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List of works by Mark T Nelson

A PLCγ1-dependent, force-sensitive signaling network in the myogenic constriction of cerebral arteries.

scientific article

A spoonful of sugar helps the KV channel activity go down

scientific article published on 03 August 2006

AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension

scientific article

ATP induces guinea pig gallbladder smooth muscle excitability via the P2Y4 receptor and COX-1 activity.

scientific article published on 24 April 2008

Acidosis dilates brain parenchymal arterioles by conversion of calcium waves to sparks to activate BK channels.

scientific article published on 17 November 2011

Activation of multiple mitogen-activated protein kinase signal transduction pathways by the endothelin B receptor requires the cytoplasmic tail

scientific article published on 01 December 1996

Activity-dependent NFATc3 nuclear accumulation in pericytes from cortical parenchymal microvessels

scientific article published on 19 September 2007

Adenosine activates ATP-sensitive potassium channels in arterial myocytes via A2 receptors and cAMP-dependent protein kinase

scientific article

Amplified NO/cGMP-mediated relaxation and ryanodine receptor-to-BKCa channel signalling in corpus cavernosum smooth muscle from phospholamban knockout mice

scientific article

Astrocytic calcium signaling: the information currency coupling neuronal activity to the cerebral microcirculation

scientific article

Astrocytic endfoot Ca2+ and BK channels determine both arteriolar dilation and constriction.

scientific article

Bayliss, myogenic tone and volume-regulated chloride channels in arterial smooth muscle

scientific article published on 01 March 1998

Beta-adrenergic relaxation of mouse urinary bladder smooth muscle in the absence of large-conductance Ca2+-activated K+ channel.

scientific article published on 13 August 2008

Calcium and diabetic vascular dysfunction. Focus on "Elevated Ca(2+) sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cells".

scientific article published on 11 November 2009

Calcium signaling in smooth muscle.

scientific article

Calcium waves in intact guinea pig gallbladder smooth muscle cells.

scientific article

Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow

scientific article published on 20 March 2017

Central role of Ca2+-dependent regulation of vascular tone in vivo

scientific article published in July 2006

Chloride channel blockers inhibit myogenic tone in rat cerebral arteries

scientific article published on 01 July 1997

Development of stress-induced bladder insufficiency requires functional TRPV1 channels

scientific article published on 08 August 2018

Differential restoration of functional hyperemia by antihypertensive drug classes in hypertension-related cerebral small vessel disease

scientific article published on 05 August 2021

Dynamic inositol trisphosphate-mediated calcium signals within astrocytic endfeet underlie vasodilation of cerebral arterioles.

scientific article

Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function.

scientific article published on May 2012

Endothelial GqPCR activity controls capillary electrical signaling and brain blood flow through PIP2 depletion

scientific article published on 26 March 2018

Endothelial SK(Ca) and IK(Ca) channels regulate brain parenchymal arteriolar diameter and cortical cerebral blood flow.

scientific article published on 22 December 2010

Endothelial histamine H1 receptor signaling reduces blood-brain barrier permeability and susceptibility to autoimmune encephalomyelitis.

scientific article

Extracellular histones induce calcium signals in the endothelium of resistance-sized mesenteric arteries and cause loss of endothelium-dependent dilation

scientific article published on 08 March 2019

Frequency encoding of cholinergic- and purinergic-mediated signaling to mouse urinary bladder smooth muscle: modulation by BK channels

scientific article published on 24 August 2006

Functional architecture of inositol 1,4,5-trisphosphate signaling in restricted spaces of myoendothelial projections

scientific article

Functional coupling of calcineurin and protein kinase A in mouse ventricular myocytes.

scientific article

Fundamental increase in pressure-dependent constriction of brain parenchymal arterioles from subarachnoid hemorrhage model rats due to membrane depolarization.

scientific article

High blood pressure arising from a defect in vascular function.

scholarly article

Hydrophobic bile salts inhibit gallbladder smooth muscle function via stimulation of GPBAR1 receptors and activation of KATP channels.

