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List of works by Bente Vilsen

A C-terminal mutation of ATP1A3 underscores the crucial role of sodium affinity in the pathophysiology of rapid-onset dystonia-parkinsonism

scientific article published on 7 April 2009

A Glu329-->Gln variant of the alpha-subunit of the rat kidney Na+,K(+)-ATPase can sustain active transport of Na+ and K+ and Na+,K(+)-activated ATP hydrolysis with normal turnover number

scientific article published on October 1993

A structural overview of the plasma membrane Na+,K+-ATPase and H+-ATPase ion pumps.

scientific article published on January 2011

ATP binding residues of sarcoplasmic reticulum Ca2+-ATPase.

scientific article published in April 2003

ATP-binding modes and functionally important interdomain bonds of sarcoplasmic reticulum Ca2+-ATPase revealed by mutation of glycine 438, glutamate 439, and arginine 678.

scientific article published on 15 May 2007

Alteration of intracellular Ca2+ transients in COS-7 cells transfected with the cDNA encoding skeletal-muscle ryanodine receptor carrying a mutation associated with malignant hyperthermia

scientific article published on August 1994

Amino acids Asn796 and Thr799 of the Ca(2+)-ATPase of sarcoplasmic reticulum bind Ca2+ at different sites.

scientific article published on June 1994

Arginine substitution of a cysteine in transmembrane helix M8 converts Na+,K+-ATPase to an electroneutral pump similar to H+,K+-ATPase

scientific article published on 27 December 2016

Asparagine 706 and glutamate 183 at the catalytic site of sarcoplasmic reticulum Ca2+-ATPase play critical but distinct roles in E2 states

scientific article published on 30 January 2006

Asparagine 905 of the mammalian phospholipid flippase ATP8A2 is essential for lipid substrate-induced activation of ATP8A2 dephosphorylation

scientific article published on 13 February 2019

Binding of cardiotonic steroids to Na<sup>+</sup>,K<sup>+</sup>-ATPase in the E2P state

scientific article published on 01 January 2021

Ca2+ occlusion in monomeric sarcoplasmic reticulum Ca-ATPase

scientific article published on 01 January 1988

Characterization of CrATP-induced calcium occlusion in membrane-bound and soluble monomeric sarcoplasmic reticulum Ca2+-ATPase

scientific article published on 01 April 1987

Characterization of detergent-solubilized sarcoplasmic reticulum Ca2+-ATPase by high-performance liquid chromatography

scientific article published in October 1986

Chimeric Ca(2+)-ATPase/Na+,K(+)-ATPase molecules. Their phosphoenzyme intermediates and sensitivity to Ca2+ and thapsigargin

scientific article published on 01 December 1993

CrATP-induced Ca2+ occlusion in mutants of the Ca(2+)-ATPase of sarcoplasmic reticulum

scientific article published on December 1992

Critical role of a transmembrane lysine in aminophospholipid transport by mammalian photoreceptor P4-ATPase ATP8A2

scientific article published on 17 January 2012

Critical roles of isoleucine-364 and adjacent residues in a hydrophobic gate control of phospholipid transport by the mammalian P4-ATPase ATP8A2.

scientific article published on 24 March 2014

Crystal structure of D351A and P312A mutant forms of the mammalian sarcoplasmic reticulum Ca(2+) -ATPase reveals key events in phosphorylation and Ca(2+) release

scientific article

Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state

scientific article published in Nature

Crystal structure of the sodium–potassium pump

scientific article

Decreased neuronal Na+, K+ -ATPase activity in Atp1a3 heterozygous mice increases susceptibility to depression-like endophenotypes by chronic variable stress

scientific article published on 13 April 2011

Deduced amino acid sequence and E1-E2 equilibrium of the sarcoplasmic reticulum Ca(2+)-ATPase of frog skeletal muscle. Comparison with the Ca(2+)-ATPase of rabbit fast twitch muscle

scientific article

Disease mutations reveal residues critical to the interaction of P4-ATPases with lipid substrates.

scientific article

Dissection of the functional differences between human secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and 2 isoenzymes by steady-state and transient kinetic analyses.

scientific article published on 6 December 2005

Dissection of the functional differences between sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) 1 and 2 isoforms and characterization of Darier disease (SERCA2) mutants by steady-state and transient kinetic analyses

scientific article published on 15 September 2003

Dissection of the functional differences between sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) 1 and 3 isoforms by steady-state and transient kinetic analyses

scientific article (publication date: 22 November 2002)

