List of works - Kenji Inaba

A PDI-catalyzed thiol-disulfide switch regulates the production of hydrogen peroxide by human Ero1.

scientific article published on 17 February 2015

A pH-regulated quality control cycle for surveillance of secretory protein assembly

scientific article

A pair of circularly permutated PDZ domains control RseP, the S2P family intramembrane protease of Escherichia coli.

scientific article published on 22 October 2008

Antipsychotic olanzapine-induced misfolding of proinsulin in the endoplasmic reticulum accounts for atypical development of diabetes

scientific article published on 17 November 2020

Cell biology of cysteine-based molecular switches

scientific article published on 6 February 2014

Characterization of the ER-resident peroxidases GPx7 and GPx8 shows the higher oxidative activity of GPx7 and its linkage to oxidative protein folding

scientific article published on 21 July 2020

Characterization of the menaquinone-dependent disulfide bond formation pathway of Escherichia coli.

scientific article published on 30 August 2004

Conversion of two-state to multi-state folding kinetics on fusion of two protein foldons

scientific article published on 01 September 2000

Coupling effects of thiol and urea-type groups for promotion of oxidative protein folding

scientific article published on 01 January 2019

Critical role of a thiolate-quinone charge transfer complex and its adduct form in de novo disulfide bond generation by DsbB.

scholarly article

Cryo-EM structures of SERCA2b reveal the mechanism of regulation by the luminal extension tail

scientific article published on 12 August 2020

Crystal structure of a protein with an artificial exon-shuffling, module M4-substituted chimera hemoglobin beta alpha, at 2.5 A resolution

scientific article

Crystal structure of the DsbB-DsbA complex reveals a mechanism of disulfide bond generation.

scientific article

Crystal structures of human Ero1α reveal the mechanisms of regulated and targeted oxidation of PDI

scientific article

Cysteines 208 and 241 in Ero1α are required for maximal catalytic turnover

scientific article

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics.

scientific article published on 27 October 2017

Design, construction, crystallization, and preliminary X-ray studies of a fine-tuning mutant (F133V) of module-substituted chimera hemoglobin

scientific article published on 01 August 1998

Disulfide bond formation network in the three biological kingdoms, bacteria, fungi and mammals.

scientific article published on 08 June 2012

Disulfide bond formation system in Escherichia coli.

scientific article published on 29 June 2009

DsbB elicits a red-shift of bound ubiquinone during the catalysis of DsbA oxidation.

scientific article published on 20 November 2003

Dynamic assembly of protein disulfide isomerase in catalysis of oxidative folding

scientific article published on 15 April 2019

Dynamic nature of disulphide bond formation catalysts revealed by crystal structures of DsbB

scientific article

Ero1-Mediated Reoxidation of Protein Disulfide Isomerase Accelerates the Folding of Cone Snail Toxins

scientific article published on 31 October 2018

Homodimerization of Nemo-like kinase is essential for activation and nuclear localization

scientific article published on 30 November 2010

Human ER Oxidoreductin-1α (Ero1α) Undergoes Dual Regulation through Complementary Redox Interactions with Protein-Disulfide Isomerase.

scientific article published on 4 October 2016

Identification of the physiological substrates of PDIp, a pancreas-specific protein disulfide isomerase family member

scientific article published in Journal of Biological Chemistry

Identification of the redox partners of ERdj5/JPDI, a PDI family member, from an animal tissue

scientific article published on 18 September 2013

Inhibition of the functional interplay between endoplasmic reticulum (ER) oxidoreduclin-1α (Ero1α) and protein-disulfide isomerase (PDI) by the endocrine disruptor bisphenol A.

scientific article published on 13 August 2014

Methods to identify the substrates of thiol-disulfide oxidoreductases

scientific article published on 13 December 2018

Molecular bases of cyclic and specific disulfide interchange between human ERO1alpha protein and protein-disulfide isomerase (PDI).

scientific article published on 11 March 2011

Observing the nonvectorial yet cotranslational folding of a multidomain protein, LDL receptor, in the ER of mammalian cells

scientific article published on 29 June 2020

One-Dimensional Sliding of p53 Along DNA Is Accelerated in the Presence of Ca(2+) or Mg(2+) at Millimolar Concentrations.

scientific article published on 2 July 2015

PDI Family Members as Guides for Client Folding and Assembly

scientific article published on 08 December 2020

Paradoxical redox properties of DsbB and DsbA in the protein disulfide-introducing reaction cascade.

