunotherapy of cytomegalovirus disease: a mouse model with 'humanized' antigen presentation as a new preclinical study tool

scientific article

Reverse genetics modification of cytomegalovirus antigenicity and immunogenicity by CD8 T-cell epitope deletion and insertion

scientific article

Revisiting CD8 T-cell 'Memory Inflation': New Insights with Implications for Cytomegaloviruses as Vaccine Vectors

scientific article published on 22 July 2020

Role for tumor necrosis factor alpha in murine cytomegalovirus transcriptional reactivation in latently infected lungs

scientific article published on January 2005

Role of antibodies in confining cytomegalovirus after reactivation from latency: three decades' résumé

scientific article published on 28 March 2019

Shedding light on the elusive role of endothelial cells in cytomegalovirus dissemination.

scientific article

Significance of herpesvirus immediate early gene expression in cellular immunity to cytomegalovirus infection ⬇️

scientific article published on November 22, 1984

Single cell detection of latent cytomegalovirus reactivation in host tissue.

scientific article published on 16 February 2011

Stalemating a clever opportunist: lessons from murine cytomegalovirus

scientific article published on May 2004

Subdominant CD8 T-cell epitopes account for protection against cytomegalovirus independent of immunodomination

scientific article published on 26 March 2008

Synergism between the components of the bipartite major immediate-early transcriptional enhancer of murine cytomegalovirus does not accelerate virus replication in cell culture and host tissues

scientific article published on 24 June 2009

TCR-ligand koff rate correlates with the protective capacity of antigen-specific CD8+ T cells for adoptive transfer

scientific article

TGF- Regulates Airway Responses Via T Cells

article

TLR3-independent activation of mast cells by cytomegalovirus contributes to control of pulmonary infection.

scientific article published on 8 May 2017

The Anti-apoptotic Murine Cytomegalovirus Protein vMIA-m38.5 Induces Mast Cell Degranulation

scientific article published on 25 August 2020

The NK cell response to mouse cytomegalovirus infection affects the level and kinetics of the early CD8(+) T-cell response.

scientific article published on 7 December 2011

The efficacy of antigen processing is critical for protection against cytomegalovirus disease in the presence of viral immune evasion proteins.

scientific article published on 24 June 2009

The immune evasion paradox: immunoevasins of murine cytomegalovirus enhance priming of CD8 T cells by preventing negative feedback regulation.

scientific article published on 24 September 2008

The major virus-producing cell type during murine cytomegalovirus infection, the hepatocyte, is not the source of virus dissemination in the host

scientific article

The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription

scientific article (publication date: May 2017)

The p36 isoform of murine cytomegalovirus m152 protein suffices for mediating innate and adaptive immune evasion.

scientific article published on 16 December 2013

The viral chemokine MCK-2 of murine cytomegalovirus promotes infection as part of a gH/gL/MCK-2 complex

scientific article

Transactivation of cellular genes involved in nucleotide metabolism by the regulatory IE1 protein of murine cytomegalovirus is not critical for viral replicative fitness in quiescent cells and host tissues

scientific article published on 06 August 2008

Tumor control in a model of bone marrow transplantation and acute liver-infiltrating B-cell lymphoma: an unpredicted novel function of cytomegalovirus

scientific article

Two antigenic peptides from genes m123 and m164 of murine cytomegalovirus quantitatively dominate CD8 T-cell memory in the H-2d haplotype

scientific article

Viral latency drives 'memory inflation': a unifying hypothesis linking two hallmarks of cytomegalovirus infection

scientific article published on 19 September 2012

List of works by Matthias J Reddehase

'Checks and balances' in cytomegalovirus-host cohabitation

A novel transmembrane domain mediating retention of a highly motile herpesvirus glycoprotein in the endoplasmic reticulum

Ablation of the regulatory IE1 protein of murine cytomegalovirus alters in vivo pro-inflammatory TNF-alpha production during acute infection

Activation of hepatic natural killer cells and control of liver-adapted lymphoma in the murine model of cytomegalovirus infection

Adoptive CD8 T cell control of pathogens cannot be improved by combining protective epitope specificities

Adverse immunological imprinting by cytomegalovirus sensitizing for allergic airway disease

An endocytic YXXΦ (YRRF) cargo sorting motif in the cytoplasmic tail of murine cytomegalovirus AP2 'adapter adapter' protein m04/gp34 antagonizes virus evasion of natural killer cells

Antigen presentation under the influence of 'immune evasion' proteins and its modulation by interferon-gamma: implications for immunotherapy of cytomegalovirus infection with antiviral CD8 T cells

Antigen-presenting cells of haematopoietic origin prime cytomegalovirus-specific CD8 T-cells but are not sufficient for driving memory inflation during viral latency.

