List of works - Gert U Van Zyl

A Clinical Prediction Rule for Protease Inhibitor Resistance in Patients Failing Second-Line Antiretroviral Therapy

scientific article published on 01 March 2019

A qualitative PCR minipool strategy to screen for virologic failure and antiretroviral drug resistance in South African patients on first-line antiretroviral therapy

scientific article published on 29 May 2014

Adult antiretroviral therapy guidelines 2017.

scientific article published on 15 July 2017

Another milestone in minimizing risks to mothers exposed to single-dose nevirapine for prevention of vertical transmission of HIV-1 to infants: what next?

scientific article published in March 2010

Antiretroviral resistance patterns and factors associated with resistance in adult patients failing NNRTI-based regimens in the Western Cape, South Africa.

scientific article published in October 2011

Antiretroviral therapy in children with tuberculosis: progress toward defining the issues.

scientific article published in April 2010

Appropriate clinical use of darunavir 800 mg

scientific article published on 18 October 2018

Barriers to HIV remission research in low- and middle-income countries.

scientific article

CD4 count-based failure criteria combined with viral load monitoring may trigger worse switch decisions than viral load monitoring alone.

scientific article published on 20 November 2015

Collaborative update of a rule-based expert system for HIV-1 genotypic resistance test interpretation

scientific article

Comparing mutational pathways to lopinavir resistance in HIV-1 subtypes B versus C

scientific article published on 07 September 2021

Deep sequencing reveals minor protease resistance mutations in patients failing a protease inhibitor regimen.

scientific article

Early Antiretroviral Therapy in South African Children Reduces HIV-1-Infected Cells and Cell-Associated HIV-1 RNA in Blood Mononuclear Cells.

scientific article

Emergence of HIV drug resistance during first- and second-line antiretroviral therapy in resource-limited settings

scientific article published on June 2013

Emerging antiretroviral drug resistance in sub-Saharan Africa: novel affordable technologies are needed to provide resistance testing for individual and public health benefits

scientific article published on November 2014

Establishing diagnostic cut-off criteria for the COBAS AmpliPrep/COBAS TaqMan HIV-1 Qualitative test through validation against the Amplicor DNA test v1.5 for infant diagnosis using dried blood spots.

scientific article published on 21 December 2011

Extraction buffer contaminated bacterially as a cause of invalid HIV-1 viral load results on the NucliSens EasyQ system.

scientific article published on 18 April 2008

Future technologies for monitoring HIV drug resistance and cure.

scientific article published on 05 January 2017

HIV drug resistance (HIVDR) in antiretroviral therapy-naïve patients in Tanzania not eligible for WHO threshold HIVDR survey is dramatically high

scientific article

HIV evolution and diversity in ART-treated patients

scientific article published on 30 January 2018

HIV-1 DNA decay is faster in children who initiate ART shortly after birth than later

scientific article published on 01 August 2019

HIV-1 antiretroviral drug resistance patterns in patients failing NNRTI-based treatment: results from a national survey in South Africa.

scientific article

Irreproducible positive results on the Cobas AmpliPrep/Cobas TaqMan HIV-1 Qual test are different qualitatively from confirmed positive results.

scientific article published on 17 October 2013

Is HIV-1C a risk factor for protease inhibitor failure?

scientific article

It is time to consider third-line options in antiretroviral-experienced paediatric patients?

scientific article published on 15 November 2011

Late Onset HIV Encephalopathy in Children with Long-Standing Virologic Suppression Followed by Slow Spontaneous Recovery despite No Change in Antiretroviral Therapy -Four Case Reports

scientific article

Lessons in diagnostic virology: expected and unexpected sources of error

scientific article published on 30 May 2019

Low lopinavir plasma or hair concentrations explain second-line protease inhibitor failures in a resource-limited setting

scientific article

Moderate levels of pre-therapy drug resistance (PDR) in a generalised epidemic: time for better first-line ART?

scientific article published on 28 August 2017

Mutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration

scientific article published on 19 March 2017

Mutational Heterogeneity in p6 Gag Late Assembly (L) Domains in HIV-1 Subtype C Viruses from South Africa

scientific article published on 28 September 2015

Neurodevelopment at 11 months after starting antiretroviral therapy within 3 weeks of life

scientific article published on 30 October 2019

Next generation sequencing improves detection of drug resistance mutations in infants after PMTCT failure

scientific article

No evidence of HIV replication in children on antiretroviral therapy.

