List of works - Adam Lesner

A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA.

scientific article published on 23 February 2018

A Peptidomimetic Fluorescent Probe to Detect the Trypsin β2 Subunit of the Human 20S Proteasome

scientific article published on 31 March 2020

A new proteinase 3 substrate with improved selectivity over human neutrophil elastase.

scientific article

A simple method for selection of trypsin chromogenic substrates using combinatorial chemistry approach.

scientific article

A soluble factor secreted by an HIV-1-resistant cell line blocks transcription through inactivating the DNA-binding capacity of the NF-kappa B p65/p50 dimer

scientific article

Analogues of Trypsin Inhibitor SFTI-1 with Disulfide Bridge Substituted by Various Length of Carbonyl Bridges

scientific article published on 01 October 2010

Analysis of the link between the redox state and enzymatic activity of the HtrA (DegP) protein from Escherichia coli.

scientific article published on 24 February 2015

Analysis of urinary cathepsin C for diagnosing Papillon-Lefèvre syndrome

scientific article published in 2016

Antimicrobial peptides (AMPs) as drug candidates: a patent review (2003-2015).

scientific article published on 9 April 2016

Application of specific cell permeable cathepsin G inhibitors resulted in reduced antigen processing in primary dendritic cells.

scientific article published on 16 July 2009

Biochemical and structural characterization of SplD protease from Staphylococcus aureus

scientific article

Biochemical properties of the HtrA homolog from bacterium Stenotrophomonas maltophilia

scientific article published on 16 November 2017

Bladder cancer detection using a peptide substrate of the 20S proteasome.

scientific article published on 21 June 2016

Cathepsin C is a novel mediator of podocyte and renal injury induced by hyperglycemia

scientific article published on 14 April 2020

Cathepsin G activity lowers plasma LDL and reduces atherosclerosis

scientific article (publication date: November 2014)

Cathepsin G deficiency reduces periaortic calcium chloride injury-induced abdominal aortic aneurysms in mice

scientific article

Chromogenic substrates of bovine beta-trypsin: the influence of an amino acid residue in P1 position on their interaction with the enzyme

scientific article published on 01 August 2001

Conjugate of Enkephalin and Temporin Peptides as a Novel Therapeutic Agent for Sepsis

scientific article published on 10 December 2018

Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis

scientific article published in Journal of Biological Chemistry

Design and synthesis of new substrates of HtrA2 protease

scientific article published on 29 January 2015

Design of selective substrates of proteinase 3 using combinatorial chemistry methods

scientific article published on 07 April 2008

Design of serine proteinase inhibitors by combinatorial chemistry using trypsin inhibitor SFTI-1 as a starting structure.

scientific article

Design, Synthesis, and Enzymatic Evaluation of Novel ZnO Quantum Dot-Based Assay for Detection of Proteinase 3 Activity.

scientific article published on 11 April 2018

Design, chemical synthesis and kinetic studies of trypsin chromogenic substrates based on the proteinase binding loop of Cucurbita maxima trypsin inhibitor (CMTI-III)

scientific article published on 01 March 2000

Designing of substrates and inhibitors of bovine alpha-chymotrypsin with synthetic phenylalanine analogues in position P(1).

scientific article published in January 2008

Determination of cathepsin G in endometrial tissue using a surface plasmon resonance imaging biosensor with tailored phosphonic inhibitor

scientific article published on 29 August 2014

Development of Chemical Tools to Monitor Human Kallikrein 13 (KLK13) Activity ⬇️

article

Development of sensitive cathepsin G fluorogenic substrate using combinatorial chemistry methods.

scientific article

Development of the first internally-quenched fluorescent substrates of human cathepsin C: The application in the enzyme detection in biological samples

scientific article published on 13 October 2016

Distance between the basic group of the amino acid residue's side chain in position P1 of trypsin inhibitor CMTI-III and Asp189 in the substrate pocket of trypsin has an essential influence on the inhibitory activity

scientific article published on 01 November 1997

Exploiting the S4-S5 specificity of human neutrophil proteinase 3 to improve the potency of peptidyl di(chlorophenyl)-phosphonate ester inhibitors: a kinetic and molecular modeling analysis.

