List of works by Ronald N. Germain

A Tunable Diffusion-Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell-to-Cell Communication in the Immune System.

scientific article

A decade of imaging cellular motility and interaction dynamics in the immune system

scientific article

A plaidoyer for 'systems immunology'.

scientific article

A remembrance of Baruj Benacerraf (AAI '57) 1920-2011.

scientific article

A small sustained increase in NOD1 abundance promotes ligand-independent inflammatory and oncogene transcriptional responses

scientific article published on 08 December 2020

A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread

scientific article

A systems analysis identifies a feedforward inflammatory circuit leading to lethal influenza infection

scientific article published on July 2013

AS03-adjuvanted H5N1 vaccine promotes antibody diversity and affinity maturation, NAI titers, cross-clade H5N1 neutralization, but not H1N1 cross-subtype neutralization

Adjuvant and carrier protein-dependent T-cell priming promotes a robust antibody response against the Plasmodium falciparum Pfs25 vaccine candidate

scientific article published on 16 January 2017

Allergen-Induced CD4+ T Cell Cytokine Production within Airway Mucosal Dendritic Cell-T Cell Clusters Drives the Local Recruitment of Myeloid Effector Cells

scientific article

An extended vision for dynamic high-resolution intravital immune imaging.

scientific article

An innately interesting decade of research in immunology

scientific article

An interactive web-based application for Comprehensive Analysis of RNAi-screen Data

scientific article

Analyzing Inter-Leukocyte Communication and Migration <i>In Vitro</i>: Neutrophils Play an Essential Role in Monocyte Activation During Swarming

scientific article published on 12 May 2021

Antigen- and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean mice

scientific article published on April 2015

B-cell follicle development remodels the conduit system and allows soluble antigen delivery to follicular dendritic cells

scientific article published on 27 August 2009

Baruj Benacerraf (1920-2011).

scientific article

CD4 T follicular helper cell dynamics during SIV infection

scientific article

CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming

scientific article published on 8 February 2017

Cancer prognosis with shallow tumor RNA sequencing

scientific article published on 10 February 2020

Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in vivo

scientific article

Chemokine-guided CD4+ T cell help enhances generation of IL-6RalphahighIL-7Ralpha high prememory CD8+ T cells

scientific article published on 01 January 2007

Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction.

scientific article published in April 2006

Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo

scientific article

Co-stimulatory function in primary germinal center responses: CD40 and B7 are required on distinct antigen-presenting cells.

scientific article

Commensal Microbiota Promote Lung Cancer Development via γδ T Cells

scientific article published on 31 January 2019

Commensal-driven immune zonation of the liver promotes host defence

scientific article published on 25 November 2020

Computational analysis of T cell receptor signaling and ligand discrimination – Past, present, and future ⬇️

scientific article published on October 20, 2010

Computational modeling of cellular signaling processes embedded into dynamic spatial contexts

scientific article

Computational reconstruction of cell and tissue surfaces for modeling and data analysis

scientific article published on 4 June 2009

Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node

scientific article

Continuous volumetric imaging via an optical phase-locked ultrasound lens

scientific article

Cooperation between CD4+ and CD8+ T cells: when, where, and how.

scientific article

Corrigendum: An interactive web-based application for Comprehensive Analysis of RNAi-screen Data.

scientific article published on 21 March 2016

DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity

scientific article

Decreased CD4 expression by polarized T helper 2 cells contributes to suboptimal TCR-induced phosphorylation and reduced Ca2+ signaling

scientific article

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

scientific article published on 02 August 2016

Dendritic cell and antigen dispersal landscapes regulate T cell immunity

scientific article

Distinct NF-κB and MAPK Activation Thresholds Uncouple Steady-State Microbe Sensing from Anti-pathogen Inflammatory Responses.

scientific article published on 26 May 2016

Distinct contributions of different CD40 TRAF binding sites to CD154-induced dendritic cell maturation and IL-12 secretion

scientific article

Dynamic imaging of T cell-dendritic cell interactions in lymph nodes

scientific article published on 01 June 2002

Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement

scientific article

Dynamic imaging of the immune system: progress, pitfalls and promise

scientific article published on July 2006

Dynamic visualization of RANKL and Th17-mediated osteoclast function.

scientific article

ERM proteins regulate cytoskeleton relaxation promoting T cell–APC conjugation

scientific article published on 01 February 2004

Erratum: Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis

scientific article published in Nature

Erratum: correction: The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate

scientific article published in Nature

Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells

scientific article published on 01 June 2006

Fibroblastic reticular cells guide T lymphocyte entry into and migration within the splenic T cell zone

scientific article

Focusing in on T cell cross-reactivity

scientific article published on May 2014

Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies

scientific article published on January 2017

Global analyses of human immune variation reveal baseline predictors of postvaccination responses

scientific article

Healing the NIH-Funded Biomedical Research Enterprise

scientific article published in June 2015

High endothelial venules as traffic control points maintaining lymphocyte population homeostasis in lymph nodes

scientific article published on 21 September 2011

High-dimensional cell-level analysis of tissues with Ce3D multiplex volume imaging

scientific article published on 26 April 2019

Highways, byways and breadcrumbs: directing lymphocyte traffic in the lymph node.

