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List of works by Joseph Takahashi

2-[125I]iodomelatonin binding sites in hamster brain membranes: pharmacological characteristics and regional distribution

scientific article published on 01 May 1988

A cholinergic antagonist, mecamylamine, blocks light-induced fos immunoreactivity in specific regions of the hamster suprachiasmatic nucleus

scientific article published in June 1993

A cholinergic antagonist, mecamylamine, blocks the phase-shifting effects of light on the circadian rhythm of locomotor activity in the golden hamster

scientific article published on February 1987

A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo

scientific article

A novel mutation in Slc2a4 as a mouse model of fatigue

scientific article published on 23 May 2019

A tunable artificial circadian clock in clock-defective mice.

scientific article

Adenylate cyclase activation shifts the phase of a circadian pacemaker

scientific article published on 01 April 1983

Aging Alters Circadian and Light-Induced Expression of Clock Genes in Golden Hamsters ⬇️

scientific article published on April 1, 2003

An actigraphy study investigating sleep in bipolar I patients, unaffected siblings and controls

scientific article published on 11 October 2016

An essential role for MEF2C in the cortical response to loss of sleep in mice

scientific article published on 27 August 2020

An evolutionary hotspot defines functional differences between CRYPTOCHROMES.

scientific article published on 19 March 2018

Anisomycin, an inhibitor of protein synthesis, perturbs the phase of a mammalian circadian pacemaker

scientific article published on 01 March 1987

BK calcium-activated potassium channels regulate circadian behavioral rhythms and pacemaker output

scientific journal article

Bioluminescence imaging of individual fibroblasts reveals persistent, independently phased circadian rhythms of clock gene expression

scientific article

Bmal1 function in skeletal muscle regulates sleep.

scientific article published on 20 July 2017

Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis

scientific article

Brain-specific rescue of Clock reveals system-driven transcriptional rhythms in peripheral tissue

scientific article (publication date: 2012)

C57BL/6N mutation in cytoplasmic FMRP interacting protein 2 regulates cocaine response

scientific article published in December 2013

CKIepsilon/delta-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock

scientific article

Calcium modulates circadian variation in cAMP-stimulated melatonin in chick pineal cells

scientific article

Cell autonomy and synchrony of suprachiasmatic nucleus circadian oscillators.

scientific article published on 12 June 2011

Central and peripheral circadian clocks in mammals

scientific article (publication date: 2012)

Central circadian control of female reproductive function

scientific article (publication date: 2013)

ChIP-seq and RNA-seq methods to study circadian control of transcription in mammals

scientific article published on 26 December 2014

Characterization of 2-[125I]iodomelatonin binding sites in hamster brain

scientific article published in December 1986

Characterization of the chicken rhodopsin promoter: identification of retina-specific and glass-like protein binding domains

scientific article published on August 1994

Chemical and structural analysis of a photoactive vertebrate cryptochrome from pigeon

scientific article published on 04 September 2019

Chemical perturbations reveal that RUVBL2 regulates the circadian phase in mammals

scientific article published on 01 May 2020

Circadian Oscillations of NADH Redox State Using a Heterologous Metabolic Sensor in Mammalian Cells

scientific article published on 19 September 2016

Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation

scholarly article

Circadian behavior and plasticity of light-induced c-fos expression in SCN of tau mutant hamsters

scientific article published in August 1998

Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis

scientific article

Circadian clock genes are ticking

scientific article published in October 1992

Circadian clock genes as modulators of sensitivity to genotoxic stress.

scientific article

Circadian clock genes contribute to the regulation of hair follicle cycling

scientific article published on 24 July 2009

Circadian clock mutation disrupts estrous cyclicity and maintenance of pregnancy

scientific article

Circadian clocks à la CREM

scientific article published in Nature

Circadian control of interferon-sensitive gene expression in murine skin

scientific article published on 04 March 2020

Circadian integration of metabolism and energetics

scientific article (publication date: 3 December 2010)