Distinct effects of Q925 mutation on intracellular and extracellular Na+ and K+ binding to the Na+, K+-ATPase

scientific article published on 16 September 2019

Distinct neurological disorders with ATP1A3 mutations

scientific article

Effect of phospholipid, detergent and protein-protein interaction on stability and phosphoenzyme isomerization of soluble sarcoplasmic reticulum Ca-ATPase

scientific article published in December 1987

Equilibrium between monomers and oligomers of soluble Ca2+-ATPase during the functional cycle

scientific article published on 01 September 1985

Fast kinetic analysis of conformational changes in mutants of the Ca(2+)-ATPase of sarcoplasmic reticulum

scientific article published on 01 February 2000

Functional comparison between secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and sarcoplasmic reticulum Ca2+-ATPase (SERCA) 1 isoforms by steady-state and transient kinetic analyses

scientific article

Functional consequences of alterations to Glu309, Glu771, and Asp800 in the Ca(2+)-ATPase of sarcoplasmic reticulum ⬇️

scientific article published on September 25, 1992

Functional consequences of alterations to Gly310, Gly770, and Gly801 located in the transmembrane domain of the Ca(2+)-ATPase of sarcoplasmic reticulum.

scientific article published on February 1992

Functional consequences of alterations to Ile279, Ile283, Glu284, His285, Phe286, and His288 in the NH2-terminal part of transmembrane helix M3 of the Na+,K(+)-ATPase

scientific article published on 7 July 2003

Functional consequences of alterations to Pro328 and Leu332 located in the 4th transmembrane segment of the alpha-subunit of the rat kidney Na+,K(+)-ATPase

scientific article published on December 1992

Functional consequences of alterations to amino acids located in the hinge domain of the Ca(2+)-ATPase of sarcoplasmic reticulum

scientific article published on August 1991

Functional consequences of alterations to hydrophobic amino acids located at the M4S4 boundary of the Ca(2+)-ATPase of sarcoplasmic reticulum

scientific article published on 01 October 1991

Functional consequences of alterations to hydrophobic amino acids located in the M4 transmembrane sector of the Ca(2+)-ATPase of sarcoplasmic reticulum.

scientific article published on August 1993

Functional consequences of charge reversals of acidic residues in M1 of the SR Ca-ATPase.

scientific article published in April 2003

Functional consequences of mutation Asn326-->Leu in the 4th transmembrane segment of the alpha-subunit of the rat kidney Na+, K(+)-ATPase.

scientific article published on April 1995

Functional consequences of mutations in the beta-strand sector of the Ca2(+)-ATPase of sarcoplasmic reticulum

scientific article published on December 1989

Functional consequences of mutations in the transmembrane core region for cation translocation and energy transduction in the Na+,K(+)-ATPase and the SR Ca(2+)-ATPase

scientific article published on 01 November 1997

Functional consequences of proline mutations in the cytoplasmic and transmembrane sectors of the Ca2(+)-ATPase of sarcoplasmic reticulum

scientific article published in 1989

Functional consequences of substitution of the seven-residue segment LysIleArgAspGlnMetAla240 located in the stalk helix S3 of the Ca(2+)-ATPase of sarcoplasmic reticulum

scientific article published on 01 September 1993

Functional consequences of the CAPOS mutation E818K of Na,K-ATPase

scientific article published in Journal of Biological Chemistry

Genetic suppression of agrin reduces mania-like behavior in Na+ , K+ -ATPase α3 mutant mice.

scientific article published on 11 May 2012

Germline De Novo Mutations in ATP1A1 Cause Renal Hypomagnesemia, Refractory Seizures, and Intellectual Disability

scientific article published on 01 November 2018

Glutamate 329 located in the fourth transmembrane segment of the alpha-subunit of the rat kidney Na+,K+-ATPase is not an essential residue for active transport of sodium and potassium ions.

scientific article published on December 1993

Glutamate transporter activity promotes enhanced Na+ /K+ -ATPase-mediated extracellular K+ management during neuronal activity.

scientific article

Glutamate-183 in the conserved TGES motif of domain A of sarcoplasmic reticulum Ca2+-ATPase assists in catalysis of E2/E2P partial reactions

scholarly article

Identification and function of a cytoplasmic K+ site of the Na+, K+ -ATPase.

scientific article published on 31 July 2008

Importance of Glu(282) in transmembrane segment M3 of the Na(+),K(+)-ATPase for control of cation interaction and conformational changes

scientific article published on 30 July 2002

Importance of Leu99 in transmembrane segment M1 of the Na+, K+ -ATPase in the binding and occlusion of K+

scientific article published on 06 June 2007

Importance of Thr214 in the conserved TGES sequence of the Na+,K+-ATPase for vanadate binding and hydrolysis of E2P.