Antigens and immunoevasins: opponents in cytomegalovirus immune surveillance

CD8 T cells control cytomegalovirus latency by epitope-specific sensing of transcriptional reactivation

CD8 T-Cell Immunotherapy of Cytomegalovirus Disease in the Murine Model

CD8 T-cell-based immunotherapy of cytomegalovirus infection: "proof of concept" provided by the murine model

Cellular reservoirs of latent cytomegaloviruses

Coincident airway exposure to low-potency allergen and cytomegalovirus sensitizes for allergic airway disease by viral activation of migratory dendritic cells

Cytomegalovirus encodes a positive regulator of antigen presentation

Cytomegalovirus misleads its host by priming of CD8 T cells specific for an epitope not presented in infected tissues

Cytomegalovirus-Associated Inhibition of Hematopoiesis Is Preventable by Cytoimmunotherapy With Antiviral CD8 T Cells

Dominant-negative FADD rescues the in vivo fitness of a cytomegalovirus lacking an antiapoptotic viral gene

Early gene m18, a novel player in the immune response to murine cytomegalovirus

Enhancement of Antigen Presentation by Deletion of Viral Immune Evasion Genes Prevents Lethal Cytomegalovirus Disease in Minor Histocompatibility Antigen-Mismatched Hematopoietic Cell Transplantation

Enhancerless cytomegalovirus is capable of establishing a low-level maintenance infection in severely immunodeficient host tissues but fails in exponential growth.

Epitope-specific in vivo protection against cytomegalovirus disease by CD8 T cells in the murine model of preemptive immunotherapy

Evaluating Human T-Cell Therapy of Cytomegalovirus Organ Disease in HLA-Transgenic Mice

Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

Exogenous introduction of an immunodominant peptide from the non-structural IE1 protein of human cytomegalovirus into the MHC class I presentation pathway by recombinant dense bodies

Frequency analysis of cytolytic T cell precursors (CTL-P) generated in vivo during lethal rabies infection of mice. I. Distinction of CTL-P with different interleukin 2 sensitivity ⬇️

Frequency analysis of cytolytic T lymphocyte precursors (CTL-P) generated in vivo during lethal rabies infection of mice. II. Rabies virus genus specificity of CTL-P ⬇️

Frequent coinfection of cells explains functional in vivo complementation between cytomegalovirus variants in the multiply infected host

From basic molecular biology to curative antiviral therapy: the success story of Hepatitis C virology

Function of the cargo sorting dileucine motif in a cytomegalovirus immune evasion protein

Hematopoietic stem cell deficiency resulting from cytomegalovirus infection of bone marrow stroma

Hematopoietic stem cell transplantation with latently infected donors does not transmit virus to immunocompromised recipients in the murine model of cytomegalovirus infection

Highly protective in vivo function of cytomegalovirus IE1 epitope-specific memory CD8 T cells purified by T-cell receptor-based cell sorting

IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection.

Identification of an atypical CD8 T cell epitope encoded by murine cytomegalovirus ORF-M54 gaining dominance after deletion of the immunodominant antiviral CD8 T cell specificities.

Immune control in the absence of immunodominant epitopes: implications for immunotherapy of cytomegalovirus infection with antiviral CD8 T cells

Immune evasion proteins enhance cytomegalovirus latency in the lungs.

Immune evasion proteins of murine cytomegalovirus preferentially affect cell surface display of recently generated peptide presentation complexes

Impairment of TGF-beta signaling in T cells increases susceptibility to experimental autoimmune hepatitis in mice

In vivo impact of cytomegalovirus evasion of CD8 T-cell immunity: facts and thoughts based on murine models.