scientific article published on 14 February 2018

Fluorescent analogs of trypsin inhibitor SFTI-1 isolated from sunflower seeds--synthesis and applications.

scientific article published on January 2014

Future of protease activity assays

scientific article published on January 2013

Highly specific substrates of proteinase 3 containing 3-(2-benzoxazol-5-yl)-l-alanine and their application for detection of this enzyme in human serum.

scientific article

Human proteinase 3 resistance to inhibition extends to alpha-2 macroglobulin

scientific article published on 29 January 2020

Hybrid analogues of SFTI-1 modified in P1position by β- and γ-amino acids andN-substituted β-alanines

scientific article published on 01 April 2013

Identification of X-DING-CD4, a new member of human DING protein family that is secreted by HIV-1 resistant CD4(+) T cells and has anti-viral activity

scientific article

Implication of the disulfide bridge in trypsin inhibitor SFTI-1 in its interaction with serine proteinases.

scientific article published on 29 October 2010

Induction of secreted human immunodeficiency virus type 1 (HIV-1) resistance factors in CD4-positive T lymphocytes by attenuated HIV-1 infection

scientific article published on March 2002

Inhibition of HIV-1 or bacterial activation of macrophages by products of HIV-1-resistant human cells.

scientific article

Inhibition of human and yeast 20S proteasome by analogues of trypsin inhibitor SFTI-1

scientific article

Inhibitors and Antibody Fragments as Potential Anti-Inflammatory Therapeutics Targeting Neutrophil Proteinase 3 in Human Disease

scientific article published on July 2016

Inhibitors of cathepsin G: a patent review (2005 to present).

scientific article published on 30 September 2013

Inhibitory activity of double-sequence analogues of trypsin inhibitor SFTI-1 from sunflower seeds: an example of peptide splicing

scientific article published on 19 April 2010

Inhibitory and antimicrobial activities of OGTI and HV-BBI peptides, fragments and analogs derived from amphibian skin

scientific article

Intra- and intersubunit changes accompanying thermal activation of the HtrA2(Omi) protease homotrimer.

scientific article published on 15 December 2015

Introduction of Pro and Its Analogues in the Conserved P1 Position of Trypsin Inhibitor SFTI-1 Retains Its Inhibitory Activity

scientific article published on 01 November 2011

Introduction of non-natural amino acid residues into the substrate-specific P1 position of trypsin inhibitor SFTI-1 yields potent chymotrypsin and cathepsin G inhibitors.

scientific article published on 27 March 2009

Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1

scientific article published on 24 November 2020

Kallikrein-Related Peptidase 14 Activates Zymogens of Membrane Type Matrix Metalloproteinases (MT-MMPs)-A CleavEx Based Analysis

scientific article published on 19 June 2020

Lactoferrin Is an Allosteric Enhancer of the Proteolytic Activity of Cathepsin G.

scientific article

Low-molecular-weight aldehyde inhibitors of cathepsin G.

scientific article

Microarray analysis of differentially expressed genes in cells resistant to HIV-1.

scientific article

Monoubiquitinated histone H1B is required for antiviral protection in CD4(+)T cells resistant to HIV-1.

scientific article published in December 2004

Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis).

scientific article published on 06 February 2013

Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases

scientific article published on 16 February 2016

New chromogenic substrates of human neutrophil cathepsin G containing non-natural aromatic amino acid residues in position P(1) selected by combinatorial chemistry methods.

scientific article

New potent cathepsin G phosphonate inhibitors

scientific article published on 31 August 2008

New selective peptidyl di(chlorophenyl) phosphonate esters for visualizing and blocking neutrophil proteinase 3 in human diseases

scientific article

Non‐Proteasomal Urine Activity in Bladder Cancer

scientific article published in 2021

Novel internally quenched substrate of the trypsin-like subunit of 20S eukaryotic proteasome

scientific article published on 24 August 2015

One Step Beyond: Design of Substrates Spanning Primed Positions of Zika Virus NS2B-NS3 Protease

scholarly article by Natalia Gruba et al published 11 October 2018 in ACS Medicinal Chemistry Letters

