List of works - Adam Lesner

Antimicrobial peptides (AMPs) as drug candidates: a patent review (2003–2015)

scientific article published on April 22, 2016

Substrate profiling of Zika virus NS2B-NS3 protease.

scientific article published on 7 October 2016

Identification of X-DING-CD4, a new member of human DING protein family that is secreted by HIV-1 resistant CD4(+) T cells and has anti-viral activity

scientific article

Sunflower Trypsin Inhibitor 1 as a Molecular Scaffold for Drug Discovery

scientific article published on December 1, 2011

A soluble factor secreted by an HIV-1-resistant cell line blocks transcription through inactivating the DNA-binding capacity of the NF-kappa B p65/p50 dimer

scientific article

Temperature-induced changes of HtrA2(Omi) protease activity and structure

scientific article

Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis).

scientific article published on 06 February 2013

Inhibition of HIV-1 or bacterial activation of macrophages by products of HIV-1-resistant human cells.

scientific article

New selective peptidyl di(chlorophenyl) phosphonate esters for visualizing and blocking neutrophil proteinase 3 in human diseases

scientific article

Induction of secreted human immunodeficiency virus type 1 (HIV-1) resistance factors in CD4-positive T lymphocytes by attenuated HIV-1 infection

scientific article published on March 2002

Monoubiquitinated histone H1B is required for antiviral protection in CD4(+)T cells resistant to HIV-1.

scientific article published in December 2004

Application of specific cell permeable cathepsin G inhibitors resulted in reduced antigen processing in primary dendritic cells

scientific article published on 16 July 2009

Introduction of non-natural amino acid residues into the substrate-specific P1 position of trypsin inhibitor SFTI-1 yields potent chymotrypsin and cathepsin G inhibitors.

scientific article published on 27 March 2009

Cathepsin G deficiency reduces periaortic calcium chloride injury-induced abdominal aortic aneurysms in mice

scientific article

Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases

scientific article published on 16 February 2016

Inhibitors of cathepsin G: a patent review (2005 to present)

scientific article published on September 30, 2013

Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases.

scientific article published on 11 February 2017

Cathepsin G activity lowers plasma LDL and reduces atherosclerosis

scientific article (publication date: November 2014)

The LA loop as an important regulatory element of the HtrA (DegP) protease from Escherichia coli: structural and functional studies

scientific article

Structural and Functional Analysis of Human HtrA3 Protease and Its Subdomains

scientific article

Design of selective substrates of proteinase 3 using combinatorial chemistry methods

scientific article published on 07 April 2008

Substrate specificity and inhibitory study of human airway trypsin-like protease.

scientific article

New chromogenic substrates of human neutrophil cathepsin G containing non-natural aromatic amino acid residues in position P(1) selected by combinatorial chemistry methods.

scientific article

Trypsin inhibitors from the garden four o'clock (Mirabilis jalapa) and spinach (Spinacia oleracea) seeds: isolation, characterization and chemical synthesis

scientific article published on 03 May 2007

Substrate specificity of human matriptase-2.

scientific article

Surface plasmon resonance imaging biosensor for cathepsin G based on a potent inhibitor: development and applications

scientific article published on 07 February 2012

New potent cathepsin G phosphonate inhibitors

scientific article published on 31 August 2008

Synthesis of novel phosphonic-type activity-based probes for neutrophil serine proteases and their application in spleen lysates of different organisms

scientific article published on 18 September 2014

Design of serine proteinase inhibitors by combinatorial chemistry using trypsin inhibitor SFTI-1 as a starting structure.

scientific article

Development of sensitive cathepsin G fluorogenic substrate using combinatorial chemistry methods.

scientific article

Selection of new chromogenic substrates of serine proteinases using combinatorial chemistry methods.

scientific article published in March 2007

The new fluorogenic substrates of neutrophil proteinase 3 optimized in prime site region.

scientific article published on 13 January 2010

Microarray analysis of differentially expressed genes in cells resistant to HIV-1.

scientific article

Substrate specificity of Staphylococcus aureus cysteine proteases--Staphopains A, B and C.

scientific article

Lactoferrin Is an Allosteric Enhancer of the Proteolytic Activity of Cathepsin G.

scientific article

A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA.

scientific article published on 23 February 2018

Implication of the disulfide bridge in trypsin inhibitor SFTI-1 in its interaction with serine proteinases.

scientific article published on 29 October 2010

Biochemical properties of the HtrA homolog from bacterium Stenotrophomonas maltophilia

scientific article published on 16 November 2017

Inhibitory activity of double-sequence analogues of trypsin inhibitor SFTI-1 from sunflower seeds: an example of peptide splicing

scientific article published on 19 April 2010

Three Wavelength Substrate System of Neutrophil Serine Proteinases

scientific article published on 08 August 2012

Future of Protease Activity Assays

scientific article published on January 1, 2013

Analysis of the link between the redox state and enzymatic activity of the HtrA (DegP) protein from Escherichia coli.

scientific article published on 24 February 2015

Peptomeric analogues of trypsin inhibitor SFTI-1 isolated from sunflower seeds

scientific article published in April 2008

Inhibitors and Antibody Fragments as Potential Anti-Inflammatory Therapeutics Targeting Neutrophil Proteinase 3 in Human Disease

scientific article published on July 2016

Intra- and intersubunit changes accompanying thermal activation of the HtrA2(Omi) protease homotrimer.

scientific article published on 15 December 2015

Biochemical and structural characterization of SplD protease from Staphylococcus aureus

scientific article

Inhibitory and antimicrobial activities of OGTI and HV-BBI peptides, fragments and analogs derived from amphibian skin

scientific article

Chromogenic substrates of bovine beta-trypsin: the influence of an amino acid residue in P1 position on their interaction with the enzyme

scientific article published on 01 August 2001

A new proteinase 3 substrate with improved selectivity over human neutrophil elastase.

scientific article

Ultrasensitive internally quenched substrates of human cathepsin L.

scientific article published on 23 August 2014

List of works by Adam Lesner

Antimicrobial peptides (AMPs) as drug candidates: a patent review (2003–2015)

Substrate profiling of Zika virus NS2B-NS3 protease.

Identification of X-DING-CD4, a new member of human DING protein family that is secreted by HIV-1 resistant CD4(+) T cells and has anti-viral activity

Sunflower Trypsin Inhibitor 1 as a Molecular Scaffold for Drug Discovery

A soluble factor secreted by an HIV-1-resistant cell line blocks transcription through inactivating the DNA-binding capacity of the NF-kappa B p65/p50 dimer

Temperature-induced changes of HtrA2(Omi) protease activity and structure

Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis).

Inhibition of HIV-1 or bacterial activation of macrophages by products of HIV-1-resistant human cells.

New selective peptidyl di(chlorophenyl) phosphonate esters for visualizing and blocking neutrophil proteinase 3 in human diseases

Induction of secreted human immunodeficiency virus type 1 (HIV-1) resistance factors in CD4-positive T lymphocytes by attenuated HIV-1 infection

Monoubiquitinated histone H1B is required for antiviral protection in CD4(+)T cells resistant to HIV-1.

Application of specific cell permeable cathepsin G inhibitors resulted in reduced antigen processing in primary dendritic cells

Introduction of non-natural amino acid residues into the substrate-specific P1 position of trypsin inhibitor SFTI-1 yields potent chymotrypsin and cathepsin G inhibitors.

Cathepsin G deficiency reduces periaortic calcium chloride injury-induced abdominal aortic aneurysms in mice

Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases

Inhibitors of cathepsin G: a patent review (2005 to present)

Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases.

Cathepsin G activity lowers plasma LDL and reduces atherosclerosis

The LA loop as an important regulatory element of the HtrA (DegP) protease from Escherichia coli: structural and functional studies

Structural and Functional Analysis of Human HtrA3 Protease and Its Subdomains

Design of selective substrates of proteinase 3 using combinatorial chemistry methods

Substrate specificity and inhibitory study of human airway trypsin-like protease.

New chromogenic substrates of human neutrophil cathepsin G containing non-natural aromatic amino acid residues in position P(1) selected by combinatorial chemistry methods.

Trypsin inhibitors from the garden four o'clock (Mirabilis jalapa) and spinach (Spinacia oleracea) seeds: isolation, characterization and chemical synthesis

Substrate specificity of human matriptase-2.

Surface plasmon resonance imaging biosensor for cathepsin G based on a potent inhibitor: development and applications

New potent cathepsin G phosphonate inhibitors

Synthesis of novel phosphonic-type activity-based probes for neutrophil serine proteases and their application in spleen lysates of different organisms

Design of serine proteinase inhibitors by combinatorial chemistry using trypsin inhibitor SFTI-1 as a starting structure.

Development of sensitive cathepsin G fluorogenic substrate using combinatorial chemistry methods.

Selection of new chromogenic substrates of serine proteinases using combinatorial chemistry methods.

The new fluorogenic substrates of neutrophil proteinase 3 optimized in prime site region.

Microarray analysis of differentially expressed genes in cells resistant to HIV-1.

Substrate specificity of Staphylococcus aureus cysteine proteases--Staphopains A, B and C.

Lactoferrin Is an Allosteric Enhancer of the Proteolytic Activity of Cathepsin G.

A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA.

Implication of the disulfide bridge in trypsin inhibitor SFTI-1 in its interaction with serine proteinases.

Biochemical properties of the HtrA homolog from bacterium Stenotrophomonas maltophilia

Inhibitory activity of double-sequence analogues of trypsin inhibitor SFTI-1 from sunflower seeds: an example of peptide splicing

Three Wavelength Substrate System of Neutrophil Serine Proteinases

Future of Protease Activity Assays

Analysis of the link between the redox state and enzymatic activity of the HtrA (DegP) protein from Escherichia coli.

Peptomeric analogues of trypsin inhibitor SFTI-1 isolated from sunflower seeds

Inhibitors and Antibody Fragments as Potential Anti-Inflammatory Therapeutics Targeting Neutrophil Proteinase 3 in Human Disease

Intra- and intersubunit changes accompanying thermal activation of the HtrA2(Omi) protease homotrimer.

Biochemical and structural characterization of SplD protease from Staphylococcus aureus

Inhibitory and antimicrobial activities of OGTI and HV-BBI peptides, fragments and analogs derived from amphibian skin

Chromogenic substrates of bovine beta-trypsin: the influence of an amino acid residue in P1 position on their interaction with the enzyme

A new proteinase 3 substrate with improved selectivity over human neutrophil elastase.

Ultrasensitive internally quenched substrates of human cathepsin L.