Insufficient Antigen Presentation Due to Viral Immune Evasion Explains Lethal Cytomegalovirus Organ Disease After Allogeneic Hematopoietic Cell Transplantation

Liver sinusoidal endothelial cells are a site of murine cytomegalovirus latency and reactivation

Lymphoma cell apoptosis in the liver induced by distant murine cytomegalovirus infection

Major histocompatibility complex class I allele-specific cooperative and competitive interactions between immune evasion proteins of cytomegalovirus

Margaret Gladys Smith, mother of cytomegalovirus: 60th anniversary of cytomegalovirus isolation

Mast cells as rapid innate sensors of cytomegalovirus by TLR3/TRIF signaling-dependent and -independent mechanisms

Mast cells expedite control of pulmonary murine cytomegalovirus infection by enhancing the recruitment of protective CD8 T cells to the lungs

Mast cells: innate attractors recruiting protective CD8 T cells to sites of cytomegalovirus infection.

Mechanism of tumor remission by cytomegalovirus in a murine lymphoma model: evidence for involvement of virally induced cellular interleukin-15.

Molecular modeling of an antigenic complex between a viral peptide and a class I major histocompatibility glycoprotein

Mouse Model of Cytomegalovirus Disease and Immunotherapy in the Immunocompromised Host: Predictions for Medical Translation that Survived the "Test of Time"

Mouse models of cytomegalovirus latency: overview

Murine cytomegalovirus immune evasion proteins operative in the MHC class I pathway of antigen processing and presentation: state of knowledge, revisions, and questions

Murine cytomegalovirus major immediate-early enhancer region operating as a genetic switch in bidirectional gene pair transcription

Murine model of cytomegalovirus latency and reactivation.

Mutual Interference between Cytomegalovirus and Reconstitution of Protective Immunity after Hematopoietic Cell Transplantation

Non-cognate bystander cytolysis by clonal epitope-specific CTL lines through CD28-CD80 interaction inhibits antibody production: A potential caveat to CD8 T-cell immunotherapy.

Non-redundant and redundant roles of cytomegalovirus gH/gL complexes in host organ entry and intra-tissue spread.

Noncanonical expression of a murine cytomegalovirus early protein CD8 T-cell epitope as an immediate early epitope based on transcription from an upstream gene.

Parameters determining the efficacy of adoptive CD8 T-cell therapy of cytomegalovirus infection.

Past, present and future of immunology in Mainz

Pediatric roots of cytomegalovirus recurrence and memory inflation in the elderly

Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors

Polyclonal cytomegalovirus-specific antibodies not only prevent virus dissemination from the portal of entry but also inhibit focal virus spread within target tissues

Positive Role of the MHC Class-I Antigen Presentation Regulator m04/gp34 of Murine Cytomegalovirus in Antiviral Protection by CD8 T Cells

Principles for studying in vivo attenuation of virus mutants: defining the role of the cytomegalovirus gH/gL/gO complex as a paradigm.

Processing and presentation of murine cytomegalovirus pORFm164-derived peptide in fibroblasts in the face of all viral immunosubversive early gene functions

Recent advances in CMV tropism, latency, and diagnosis during aging.

Reconstitution of CD8 T Cells Protective against Cytomegalovirus in a Mouse Model of Hematopoietic Cell Transplantation: Dynamics and Inessentiality of Epitope Immunodominance.

Reconstitution of CD8 T cells is essential for the prevention of multiple-organ cytomegalovirus histopathology after bone marrow transplantation ⬇️

Refining human T-cell immunotherapy of cytomegalovirus disease: a mouse model with 'humanized' antigen presentation as a new preclinical study tool

Reverse genetics modification of cytomegalovirus antigenicity and immunogenicity by CD8 T-cell epitope deletion and insertion

Revisiting CD8 T-cell 'Memory Inflation': New Insights with Implications for Cytomegaloviruses as Vaccine Vectors

Role for tumor necrosis factor alpha in murine cytomegalovirus transcriptional reactivation in latently infected lungs

Role of antibodies in confining cytomegalovirus after reactivation from latency: three decades' résumé

Shedding light on the elusive role of endothelial cells in cytomegalovirus dissemination.

Significance of herpesvirus immediate early gene expression in cellular immunity to cytomegalovirus infection ⬇️

Single cell detection of latent cytomegalovirus reactivation in host tissue.