PEGylated substrates of NSP4 protease: A tool to study protease specificity.

scientific article

Pegylated fluorescent peptides as substrates of proteolytic enzymes

scientific article published on 01 December 2012

Peptomeric analogues of trypsin inhibitor SFTI-1 isolated from sunflower seeds

scientific article published in April 2008

Processing and Maturation of Cathepsin C Zymogen: A Biochemical and Molecular Modeling Analysis

scientific article published on 25 September 2019

Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases.

scientific article published on 11 February 2017

Properties of the HtrA Protease From Bacterium Helicobacter pylori Whose Activity Is Indispensable for Growth Under Stress Conditions

scientific article

Proteinase 3 phosphonic inhibitors

scientific article published on 13 March 2019

Proteolysis in health and disease

scientific article published on 01 January 2013

Selection of Effective HTRA3 Activators Using Combinatorial Chemistry.

scientific article published on 25 July 2017

Selection of new chromogenic substrates of serine proteinases using combinatorial chemistry methods.

scientific article

Selection of peptomeric inhibitors of bovine alpha-chymotrypsin and cathepsin G based on trypsin inhibitor SFTI-1 using a combinatorial chemistry approach

scientific article

Simplified, serine-rich theta-defensin analogues as antitumour peptides.

scientific article published on 22 December 2016

Structural Determinants of Substrate Specificity of SplF Protease from

scientific article published on 23 February 2021

Structural and Functional Analysis of Human HtrA3 Protease and Its Subdomains

scientific article

Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C

scientific article published on 09 April 2019

Substrate profiling of Finegoldia magna SufA protease, inhibitor screening and application to prevent human fibrinogen degradation and bacteria growth in vitro.

scientific article

Substrate profiling of Zika virus NS2B-NS3 protease.

scientific article published on 7 October 2016

Substrate specificity and inhibitory study of human airway trypsin-like protease.

scientific article

Substrate specificity of Staphylococcus aureus cysteine proteases--Staphopains A, B and C.

scientific article

Substrate specificity of human matriptase-2.

scientific article

Sunflower trypsin inhibitor 1 as a molecular scaffold for drug discovery

scientific article published on December 2011

Surface plasmon resonance imaging biosensor for cathepsin G based on a potent inhibitor: development and applications

scientific article published on 07 February 2012

Synthesis and Evaluation of Biological Activity of Antimicrobial--Pro-Proliferative Peptide Conjugates

scientific article

Synthesis of novel phosphonic-type activity-based probes for neutrophil serine proteases and their application in spleen lysates of different organisms.

scientific article published on 18 September 2014

Temperature-induced changes of HtrA2(Omi) protease activity and structure

scientific article

The Bactericidal Activity of Temporin Analogues Against Methicillin Resistant Staphylococcus aureus

scientific article published on 25 September 2019

The LA loop as an important regulatory element of the HtrA (DegP) protease from Escherichia coli: structural and functional studies.

scientific article

The LD loop as an important structural element required for transmission of the allosteric signal in the HtrA (DegP) protease from Escherichia coli.

scientific article published on 28 July 2016

The influence of substrate peptide length on human beta-tryptase specificity

scientific article

The new fluorogenic substrates of neutrophil proteinase 3 optimized in prime site region.

scientific article published on 13 January 2010

The role of the LB structural loop and its interactions with the PDZ domain of the human HtrA3 protease.

scientific article published on 19 June 2017

Three Wavelength Substrate System of Neutrophil Serine Proteinases

scientific article published on 08 August 2012

Trypsin inhibitors from the garden four o'clock (Mirabilis jalapa) and spinach (Spinacia oleracea) seeds: isolation, characterization and chemical synthesis

scientific article published on 03 May 2007

Ultrasensitive internally quenched substrates of human cathepsin L.

scientific article published on 23 August 2014

Visualization of kallikreins in thyroid epithelial and carcinoma cells

scholarly article by Eileen Kroll et al published 13 May 2016 in Endocrine Abstracts

List of works by Adam Lesner

A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA.