scientific article published on 12 July 2010

Hypercontractility and impaired sildenafil relaxations in the BKCa channel deletion model of erectile dysfunction

scientific article published on 14 May 2008

Inhibition of vascular smooth muscle inward-rectifier K+ channels restores myogenic tone in mouse urinary bladder arterioles.

scientific article published in February 2017

Inositol trisphosphate receptor calcium release is required for cerebral artery smooth muscle cell proliferation.

scientific article

Intraluminal pressure is a stimulus for NFATc3 nuclear accumulation: role of calcium, endothelium-derived nitric oxide, and cGMP-dependent protein kinase

scientific article published on 19 December 2003

Inversion of neurovascular coupling by subarachnoid blood depends on large-conductance Ca2+-activated K+ (BK) channels.

scientific article

Inward rectifier potassium (Kir2.1) channels as end-stage boosters of endothelium-dependent vasodilators.

scientific article

Ion channels in smooth muscle: regulators of intracellular calcium and contractility.

scientific article

Local control of TRPV4 channels by AKAP150-targeted PKC in arterial smooth muscle

scientific article

Local potassium signaling couples neuronal activity to vasodilation in the brain.

scientific article published in November 2006

Location, Location, Location: Juxtaposed calcium-signaling microdomains as a novel model of the vascular smooth muscle myogenic response

scientific article published in August 2015

Mechanisms of enhanced basal tone of brain parenchymal arterioles during early postischemic reperfusion: role of ET-1-induced peroxynitrite generation.

scientific article published on 19 June 2013

Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics

scientific article published on August 2016

Membrane depolarization mediates phosphorylation and nuclear translocation of CREB in vascular smooth muscle cells.

scientific article

Molecular coding of Kv1 channels to oppose myogenic constriction

scientific article published on 01 July 2006

Morphological and physiological evidence for interstitial cell of Cajal-like cells in the guinea pig gallbladder

scientific article published on 04 January 2007

NFAT regulation in smooth muscle

scientific article

NFATc3 regulates BK channel function in murine urinary bladder smooth muscle.

scientific article published on 25 June 2008

NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions.

scientific article

Nerve-evoked purinergic signalling suppresses action potentials, Ca2+ flashes and contractility evoked by muscarinic receptor activation in mouse urinary bladder smooth muscle

scientific article published on 07 September 2009

Neurovascular signaling in the brain and the pathological consequences of hypertension

scientific article published on 25 October 2013

Opposing actions of inositol 1,4,5-trisphosphate and ryanodine receptors on nuclear factor of activated T-cells regulation in smooth muscle

scientific article

Opposing effects of aluminum on inward-rectifier potassium currents in bean root-tip protoplasts.

scientific article published in March 2004

Opposing roles of smooth muscle BK channels and ryanodine receptors in the regulation of nerve-evoked constriction of mesenteric resistance arteries

scientific article published on 07 February 2014

Orchestrating Ca2+ influx through Ca(V)1.2 and Ca(V)3.x channels in human cerebral arteries.

scientific article published on June 2015

Oxidation of cysteine 117 stimulates constitutive activation of the type Iα cGMP-dependent protein kinase

scientific article published in Journal of Biological Chemistry

PACAP38-Mediated Bladder Afferent Nerve Activity Hyperexcitability and Ca2+ Activity in Urothelial Cells from Mice

scientific article published on 19 July 2018

PIP depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells

scientific article published on 07 August 2018

Perturbations of the cerebrovascular matrisome: A convergent mechanism in small vessel disease of the brain?

scientific article published on 8 April 2015

Pharmacological inhibitors of TRPV4 channels reduce cytokine production, restore endothelial function and increase survival in septic mice

scientific article (publication date: 22 September 2016)

Pinacidil induces vascular dilation and hyperemia in vivo and does not impact biophysical properties of neurons and astrocytes in vitro.

scientific article published on April 2009

Potassium channelopathy-like defect underlies early-stage cerebrovascular dysfunction in a genetic model of small vessel disease.

scientific article

Pressure-induced oxidative activation of PKG enables vasoregulation by Ca2+ sparks and BK channels.