scientific article published in April 2003

Importance of a Potential Protein Kinase A Phosphorylation Site of Na+,K+-ATPase and Its Interaction Network for Na+ Binding

scientific article published on 24 March 2016

Importance of conserved N-domain residues Thr441, Glu442, Lys515, Arg560, and Leu562 of sarcoplasmic reticulum Ca2+-ATPase for MgATP binding and subsequent catalytic steps. Plasticity of the nucleotide-binding site

scientific article published on 20 March 2003

Importance of conserved Thr214 in domain A of the Na+,K+ -ATPase for stabilization of the phosphoryl transition state complex in E2P dephosphorylation

scientific journal article

Importance of transmembrane segment M1 of the sarcoplasmic reticulum Ca2+-ATPase in Ca2+ occlusion and phosphoenzyme processing

scientific article published on 30 January 2004

Importance of transmembrane segment M3 of Na+,K+-ATPase for control of conformational changes and the cytoplasmic entry pathway for Na

scientific article published on 01 April 2003

Importance of transmembrane segment M3 of the sarcoplasmic reticulum Ca2+-ATPase for control of the gateway to the Ca2+ sites

scientific article published on 23 April 2001

Inhibition of phosphorylation of na+,k+-ATPase by mutations causing familial hemiplegic migraine

scientific article published on 23 November 2011

Interaction between the catalytic site and the A-M3 linker stabilizes E2/E2P conformational states of Na+,K+-ATPase.

scientific article published on 30 November 2004

Interaction of nucleotides with Asp(351) and the conserved phosphorylation loop of sarcoplasmic reticulum Ca(2+)-ATPase

scientific article published in September 1999

Interdependence of Ca2+ occlusion sites in the unphosphorylated sarcoplasmic reticulum Ca(2+)-ATPase complex with CrATP.

scientific article published in February 1992

Leucine 332 at the Boundary Between the Fourth Transmembrane Segment and the Cytoplasmic Domain of Na+,K+-ATPase Plays a Pivotal Role in the Ion Translocating Conformational Changes ⬇️

scientific article published on October 28, 1997

Localization of E1-E2 conformational transitions of sarcoplasmic reticulum Ca-ATPase by tryptic cleavage and hydrophobic labeling

scientific article published on 01 January 1986

Localization of a K+ -binding site involved in dephosphorylation of the sarcoplasmic reticulum Ca2+ -ATPase.

scientific article published on 21 September 2004

Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase α3 sodium pump

scientific article published on 24 October 2011

Molecular cloning and characterization of porcine Na⁺/K⁺-ATPase isoforms α1, α2, α3 and the ATP1A3 promoter

scientific article

Molecular cloning, functional expression and tissue distribution of the cDNA encoding frog skeletal muscle calsequestrin

scientific article published on May 1992

Mutagenesis of Sarcoplasmic Reticulum Ca(2+)-ATPase

scientific article

Mutagenesis of residues involved in control of the Ca2+ entry pathway and conformational changes associated with Ca2+ binding in the SR Ca2+-ATPase.

scientific article published in April 2003

Mutagenesis of segment 487Phe-Ser-Arg-Asp-Arg-Lys492 of sarcoplasmic reticulum Ca2+-ATPase produces pumps defective in ATP binding

scientific article published on 01 October 1996

Mutant Glu781-->Ala of the rat kidney Na+,K(+)-ATPase displays low cation affinity and catalyzes ATP hydrolysis at a high rate in the absence of potassium ions.

scientific article published in January 1995

Mutant Phe788 --> Leu of the Na+,K+-ATPase is inhibited by micromolar concentrations of potassium and exhibits high Na+-ATPase activity at low sodium concentrations

scientific article published on 01 August 1999

Mutation I810N in the alpha3 isoform of Na+,K+-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS.

scientific article

Mutation Lys758 → Ile of the Sarcoplasmic Reticulum Ca2+-ATPase Enhances Dephosphorylation ofE 2 P and Inhibits theE 2 to E 1Ca2Transition ⬇️

scientific article published on November 28, 1997

Mutation of Gly-94 in transmembrane segment M1 of Na+,K+-ATPase interferes with Na+ and K+ binding in E2P conformation

scientific article

Mutation to the glutamate in the fourth membrane segment of Na+,K+-ATPase and Ca2+-ATPase affects cation binding from both sides of the membrane and destabilizes the occluded enzyme forms

scientific article published in August 1998

Mutational analysis of the role of Glu309 in the sarcoplasmic reticulum Ca(2+)-ATPase of frog skeletal muscle

scientific article published on July 1992

Mutational analysis of the role of Lys684 in the Ca(2+)-ATPase of sarcoplasmic reticulum

scientific article published in January 1992

Mutational effects on conformational changes of the dephospho- and phospho-forms of the Na+,K+-ATPase.

