List of works - Holly Anderton

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

scientific article published on 19 June 2020

Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease

scientific article published on 08 July 2020

Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim

scientific journal article

Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response

scientific article published on 7 February 2011

Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity

scientific article published on 22 November 2019

IAPs limit activation of RIP kinases by TNF receptor 1 during development

scientific article published on 10 February 2012

In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8

scientific article

In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-κB and activation of caspase-8.

scientific article published on January 2016

Inhibitor of Apoptosis Proteins (IAPs) Limit RIPK1-Mediated Skin Inflammation

scientific article published on 21 June 2017

Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation

scientific article published in February 2012

Linear ubiquitination prevents inflammation and regulates immune signalling

scientific article

RIPK1 is not essential for TNFR1-induced activation of NF-kappaB.

scientific article published on 20 November 2009

RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development

scientific article published on 05 September 2018

RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis

scientific article published on 8 May 2014

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

scientific article

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.

scientific article

TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1

scientific article published on 23 December 2015

Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival.

scientific article published on September 2015

Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.

scientific article

cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner

scientific article published on 04 February 2014

List of works by Holly Anderton

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease

Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim

Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response

Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity

IAPs limit activation of RIP kinases by TNF receptor 1 during development

In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8

In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-κB and activation of caspase-8.

Inhibitor of Apoptosis Proteins (IAPs) Limit RIPK1-Mediated Skin Inflammation

Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation

Linear ubiquitination prevents inflammation and regulates immune signalling

RIPK1 is not essential for TNFR1-induced activation of NF-kappaB.

RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development

RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.

TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1

Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival.

Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.

cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner