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List of works by Frank Tacke

A Randomized, Placebo-Controlled Trial of Cenicriviroc for Treatment of Nonalcoholic Steatohepatitis with Fibrosis.

scientific article published on 17 August 2017

A not so easy genotype-striking regional differences in SOF/RBV treatment responses in HCV GT2.

scientific article published in August 2017

A novel model of demyelinating encephalomyelitis induced by monocytes and dendritic cells

scientific article published on 01 November 2006

A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis

scientific article

A rare case of HBV genotype fluctuation (shifting and reversion) after liver transplantation

scientific article published on 21 August 2015

Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults

scientific article

Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts.

scientific article

Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans

scientific article

Antiviral Therapy in Patients with Viral Hepatitis and Hepatocellular Carcinoma: Indications and Prognosis

scientific article

Artificial intelligence and pathology: From principles to practice and future applications in histomorphology and molecular profiling

scientific article published on 23 February 2021

BMP feed-forward loop promotes terminal differentiation in gastric glands and is interrupted by H. pylori-driven inflammation

scientific article published on 24 March 2022

Basal core promoter and precore mutations in the hepatitis B virus genome enhance replication efficacy of Lamivudine-resistant mutants

scientific article

Baseline risk factors determine lack of biochemical response after SVR in chronic hepatitis C patients treated with DAAs

scientific article published on 25 July 2019

Bile duct ligation in mice: induction of inflammatory liver injury and fibrosis by obstructive cholestasis

scientific article

Blood monocyte subsets differentially give rise to CD103+ and CD103- pulmonary dendritic cell populations

scientific article published on 01 March 2008

CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis.

scientific article

CCR2 mediates homeostatic and inflammatory release of Gr1(high) monocytes from the bone marrow, but is dispensable for bladder infiltration in bacterial urinary tract infection

scientific journal article

Cenicriviroc Treatment for Adults with Nonalcoholic Steatohepatitis and Fibrosis: Final Analysis of the Phase 2b CENTAUR Study

scientific article published on 13 January 2020

Chemokine receptor CCR6-dependent accumulation of γδ T cells in injured liver restricts hepatic inflammation and fibrosis.

scientific article

Circulating Levels of Osteopontin Predict Patients' Outcome after Resection of Colorectal Liver Metastases

scientific article published on 26 October 2018

Circulating levels of microRNA193a-5p predict outcome in early stage hepatocellular carcinoma

scientific article published on 22 September 2020

Circulating microRNA-150 serum levels predict survival in patients with critical illness and sepsis

scientific article

Clinical relevance of copeptin plasma levels as a biomarker of disease severity and mortality in critically ill patients

scientific article published on 05 July 2018

Combining GP73 with liver stiffness measurements: A proof-of-concept for non-invasive fibrosis assessment in antiviral-naïve HBV patients.

scientific article published in November 2017

Comparison of gene expression profiles between human and mouse monocyte subsets

scientific article

Deciphering the Immune Microenvironment on A Single Archival Formalin-Fixed Paraffin-Embedded Tissue Section by An Immediately Implementable Multiplex Fluorescence Immunostaining Protocol

scientific article published on 28 August 2020

Differential impact of the dual CCR2/CCR5 inhibitor cenicriviroc on migration of monocyte and lymphocyte subsets in acute liver injury

scientific article

Distinct histopathological phenotypes of severe alcoholic hepatitis suggest different mechanisms driving liver injury and failure

scientific article published in 2022

Editorial: prevalence, progression rates and mortality predictors of non-alcoholic fatty liver disease reflected by German statutory health insurance data

scientific article published on 01 October 2020

Elevated MR-proANP plasma concentrations are associated with sepsis and predict mortality in critically ill patients

scientific article published on 12 December 2019

Elevated Serum Levels of Mixed Lineage Kinase Domain-Like Protein Predict Survival of Patients during Intensive Care Unit Treatment.

scientific article published on 11 February 2018

Elevated circulating soluble interleukin-2 receptor in patients with chronic liver diseases is associated with non-classical monocytes

scientific article

Erratum: Hohlstein, P. et al. Prognostic Relevance of Altered Lymphocyte Subpopulations in Critical Illness and Sepsis. Journal of Clinical Medicine 2019, 8, 353

scientific article published on 23 August 2019

Establishment of gastrointestinal assembloids to study the interplay between epithelial crypts and their mesenchymal niche

scientific article published in 2023

Experimental liver fibrosis research: update on animal models, legal issues and translational aspects

scientific article published on October 2013

Fibrogenic Pathways in Metabolic Dysfunction Associated Fatty Liver Disease (MAFLD)

scientific article published in 2022

From proteomic multimarker profiling to interesting proteins: thymosin-β(4) and kininogen-1 as new potential biomarkers for inflammatory hepatic lesions

scientific article

Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis

scientific article

Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice

scientific article

Genomic Diversity of Hepatitis B Virus Infection Associated With Fulminant Hepatitis B Development

scientific article

Gold Nanocarriers for Macrophage-Targeted Therapy of Human Immunodeficiency Virus.

scientific article

Growth Differentiation Factor-15 Is a Predictor of Mortality in Critically Ill Patients with Sepsis.

scientific article published on 18 October 2017

Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function.

scientific article

Hepatic recruitment of the inflammatory Gr1+monocyte subset upon liver injury promotes hepatic fibrosis

scientific article published on 01 July 2009

High Circulating Caspase-Cleaved Keratin 18 Fragments (M30) Indicate Short-Term Mortality in Critically Ill Patients

scientific article published on 08 July 2018

High Protein Intake Is Associated With Histological Disease Activity in Patients With NAFLD

scientific article published on 26 March 2020

High mobility group box 1 as a biomarker in critically ill patients

article

How effective are nonalcoholic fatty liver disease models for drug discovery?

scientific article published on 11 June 2020

Identifying High-Risk NASH Patients: What We Know so Far

scientific article published on 21 August 2020

Immature monocytes acquire antigens from other cells in the bone marrow and present them to T cells after maturing in the periphery

scientific article

Immune surveillance of liver cancer in non-alcoholic fatty liver disease: excess lipids cause CD4 T-cells loss and promote hepatocellular carcinoma development

scientific article

Impact of Angiogenesis- and Hypoxia-Associated Polymorphisms on Tumor Recurrence in Patients with Hepatocellular Carcinoma Undergoing Surgical Resection

scientific article published on 18 December 2020

In Vivo Models for Cholangiocarcinoma-What Can We Learn for Human Disease?

scientific article published on 15 July 2020

Increased liver stiffness denotes hepatic dysfunction and mortality risk in critically ill non-cirrhotic patients at a medical ICU

scientific article

Inhibition of LTβR signalling activates WNT-induced regeneration in lung

scientific article published on 04 November 2020

Interleukin-8 Is Activated in Patients with Chronic Liver Diseases and Associated with Hepatic Macrophage Accumulation in Human Liver Fibrosis ⬇️

scientific article published on June 22, 2011

Interleukins in chronic liver disease: lessons learned from experimental mouse models

scientific article

Ischemia-Reperfusion Injury in Marginal Liver Grafts and the Role of Hypothermic Machine Perfusion: Molecular Mechanisms and Clinical Implications

scientific article published on 20 March 2020

Isolation and Culture of Primary Murine Hepatic Stellate Cells

scientific article published in January 2017

Langerhans cells arise from monocytes in vivo

scientific article

Liver Macrophages: Old Dogmas and New Insights.

scientific article published on 22 April 2019

Liver inflammation abrogates immunological tolerance induced by Kupffer cells.

scientific article published on 22 April 2015

Machine perfusion for liver transplantation in the era of marginal organs-New kids on the block

scientific article published on 29 September 2018

Management of hepatitis C virus infection in the Asia-Pacific region: an update

scientific article

Mechanisms of liver fibrosis resolution

scientific article

Micro-RNA Profiling in Human Serum Reveals Compartment-Specific Roles of miR-571 and miR-652 in Liver Cirrhosis ⬇️

scientific article published on March 7, 2012

Midregional Proadrenomedullin (MRproADM) Serum Levels in Critically Ill Patients Are Associated with Short-Term and Overall Mortality during a Two-Year Follow-Up

scientific article published on 07 August 2020

Migratory fate and differentiation of blood monocyte subsets

scientific article published on 10 July 2006

Modulation of dendritic cell trafficking to and from the airways

scientific article published on 01 March 2006

Molecular identification of hepatitis B virus genotypes/subgenotypes: revised classification hurdles and updated resolutions

scientific article

Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques

scientific article

Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice

scientific article

Myeloid cells in liver and bone marrow acquire a functionally distinct inflammatory phenotype during obesity-related steatohepatitis

scientific article published on 10 May 2019

Neutrophils are a main source of circulating suPAR predicting outcome in critical illness

scientific article published on 27 April 2019

New drugs for NAFLD: lessons from basic models to the clinic

scientific article published on 04 December 2019

Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications

scientific article published on 30 June 2018

Outcomes of Liver Resections after Liver Transplantation at a High-Volume Hepatobiliary Center

