List of works by David A Jans

70-kDa heat shock cognate protein hsc70 mediates calmodulin-dependent nuclear import of the sex-determining factor SRY

scientific article published on 12 December 2012

A microtubule-facilitated nuclear import pathway for cancer regulatory proteins.

scientific article published on June 2007

A monopartite sequence is essential for p45 NF‐E2 nuclear translocation, transcriptional activity and platelet production ⬇️

scientific article published on November 1, 2010

A novel nuclear trafficking module regulates the nucleocytoplasmic localization of the rabies virus interferon antagonist, P protein

scientific article

A nuclear transport inhibitor that modulates the unfolded protein response and provides in vivo protection against lethal dengue virus infection.

scientific article

A tumor cell-specific nuclear targeting signal within chicken anemia virus VP3/apoptin.

scientific article published on January 2005

An AlphaScreen®-based assay for high-throughput screening for specific inhibitors of nuclear import.

scientific article published on February 2011

An efficient system for high-level expression and easy purification of authentic recombinant proteins

scientific article published on May 2004

An importin alpha/beta-recognized bipartite nuclear localization signal mediates targeting of the human herpes simplex virus type 1 DNA polymerase catalytic subunit pUL30 to the nucleus.

scientific article

Apoptin is modified by SUMO conjugation and targeted to promyelocytic leukemia protein nuclear bodies.

scientific article published on 21 August 2006

Arginine methylation increases the stability of human immunodeficiency virus type 1 Tat.

scientific article published on 02 September 2009

Association of respiratory syncytial virus M protein with viral nucleocapsids is mediated by the M2-1 protein

scientific article published on 25 June 2008

Author Correction: Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design

scientific article published in Scientific Reports

Binding of p110 retinoblastoma protein inhibits nuclear import of simian virus SV40 large tumor antigen

scientific article

Bovine ephemeral fever rhabdovirus α1 protein has viroporin-like properties and binds importin β1 and importin 7.

scientific article

CRM1-mediated Nuclear Export of Dengue Virus RNA Polymerase NS5 Modulates Interleukin-8 Induction and Virus Production

scientific article (publication date: 5 June 2009)

Calmodulin-dependent nuclear import of HMG-box family nuclear factors: importance of the role of SRY in sex reversal.

scientific article

Central role of nuclear transport in signalling, viral infection and development.

scientific article

Central role of the respiratory syncytial virus matrix protein in infection.

scientific article published on September 2006

Changing subcellular localization of nuclear transport factors during human spermatogenesis.

scientific article

Comment onPhosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insightsby Rónaet al.(2013)

scientific article published on 30 September 2014

Compound effects of point mutations causing campomelic dysplasia/autosomal sex reversal upon SOX9 structure, nuclear transport, DNA binding, and transcriptional activation

scientific article (publication date: 27 July 2001)

Conservation of a unique mechanism of immune evasion across the Lyssavirus genus.

scientific article

Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting

scientific article published on 08 May 2018

Cytokine-induced slowing of STAT3 nuclear import; faster basal trafficking of the STAT3β isoform.

scientific article

Defective importin beta recognition and nuclear import of the sex-determining factor SRY are associated with XY sex-reversing mutations.

scientific article

Dengue virus RNA polymerase NS5: a potential therapeutic target?

scientific article published on December 2006

Development of a pipeline for automated, high-throughput analysis of paraspeckle proteins reveals specific roles for importin α proteins.

scientific article published on 27 February 2017

Developmentally regulated SMAD2 and SMAD3 utilization directs activin signaling outcomes.

scientific article published on July 2009

Distinct effects of importin α2 and α4 on Oct3/4 localization and expression in mouse embryonic stem cells.

scientific article

Drivers of germ cell maturation.

scientific article

Dual modes of rabies P-protein association with microtubules: a novel strategy to suppress the antiviral response.

scientific article published on 22 September 2009

Dual nuclear import mechanisms of sex determining factor SRY: intracellular Ca 2+ as a switch ⬇️

scientific article published on November 4, 2010

Dynamic Nucleolar Targeting of Dengue Virus Polymerase NS5 in Response to Extracellular pH

scientific article published on 13 April 2016

Enhanced tumour cell nuclear targeting in a tumour progression model

scientific article

Enhancement of protein transduction-mediated nuclear delivery by interaction with dynein/microtubules.