Circadian regulation of iodopsin gene expression in embryonic photoreceptors in retinal cell culture

scientific article published on 01 April 1993

Circadian rhythms in parasites

scientific article published on 12 October 2017

Circadian rhythms. ICER is nicer at night (sir!).

scientific article published in February 1994

Circadian rhythms. Ion channels get the message

scientific article published in July 1996

Circadian rhythms: From gene expression to behavior ⬇️

scientific article published on December 1, 1991

Circadian rhythms: molecular basis of the clock

scientific article published in October 1998

Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex

scientific article

Circadian-clock regulation of gene expression

scientific article

Clock controls circadian period in isolated suprachiasmatic nucleus neurons

scientific article (publication date: December 1998)

Closing the Circadian Loop: CLOCK-Induced Transcription of Its Own Inhibitors per and tim ⬇️

scientific article published on June 5, 1998

Comparison of visual sensitivity for suppression of pineal melatonin and circadian phase-shifting in the golden hamster

scientific article published in July 1991

Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm

scientific article

Coordinated transcription of key pathways in the mouse by the circadian clock

scientific article (publication date: 3 May 2002)

Critical period for cycloheximide blockade of light-induced phase advances of the circadian locomotor activity rhythm in golden hamsters

scientific article published in November 1996

Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex

scientific article

Cyclic AMP-dependent melatonin production in Y79 human retinoblastoma cells

scientific article published on 01 July 1989

Cycling Transcriptional Networks Optimize Energy Utilization on a Genome Scale

scientific article

Day/night differences in the stimulation of adenylate cyclase activity by calcium/calmodulin in chick pineal cell cultures: evidence for circadian regulation of cyclic AMP.

scientific article published in December 1998

Depressive-like behavior and stress reactivity are independent traits in a Wistar Kyoto x Fisher 344 cross

scientific article published in April 2003

Differential effects of light and feeding on circadian organization of peripheral clocks in a forebrain Bmal1 mutant

scientific article

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

scientific article

Dissecting the functions of the mammalian clock protein BMAL1 by tissue-specific rescue in mice

scientific article published on November 2006

Divergent and nonuniform gene expression patterns in mouse brain

scientific article

Dynamics of noradrenergic circadian input to the chicken pineal gland

scientific article published in October 1986

Effects of age on circadian rhythms are similar in wild-type and heterozygous Clock mutant mice.

scientific article published on April 2004

Effects of aging on lens transmittance and retinal input to the suprachiasmatic nucleus in golden hamsters

scientific article

Effects of aging on light-induced phase-shifting of circadian behavioral rhythms, fos expression and CREB phosphorylation in the hamster suprachiasmatic nucleus

scientific article published in February 1996

Emergence of noise-induced oscillations in the central circadian pacemaker

scientific article

Enriching the Circadian Proteome

scientific article published in January 2017

Epidermal stem cells ride the circadian wave

scientific article published on 29 November 2013

Epigenetic inheritance of circadian period in clonal cells

scientific article published on 27 May 2020

FGF21 regulates metabolism and circadian behavior by acting on the nervous system

scientific article published on 11 August 2013

Familial advanced sleep phase syndrome

scientific article published in July 2001

Finding new clock components: past and future.

scientific article

Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1.

scientific article published on 31 January 2017

Forward genetic screens to identify circadian rhythm mutants in mice

scientific article published on January 2005

Fos protein expression in the circadian clock is not associated with phase shifts induced by a nonphotic stimulus, triazolam

scientific article published on 01 December 1993

Future of genetics of mood disorders research

scientific article

Gene set enrichment in eQTL data identifies novel annotations and pathway regulators

scientific article

Generation of N-Ethyl-N-nitrosourea (ENU) Diabetes Models in Mice Demonstrates Genotype-specific Action of Glucokinase Activators ⬇️

scientific article published on September 15, 2011

Generation, characterization, and molecular cloning of the Noerg-1 mutation of rhodopsin in the mouse

scientific article

Generation, identification and functional characterization of the nob4 mutation of Grm6 in the mouse.

scientific article published on January 2007

Genetic analysis of the stress-responsive adrenocortical axis

scientific article published on 8 August 2006

Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder

scientific article published on 28 December 2015

Genetic suppression of the circadian Clock mutation by the melatonin biosynthesis pathway

scientific article

Genetics of Circadian Rhythms in Mammalian Model Organisms ⬇️

scientific article published on January 1, 2011

Genomewide association analysis in diverse inbred mice: power and population structure

scientific article published on 3 April 2007

Ghrelin-immunopositive hypothalamic neurons tie the circadian clock and visual system to the lateral hypothalamic arousal center

scientific article published on 18 August 2012

HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections.

scientific article published on 2 October 2017

Hepatocyte circadian clock controls acetaminophen bioactivation through NADPH-cytochrome P450 oxidoreductase

scientific article

Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening ⬇️

scientific article published on December 19, 2011

Identification of genetic loci involved in diabetes using a rat model of depression.

scientific article published on 22 August 2009

Identification of mutations through dominant screening for obesity using C57BL/6 substrains

scientific article published on 02 September 2016

Identification of the circadian transcriptome in adult mouse skeletal muscle

scientific article published on 05 June 2007

Immunocytochemical localization of serotonergic fibers innervating the ocular circadian system of Aplysia

scientific article published on January 1989

Impaired limbic gamma oscillatory synchrony during anxiety-related behavior in a genetic mouse model of bipolar mania

scientific article

Implementing large-scale ENU mutagenesis screens in North America

scientific article

In vivo single-cell detection of metabolic oscillations in stem cells

scientific article published on 24 December 2014

Inducible and reversible Clock gene expression in brain using the tTA system for the study of circadian behavior

scientific article published on 5 January 2007

Intercellular coupling confers robustness against mutations in the SCN circadian clock network

scientific article

Interpretation of the mouse electroretinogram.

scientific article published on 17 July 2007

Lability of circadian pacemaker amplitude in chick pineal cells: a temperature-dependent process

scientific article published in August 1997

Large-scale mutagenesis and phenotypic screens for the nervous system and behavior in mice.

scientific article

Large-scale mutagenesis of the mouse to understand the genetic bases of nervous system structure and function

scientific article

Light, immediate-early genes, and circadian rhythms

scientific article

Light-dependent activation of rod transducin by pineal opsin

scientific article published on October 1998

Light-dependent regulation of dopamine receptors in mammalian retina

scientific article published on June 1985

Light-induced decrease of serotonin N-acetyltransferase activity and melatonin in the chicken pineal gland and retina

scientific article published on 01 May 1983

Lithium ameliorates nucleus accumbens phase-signaling dysfunction in a genetic mouse model of mania.

scientific article

Locomotor response to an open field during C57BL/6J active and inactive phases: differences dependent on conditions of illumination

scientific article

Loss of ZBTB20 impairs circadian output and leads to unimodal behavioral rhythms

scientific article published on 22 September 2016

Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription

scientific article

Mammalian circadian biology: elucidating genome-wide levels of temporal organization

scientific article (publication date: 2004)

Mania-like behavior induced by disruption of CLOCK

scientific article

Maternal behavior modulates X-linked inheritance of behavioral coping in the defensive burying test.

scientific article

Mean-Variance QTL Mapping Identifies Novel QTL for Circadian Activity and Exploratory Behavior in Mice

scientific article published on 10 December 2018

Measurement of hypocretin/orexin content in the mouse brain using an enzyme immunoassay: the effect of circadian time, age and genetic background

scientific article published in December 2002

Methods to record circadian rhythm wheel running activity in mice

scientific article published on January 2005

Mice under Caloric Restriction Self-Impose a Temporal Restriction of Food Intake as Revealed by an Automated Feeder System

scientific article published in July 2017

Molecular architecture of the mammalian circadian clock

scientific article

Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex.

