List of works by Robert A. Holt

A Rapid and Sensitive Nucleic Acid Amplification Technique for Mycoplasma Screening of Cell Therapy Products

scientific article published on 30 January 2020

A census of predicted mutational epitopes suitable for immunologic cancer control.

scientific article published on 9 January 2010

A clinically validated diagnostic second-generation sequencing assay for detection of hereditary BRCA1 and BRCA2 mutations.

scientific article

A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome

scientific article

A high-throughput protocol for isolating cell-free circulating tumor DNA from peripheral blood

scientific article published on 01 February 2019

A high-throughput screen identifying sequence and promiscuity characteristics of the loxP spacer region in Cre-mediated recombination

scientific article

A library-based screening method identifies neoantigen-reactive T cells in peripheral blood prior to relapse of ovarian cancer.

scientific article published on 21 September 2017

A mouse atlas of gene expression: large-scale digital gene-expression profiles from precisely defined developing C57BL/6J mouse tissues and cells.

scientific article

A physical map of the highly heterozygous Populus genome: integration with the genome sequence and genetic map and analysis of haplotype variation

article

A regulatory toolbox of MiniPromoters to drive selective expression in the brain

scientific article

A salmonid EST genomic study: genes, duplications, phylogeny and microarrays

scientific article

A survey of Fusobacterium nucleatum genes modulated by host cell infection

scientific article published on 29 October 2019

Activation of an endogenous retrovirus-associated long non-coding RNA in human adenocarcinoma.

scientific article published on 5 March 2015

Age- and disease-dependent HERV-W envelope allelic variation in brain: association with neuroimmune gene expression

scientific article (publication date: 29 April 2011)

An integrated strategy to study muscle development and myofilament structure in Caenorhabditis elegans

scientific article

Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression

scientific article

Assembly of the Complete Sitka Spruce Chloroplast Genome Using 10X Genomics' GemCode Sequencing Data.

scientific article

Automated high throughput nucleic acid purification from formalin-fixed paraffin-embedded tissue samples for next generation sequence analysis. ⬇️

scientific article

BACE1 gene promoter single-nucleotide polymorphisms in Alzheimer's disease

scientific article

Base excision repair deficiency signatures implicate germline and somatic MUTYH aberrations in pancreatic ductal adenocarcinoma and breast cancer oncogenesis

scientific article published on 01 April 2019

Brain microbiota disruption within inflammatory demyelinating lesions in multiple sclerosis

scientific article

Building Canadian capacity for CAR-T cells in relapsed/refractory acute lymphoblastic leukaemia: a retrospective cohort study

scientific article published on 20 July 2020

Cell-Based Therapeutics: Making a Faustian Pact with Biology.

scientific article published on 24 January 2017

Characteristics of TCR Repertoire Associated With Successful Immune Checkpoint Therapy Responses

scientific article published on 14 October 2020

Chronic diazepam exposure decreases transcription of the rat GABA(A) receptor gamma2-subunit gene.

scientific article published in August 1997

Chronic treatment with diazepam or abecarnil differently affects the expression of GABAA receptor subunit mRNAs in the rat cortex.

scientific article published in January 1996

Chronic zolpidem treatment alters GABAA receptor mRNA levels in the rat cortex ⬇️

scientific article published on June 25, 1997

Clonal evolution of high-grade serous ovarian carcinoma from primary to recurrent disease

scientific article published on 29 November 2012

Co-occurrence of anaerobic bacteria in colorectal carcinomas.

scientific article published on 15 May 2013

Combined immunodeficiency associated with homozygous MALT1 mutations

scientific article published on 12 December 2013

Comparative genome and proteome analysis of Anopheles gambiae and Drosophila melanogaster

scientific article (publication date: 4 October 2002)

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

article

Comprehensive Characterization of Cancer Driver Genes and Mutations

article

Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma

article

DNA copy-number analysis in bipolar disorder and schizophrenia reveals aberrations in genes involved in glutamate signaling.