scientific article published in December 2009

Exportin-1-Dependent Nuclear Export of DEAD-box Helicase DDX3X is Central to its Role in Antiviral Immunity

scientific article published on 30 September 2019

Expression of nuclear transport importins beta 1 and beta 3 is regulated during rodent spermatogenesis.

scientific article published on 28 September 2005

Fast track, dynein-dependent nuclear targeting of human immunodeficiency virus Vpr protein; impaired trafficking in a clinical isolate

scientific article published on 11 January 2016

Fatty Acid-binding Proteins 1 and 2 Differentially Modulate the Activation of Peroxisome Proliferator-activated Receptor α in a Ligand-selective Manner

scientific article published on 6 April 2015

HIV-1 integrase is capable of targeting DNA to the nucleus via an importin alpha/beta-dependent mechanism.

scientific article published on September 2006

High Throughput Screening Targeting the Dengue NS3-NS5 Interface Identifies Antivirals against Dengue, Zika and West Nile Viruses

scientific article published in 2022

Human cytomegalovirus (HCMV) DNA polymerase processivity factor ppUL44 dimerizes in the cytosol before translocation to the nucleus.

scientific article published in June 2006

Hyper-dependence of breast cancer cell types on the nuclear transporter Importin β1.

scientific article published on 8 May 2015

Hyperosmotic stress sustains cytokine-stimulated phosphorylation of STAT3, but slows its nuclear trafficking and impairs STAT3-dependent transcription.

scientific article published on 3 January 2014

Identification of a role for nucleolin in rabies virus infection

scientific article

Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association.

scientific article published on June 2005

Identification of novel antivirals inhibiting recognition of Venezuelan equine encephalitis virus capsid protein by the Importin α/β1 heterodimer through high-throughput screening

scientific article published on 11 January 2018

Importin alpha mRNAs have distinct expression profiles during spermatogenesis.

scientific article published in January 2006

Importin alpha2-interacting proteins with nuclear roles during mammalian spermatogenesis.

scientific article

Inhibition of nuclear import mediated by the Rev-arginine rich motif by RNA molecules.

scientific article

Interaction of rabies virus P-protein with STAT proteins is critical to lethal rabies disease.

scientific article published on 23 December 2013

Interaction of the nuclear localizing cytolytic granule serine protease granzyme B with importin alpha or beta: modulation by the serpin inhibitor PI-9.

scientific article

Interactome of the inhibitory isoform of the nuclear transporter Importin 13.

scientific article

Interactome of the negative regulator of nuclear import BRCA1-binding protein 2

scientific article

Interleukin-15 mediates potent antiviral responses via an interferon-dependent mechanism.

scientific article

Intracellular calcium levels can regulate Importin-dependent nuclear import.

scientific article published on 19 June 2014

Intracellular mobility and nuclear trafficking of the stress-activated kinase JNK1 are impeded by hyperosmotic stress

scientific article

Investigating dengue virus nonstructural protein 5 (NS5) nuclear import.

scientific article published on January 2014

Ivermectin as a Broad-Spectrum Host-Directed Antiviral: The Real Deal?

scientific article published on 15 September 2020

Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus

scientific article published in May 2012

Kinetic properties of nuclear transport conferred by the retinoblastoma (Rb) NLS

scientific article published on 01 July 2005

LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility

scientific journal article

Laminopathy-inducing lamin A mutants can induce redistribution of lamin binding proteins into nuclear aggregates

scientific article published on 14 November 2005

Mice Lacking Hbp1 Function Are Viable and Fertile

scientific article

Mitochondrial protein p32/HAPB1/gC1qR/C1qbp is required for efficient respiratory syncytial virus production.

scientific article published on 30 May 2017

Modulation of host cell nucleocytoplasmic trafficking during picornavirus infection.

scientific article published on February 2012

New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein

scientific journal article

Novel Flavivirus Antiviral That Targets the Host Nuclear Transport Importin α/β1 Heterodimer

scientific article published on 24 March 2019

Novel dengue virus inhibitor 4-HPR activates ATF4 independent of protein kinase R-like Endoplasmic Reticulum Kinase and elevates levels of eIF2α phosphorylation in virus infected cells

scientific article

Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design.

scientific article published on 18 December 2017

Nuclear Trafficking of the Rabies Virus Interferon Antagonist P-Protein Is Regulated by an Importin-Binding Nuclear Localization Sequence in the C-Terminal Domain.

scientific article

Nuclear Transport of Respiratory Syncytial Virus Matrix Protein Is Regulated by Dual Phosphorylation Sites

scientific article published on 20 July 2022

Nuclear drug delivery to target tumour cells.