A Peptidomimetic Fluorescent Probe to Detect the Trypsin β2 Subunit of the Human 20S Proteasome

A new proteinase 3 substrate with improved selectivity over human neutrophil elastase.

A simple method for selection of trypsin chromogenic substrates using combinatorial chemistry approach.

A soluble factor secreted by an HIV-1-resistant cell line blocks transcription through inactivating the DNA-binding capacity of the NF-kappa B p65/p50 dimer

Analogues of Trypsin Inhibitor SFTI-1 with Disulfide Bridge Substituted by Various Length of Carbonyl Bridges

Analysis of the link between the redox state and enzymatic activity of the HtrA (DegP) protein from Escherichia coli.

Analysis of urinary cathepsin C for diagnosing Papillon-Lefèvre syndrome

Antimicrobial peptides (AMPs) as drug candidates: a patent review (2003-2015).

Application of specific cell permeable cathepsin G inhibitors resulted in reduced antigen processing in primary dendritic cells.

Biochemical and structural characterization of SplD protease from Staphylococcus aureus

Biochemical properties of the HtrA homolog from bacterium Stenotrophomonas maltophilia

Bladder cancer detection using a peptide substrate of the 20S proteasome.

Cathepsin C is a novel mediator of podocyte and renal injury induced by hyperglycemia

Cathepsin G activity lowers plasma LDL and reduces atherosclerosis

Cathepsin G deficiency reduces periaortic calcium chloride injury-induced abdominal aortic aneurysms in mice

Chromogenic substrates of bovine beta-trypsin: the influence of an amino acid residue in P1 position on their interaction with the enzyme

Conjugate of Enkephalin and Temporin Peptides as a Novel Therapeutic Agent for Sepsis

Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis

Design and synthesis of new substrates of HtrA2 protease

Design of selective substrates of proteinase 3 using combinatorial chemistry methods

Design of serine proteinase inhibitors by combinatorial chemistry using trypsin inhibitor SFTI-1 as a starting structure.

Design, Synthesis, and Enzymatic Evaluation of Novel ZnO Quantum Dot-Based Assay for Detection of Proteinase 3 Activity.

Design, chemical synthesis and kinetic studies of trypsin chromogenic substrates based on the proteinase binding loop of Cucurbita maxima trypsin inhibitor (CMTI-III)

Designing of substrates and inhibitors of bovine alpha-chymotrypsin with synthetic phenylalanine analogues in position P(1).

Determination of cathepsin G in endometrial tissue using a surface plasmon resonance imaging biosensor with tailored phosphonic inhibitor

Development of Chemical Tools to Monitor Human Kallikrein 13 (KLK13) Activity ⬇️

Development of sensitive cathepsin G fluorogenic substrate using combinatorial chemistry methods.

Development of the first internally-quenched fluorescent substrates of human cathepsin C: The application in the enzyme detection in biological samples

Distance between the basic group of the amino acid residue's side chain in position P1 of trypsin inhibitor CMTI-III and Asp189 in the substrate pocket of trypsin has an essential influence on the inhibitory activity

Exploiting the S4-S5 specificity of human neutrophil proteinase 3 to improve the potency of peptidyl di(chlorophenyl)-phosphonate ester inhibitors: a kinetic and molecular modeling analysis.

Fluorescent analogs of trypsin inhibitor SFTI-1 isolated from sunflower seeds--synthesis and applications.

Future of protease activity assays

Highly specific substrates of proteinase 3 containing 3-(2-benzoxazol-5-yl)-l-alanine and their application for detection of this enzyme in human serum.