scientific article published on 24 January 2006

Defining the clonality of peripheral T cell lymphomas using RNA-seq.

scientific article published on 21 December 2016

Derivation of HLA types from shotgun sequence datasets.

scientific article published on 10 December 2012

Efficacy and safety of chimeric antigen receptor T-cell (CAR-T) therapy in patients with haematological and solid malignancies: protocol for a systematic review and meta-analysis.

scientific article published on 29 December 2017

Efficient assembly of very short oligonucleotides using T4 DNA Ligase ⬇️

scientific article published on November 9, 2010

Exhaustive T-cell repertoire sequencing of human peripheral blood samples reveals signatures of antigen selection and a directly measured repertoire size of at least 1 million clonotypes.

scientific article

Functional characterization of a catabolic plasmid from polychlorinated- biphenyl-degrading Rhodococcus sp. strain RHA1

scientific article (publication date: November 2004)

Functional genomics of the cilium, a sensory organelle

scientific journal article

Gene discovery for the bark beetle-vectored fungal tree pathogen Grosmannia clavigera.

scientific article

Generation, annotation, analysis and database integration of 16,500 white spruce EST clusters.

scientific article

Genome and transcriptome analyses of the mountain pine beetle-fungal symbiont Grosmannia clavigera, a lodgepole pine pathogen

scientific article

Genome and transcriptome biomarkers of response to immune checkpoint inhibitors in advanced solid tumours

scientific article published on 05 October 2020

Genome sequence of the Brown Norway rat yields insights into mammalian evolution

scientific article

Genome variation in Cryptococcus gattii, an emerging pathogen of immunocompetent hosts.

scientific article

Genomics of hybrid poplar (Populus trichocarpax deltoides) interacting with forest tent caterpillars (Malacosoma disstria): normalized and full-length cDNA libraries, expressed sequence tags, and a cDNA microarray for the study of [...]

scientific article

Identification by full-coverage array CGH of human DNA copy number increases relative to chimpanzee and gorilla.

scientific article

Identification of a CD8+ T-cell response to a predicted neoantigen in malignant mesothelioma

scientific article published on 03 November 2019

Identification of a set of genes showing regionally enriched expression in the mouse brain

scientific article

Immunogenomics: a foundation for intelligent immune design.

scientific article published on 19 November 2015

Immunotherapy for Lung Malignancies: From Gene Sequencing to Novel Therapies

scientific article

Increasing quality, throughput and speed of sample preparation for strand-specific messenger RNA sequencing

scientific article

Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer

scientific article published on 10 May 2018

Invasion by Fusobacterium nucleatum Causes Upregulation of dll4 and klf4 Expression in Caco2 Cells

scientific article published on 26 October 2020

Large-scale production of SAGE libraries from microdissected tissues, flow-sorted cells, and cell lines

scientific article

LongSAGE profiling of nine human embryonic stem cell lines.

scientific article published on January 2007

Low Mutation Burden in Ovarian Cancer May Limit the Utility of Neoantigen-Targeted Vaccines.

scientific article

Malignant cells from pleural fluids in malignant mesothelioma patients reveal novel mutations.

scientific article published on 9 March 2018

Metagenomic and metabolomic characterization of rabies encephalitis: new insights into the treatment of an ancient disease.

scientific article

Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution

scientific article (publication date: 8 October 2009)

Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival

scientific article

Neoantigen characteristics in the context of the complete predicted MHC class I self-immunopeptidome

scientific article published on 22 December 2018

Next generation tools for high-throughput promoter and expression analysis employing single-copy knock-ins at the Hprt1 locus.

scientific article published on 3 December 2008

Non-coding-regulatory regions of human brain genes delineated by bacterial artificial chromosome knock-in mice

scientific article

Nonlinear electrophoretic response yields a unique parameter for separation of biomolecules.