scientific article published on 15 October 2009

Nuclear import and export inhibitors alter capsid protein distribution in mammalian cells and reduce Venezuelan Equine Encephalitis Virus replication

scientific article published on 22 October 2013

Nuclear import inhibitor N-(4-hydroxyphenyl) retinamide targets Zika virus (ZIKV) nonstructural protein 5 to inhibit ZIKV infection.

scientific article published on 4 October 2017

Nuclear import of the pre-integration complex (PIC): the Achilles heel of HIV?

scientific article

Nuclear import of β-dystroglycan is facilitated by ezrin-mediated cytoskeleton reorganization

scientific article

Nuclear import pathway of the telomere elongation suppressor TRF1: inhibition by importin alpha.

scientific article

Nuclear localization and secretion competence are conserved among henipavirus matrix proteins.

scientific article published on 5 January 2017

Nuclear localization of dengue virus (DENV) 1-4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin.

scientific article published on 14 June 2013

Nuclear localization of the dystrophin-associated protein α-dystrobrevin through importin α2/β1 is critical for interaction with the nuclear lamina/maintenance of nuclear integrity.

scientific article published on 30 January 2015

Nuclear trafficking of proteins from RNA viruses: potential target for antivirals?

scientific article published on 28 June 2012

Nuclear transport of parathyroid hormone (PTH)-related protein is dependent on microtubules.

scientific article published in February 2002

Nuclear transporter Importin-13 plays a key role in the oxidative stress transcriptional response

scientific article published on 08 October 2021

Nucleocytoplasmic Trafficking of Dengue Non-structural Protein 5 as a Target for Antivirals.

scientific article published in January 2018

Nucleocytoplasmic shuttling of the Duchenne muscular dystrophy gene product dystrophin Dp71d is dependent on the importin α/β and CRM1 nuclear transporters and microtubule motor dynein.

scientific article published on 30 January 2014

Nucleocytoplasmic shuttling of the West Nile virus RNA-dependent RNA polymerase NS5 is critical to infection.

scientific article

Nucleocytoplasmic trafficking of Nipah virus W protein involves multiple discrete interactions with the nuclear import and export machinery.

scientific article

Nullbasic, a potent anti-HIV tat mutant, induces CRM1-dependent disruption of HIV rev trafficking

scientific article

Overlapping binding sites for importin β1 and suppressor of fused (SuFu) on glioma-associated oncogene homologue 1 (Gli1) regulate its nuclear localization.

scientific article published in August 2014

Oxidative stress impairs multiple regulatory events to drive persistent cytokine-stimulated STAT3 phosphorylation.

scientific article published on March 2014

PKA-site phosphorylation of importin13 regulates its subcellular localization and nuclear transport function

scientific article published on 31 August 2018

Probing the Specificity of Binding to the Major Nuclear Localization Sequence-binding Site of Importin-  Using Oriented Peptide Library Screening

scientific article

Proteases of human rhinovirus: role in infection.

scientific article published on January 2015

Protein transduction: cell penetrating peptides and their therapeutic applications

scientific article

Protein-protein interactions in RSV assembly: potential targets for attenuating RSV strains.

scientific article published on April 2012

Putting things in place for fertilization: discovering roles for importin proteins in cell fate and spermatogenesis

scientific article

Quantifying the dynamics of the oligomeric transcription factor STAT3 by pair correlation of molecular brightness

scientific article published on 24 March 2016

Quantitative Analysis of the Microtubule Interaction of Rabies Virus P3 Protein: Roles in Immune Evasion and Pathogenesis.

scientific article published on 21 September 2016

Quantitative analysis of DNA-protein interactions using double-labeled native gel electrophoresis and fluorescence-based imaging.

scientific article published in August 2006

Quantitative analysis of localization and nuclear aggregate formation induced by GFP-lamin A mutant proteins in living HeLa cells.

scientific article published on July 2006

Quantitative analysis of protein-protein interactions by native page/fluorimaging.

scientific article published in July 2005

RK-33 Is a Broad-Spectrum Antiviral Agent That Targets DEAD-Box RNA Helicase DDX3X

scientific article published on 09 January 2020

Recognition by host nuclear transport proteins drives disorder-to-order transition in Hendra virus V.

scientific article published on 10 January 2018

Recombinant modular transporters for cell-specific nuclear delivery of locally acting drugs enhance photosensitizer activity.

