List of works - W. Wei-Lynn Wong

Another facet of ubiquitylation: death

scientific article published on 30 September 2009

Autoreactive T cells induce necrosis and not BCL-2-regulated or death receptor-mediated apoptosis or RIPK3-dependent necroptosis of transplanted islets in a mouse model of type 1 diabetes.

scientific article published on 10 October 2014

BRD9 is a druggable component of interferon-stimulated gene expression and antiviral activity

scientific article published on 16 August 2021

Bcl-2 family proteins: the sentinels of the mitochondrial apoptosis pathway.

scientific article published on June 2008

Caspase-8 modulates physiological and pathological angiogenesis during retina development

scientific article published on 01 December 2019

Cell death research, on an island girt by sea.

scientific article published on 16 March 2012

Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment

scientific article

Characterization of the apoptotic response of human leukemia cells to organosulfur compounds

scientific article

Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways.

scientific article published on 20 January 2017

Correction: TNFR2 induced priming of the inflammasome leads to a RIPK1-dependent cell death in the absence of XIAP

scientific article published on 23 January 2020

Correction: TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1.

scientific article published on 27 June 2017

Determinants of sensitivity to lovastatin-induced apoptosis in multiple myeloma

scientific article published on 01 June 2007

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

scientific article

In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8

scientific article

In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-κB and activation of caspase-8.

scientific article published on January 2016

Inhibitor of apoptosis proteins are required for effective fusion of autophagosomes with lysosomes.

scientific article published on 9 May 2018

Linear ubiquitination prevents inflammation and regulates immune signalling

scientific article

Loss of BID Delays FASL-Induced Cell Death of Mouse Neutrophils and Aggravates DSS-Induced Weight Loss.

scientific article published on 28 February 2018

NET formation can occur independently of RIPK3 and MLKL signaling

scientific article

Necroptosis Execution Is Mediated by Plasma Membrane Nanopores Independent of Calcium

scientific article published on April 2017

RIPK1/RIPK3 promotes vascular permeability to allow tumor cell extravasation independent of its necroptotic function.

scientific article

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

scientific article

Regulating the balance between necroptosis, apoptosis and inflammation by inhibitors of apoptosis proteins.

scientific article published on December 2016

Response to Heard et al.

scientific article published in October 2015

SMAC mimetics promote NIK-dependent inhibition of CD4+ TH17 cell differentiation

scientific article published on 27 August 2019

TNF induced inhibition of Cirbp expression depends on RelB NF-κB signalling pathway

scientific article published on 14 November 2015

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.

scientific article

TNFR2 induced priming of the inflammasome leads to a RIPK1-dependent cell death in the absence of XIAP

scientific article published on 20 September 2019

TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis.

scientific article published on December 2009

TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1

scientific article published on 23 December 2015

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha.

scientific article published on 7 July 2008

Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival.

scientific article published on September 2015

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics

scientific article published on 12 September 2016

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics.

scientific article published in February 2016

The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

article

Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding

scientific article published on 01 August 2017

Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.

scientific article

Unravelling the complexities of the NF-kappaB signalling pathway using mouse knockout and transgenic models.

scientific article published on October 2006

cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner

scientific article published on 04 February 2014

List of works by W. Wei-Lynn Wong

Another facet of ubiquitylation: death

Autoreactive T cells induce necrosis and not BCL-2-regulated or death receptor-mediated apoptosis or RIPK3-dependent necroptosis of transplanted islets in a mouse model of type 1 diabetes.

BRD9 is a druggable component of interferon-stimulated gene expression and antiviral activity

Bcl-2 family proteins: the sentinels of the mitochondrial apoptosis pathway.

Caspase-8 modulates physiological and pathological angiogenesis during retina development

Cell death research, on an island girt by sea.

Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment

Characterization of the apoptotic response of human leukemia cells to organosulfur compounds

Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways.

Correction: TNFR2 induced priming of the inflammasome leads to a RIPK1-dependent cell death in the absence of XIAP

Correction: TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1.

Determinants of sensitivity to lovastatin-induced apoptosis in multiple myeloma

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8

In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-κB and activation of caspase-8.

Inhibitor of apoptosis proteins are required for effective fusion of autophagosomes with lysosomes.

Linear ubiquitination prevents inflammation and regulates immune signalling

Loss of BID Delays FASL-Induced Cell Death of Mouse Neutrophils and Aggravates DSS-Induced Weight Loss.

NET formation can occur independently of RIPK3 and MLKL signaling

Necroptosis Execution Is Mediated by Plasma Membrane Nanopores Independent of Calcium

RIPK1/RIPK3 promotes vascular permeability to allow tumor cell extravasation independent of its necroptotic function.

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

Regulating the balance between necroptosis, apoptosis and inflammation by inhibitors of apoptosis proteins.

Response to Heard et al.

SMAC mimetics promote NIK-dependent inhibition of CD4+ TH17 cell differentiation

TNF induced inhibition of Cirbp expression depends on RelB NF-κB signalling pathway

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.

TNFR2 induced priming of the inflammasome leads to a RIPK1-dependent cell death in the absence of XIAP

TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis.

TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha.

Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival.

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics.

The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding

Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.

Unravelling the complexities of the NF-kappaB signalling pathway using mouse knockout and transgenic models.

cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner