List of works - Natalie L Trevaskis

50years of oral lipid-based formulations: Provenance, progress and future perspectives

scientific article published on 15 April 2016

A mouse model to evaluate the impact of species, sex, and lipid load on lymphatic drug transport

scientific article

A new in vitro lipid digestion - in vivo absorption model to evaluate the mechanisms of drug absorption from lipid-based formulations

scientific article published on 24 December 2015

Acute hypertriglyceridemia promotes intestinal lymphatic lipid and drug transport: a positive feedback mechanism in lipid and drug absorption.

scientific article

An Acute and Coincident Increase in FABP Expression and Lymphatic Lipid and Drug Transport Occurs During Intestinal Infusion of Lipid-Based Drug Formulations to Rats

scientific article published on 01 August 2006

An examination of the interplay between enterocyte-based metabolism and lymphatic drug transport in the rat.

scientific article published on 7 February 2006

Constitutive Triglyceride Turnover into the Mesenteric Lymph Is Unable to Support Efficient Lymphatic Transport of a Biomimetic Triglyceride Prodrug

scientific article published on 29 January 2016

Correlating in Vitro Solubilization and Supersaturation Profiles with in Vivo Exposure for Lipid Based Formulations of the CETP Inhibitor CP-532,623.

scientific article

Distribution of therapeutic proteins into thoracic lymph after intravenous administration is protein size-dependent and primarily occurs within the liver and mesentery.

scientific article published on 3 January 2018

Fatty Acid Binding Proteins: Potential Chaperones of Cytosolic Drug Transport in the Enterocyte?

scientific article published on 27 April 2011

From sewer to saviour - targeting the lymphatic system to promote drug exposure and activity.

scientific article published on 16 October 2015

Glyceride-Mimetic Prodrugs Incorporating Self-Immolative Spacers Promote Lymphatic Transport, Avoid First-Pass Metabolism, and Enhance Oral Bioavailability.

scientific article published on 2 August 2016

In vitro-in vivo evaluation of lipid based formulations of the CETP inhibitors CP-529,414 (torcetrapib) and CP-532,623

scientific article published on 23 August 2014

Intestinal bile secretion promotes drug absorption from lipid colloidal phases via induction of supersaturation

scientific article published on 27 March 2013

Intestinal lymphatic transport enhances the post-prandial oral bioavailability of a novel cannabinoid receptor agonist via avoidance of first-pass metabolism.

scientific article published on 12 March 2009

Intravenous dosing conditions may affect systemic clearance for highly lipophilic drugs: implications for lymphatic transport and absolute bioavailability studies.

scientific article published on 23 May 2012

Lipid absorption triggers drug supersaturation at the intestinal unstirred water layer and promotes drug absorption from mixed micelles

scientific article published on 21 June 2013

Lipid-based formulations and drug supersaturation: harnessing the unique benefits of the lipid digestion/absorption pathway.

scientific article published on 04 July 2013

Lymphatic Transport and Lymphocyte Targeting of a Triglyceride Mimetic Prodrug Is Enhanced in a Large Animal Model: Studies in Greyhound Dogs.

scientific article published on 8 September 2016

Lymphatic Uptake of Liposomes after Intraperitoneal Administration Primarily Occurs via the Diaphragmatic Lymphatics and is Dependent on Liposome Surface Properties

scientific article published on 01 November 2019

Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in rats

scientific article

Profiling the role of deacylation-reacylation in the lymphatic transport of a triglyceride-mimetic prodrug

scientific article published on 02 December 2014

Promoting intestinal lymphatic transport targets a liver-X receptor (LXR) agonist (WAY-252,623) to lymphocytes and enhances immunomodulation

scientific article published on 03 January 2019

Recent advances in lipid-based formulation technology.

scientific article published on 26 October 2013

Single Intravenous Dose of Novel Flurbiprofen-Loaded Proniosome Formulations Provides Prolonged Systemic Exposure and Anti-inflammatory Effect.

scientific article published on 15 September 2016

Strategies to address low drug solubility in discovery and development.

scientific article published on January 2013

Targeted delivery of a model immunomodulator to the lymphatic system: comparison of alkyl ester versus triglyceride mimetic lipid prodrug strategies

scientific article published on 05 January 2014

Targeted drug delivery to lymphocytes: a route to site-specific immunomodulation?

scientific article published on 12 November 2010

The Role of the Intestinal Lymphatics in the Absorption of Two Highly Lipophilic Cholesterol Ester Transfer Protein Inhibitors (CP524,515 and CP532,623)

scientific article published on 11 March 2010

The impact of lymphatic transport on the systemic disposition of lipophilic drugs.

scientific article

The lymph lipid precursor pool is a key determinant of intestinal lymphatic drug transport.