scientific article published on June 2002

Preparation of Selenoinsulin as a Long-Lasting Insulin Analogue.

scientific article

Progressive quality control of secretory proteins in the early secretory compartment by ERp44

scientific article

Radically different thioredoxin domain arrangement of ERp46, an efficient disulfide bond introducer of the mammalian PDI family

scientific article

Redox-assisted regulation of Ca2+ homeostasis in the endoplasmic reticulum by disulfide reductase ERdj5.

scientific article published on 30 September 2016

Redox-dependent domain rearrangement of protein disulfide isomerase coupled with exposure of its substrate-binding hydrophobic surface

scientific article

Role of the cytosolic loop of DsbB in catalytic turnover of the ubiquinone-DsbB complex.

scientific article

Structural Basis of Sarco/Endoplasmic Reticulum Ca2+-ATPase 2b Regulation via Transmembrane Helix Interplay

scientific article published on 01 April 2019

Structural and functional effects of pseudo-module substitution in hemoglobin subunits. New structural and functional units in globin structure

scientific article published on 01 April 1998

Structural and functional roles of heme binding module in globin proteins: identification of the segment regulating the heme binding structure.

scientific article published in January 1998

Structural and functional roles of modules in hemoglobin. Substitution of module M4 in hemoglobin subunits

scientific article published on 01 November 1997

Structural basis of a Ni acquisition cycle for [NiFe] hydrogenase by Ni-metallochaperone HypA and its enhancer

scientific article published on 8 June 2015

Structural basis of pH-dependent client binding by ERp44, a key regulator of protein secretion at the ER-Golgi interface.

scientific article published on 3 April 2017

Structural basis of protein disulfide bond generation in the cell.

scientific article published on 27 July 2010

Structure and mechanisms of the DsbB-DsbA disulfide bond generation machine.

scientific article published on 26 November 2007

Structure, mechanism, and evolution of Ero1 family enzymes.

scientific article published on 25 January 2012

Structures and functions of protein disulfide isomerase family members involved in proteostasis in the endoplasmic reticulum

scientific article

Structures, Mechanisms, and Physiological Functions of Zinc Transporters in Different Biological Kingdoms

scientific article published in 2024

Substitution of the heme binding module in hemoglobin alpha- and beta-subunits. Implication for different regulation mechanisms of the heme proximal structure between hemoglobin and myoglobin

scientific article published on 01 April 2000

The Highly Dynamic Nature of ERdj5 Is Key to Efficient Elimination of Aberrant Protein Oligomers through ER-Associated Degradation

scientific article published on 2 May 2017

The membrane topology of vitamin K epoxide reductase is conserved between human isoforms and the bacterial enzyme.

scientific article published on 15 January 2016

The α-proteobacteria Wolbachia pipientis protein disulfide machinery has a regulatory mechanism absent in γ-proteobacteria.

scientific article

Zinc regulates ERp44-dependent protein quality control in the early secretory pathway

scientific article published in Nature Communications

List of works by Kenji Inaba

A PDI-catalyzed thiol-disulfide switch regulates the production of hydrogen peroxide by human Ero1.

A pH-regulated quality control cycle for surveillance of secretory protein assembly

A pair of circularly permutated PDZ domains control RseP, the S2P family intramembrane protease of Escherichia coli.

Antipsychotic olanzapine-induced misfolding of proinsulin in the endoplasmic reticulum accounts for atypical development of diabetes

Cell biology of cysteine-based molecular switches

Characterization of the ER-resident peroxidases GPx7 and GPx8 shows the higher oxidative activity of GPx7 and its linkage to oxidative protein folding

Characterization of the menaquinone-dependent disulfide bond formation pathway of Escherichia coli.

Conversion of two-state to multi-state folding kinetics on fusion of two protein foldons

Coupling effects of thiol and urea-type groups for promotion of oxidative protein folding

Critical role of a thiolate-quinone charge transfer complex and its adduct form in de novo disulfide bond generation by DsbB.

Cryo-EM structures of SERCA2b reveal the mechanism of regulation by the luminal extension tail

Crystal structure of a protein with an artificial exon-shuffling, module M4-substituted chimera hemoglobin beta alpha, at 2.5 A resolution

Crystal structure of the DsbB-DsbA complex reveals a mechanism of disulfide bond generation.