scientific article

Molecular components of the Mammalian circadian clock

scientific article

Molecular components of the circadian clock in mammals

scientific article

Molecular components of the mammalian circadian clock

scientific article

Mop3 is an essential component of the master circadian pacemaker in mammals

scientific journal article

Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies

scientific journal article

Mouse chimeras and their application to circadian biology

scientific article published on January 2005

Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior

scientific article

Mutant Mice and Neuroscience: Recommendations Concerning Genetic Background

article

N-acetyltransferase and protein synthesis modulate melatonin production by Y79 human retinoblastoma cells

scientific article published on February 1991

Narcolepsy genes wake up the sleep field

scientific article published in September 1999

Neuromedin s-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms

scientific article published in March 2015

Neuronal Myocyte-Specific Enhancer Factor 2D (MEF2D) Is Required for Normal Circadian and Sleep Behavior in Mice

scientific article published on 16 August 2019

Neuropeptide Y stimulates luteinizing hormone-releasing hormone release from superfused hypothalamic GT1-7 cells

scientific article published on October 1994

Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge

scientific article published on 28 August 2019

Noise-driven cellular heterogeneity in circadian periodicity

scientific article published on 01 May 2020

Nonphotic phase-shifting in clock mutant mice

scientific article published on 01 March 2000

Obesity and metabolic syndrome in circadian Clock mutant mice

scientific article

PARP around the clock

scientific article

Period2 3'-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein accumulation.

scientific article published on 2 October 2017

Pharmacological and genetic approaches for the study of circadian rhythms in mammals.

scientific article published on July 1995

Phase shifting the circadian clock with cycloheximide: response of hamsters with an intact or a split rhythm of locomotor activity

scientific article

Phosphorylation of LSD1 by PKCα is crucial for circadian rhythmicity and phase resetting.

scientific article

Phosphorylation of the cryptochrome 1 C-terminal tail regulates circadian period length

scientific journal article

Photic and circadian expression of luciferase in mPeriod1 - luc transgenic mice in vivo ⬇️

scientific article published on December 18, 2001

Photic and circadian regulation of c-fos gene expression in the hamster suprachiasmatic nucleus.

scientific article

Photic threshold for stimulation of testicular growth and pituitary FSH release in male Djungarian hamsters

scientific article published in April 1990

Pineal opsin: a nonvisual opsin expressed in chick pineal

scientific article published on 01 March 1995

Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau.

scientific article

Quantitative trait loci associated with elevated thyroid-stimulating hormone in the Wistar-Kyoto rat.

scientific article published on 28 October 2004

Quantitative two-dimensional gel electrophoretic analysis of clock-controlled proteins in cultured chick pineal cells: circadian regulation of tryptophan hydroxylase

scientific article published in September 1996

RNA synthesis inhibitors increase melatonin production in Y79 human retinoblastoma cells

scientific article

Real-time luminescence reporting of circadian gene expression in mammals.

scientific article published on January 2005

Regulation of Circadian Rhythmicity ⬇️

scientific article published on September 17, 1982

Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists

scientific article

Regulation of dopaminergic transmission and cocaine reward by the Clock gene

scientific article

Regulation of jun-B messenger RNA and AP-1 activity by light and a circadian clock

scientific article published in March 1992

Regulation of the vgf gene in the golden hamster suprachiasmatic nucleus by light and by the circadian clock

scientific article published in February 1997

Results from screening over 9000 mutation-bearing mice for defects in the electroretinogram and appearance of the fundus.

scientific article published on December 2004

Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses

scientific article published in November 1998

Role of the CLOCK protein in the mammalian circadian mechanism

scientific article

Searching for genes underlying behavior: lessons from circadian rhythms.

