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List of works by Grant W Brown

A Role for USP7 in DNA Replication

scientific article

A conserved domain of Schizosaccharomyces pombe dfp1(+) is uniquely required for chromosome stability following alkylation damage during S phase

scientific article

A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage

scientific article

A high-throughput confocal fluorescence microscopy platform to study DNA replication stress in yeast cells

scientific article published on January 2015

A high-throughput yeast assay identifies synergistic drug combinations

scientific article published on June 2013

A survey of essential gene function in the yeast cell division cycle

scientific article

Analysis of Replicating Yeast Chromosomes by DNA Combing

scientific article

Assembly of Slx4 signaling complexes behind DNA replication forks

scientific article

BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates

scientific article

BLM and RMI1 alleviate RPA inhibition of TopoIIIα decatenase activity

scientific article

Budding yeast Mms22 and Mms1 regulate homologous recombination induced by replisome blockage

scientific article

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

scientific article published on 17 February 2017

Cdc7 kinases (DDKs) and checkpoint responses: lessons from two yeasts

scientific article published on November 2003

Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells

scientific article

Clustering with Overlap for Genetic Interaction Networks via Local Search Optimization

Comparative chemogenomics to examine the mechanism of action of dna-targeted platinum-acridine anticancer agents

scientific article

Comparative genome hybridization on tiling microarrays to detect aneuploidies in yeast

scientific article published in January 2009

Complex mutation profiles in mismatch repair and ribonucleotide reductase mutants reveal novel repair substrate specificity of MutS homolog (MSH) complexes

scientific article published on 30 July 2022

Conservation of structure and function of DNA replication protein A in the trypanosomatid Crithidia fasciculata ⬇️

scientific article published on November 1, 1992

Controlling initiation during the cell cycle. DNA replication.

scientific article published on March 1996

DNA Replication Profiling Using Deep Sequencing

scientific article

Dampening DNA damage checkpoint signalling via coordinated BRCT domain interactions

scientific article published on 20 April 2015

Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress

scientific article

Dissecting the DNA damage response using functional genomics approaches in S. cerevisiae

scientific article published on 23 May 2009

Diversity of eukaryotic DNA replication origins revealed by genome-wide analysis of chromatin structure

scientific article

E4F1 is a master regulator of CHK1-mediated functions

scientific article

Elg1 forms an alternative RFC complex important for DNA replication and genome integrity

scientific article

Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype

scientific article published on 10 January 2012

Exploring Quantitative Yeast Phenomics with Single-Cell Analysis of DNA Damage Foci.

scientific article published on 7 September 2016

Fanconi anemia signaling and Mus81 cooperate to safeguard development and crosslink repair

scientific article

Flap endonuclease overexpression drives genome instability and DNA damage hypersensitivity in a PCNA-dependent manner.

scientific article

Functional annotation of chemical libraries across diverse biological processes.

scientific article published on 24 July 2017

Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map

scientific article (publication date: 12 April 2007)

Functional targeting of DNA damage to a nuclear pore-associated SUMO-dependent ubiquitin ligase

scientific article

Genetic Regulation of Dna2 Localization During the DNA Damage Response

scientific article

Genetic background and mistranslation frequency determine the impact of mistranslating tRNASerUGG

scientific article published in 2022

Genetic dissection of parallel sister-chromatid cohesion pathways

scientific article

Genome rearrangements caused by depletion of essential DNA replication proteins in Saccharomyces cerevisiae

scientific article published on 5 June 2012

Genome-Scale Genetic Interactions and Cell Imaging Confirm Cytokinesis as Deleterious to Transient Topoisomerase II Deficiency in Saccharomyces cerevisiae.

scientific article published on 24 August 2017

Genomic approaches for identifying DNA damage response pathways in S. cerevisiae.

scientific article

Global analysis of SUMO chain function reveals multiple roles in chromatin regulation

scientific article published on April 2013

Global mapping of the yeast genetic interaction network

scientific article

HELB Is a Feedback Inhibitor of DNA End Resection

scientific journal article

Haploinsufficiency of an RB-E2F1-Condensin II complex leads to aberrant replication and aneuploidy

scientific article published on 16 April 2014

High-throughput fluorescence microscopic analysis of protein abundance and localization in budding yeast

scientific article published on 19 February 2016

High-throughput platform for yeast morphological profiling predicts the targets of bioactive compounds

scientific article published on 27 January 2022

Human topoisomerase IIIalpha is a single-stranded DNA decatenase that is stimulated by BLM and RMI1

scientific article

Identification of protein complexes required for efficient sister chromatid cohesion

scientific article

Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways

scientific article

Interaction of the S phase regulator cdc18 with cyclin-dependent kinase in fission yeast.