scientific article published on 11 September 2017

Nucleoside reverse transcriptase inhibitor resistance mutations associated with first-line stavudine-containing antiretroviral therapy: programmatic implications for countries phasing out stavudine

scientific article published on June 2013

NucliSens EasyQ® HIV-1 V1.2 system: Detection of human plasma-derived background signal

article

Paper-based detection of HIV-1 drug resistance using isothermal amplification and an oligonucleotide ligation assay

scientific article published on 8 December 2017

Pharmacogenetics and pharmacokinetics of CNS penetration of efavirenz and its metabolites

scientific article published on 01 March 2019

Pooled PCR testing of dried blood spots for infant HIV diagnosis is cost efficient and accurate

article

Pooled testing: A tool to increase efficiency of infant HIV diagnosis and virological monitoring

scientific article published on 11 August 2020

Pooling Strategies to Reduce the Cost of HIV-1 RNA Load Monitoring in a Resource-Limited Setting ⬇️

scientific article published on January 15, 2011

Prevalence of Antiretroviral Drug Resistance in Patients Who Are Not Responding to Protease Inhibitor-Based Treatment: Results From the First National Survey in South Africa.

scientific article published on 20 October 2016

Protease inhibitor resistance in South African children with virologic failure.

scientific article published in December 2009

Rapid decline of HIV-1 DNA and RNA in infants starting very early ART may pose a diagnostic challenge

scientific article published on 13 January 2018

Rapid emergence of resistance to antiretroviral treatment after undisclosed prior exposure: A case report

scientific article published on 30 July 2019

Significantly Diminished Long-Term Specificity of the BED Capture Enzyme Immunoassay Among Patients With HIV-1 With Very Low CD4 Counts and Those on Antiretroviral Therapy

article

Southern African HIV Clinicians Society Guidance on the use of dolutegravir in first-line antiretroviral therapy

scientific article published on 17 October 2018

Southern African Treatment Resistance Network (SATuRN) RegaDB HIV drug resistance and clinical management database: supporting patient management, surveillance and research in southern Africa

scientific article published on 6 February 2014

Surveillance of transmitted resistance to antiretroviral drug classes among young children in the Western Cape Province of South Africa.

scientific article published in April 2010

The effect of interventions on the transmission and spread of HIV in South Africa: a phylodynamic analysis

article

Trends in Genotypic HIV-1 Antiretroviral Resistance between 2006 and 2012 in South African Patients Receiving First- and Second-Line Antiretroviral Treatment Regimens

scientific article (publication date: 2013)

Virologic failure among children taking lopinavir/ritonavir-containing first-line antiretroviral therapy in South Africa

scientific article

Young age a predictor of weak reactivity in a rapid antibody test in infants infected with HIV

article

Zidovudine with nevirapine for the prevention of HIV mother-to-child transmission reduces nevirapine resistance in mothers from the Western Cape, South Africa.

scientific article published on June 2008

List of works by Gert U Van Zyl

A Clinical Prediction Rule for Protease Inhibitor Resistance in Patients Failing Second-Line Antiretroviral Therapy

A qualitative PCR minipool strategy to screen for virologic failure and antiretroviral drug resistance in South African patients on first-line antiretroviral therapy

Adult antiretroviral therapy guidelines 2017.

Another milestone in minimizing risks to mothers exposed to single-dose nevirapine for prevention of vertical transmission of HIV-1 to infants: what next?

Antiretroviral resistance patterns and factors associated with resistance in adult patients failing NNRTI-based regimens in the Western Cape, South Africa.

Antiretroviral therapy in children with tuberculosis: progress toward defining the issues.

Appropriate clinical use of darunavir 800 mg

Barriers to HIV remission research in low- and middle-income countries.

CD4 count-based failure criteria combined with viral load monitoring may trigger worse switch decisions than viral load monitoring alone.

Collaborative update of a rule-based expert system for HIV-1 genotypic resistance test interpretation

Comparing mutational pathways to lopinavir resistance in HIV-1 subtypes B versus C

Deep sequencing reveals minor protease resistance mutations in patients failing a protease inhibitor regimen.

Early Antiretroviral Therapy in South African Children Reduces HIV-1-Infected Cells and Cell-Associated HIV-1 RNA in Blood Mononuclear Cells.

