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List of works by Brandon J Aubrey

An inducible lentiviral guide RNA platform enables the identification of tumor-essential genes and tumor-promoting mutations in vivo

scientific article

BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells.

scientific article published on 08 March 2016

How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?

scientific article published on 17 November 2017

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

scientific article published in Nature

Loss of TRP53 reduces but does not overcome dependency of lymphoma cells on MCL-1

scientific article published in 2022

Loss of a Single Mcl-1 Allele Inhibits MYC-Driven Lymphomagenesis by Sensitizing Pro-B Cells to Apoptosis

scientific article published on 2 March 2016

Mutant TRP53 exerts a target gene-selective dominant-negative effect to drive tumor development

scientific article published on 26 October 2018

PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia

scientific article published on 12 February 2019

RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice.

scientific article published on 12 September 2016

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

scientific article published on January 2014

The BH3-only proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL.

scientific article

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

scientific article published on 19 October 2016

Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells.

scientific article published on 18 February 2016

Tumor-Suppressor Functions of the TP53 Pathway

scientific article published on 2 May 2016

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