scientific article published on 17 November 2020

Overexpression of c-myc in hepatocytes promotes activation of hepatic stellate cells and facilitates the onset of liver fibrosis

scientific journal article

Pharmacological Intervention in Hepatic Stellate Cell Activation and Hepatic Fibrosis

scientific article

Pharmacological inhibition of the chemokine CXCL16 diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury

scientific article

Prevention and Management of CMV Infections after Liver Transplantation: Current Practice in German Transplant Centers

scientific article published on 23 July 2020

Prevention of stress-related ulcer bleeding at the intensive care unit: Risks and benefits of stress ulcer prophylaxis

scientific article

Primary Neuroendocrine Neoplasms of the Breast: Case Series and Literature Review

scientific article published on 20 March 2020

Primary cultures of glomerular parietal epithelial cells or podocytes with proven origin

scientific article

Prognostic Relevance of Altered Lymphocyte Subpopulations in Critical Illness and Sepsis

scientific article published on 12 March 2019

Publisher Correction: Inhibition of LTβR signalling activates WNT-induced regeneration in lung

scientific article published on 22 December 2020

Recent Advances and the Potential for Clinical Use of Autofluorescence Detection of Extra-Ophthalmic Tissues

scientific article published on 30 April 2020

Recent advances in understanding liver fibrosis: bridging basic science and individualized treatment concepts.

scientific article published on 27 June 2018

Regulation and prognostic relevance of serum ghrelin concentrations in critical illness and sepsis

scientific article

Regulatory T cells and immune tolerance to coagulation factor IX in the context of intramuscular AAV1 gene transfer

scientific article

Relevance of Autophagy in Parenchymal and Non-Parenchymal Liver Cells for Health and Disease

article

Relevance of serum leptin and leptin-receptor concentrations in critically ill patients

scientific article

Report on the AASLD/EASL Joint Workshop on Clinical Trial Endpoints in NAFLD

scientific article published on 09 July 2019

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

scientific article published on 09 October 2019

Response to the "Letter to the editor regarding article, 'High-mobility group box 1 as a biomarker in critically ill patients'."

scientific article published on 25 November 2018

Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes

scientific article published on 8 November 2004

Serum Levels of Kisspeptin Are Elevated in Patients with Pancreatic Cancer

scientific article published on 20 October 2019

Serum Levels of miR-143 Predict Survival in Critically Ill Patients

scientific article published on 23 October 2019

Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis

scientific article published on 17 April 2020

Serum levels of circulating microRNA-107 are elevated in patients with early-stage HCC

scientific article published on 12 March 2021

Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis

scientific article published on 11 August 2015

Single Cell RNA Sequencing Identifies Subsets of Hepatic Stellate Cells and Myofibroblasts in Liver Fibrosis

scientific article published on 24 May 2019

Soluble Urokinase Plasminogen Activator Receptor (suPAR) Concentrations are Elevated in Patients with Neuroendocrine Malignancies

scientific article published on 31 May 2020

TNFα-mediated liver destruction by Kupffer cells and Ly6Chi monocytes during Entamoeba histolytica infection

scientific article

The Effects of MELD-Based Liver Allocation on Patient Survival and Waiting List Mortality in a Country with a Low Donation Rate

scientific article published on 19 June 2020

The Unexpected Role of Neutrophils for Resolving Liver Inflammation by Transmitting MicroRNA-223 to Macrophages

scientific article published on 31 December 2019

The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD

scientific article published on 14 March 2022

The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance

scientific article

The role of the innate immune system in the development and treatment of hepatocellular carcinoma

scientific article published on 31 January 2020

Thrombopoietin serum levels are elevated in patients with hepatitis B/C infection compared to other causes of chronic liver disease

scientific article

Tip-DC development during parasitic infection is regulated by IL-10 and requires CCL2/CCR2, IFN-gamma and MyD88 signaling

scientific article

Treatment for hepatitis B in patients with drug resistance

scientific article

Treatment of Anti-HLA Donor-Specific Antibodies Results in Increased Infectious Complications and Impairs Survival after Liver Transplantation

scientific article published on 09 December 2020

Usefulness of suPAR as a biological marker in patients with systemic inflammation or infection: a systematic review

scientific article

Visfatin Serum Levels Predict Mortality in Critically Ill Patients

scientific article published on 26 August 2018

Y-box protein-1/p18 fragment identifies malignancies in patients with chronic liver disease

scientific article

miR-155 Predicts Long-Term Mortality in Critically Ill Patients Younger than 65 Years

scientific article published on 24 February 2019

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