Crystal structures of human Ero1α reveal the mechanisms of regulated and targeted oxidation of PDI

Cysteines 208 and 241 in Ero1α are required for maximal catalytic turnover

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics.

Design, construction, crystallization, and preliminary X-ray studies of a fine-tuning mutant (F133V) of module-substituted chimera hemoglobin

Disulfide bond formation network in the three biological kingdoms, bacteria, fungi and mammals.

Disulfide bond formation system in Escherichia coli.

DsbB elicits a red-shift of bound ubiquinone during the catalysis of DsbA oxidation.

Dynamic assembly of protein disulfide isomerase in catalysis of oxidative folding

Dynamic nature of disulphide bond formation catalysts revealed by crystal structures of DsbB

Ero1-Mediated Reoxidation of Protein Disulfide Isomerase Accelerates the Folding of Cone Snail Toxins

Homodimerization of Nemo-like kinase is essential for activation and nuclear localization

Human ER Oxidoreductin-1α (Ero1α) Undergoes Dual Regulation through Complementary Redox Interactions with Protein-Disulfide Isomerase.

Identification of the physiological substrates of PDIp, a pancreas-specific protein disulfide isomerase family member

Identification of the redox partners of ERdj5/JPDI, a PDI family member, from an animal tissue

Inhibition of the functional interplay between endoplasmic reticulum (ER) oxidoreduclin-1α (Ero1α) and protein-disulfide isomerase (PDI) by the endocrine disruptor bisphenol A.

Methods to identify the substrates of thiol-disulfide oxidoreductases

Molecular bases of cyclic and specific disulfide interchange between human ERO1alpha protein and protein-disulfide isomerase (PDI).

Observing the nonvectorial yet cotranslational folding of a multidomain protein, LDL receptor, in the ER of mammalian cells

One-Dimensional Sliding of p53 Along DNA Is Accelerated in the Presence of Ca(2+) or Mg(2+) at Millimolar Concentrations.

PDI Family Members as Guides for Client Folding and Assembly

Paradoxical redox properties of DsbB and DsbA in the protein disulfide-introducing reaction cascade.

Preparation of Selenoinsulin as a Long-Lasting Insulin Analogue.

Progressive quality control of secretory proteins in the early secretory compartment by ERp44

Radically different thioredoxin domain arrangement of ERp46, an efficient disulfide bond introducer of the mammalian PDI family

Redox-assisted regulation of Ca2+ homeostasis in the endoplasmic reticulum by disulfide reductase ERdj5.

Redox-dependent domain rearrangement of protein disulfide isomerase coupled with exposure of its substrate-binding hydrophobic surface

Role of the cytosolic loop of DsbB in catalytic turnover of the ubiquinone-DsbB complex.

Structural Basis of Sarco/Endoplasmic Reticulum Ca2+-ATPase 2b Regulation via Transmembrane Helix Interplay

Structural and functional effects of pseudo-module substitution in hemoglobin subunits. New structural and functional units in globin structure

Structural and functional roles of heme binding module in globin proteins: identification of the segment regulating the heme binding structure.

Structural and functional roles of modules in hemoglobin. Substitution of module M4 in hemoglobin subunits

Structural basis of a Ni acquisition cycle for [NiFe] hydrogenase by Ni-metallochaperone HypA and its enhancer

Structural basis of pH-dependent client binding by ERp44, a key regulator of protein secretion at the ER-Golgi interface.

Structural basis of protein disulfide bond generation in the cell.

Structure and mechanisms of the DsbB-DsbA disulfide bond generation machine.

Structure, mechanism, and evolution of Ero1 family enzymes.

Structures and functions of protein disulfide isomerase family members involved in proteostasis in the endoplasmic reticulum

Structures, Mechanisms, and Physiological Functions of Zinc Transporters in Different Biological Kingdoms

Substitution of the heme binding module in hemoglobin alpha- and beta-subunits. Implication for different regulation mechanisms of the heme proximal structure between hemoglobin and myoglobin

The Highly Dynamic Nature of ERdj5 Is Key to Efficient Elimination of Aberrant Protein Oligomers through ER-Associated Degradation

The membrane topology of vitamin K epoxide reductase is conserved between human isoforms and the bacterial enzyme.

The α-proteobacteria Wolbachia pipientis protein disulfide machinery has a regulatory mechanism absent in γ-proteobacteria.

Zinc regulates ERp44-dependent protein quality control in the early secretory pathway