scientific article

Oligonucleotide microarray analysis of genomic imbalance in children with mental retardation

scientific article

Partnering with patients to get better outcomes with chimeric antigen receptor T-cell therapy: towards engagement of patients in early phase trials

scientific article published on 14 October 2020

Profiling tissue-resident T cell repertoires by RNA sequencing

scientific article published on 30 November 2015

Rapid selection and identification of functional CD8+ T cell epitopes from large peptide-coding libraries

scientific article published on 07 October 2019

Retina restored and brain abnormalities ameliorated by single-copy knock-in of human NR2E1 in null mice

scientific article published on 30 January 2012

Risks and Benefits of Chimeric Antigen Receptor T-Cell (CAR-T) Therapy in Cancer: A Systematic Review and Meta-Analysis

scientific article published on 14 February 2019

SP1 regulates a human SNAP-25 gene expression.

scientific article published on 10 January 2008

Salmo salar and Esox lucius full-length cDNA sequences reveal changes in evolutionary pressures on a post-tetraploidization genome.

scientific article

Sample Tracking Using Unique Sequence Controls

scientific article published on 16 December 2019

Satellog: a database for the identification and prioritization of satellite repeats in disease association studies.

scientific article

Sequence analysis of T-cell repertoires in health and disease.

scientific article published on 30 October 2013

Sequencing and analysis of 10,967 full-length cDNA clones from Xenopus laevis and Xenopus tropicalis reveals post-tetraploidization transcriptome remodeling

scientific article

Sequencing of the human IG light chain loci from a hydatidiform mole BAC library reveals locus-specific signatures of genetic diversity

scientific article

Simple, robust methods for high-throughput nanoliter-scale DNA sequencing

scientific article

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

scientific article

Surveillance of the tumor mutanome by T cells during progression from primary to recurrent ovarian cancer.

scientific article

Synthetic genomes brought closer to life.

scientific article published in March 2008

Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia

scientific article published on 02 July 2019

T-cell epitope discovery technologies

scientific article

Targeted CNS Delivery Using Human MiniPromoters and Demonstrated Compatibility with Adeno-Associated Viral Vectors.

scientific article published on January 2014

Targeting the undruggable: immunotherapy meets personalized oncology in the genomic era.

scientific article

The Anopheles gambiae genome: an update

scientific article published on February 2004

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

article

The Genome Sequence of the Malaria Mosquito Anopheles gambiae

scientific article

The Genome of Black Cottonwood, Populus trichocarpa (Torr. & Gray)

scientific article

The Genome sequence of the SARS-associated coronavirus

scientific article

The Immune Landscape of Cancer

scientific article published on 01 August 2019

The Immune Landscape of Cancer.

scientific article published on 4 April 2018

The North American bullfrog draft genome provides insight into hormonal regulation of long noncoding RNA.

scientific article

The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse

scientific article

The completion of the Mammalian Gene Collection (MGC).

scientific article published on 18 September 2009

The genome sequence of Drosophila melanogaster

scientific article

The genome sequence of taurine cattle: a window to ruminant biology and evolution

scientific article

The molecular signature and cis-regulatory architecture of a C. elegans gustatory neuron.

scientific article

The new paradigm of flow cell sequencing.

scientific article published on June 2008

The sensitivity of massively parallel sequencing for detecting candidate infectious agents associated with human tissue

scientific article published on 13 May 2011

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

scientific article

Transient Treg depletion enhances therapeutic anti-cancer vaccination.

scientific article

Tumor Potentiating Mechanisms of Fusobacterium nucleatum, A Multifaceted Microbe.

scientific article published on 28 January 2017

Twenty-Seven Tamoxifen-Inducible iCre-Driver Mouse Strains for Eye and Brain, Including Seventeen Carrying a New Inducible-First Constitutive-Ready Allele

article

Whole exome sequencing of an asbestos-induced wild-type murine model of malignant mesothelioma

scientific article

Whole-genome sequencing and social-network analysis of a tuberculosis outbreak

scientific article (publication date: 24 February 2011)

XLF deficiency results in reduced N-nucleotide addition during V(D)J recombination.

scientific article

rAAV-compatible MiniPromoters for restricted expression in the brain and eye.

scientific article published on 10 May 2016

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