scientific article published on 8 April 2003

Regulated nucleocytoplasmic transport in spermatogenesis: a driver of cellular differentiation?

scientific article

Regulating post-mitotic nuclear access: Cdk1-phosphorylation of NLSs.

scientific article published on January 2015

Regulation of nucleocytoplasmic trafficking of viral proteins: an integral role in pathogenesis?

scientific article published on 16 April 2011

Respiratory syncytial virus co-opts host mitochondrial function to favour infectious virus production

scientific article published on 27 June 2019

Respiratory virus modulation of host nucleocytoplasmic transport; target for therapeutic intervention?

scientific article

Rhinovirus 16 2A Protease Affects Nuclear Localization of 3CD during Infection

scientific article published on 28 September 2016

Rhinovirus 3C protease facilitates specific nucleoporin cleavage and mislocalisation of nuclear proteins in infected host cells.

scientific article

Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-α

scientific article

Rotavirus inhibits IFN-induced STAT nuclear translocation by a mechanism that acts after STAT binding to importin-α.

scientific article published on 9 May 2014

Secret life of importin-β; solenoid flexibility as the key to transport through the nuclear pore.

scientific article published on 25 May 2016

Selective Inhibitor of Nuclear Export (SINE) Compounds Alter New World Alphavirus Capsid Localization and Reduce Viral Replication in Mammalian Cells

scientific article

Specific interaction with the nuclear transporter importin α2 can modulate paraspeckle protein 1 delivery to nuclear paraspeckles

scientific article

Structural basis for nuclear import selectivity of pioneer transcription factor SOX2

scientific article published in 2021

Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha

scientific article (publication date: 25 July 2003)

Subversion of Host Cell Mitochondria by RSV to Favor Virus Production is Dependent on Inhibition of Mitochondrial Complex I and ROS Generation

scientific article published on 11 November 2019

Tetraspanins in viral infections: a fundamental role in viral biology?

scientific article

The BRCA-1 binding protein BRAP2 is a novel, negative regulator of nuclear import of viral proteins, dependent on phosphorylation flanking the nuclear localization signal.

scientific article published on 29 December 2009

The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production

scientific article

The C-terminal nuclear localization signal of the sex-determining region Y (SRY) high mobility group domain mediates nuclear import through importin beta 1.

scientific article published on 04 September 2001

The Thr205 phosphorylation site within respiratory syncytial virus matrix (M) protein modulates M oligomerization and virus production

scientific article

The ataxin-1 interactome reveals direct connection with multiple disrupted nuclear transport pathways

scientific article published on 03 July 2020

The biarsenical dye Lumio exhibits a reduced ability to specifically detect tetracysteine-containing proteins within live cells.

scientific article published on 6 September 2007

The immune evasion function of J and Beilong virus V proteins is distinct from that of other paramyxoviruses, consistent with their inclusion in the proposed genus Jeilongvirus

scientific article published on 24 December 2015

The nuclear import factor importin α4 can protect against oxidative stress

scientific journal article

The p53-induced factor Ei24 inhibits nuclear import through an importin β-binding-like domain

scientific journal article

The protein arginine methyltransferase PRMT6 inhibits HIV-1 Tat nucleolar retention

scientific article

The rabies virus interferon antagonist P protein interacts with activated STAT3 and inhibits Gp130 receptor signaling

scientific article published on 22 May 2013

The tumour specific pro-apoptotic factor apoptin (Vp3) from chicken anaemia virus.

scientific article published on February 2004

The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65.

scientific article

The α-importome of mammalian germ cell maturation provides novel insights for importin biology.

scientific article published on 30 April 2014

Towards safe, non-viral therapeutic gene expression in humans.

scientific article

TrawlerWeb: an online de novo motif discovery tool for next-generation sequencing datasets.

scientific article published on 5 April 2018

Tumor cell-specific photothermal killing by SELEX-derived DNA aptamer-targeted gold nanorods.

scientific article published on 8 December 2015

Tumour necrosis factor alpha (TNF- ) stimulation of cells with established dengue virus type 2 infection induces cell death that is accompanied by a reduced ability of TNF- to activate nuclear factor B and reduced sphingosine kinase-1 activity

scientific article published on 09 December 2010

c-Jun N-terminal kinase activity is required for efficient respiratory syncytial virus production

scientific article published on 3 January 2017

p32 protein levels are integral to mitochondrial and endoplasmic reticulum morphology, cell metabolism and survival.

scientific article published on August 2013

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