Human proteinase 3 resistance to inhibition extends to alpha-2 macroglobulin

Hybrid analogues of SFTI-1 modified in P1position by β- and γ-amino acids andN-substituted β-alanines

Identification of X-DING-CD4, a new member of human DING protein family that is secreted by HIV-1 resistant CD4(+) T cells and has anti-viral activity

Implication of the disulfide bridge in trypsin inhibitor SFTI-1 in its interaction with serine proteinases.

Induction of secreted human immunodeficiency virus type 1 (HIV-1) resistance factors in CD4-positive T lymphocytes by attenuated HIV-1 infection

Inhibition of HIV-1 or bacterial activation of macrophages by products of HIV-1-resistant human cells.

Inhibition of human and yeast 20S proteasome by analogues of trypsin inhibitor SFTI-1

Inhibitors and Antibody Fragments as Potential Anti-Inflammatory Therapeutics Targeting Neutrophil Proteinase 3 in Human Disease

Inhibitors of cathepsin G: a patent review (2005 to present).

Inhibitory activity of double-sequence analogues of trypsin inhibitor SFTI-1 from sunflower seeds: an example of peptide splicing

Inhibitory and antimicrobial activities of OGTI and HV-BBI peptides, fragments and analogs derived from amphibian skin

Intra- and intersubunit changes accompanying thermal activation of the HtrA2(Omi) protease homotrimer.

Introduction of Pro and Its Analogues in the Conserved P1 Position of Trypsin Inhibitor SFTI-1 Retains Its Inhibitory Activity

Introduction of non-natural amino acid residues into the substrate-specific P1 position of trypsin inhibitor SFTI-1 yields potent chymotrypsin and cathepsin G inhibitors.

Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1

Kallikrein-Related Peptidase 14 Activates Zymogens of Membrane Type Matrix Metalloproteinases (MT-MMPs)-A CleavEx Based Analysis

Lactoferrin Is an Allosteric Enhancer of the Proteolytic Activity of Cathepsin G.

Low-molecular-weight aldehyde inhibitors of cathepsin G.

Microarray analysis of differentially expressed genes in cells resistant to HIV-1.

Monoubiquitinated histone H1B is required for antiviral protection in CD4(+)T cells resistant to HIV-1.

Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis).

Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases

New chromogenic substrates of human neutrophil cathepsin G containing non-natural aromatic amino acid residues in position P(1) selected by combinatorial chemistry methods.

New potent cathepsin G phosphonate inhibitors

New selective peptidyl di(chlorophenyl) phosphonate esters for visualizing and blocking neutrophil proteinase 3 in human diseases

Non‐Proteasomal Urine Activity in Bladder Cancer

Novel internally quenched substrate of the trypsin-like subunit of 20S eukaryotic proteasome

One Step Beyond: Design of Substrates Spanning Primed Positions of Zika Virus NS2B-NS3 Protease

PEGylated substrates of NSP4 protease: A tool to study protease specificity.

Pegylated fluorescent peptides as substrates of proteolytic enzymes

Peptomeric analogues of trypsin inhibitor SFTI-1 isolated from sunflower seeds

Processing and Maturation of Cathepsin C Zymogen: A Biochemical and Molecular Modeling Analysis

Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases.

Properties of the HtrA Protease From Bacterium Helicobacter pylori Whose Activity Is Indispensable for Growth Under Stress Conditions

Proteinase 3 phosphonic inhibitors

Proteolysis in health and disease

Selection of Effective HTRA3 Activators Using Combinatorial Chemistry.

Selection of new chromogenic substrates of serine proteinases using combinatorial chemistry methods.

Selection of peptomeric inhibitors of bovine alpha-chymotrypsin and cathepsin G based on trypsin inhibitor SFTI-1 using a combinatorial chemistry approach

Simplified, serine-rich theta-defensin analogues as antitumour peptides.

Structural Determinants of Substrate Specificity of SplF Protease from

Structural and Functional Analysis of Human HtrA3 Protease and Its Subdomains

Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C

Substrate profiling of Finegoldia magna SufA protease, inhibitor screening and application to prevent human fibrinogen degradation and bacteria growth in vitro.

Substrate profiling of Zika virus NS2B-NS3 protease.