scientific article published on 10 July 2007

Histo-cytometry: a method for highly multiplex quantitative tissue imaging analysis applied to dendritic cell subset microanatomy in lymph nodes

scientific article

Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells

scientific article published on 12 August 2019

House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

scientific article

Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity

article

IBEX: A versatile multiplex optical imaging approach for deep phenotyping and spatial analysis of cells in complex tissues

scientific article published on 21 December 2020

IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses

scientific article published on 06 August 2019

ILC2s - resident lymphocytes pre-adapted to a specific tissue or migratory effectors that adapt to where they move?

scientific article published on 23 November 2018

Illuminating the landscape of in vivo immunity: insights from dynamic in situ imaging of secondary lymphoid tissues

scientific article published in September 2004

Imaging of T-cell interactions with antigen presenting cells in culture and in intact lymphoid tissue.

scientific article

Immune Modulation Therapy and Imaging: Workshop Report

scientific article published on 17 August 2017

Immune complexes stimulate CCR7-dependent dendritic cell migration to lymph nodes

scientific article

Immune homeostasis enforced by co-localized effector and regulatory T cells

scientific article

Immune regulation by glucocorticoids can be linked to cell type-dependent transcriptional responses

scientific article published on 23 January 2019

In vivo antigen presentation.

scientific article published on February 2004

In vivo imaging reveals an essential role for neutrophils in leishmaniasis transmitted by sand flies.

scientific article published on August 2008

Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism.

scientific article published on 22 January 2018

Intradermal Delivery of Bacteria by Using Microneedle Arrays

scientific article published on 22 August 2018

Intravital imaging reveals limited antigen presentation and T cell effector function in mycobacterial granulomas.

scientific article

Intubation-free in vivo imaging of the tracheal mucosa using two-photon microscopy.

scientific article

Key role of local regulation in chemosensing revealed by a new molecular interaction-based modeling method

scientific article

Key role of local regulation in chemosensing revealed by a new molecular interaction-based modeling method

scientific article published on 25 May 2006

L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells.

scientific article published on 27 May 2007

Life and death as a T lymphocyte: from immune protection to HIV pathogenesis

scientific article

Ligand-dependent regulation of T cell development and activation

scientific article

Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance

scientific article published on 05 December 2019

Lymph-node resident CD8α+ dendritic cells capture antigens from migratory malaria sporozoites and induce CD8+ T cell responses

scientific article

MHC-dependent survival of naïve T cells? A complicated answer to a simple question

scientific article

Macrophage and T cell dynamics during the development and disintegration of mycobacterial granulomas

scientific article

Making friends in out-of-the-way places: how cells of the immune system get together and how they conduct their business as revealed by intravital imaging

scientific article published on 01 February 2008

Memory-phenotype CD4+ T cells spontaneously generated under steady-state conditions exert innate TH1-like effector function

scientific article

Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity

scientific article published on October 2015

Migrating Myeloid Cells Sense Temporal Dynamics of Chemoattractant Concentrations

scientific article published in November 2017

Modeling T cell antigen discrimination based on feedback control of digital ERK responses

scientific article

Multiplex, quantitative cellular analysis in large tissue volumes with clearing-enhanced 3D microscopy (Ce3D).

scientific article published on 14 August 2017

NK-DC crosstalk controls the autopathogenic Th17 response through an innate IFN-γ-IL-27 axis

scientific article

National Cancer Institute Think-Tank Meeting Report on Proteomic Cartography and Biomarkers at the Single-Cell Level: Interrogation of Premalignant Lesions

scientific article published on 02 April 2020

Natural killer cell behavior in lymph nodes revealed by static and real-time imaging.

scientific article

Navigating the network: signaling cross-talk in hematopoietic cells.

scientific article published on 19 March 2009

Network representations of immune system complexity

scientific article

Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo

scientific article

Niche-Specific Re-Programming of Epigenetic Landscapes Drives Myeloid Cell Diversity in NASH

scientific article published on 27 February 2020

Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis

scientific article published on 28 April 2020

Obituary: Charles A. Janeway Jr (1943-2003).

scientific article

On the role of self-recognition in T cell responses to foreign antigen

scientific article

Open questions: a rose is a rose is a rose--or not?

scientific article published on 31 January 2014

Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84.

scientific article

Pathogen-related differences in the abundance of presented antigen are reflected in CD4+ T cell dynamic behavior and effector function in the lung

scientific article

Peripheral prepositioning and local CXCL9 chemokine-mediated guidance orchestrate rapid memory CD8+ T cell responses in the lymph node

scientific article

Perspectives for computer modeling in the study of T cell activation

scientific article

Prime and target immunization protects against liver-stage malaria in mice

scholarly article by Anita Gola et al published 26 September 2018 in Science Translational Medicine

Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets.

scientific article

Quantification of lymph node transit times reveals differences in antigen surveillance strategies of naive CD4+ and CD8+ T cells

scientific article

Quantifying cellular interaction dynamics in 3D fluorescence microscopy data

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Quantifying in situ adaptive immune cell cognate interactions in humans

scientific article published on 18 February 2019

Quantitative challenges in understanding ligand discrimination by alphabeta T cells

scientific article

Recent progress using systems biology approaches to better understand molecular mechanisms of immunity

scientific article published on 11 December 2012

Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction

scientific article

Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage

scientific article published on 04 April 2019

Response to 'Class II essential for CD4 survival'

article

Revisiting thymic positive selection and the mature T cell repertoire for antigen

scientific article

Robust control of the adaptive immune system

scientific article published on 29 December 2017

S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense.

scientific article

SAP-controlled T-B cell interactions underlie germinal centre formation

scientific article published on October 2008

Seeing is believing: a focus on the contribution of microscopic imaging to our understanding of immune system function

scientific article published on November 2007

Self-recognition and the regulation of CD4+ T cell survival.

scientific article

Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes

scientific article

Spatial distribution and function of T follicular regulatory cells in human lymph nodes

scientific article published on 16 May 2018

Spatial mapping of protein composition and tissue organization: a primer for multiplexed antibody-based imaging

scientific article published in 2021

Spatiotemporal basis of innate and adaptive immunity in secondary lymphoid tissue

scientific article

Special regulatory T-cell review: A rose by any other name: from suppressor T cells to Tregs, approbation to unbridled enthusiasm

scientific article published on January 2008

Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis

scientific article

Strategically localized dendritic cells promote rapid T cell responses to lymph-borne particulate antigens

scientific article published on 27 December 2014

Stromal cell contributions to the homeostasis and functionality of the immune system.

scientific article

Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes

scientific article

Superpenetration optical microscopy by iterative multiphoton adaptive compensation technique

scientific article

Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity

scientific article published on 27 January 2017

Systems biology in immunology: a computational modeling perspective.

scientific article

T cell heterogeneity: firmly fixed, predominantly plastic or merely malleable?

scientific article published on 01 May 2008

T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigens

scientific article published on 03 January 2013

T-cell activation: the power of one.

scientific article

T-cell development and the CD4-CD8 lineage decision

scientific article

T-cell-receptor-dependent signal intensity dominantly controls CD4(+) T cell polarization In Vivo

scientific article

TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

scientific article published on 10 February 2003

Targeted Proteomics-Driven Computational Modeling of Macrophage S1P Chemosensing

scientific article

The Cellular Determinants of Adaptive Immunity

scientific article published on 10 September 2019

The Chemoattractant Receptor Ebi2 Drives Intranodal Naive CD4+ T Cell Peripheralization to Promote Effective Adaptive Immunity

scientific article published on 30 April 2019

The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation

scientific article

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.

scientific article

The future of immunoimaging--deeper, bigger, more precise, and definitively more colorful.

scientific article

The human condition: an immunological perspective

scientific article

The in situ dynamics of dendritic cell interactions ⬇️

scientific article published on August 1, 2010

The lymph node at a glance - how spatial organization optimizes the immune response

scientific article published on 06 March 2020

The multiple faces of leukocyte interstitial migration

scientific article

The race for the prize: T-cell trafficking strategies for optimal surveillance

scientific article

Thinking differently about ILCs-Not just tissue resident and not just the same as CD4 T-cell effectors

scientific article published on 01 November 2018

Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors

scientific article published on 01 March 2019

Trafficking of a dual-modality magnetic resonance and fluorescence imaging superparamagnetic iron oxide-based nanoprobe to lymph nodes.

scientific article

Tuning of antigen sensitivity by T cell receptor-dependent negative feedback controls T cell effector function in inflamed tissues

scientific article

Uncovering the role of invariant chain in controlling MHC class II antigen capture

scientific article

Vaccines and the future of human immunology

scientific article published on October 2010

Variability and robustness in T cell activation from regulated heterogeneity in protein levels

scientific article

Visualization and dynamic analysis of host-pathogen interactions

scientific article published on 03 April 2014

Visualization and identification of IL-7 producing cells in reporter mice

scientific article

Will Systems Biology Deliver Its Promise and Contribute to the Development of New or Improved Vaccines? What Really Constitutes the Study of "Systems Biology" and How Might Such an Approach Facilitate Vaccine Design

scientific article published on 16 October 2017

William E. Paul (1936-2015).

scientific article published on October 2015

William E. Paul, M.D. (1936-2015), President, The American Association of Immunologists, 1986-1987.

scientific article published in December 2015

William E. Paul, M.D. (1936–2015).

scientific article

William E. Paul, MD (1936-2015)

scientific article published on 01 December 2015

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