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List of works by Nick Barker

A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells

scientific article published in 2021

Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth

scientific article

Alteration of colonic stem cell gene signatures during the regenerative response to injury ⬇️

scientific article published on June 30, 2012

Cell transcriptomic atlas of the non-human primate Macaca fascicularis

scientific article published on 13 April 2022

Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis ⬇️

scientific article published on November 16, 2010

Crypt stem cells as the cells-of-origin of intestinal cancer

scientific article

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4 ⬇️

scientific article published on August 1, 1998

Developmental stage‐specific contribution of LGR5+ cells to basal and luminal epithelial lineages in the postnatal mammary gland ⬇️

scientific article published on November 1, 2012

E-cadherin can limit the transforming properties of activating β-catenin mutations

scientific article published on 3 August 2015

Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5(+) stem cells

scientific article

Gastrointestinal stem cells in self-renewal and cancer ⬇️

scientific article published on 05 July 2011

Gut stem cells in tissue renewal and disease: methods, markers, and myths ⬇️

scientific article published on May 29, 2012

Identifying the Stem Cell of the Intestinal Crypt: Strategies and Pitfalls ⬇️

scientific article published on October 5, 2012

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

scientific article published on 25 August 2016

Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties

scientific article

Lgr proteins in epithelial stem cell biology ⬇️

scientific article published on June 1, 2013

Lgr5 and Lgr6 as markers to study adult stem cell roles in self-renewal and cancer ⬇️

scientific article published on October 17, 2011

Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo

scientific article published on 09 June 2017

Sequence diversity present within the 5′ upstream regions of BoLA class I genes ⬇️

scientific article published on January 1, 1997

Spasmolytic polypeptide-expressing metaplasia (SPEM) in the gastric oxyntic mucosa does not arise from Lgr5-expressing cells ⬇️

scientific article published on December 23, 2011

Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue.

scientific article published in February 2010

Stem cell reprogramming as a driver of basal cell carcinoma ⬇️

scientific article published on December 1, 2012

Sumoylation by Ubc9 Regulates the Stem Cell Compartment and Structure and Function of the Intestinal Epithelium in Mice ⬇️

scientific article published on October 14, 2010

Targeted ablation of Lgr5-expressing intestinal stem cells in diphtheria toxin receptor-based mouse and organoid models

scientific article published on 18 May 2022

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers

scientific article published on 12 June 2012

Tumor environment: a potent driving force in colorectal cancer? ⬇️

scientific article published on 01 December 2001

p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium

scientific article

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