scientific article published on 11 October 2016

Properties and molecular basis of the mouse urinary bladder voltage-gated K+ current.

scientific article published on 4 April 2003

Properties of a tonically active, sodium-permeable current in mouse urinary bladder smooth muscle

scientific article published on 21 January 2004

Prostaglandin E2, a postulated astrocyte-derived neurovascular coupling agent, constricts rather than dilates parenchymal arterioles.

scientific article published on 6 February 2013

Protein kinases: tuners of the BKCa channel in smooth muscle.

scientific article

Purinergic regulation of vascular tone in the retrotrapezoid nucleus is specialized to support the drive to breathe.

scientific article

Purinergic signalling underlies transforming growth factor-β-mediated bladder afferent nerve hyperexcitability.

scientific article

Reduced Ca2+ spark activity after subarachnoid hemorrhage disables BK channel control of cerebral artery tone.

scientific article

Reducing Timp3 or vitronectin ameliorates disease manifestations in CADASIL mice.

scientific article published on 09 December 2015

Regulation of arterial tone by calcium-dependent K+ channels and ATP-sensitive K+ channels.

scientific article

Role for pituitary adenylate cyclase activating polypeptide in cystitis-induced plasticity of micturition reflexes

scientific article published in December 2005

Role of Ryanodine Type 2 Receptors in Elementary Ca Signaling in Arteries and Vascular Adaptive Responses

article

Ryanodine receptors, calcium signaling, and regulation of vascular tone in the cerebral parenchymal microcirculation.

scientific article published on May 2013

Small-conductance, Ca(2+) -activated K+ channel 2 is the key functional component of SK channels in mouse urinary bladder

scientific article published on 19 March 2008

Social stress induces changes in urinary bladder function, bladder NGF content, and generalized bladder inflammation in mice

scientific article

Stress-induced glucocorticoid signaling remodels neurovascular coupling through impairment of cerebrovascular inwardly rectifying K+ channel function

scientific article

Subarachnoid blood converts neurally evoked vasodilation to vasoconstriction in rat brain cortex.

scientific article published on January 2013

Sympathetic nerve stimulation induces local endothelial Ca2+ signals to oppose vasoconstriction of mouse mesenteric arteries.

scientific article

TRPV4 and KRAS and FGFR1 gain-of-function mutations drive giant cell lesions of the jaw

scientific article published in Nature Communications

TRPV4 channels stimulate Ca2+-induced Ca2+ release in astrocytic endfeet and amplify neurovascular coupling responses.

scientific article

TRPV4 forms a novel Ca2+ signaling complex with ryanodine receptors and BKCa channels.

scientific article

The K+ channel KIR2.1 functions in tandem with proton influx to mediate sour taste transduction.

scientific article

The KV 7 channel activator retigabine suppresses mouse urinary bladder afferent nerve activity without affecting detrusor smooth muscle K+ channel currents

scientific article published on 26 December 2018

Transient contractions of urinary bladder smooth muscle are drivers of afferent nerve activity during filling

scientific article published on 14 March 2016

Transient receptor potential (TRP) channels, vascular tone and autoregulation of cerebral blood flow.

scientific article

Transient receptor potential channels regulate myogenic tone of resistance arteries

scientific article published on 01 February 2002

Transient receptor potential vanilloid-4 channels are involved in diminished myogenic tone in brain parenchymal arterioles in response to chronic hypoperfusion in mice

scientific article published on 16 September 2018

Traumatic Brain Injury Causes Endothelial Dysfunction in the Systemic Microcirculation through Arginase-1-Dependent Uncoupling of Endothelial Nitric Oxide Synthase.

scientific article published on 13 January 2016

Uncoupling of neurovascular communication after transient global cerebral ischemia is caused by impaired parenchymal smooth muscle Kir channel function

scientific article published on 06 April 2016

Vascular TRP channels: performing under pressure and going with the flow

scientific article

Vascular control of the CO2/H+ dependent drive to breathe

scientific article published on 14 September 2020

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