scientific article

Second-generation high-throughput forward genetic screen in mice to isolate subtle behavioral mutants ⬇️

scientific article published on 06 September 2011

Sensitivity and integration in a visual pathway for circadian entrainment in the hamster (Mesocricetus auratus).

scientific article published in August 1991

Sequence interpretation. Functional annotation of mouse genome sequences

scientific article

Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins

scientific article

Sex- and lineage-specific inheritance of depression-like behavior in the rat

scientific article published on August 2004

Sleeping sickness disrupts the sleep-regulating adenosine system

scientific article published on 22 October 2020

Sleeping sickness is a circadian disorder

scientific article published on 4 January 2018

Small molecule modifiers of circadian clocks.

scientific article

Stopping time: the genetics of fly and mouse circadian clocks.

scientific article

Synchronization between peripheral circadian clock and feeding-fasting cycles in microfluidic device sustains oscillatory pattern of transcriptome

scientific article published on 26 October 2021

System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock

scientific article published in February 2007

TH17 cell differentiation is regulated by the circadian clock.

scientific article

Temperature as a universal resetting cue for mammalian circadian oscillators

scientific article

Test- and behavior-specific genetic factors affect WKY hypoactivity in tests of emotionality.

scientific article published on 20 February 2006

The Physiology of Circadian Pacemakers ⬇️

scientific article published on January 1, 1978

The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome.

scientific article published on April 2016

The Xenopus clock gene is constitutively expressed in retinal photoreceptors.

scientific article

The cancer connection

scientific article published in Nature

The circadian clock in skin: implications for adult stem cells, tissue regeneration, cancer, aging, and immunity

scientific article published on 13 January 2015

The gene for soluble N-ethylmaleimide sensitive factor attachment protein alpha is mutated in hydrocephaly with hop gait (hyh) mice

scientific journal article

The genetics of mammalian circadian order and disorder: implications for physiology and disease

scientific article (publication date: October 2008)

The malaria parasite has an intrinsic clock

scientific article

The meter of metabolism

scientific article

The mouse Clock locus: sequence and comparative analysis of 204 kb from mouse chromosome 5.

scientific article

Time- and exercise-dependent gene regulation in human skeletal muscle ⬇️

scientific article published on September 25, 2003

Tissue-specific FAH deficiency alters sleep-wake patterns and results in chronic tyrosinemia in mice

scientific article published on 14 October 2019

Transcriptional architecture and chromatin landscape of the core circadian clock in mammals

scientific article

Transcriptional architecture of the mammalian circadian clock

scientific article published on 19 December 2016

Transcriptional program of Kpna2/Importin-α2 regulates cellular differentiation-coupled circadian clock development in mammalian cells

scientific article

Trypanosoma brucei metabolism is under circadian control

scientific article published on 13 March 2017

Twenty-four hour oscillation of cAMP in chick pineal cells: role of cAMP in the acute and circadian regulation of melatonin production

scientific article

Usf1, a suppressor of the circadian Clock mutant, reveals the nature of the DNA-binding of the CLOCK:BMAL1 complex in mice.

scientific article published on 9 April 2013

Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse

scientific article

Vasoactive intestinal polypeptide (VIP)-expressing neurons in the suprachiasmatic nucleus provide sparse GABAergic outputs to local neurons with circadian regulation occurring distal to the opening of postsynaptic GABAA ionotropic receptors

scientific article

Vasopressin regulation of the proestrous luteinizing hormone surge in wild-type and Clock mutant mice

scientific article published on 26 July 2006

Visual sensitivities of nur77 (NGFI-B) and zif268 (NGFI-A) induction in the suprachiasmatic nucleus are dissociated from c-fos induction and behavioral phase-shifting responses

scientific article published in June 1997

X-linked and lineage-dependent inheritance of coping responses to stress

scientific article published on 01 November 2003

Xenobiotic metabolism in the fourth dimension: PARtners in time

scientific article

cAMP-dependent signaling as a core component of the mammalian circadian pacemaker

scientific article

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