scientific article

The mechanism of lymphatic access of two cholesteryl ester transfer protein inhibitors (CP524,515 and CP532,623) and evaluation of their impact on lymph lipoprotein profiles

scientific article published on 16 July 2010

The mechanisms of pharmacokinetic food-drug interactions - A perspective from the UNGAP group

scientific article published on 08 April 2019

The mesenteric lymph duct cannulated rat model: application to the assessment of intestinal lymphatic drug transport

scientific article

The potential for drug supersaturation during intestinal processing of lipid-based formulations may be enhanced for basic drugs

scientific article published on 10 June 2013

Therapeutic delivery to the peritoneal lymphatics: Current understanding, potential treatment benefits and future prospects

scientific article published on 22 June 2019

Transient Supersaturation Supports Drug Absorption from Lipid-Based Formulations for Short Periods of Time, but Ongoing Solubilization Is Required for Longer Absorption Periods.

scientific article published on 21 December 2016

List of works by Natalie L Trevaskis

50years of oral lipid-based formulations: Provenance, progress and future perspectives

A mouse model to evaluate the impact of species, sex, and lipid load on lymphatic drug transport

A new in vitro lipid digestion - in vivo absorption model to evaluate the mechanisms of drug absorption from lipid-based formulations

Acute hypertriglyceridemia promotes intestinal lymphatic lipid and drug transport: a positive feedback mechanism in lipid and drug absorption.

An Acute and Coincident Increase in FABP Expression and Lymphatic Lipid and Drug Transport Occurs During Intestinal Infusion of Lipid-Based Drug Formulations to Rats

An examination of the interplay between enterocyte-based metabolism and lymphatic drug transport in the rat.

Constitutive Triglyceride Turnover into the Mesenteric Lymph Is Unable to Support Efficient Lymphatic Transport of a Biomimetic Triglyceride Prodrug

Correlating in Vitro Solubilization and Supersaturation Profiles with in Vivo Exposure for Lipid Based Formulations of the CETP Inhibitor CP-532,623.

Distribution of therapeutic proteins into thoracic lymph after intravenous administration is protein size-dependent and primarily occurs within the liver and mesentery.

Fatty Acid Binding Proteins: Potential Chaperones of Cytosolic Drug Transport in the Enterocyte?

From sewer to saviour - targeting the lymphatic system to promote drug exposure and activity.

Glyceride-Mimetic Prodrugs Incorporating Self-Immolative Spacers Promote Lymphatic Transport, Avoid First-Pass Metabolism, and Enhance Oral Bioavailability.

In vitro-in vivo evaluation of lipid based formulations of the CETP inhibitors CP-529,414 (torcetrapib) and CP-532,623

Intestinal bile secretion promotes drug absorption from lipid colloidal phases via induction of supersaturation

Intestinal lymphatic transport enhances the post-prandial oral bioavailability of a novel cannabinoid receptor agonist via avoidance of first-pass metabolism.

Intravenous dosing conditions may affect systemic clearance for highly lipophilic drugs: implications for lymphatic transport and absolute bioavailability studies.

Lipid absorption triggers drug supersaturation at the intestinal unstirred water layer and promotes drug absorption from mixed micelles

Lipid-based formulations and drug supersaturation: harnessing the unique benefits of the lipid digestion/absorption pathway.

Lymphatic Transport and Lymphocyte Targeting of a Triglyceride Mimetic Prodrug Is Enhanced in a Large Animal Model: Studies in Greyhound Dogs.

Lymphatic Uptake of Liposomes after Intraperitoneal Administration Primarily Occurs via the Diaphragmatic Lymphatics and is Dependent on Liposome Surface Properties

Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in rats

Profiling the role of deacylation-reacylation in the lymphatic transport of a triglyceride-mimetic prodrug

Promoting intestinal lymphatic transport targets a liver-X receptor (LXR) agonist (WAY-252,623) to lymphocytes and enhances immunomodulation

Recent advances in lipid-based formulation technology.

Single Intravenous Dose of Novel Flurbiprofen-Loaded Proniosome Formulations Provides Prolonged Systemic Exposure and Anti-inflammatory Effect.

Strategies to address low drug solubility in discovery and development.

Targeted delivery of a model immunomodulator to the lymphatic system: comparison of alkyl ester versus triglyceride mimetic lipid prodrug strategies

Targeted drug delivery to lymphocytes: a route to site-specific immunomodulation?

The Role of the Intestinal Lymphatics in the Absorption of Two Highly Lipophilic Cholesterol Ester Transfer Protein Inhibitors (CP524,515 and CP532,623)

The impact of lymphatic transport on the systemic disposition of lipophilic drugs.

The lymph lipid precursor pool is a key determinant of intestinal lymphatic drug transport.

The mechanism of lymphatic access of two cholesteryl ester transfer protein inhibitors (CP524,515 and CP532,623) and evaluation of their impact on lymph lipoprotein profiles

The mechanisms of pharmacokinetic food-drug interactions - A perspective from the UNGAP group

The mesenteric lymph duct cannulated rat model: application to the assessment of intestinal lymphatic drug transport

The potential for drug supersaturation during intestinal processing of lipid-based formulations may be enhanced for basic drugs

Therapeutic delivery to the peritoneal lymphatics: Current understanding, potential treatment benefits and future prospects

Transient Supersaturation Supports Drug Absorption from Lipid-Based Formulations for Short Periods of Time, but Ongoing Solubilization Is Required for Longer Absorption Periods.