scientific article

Intersection of calorie restriction and magnesium in the suppression of genome-destabilizing RNA-DNA hybrids

scientific article published on 29 August 2016

Isolation of the genes encoding the 51-kilodalton and 28-kilodalton subunits of Crithidia fasciculata replication protein A.

scientific article published on January 1994

Leveraging DNA damage response signaling to identify yeast genes controlling genome stability

scientific article published on 26 February 2015

MTE1 Functions with MPH1 in Double-Strand Break Repair

scientific article published on 26 February 2016

Mapping DNA damage-dependent genetic interactions in yeast via party mating and barcode fusion genetics.

scientific article

Mapping the cellular response to small molecules using chemogenomic fitness signatures

scientific article

Mms1 and Mms22 stabilize the replisome during replication stress

scientific article published on 18 May 2011

Monoclonal antibodies to the major nonstructural nuclear protein of minute virus of mice ⬇️

scientific article published on March 1, 1991

New azole antifungal agents with novel modes of action: synthesis and biological studies of new tridentate ligands based on pyrazole and triazole

scientific article

P-body proteins regulate transcriptional rewiring to promote DNA replication stress resistance

scientific article published on 15 September 2017

Post-replication repair: Rad5/HLTF regulation, activity on undamaged templates, and relationship to cancer

scientific article published on 01 June 2019

Progerin-Induced Replication Stress Facilitates Premature Senescence in Hutchinson-Gilford Progeria Syndrome

scientific article

Purification and characterization of DNA ligase I from the trypanosomatid Crithidia fasciculata

scientific article published in August 1992

Purification of Hsk1, a Minichromosome Maintenance Protein Kinase from Fission Yeast ⬇️

scientific article published on August 21, 1998

Putting genetic interactions in context through a global modular decomposition

scientific article

Quantitative analysis of fitness and genetic interactions in yeast on a genome scale

scientific article

RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability

scientific article

RMI1 promotes DNA replication fork progression and recovery from replication fork stress

scientific article

RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex

scientific article

Rad5 Recruits Error-Prone DNA Polymerases for Mutagenic Repair of ssDNA Gaps on Undamaged Templates

scientific article published on 04 February 2019

Regulation of rtt107 recruitment to stalled DNA replication forks by the cullin rtt101 and the rtt109 acetyltransferase

scientific article

Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation

scientific article

Replication protein A from the trypanosomatid Crithidia fasciculata is inactive in the primosome assembly step of SV40 DNA replication.

scientific article

Schizosaccharomyces pombe Hsk1p is a potential cds1p target required for genome integrity.

scientific article

Single-Molecule Analysis of Replicating Yeast Chromosomes

scientific article published in February 2016

Slx4 and Rtt107 control checkpoint signalling and DNA resection at double-strand breaks.

scientific article

Slx4 regulates DNA damage checkpoint-dependent phosphorylation of the BRCT domain protein Rtt107/Esc4

scientific article

Smc5/6 Mediated Sumoylation of the Sgs1-Top3-Rmi1 Complex Promotes Removal of Recombination Intermediates.

scientific article

Suppression of genomic instability by SLX5 and SLX8 in Saccharomyces cerevisiae

scientific article

Systematic analysis of complex genetic interactions.

scientific article

Termination of Replication Stress Signaling via Concerted Action of the Slx4 Scaffold and the PP4 Phosphatase

scientific article

The Budding Yeast "Saccharomyces cerevisiae" as a Drug Discovery Tool to Identify Plant-Derived Natural Products with Anti-Proliferative Properties

scientific article published on 23 June 2011

The INO80 chromatin remodeling complex prevents polyploidy and maintains normal chromatin structure at centromeres

scientific article

The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination

scientific article

The Monoterpene Carvacrol Generates Endoplasmic Reticulum Stress in the Pathogenic Fungus Candida albicans

scientific article published on 26 May 2015

The N- and C-termini of Elg1 contribute to the maintenance of genome stability

scientific article

The budding yeast RSC complex maintains ploidy by promoting spindle pole body insertion

scientific article published on 06 June 2018

The origin recognition complex links replication, sister chromatid cohesion and transcriptional silencing in Saccharomyces cerevisiae

scientific article

The synthetic genetic interaction spectrum of essential genes

article

Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation

scientific article published on 04 August 2013

Unification of Protein Abundance Datasets Yields a Quantitative Saccharomyces cerevisiae Proteome

scientific article published on 17 January 2018

YGR042W/MTE1 Functions in Double-Strand Break Repair with MPH1

cdc18+ regulates initiation of DNA replication in Schizosaccharomyces pombe.

scientific article published on February 1996

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