scientific article published in May 2001

Mutations Phe785Leu and Thr618Met in Na+,K+-ATPase, associated with familial rapid-onset dystonia parkinsonism, interfere with Na+ interaction by distinct mechanisms.

scientific article

Neurological disease mutations of α3 Na+,K+-ATPase: Structural and functional perspectives and rescue of compromised function.

scientific article

Occlusion of 22Na+ and 86Rb+ in membrane-bound and soluble protomeric alpha beta-units of Na,K-ATPase

scientific article published on January 1988

Occlusion of 22Na+ and 86Rb+ in membrane-bound and soluble protomeric alpha beta-units of Na,K-ATPase

scientific article published on 01 January 1988

Occlusion of 22Na+ and 86Rb+ in membrane-bound and soluble protomeric alpha beta-units of Na,K-ATPase

scientific article published on 01 August 1987

Occlusion of Ca2+ in soluble monomeric sarcoplasmic reticulum Ca2+-ATPase

scientific article published on 01 March 1986

Overview: subunit interaction and conformational states. Ca-ATPase and Na,K-ATPase compared.

scientific article

P-type ATPases as drug targets: tools for medicine and science.

scientific article published on April 2009

Primary ion pumps

scientific article published on August 1990

Radiation inactivation analysis of sarcoplasmic reticulum Ca-ATPase in membrane-bound form and in detergent-solubilized monomeric states

scientific article published on 01 July 1988

Reaction of phenylhydrazine with erythrocytes. Cross-linking of spectrin by disulfide exchange with oxidized hemoglobin

scientific article published on 01 September 1984

Relationship between intracellular Na+ concentration and reduced Na+ affinity in Na+,K+-ATPase mutants causing neurological disease

scientific article published on 19 December 2013

Rescue of Na+ affinity in aspartate 928 mutants of Na+,K+-ATPase by secondary mutation of glutamate 314.

scientific article published on 24 February 2015

Roles of conserved P domain residues and Mg2+ in ATP binding in the ground and Ca2+-activated states of sarcoplasmic reticulum Ca2+-ATPase

scientific article

Roles of transmembrane segment M1 of Na+,K+-ATPase and Ca2-ATPase, the gatekeeper and the pivot.

scientific article published on December 2007

Site‐Directed Mutagenesis Analysis of the Role of the M5S5 Sector of the Sarcoplasmic Reticulum Ca2+‐ATPasea ⬇️

scientific article published on 01 November 1997

Somatic ATP1A1, ATP2B3, and KCNJ5 mutations in aldosterone-producing adenomas

scientific article

Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension

scientific article

Specific mutations in mammalian P4-ATPase ATP8A2 catalytic subunit entail differential glycosylation of the accessory CDC50A subunit

scientific article published on 22 November 2015

Structural basis for the E1/E1P-E2/E2P conformation changes in the sarcoplasmic reticulum Ca(2+)-ATPase studied by site-specific mutagenesis

scientific article

Structure-function relationships in the Ca(2+)-ATPase of sarcoplasmic reticulum studied by use of the substrate analogue CrATP and site-directed mutagenesis. Comparison with the Na+,K(+)-ATPase

scientific article published on January 1995

Structure-function relationships of cation translocation by Ca(2+)- and Na+, K(+)-ATPases studied by site-directed mutagenesis.

scientific article published on February 1995

Structure-function relationships of the calcium binding sites of the sarcoplasmic reticulum Ca(2+)-ATPase

scientific article published on 01 August 1998

The C terminus of Na+,K+-ATPase controls Na+ affinity on both sides of the membrane through Arg935.

scientific article published on 05 May 2009

The Na+,K+ pump continues to cause surprise

scientific article

The rapid-onset dystonia parkinsonism mutation D923N of the Na+, K+-ATPase alpha3 isoform disrupts Na+ interaction at the third Na+ site

scientific article

The structure of the Na+,K+-ATPase and mapping of isoform differences and disease-related mutations

scientific article published on January 2009

The α2β2 isoform combination dominates the astrocytic Na(+) /K(+) -ATPase activity and is rendered nonfunctional by the α2.G301R familial hemiplegic migraine type 2-associated mutation.

scientific article published on 08 August 2017

Transmembrane segment M3 is essential to thapsigargin sensitivity of the sarcoplasmic reticulum Ca(2+)-ATPase

scientific article published on 01 October 1994

Use of a small TSK GSW high-performance liquid chromatographic column for large-zone chromatographic studies of monomer-oligomer equilibria of membrane protein

scientific article published on 01 June 1988

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