Emergence of HIV drug resistance during first- and second-line antiretroviral therapy in resource-limited settings

Emerging antiretroviral drug resistance in sub-Saharan Africa: novel affordable technologies are needed to provide resistance testing for individual and public health benefits

Establishing diagnostic cut-off criteria for the COBAS AmpliPrep/COBAS TaqMan HIV-1 Qualitative test through validation against the Amplicor DNA test v1.5 for infant diagnosis using dried blood spots.

Extraction buffer contaminated bacterially as a cause of invalid HIV-1 viral load results on the NucliSens EasyQ system.

Future technologies for monitoring HIV drug resistance and cure.

HIV drug resistance (HIVDR) in antiretroviral therapy-naïve patients in Tanzania not eligible for WHO threshold HIVDR survey is dramatically high

HIV evolution and diversity in ART-treated patients

HIV-1 DNA decay is faster in children who initiate ART shortly after birth than later

HIV-1 antiretroviral drug resistance patterns in patients failing NNRTI-based treatment: results from a national survey in South Africa.

Irreproducible positive results on the Cobas AmpliPrep/Cobas TaqMan HIV-1 Qual test are different qualitatively from confirmed positive results.

Is HIV-1C a risk factor for protease inhibitor failure?

It is time to consider third-line options in antiretroviral-experienced paediatric patients?

Late Onset HIV Encephalopathy in Children with Long-Standing Virologic Suppression Followed by Slow Spontaneous Recovery despite No Change in Antiretroviral Therapy -Four Case Reports

Lessons in diagnostic virology: expected and unexpected sources of error

Low lopinavir plasma or hair concentrations explain second-line protease inhibitor failures in a resource-limited setting

Moderate levels of pre-therapy drug resistance (PDR) in a generalised epidemic: time for better first-line ART?

Mutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration

Mutational Heterogeneity in p6 Gag Late Assembly (L) Domains in HIV-1 Subtype C Viruses from South Africa

Neurodevelopment at 11 months after starting antiretroviral therapy within 3 weeks of life

Next generation sequencing improves detection of drug resistance mutations in infants after PMTCT failure

No evidence of HIV replication in children on antiretroviral therapy.

Nucleoside reverse transcriptase inhibitor resistance mutations associated with first-line stavudine-containing antiretroviral therapy: programmatic implications for countries phasing out stavudine

NucliSens EasyQ® HIV-1 V1.2 system: Detection of human plasma-derived background signal

Paper-based detection of HIV-1 drug resistance using isothermal amplification and an oligonucleotide ligation assay

Pharmacogenetics and pharmacokinetics of CNS penetration of efavirenz and its metabolites

Pooled PCR testing of dried blood spots for infant HIV diagnosis is cost efficient and accurate

Pooled testing: A tool to increase efficiency of infant HIV diagnosis and virological monitoring

Pooling Strategies to Reduce the Cost of HIV-1 RNA Load Monitoring in a Resource-Limited Setting ⬇️

Prevalence of Antiretroviral Drug Resistance in Patients Who Are Not Responding to Protease Inhibitor-Based Treatment: Results From the First National Survey in South Africa.

Protease inhibitor resistance in South African children with virologic failure.

Rapid decline of HIV-1 DNA and RNA in infants starting very early ART may pose a diagnostic challenge

Rapid emergence of resistance to antiretroviral treatment after undisclosed prior exposure: A case report

Significantly Diminished Long-Term Specificity of the BED Capture Enzyme Immunoassay Among Patients With HIV-1 With Very Low CD4 Counts and Those on Antiretroviral Therapy

Southern African HIV Clinicians Society Guidance on the use of dolutegravir in first-line antiretroviral therapy

Southern African Treatment Resistance Network (SATuRN) RegaDB HIV drug resistance and clinical management database: supporting patient management, surveillance and research in southern Africa

Surveillance of transmitted resistance to antiretroviral drug classes among young children in the Western Cape Province of South Africa.

The effect of interventions on the transmission and spread of HIV in South Africa: a phylodynamic analysis

Trends in Genotypic HIV-1 Antiretroviral Resistance between 2006 and 2012 in South African Patients Receiving First- and Second-Line Antiretroviral Treatment Regimens

Virologic failure among children taking lopinavir/ritonavir-containing first-line antiretroviral therapy in South Africa

Young age a predictor of weak reactivity in a rapid antibody test in infants infected with HIV

Zidovudine with nevirapine for the prevention of HIV mother-to-child transmission reduces nevirapine resistance in mothers from the Western Cape, South Africa.