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List of works by John W. Semple

A comprehensive study of ovine haemostasis to assess suitability to model human coagulation.

scientific article published on 27 May 2014

A highly purified form of staphylococcal protein A alleviates murine immune thrombocytopenia (ITP).

scientific article

A murine model of severe immune thrombocytopenia is induced by antibody- and CD8+ T cell-mediated responses that are differentially sensitive to therapy

scientific article

A novel immunosuppressive pathway involving peroxynitrite-mediated [corrected] nitration of platelet antigens within antigen-presenting cells

scientific article published on 28 June 2008

A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy

scientific article

A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg?

scientific article

About the mechanism of action of WinRho SDF

scientific article published on 01 February 2007

Acid sphingomyelinase mediates murine acute lung injury following transfusion of aged platelets

scientific article published on 10 March 2017

Acute Lung Injury Causes Asynchronous Alveolar Ventilation That Can Be Corrected by Individual Sighs

scientific article published on 29 October 2015

Alleviation of gram-negative bacterial lung inflammation by targeting HECTD2.

scientific article published on December 2016

Allogeneic platelet transfusions prevent murine T-cell-mediated immune thrombocytopenia

scientific article

An update on the pathophysiology of immune thrombocytopenia

scientific article published on 29 August 2020

Anti-D (WinRho SD) treatment of children with chronic autoimmune thrombocytopenic purpura stimulates transient cytokine/chemokine production

scientific article

Anti-D initially stimulates an Fc-dependent leukocyte oxidative burst and subsequently suppresses erythrophagocytosis via interleukin-1 receptor antagonist

scientific article published on 26 June 2003

Antigen binding and processing by B-cell antigen-presenting cells: influence on T- and B-cell activation

scientific article published in January 1989

Antiplatelet antibody-induced thrombocytopenia does not correlate with megakaryocyte abnormalities in murine immune thrombocytopenia

scientific article published on 01 July 2018

Autoimmune pathogenesis and autoimmune hemolytic anemia

scientific article

Biological and structural characterization of murine TRALI antibody reveals increased Fc-mediated complement activation

scientific article published on 01 August 2020

Bregging rights in ITP ⬇️

scientific article published on October 18, 2012

C-reactive protein boosts antibody-mediated platelet destruction

scientific article

C-reactive protein enhances murine antibody-mediated transfusion-related acute lung injury

scientific article

CD20+ B-cell depletion therapy suppresses murine CD8+ T-cell-mediated immune thrombocytopenia

scientific article

Cellular immune dysfunction in immune thrombocytopenia (ITP).

scientific article

Cellular immune mechanisms in autoimmune thrombocytopenic purpura: An update

scientific article

Cellular immune mechanisms in chronic autoimmune thrombocytopenic purpura (ATP)

scientific article published on January 1, 1992

Characterization of platelet-reactive antibodies in children with varicella-associated acute immune thrombocytopenic purpura (ITP).

scientific article

Comparison of platelet immunity in patients with SLE and with ITP.

scientific article

Current problems and future directions of transfusion‐induced alloimmunization: summary of an NHLBI working group ⬇️

scientific article published on January 20, 2011

DJ-1/PARK7 Impairs Bacterial Clearance in Sepsis.

scientific article published on 13 October 2016

Differences in serum cytokine levels in acute and chronic autoimmune thrombocytopenic purpura: relationship to platelet phenotype and antiplatelet T-cell reactivity

scientific article

Downregulation of the anti-HLA alloimmune response by variable region-reactive (anti-idiotypic) antibodies in leukemic patients transfused with platelet concentrates

scientific article published on 01 January 1993

Elevation of C-reactive protein levels in patients with transfusion-related acute lung injury.

scientific article published on 25 October 2016

Epitope specificity and isotype of monoclonal anti-D antibodies dictate their ability to inhibit phagocytosis of opsonized platelets

scientific article

Evaluation of Platelet Responses in Transfusion-Related Acute Lung Injury (TRALI)

scientific article published on 16 September 2020

Evaluation of platelet gel characteristics using thrombin produced by the thrombin processing device: a comparative study

scientific article

Extreme leukoreduction of major histocompatibility complex class II positive B cells enhances allogeneic platelet immunity

scientific article published on 01 January 1999

FcγRI and FcγRIII on splenic macrophages mediate phagocytosis of anti-glycoprotein IIb/IIIa autoantibody-opsonized platelets in immune thrombocytopenia

scientific article published on 27 February 2020

Flow cytometric analysis of platelets from childrenwith the Wiskott‐Aldrich syndrome reveals defects in platelet development, activation and structure ⬇️

scientific article published on June 1, 1997

Flow cytometric evaluation of platelet activation in blood collected into EDTA vs. Diatube-H, a sodium citrate solution supplemented with theophylline, adenosine, and dipyridamole

scientific article published on 01 September 1995

Flow cytometric parameters for characterizing platelet activation by measuring P-selectin (CD62) expression: theoretical consideration and evaluation in thrombin-treated platelet populations

scientific article published on 01 March 2000

Gamma-globulins prepared from sera of multiparous women bind anti-HLA antibodies and inhibit an established in vivo human alloimmune response.

scientific article

Gastrointestinal microbiota contributes to the development of murine transfusion-related acute lung injury

article

HLA alloimmunization against platelet transfusions: pathophysiology, significance, prevention and management ⬇️

scientific article published on April 1, 2012

ITP has elevated BAFF expression

scientific article published on 01 December 2009

ITP three R's: regulation, routing, rituximab

scientific article published on 01 August 2008

ITP: a new regulatory issue!

scientific article

IVIG induces dose-dependent amelioration of ITP in rodent models

scientific article published on 01 February 2003

IVIg inhibits reticuloendothelial system function and ameliorates murine passive-immune thrombocytopenia independent of anti-idiotype reactivity.

scientific article

IgG antiplatelet immunity is dependent on an early innate natural killer cell-derived interferon-gamma response that is regulated by CD8+ T cells

scientific article

Immune responsiveness against allogeneic platelet transfusions is determined by the recipient's major histocompatibility complex class II phenotype

scientific article published on 01 November 2004

Immunobiology of T helper cells and antigen‐presenting cells in autoimmune thrombocytopenic purpura (ITP) ⬇️

scientific article published on June 1, 1998

In HPA 1a-immunized women the decrease in anti-HPA 1a antibody level during pregnancy is not associated with anti-idiotypic antibodies

scientific article published on 30 January 2009

Increased antiplatelet T helper lymphocyte reactivity in patients with autoimmune thrombocytopenia ⬇️

scientific article published on November 15, 1991

Indirect allorecognition of platelets by T helper cells during platelet transfusions correlates with anti-major histocompatibility complex antibody and cytotoxic T lymphocyte formation ⬇️

scientific article published on July 15, 1995

Induction of a secondary human anti-HLA alloimmune response in severe combined immunodeficient mice engrafted with human lymphocytes

scientific article published on 01 November 1997

Infections, antigen-presenting cells, T cells, and immune tolerance: their role in the pathogenesis of immune thrombocytopenia

scientific article

Influence of antigen processing on immune responsiveness

scientific article published on July 1988

Inhibition of xenogeneic GVHD by PEN110 treatment of donor human PBMNCs

scientific article published in February 2004

Innate and adaptive immunity in immune thrombocytopenia

scientific article

Intravenous immunoglobulin and anti-D in idiopathic thrombocytopenic purpura (ITP): mechanisms of action

scientific article

Intravenous immunoglobulin inhibits anti-glycoprotein IIb-induced platelet apoptosis in a murine model of immune thrombocytopenia

scientific article

Intravenous immunoglobulin prevents murine antibody-mediated acute lung injury at the level of neutrophil reactive oxygen species (ROS) production

scientific article

Intravenous immunoglobulin treatment of spleen cells from patients with immune thrombocytopenia significantly increases the percentage of myeloid-derived suppressor cells

scientific article published on 6 February 2017

Leukoreduction just doesn't "take away" immunogenic leukcocytes, it creates an immunosuppressive leukocyte dose.

scientific article

Low levels of interleukin-10 in patients with transfusion-related acute lung injury

scientific article published on August 2017

Management of immune thrombocytopenic purpura in children: potential role of novel agents

scientific article

Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets

scientific article published on 08 September 2017

Mechanisms and therapeutic prospects of thrombopoietin receptor agonists

scientific article published on 19 October 2019

Megakaryocytes listen for their progeny's progeny during inflammation

scientific article published on 21 December 2020

Microparticles as biomarkers of lung disease: enumeration in biological fluids using lipid bilayer microspheres

scientific article published on 4 March 2016

Move over Tregs, MDSCs are here

scientific article

Moving target PF4 directs HIT responses

article

Natural killer cell numbers and activity in patients with chronic autoimmune thrombocytopenic purpura

scientific article published on 01 February 1994

Naturally processed heterodimeric disulfide-linked insulin peptides bind to major histocompatibility class II molecules on thymic epithelial cells

scientific article

New Emerging Developments of Platelets in Transfusion Medicine

scientific article published on 07 October 2020

Nouvelle cuisine: platelets served with inflammation

scientific article

Osteopontin mediates murine transfusion-related acute lung injury via stimulation of pulmonary neutrophil accumulation

scientific article published on 10 May 2019

Pathogenesis of immune thrombocytopenia

scientific article

Pathogenesis and Therapeutic Mechanisms in  Immune Thrombocytopenia (ITP)

scientific article

Pathogenic T-cell responses in patients with autoimmune thrombocytopenic purpura

scientific article

Pathways of processing of insulin by antigen-presenting cells

scientific article published on December 1988

Peripheral blood monocyte-derived chemokine blockade prevents murine transfusion-related acute lung injury (TRALI)

scientific article published on 17 March 2014

Plasma-derived biological medicines used to promote haemostasis

scientific article published on 01 May 2008

Platelet Extracellular Vesicles mediate Transfusion-related Acute Lung Injury by imbalancing the Sphingolipid Rheostat

scientific article published on 24 November 2020

Platelet GPIb-IX has suppressive effects on septic inflammation

scientific article published on 01 May 2014

Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo

scientific article

Platelet and immune responses to oral cyclic dexamethasone therapy in childhood chronic immune thrombocytopenic purpura

scientific article

Platelet and red blood cell phagocytosis kinetics are differentially controlled by phosphatase activity within mononuclear cells

scientific article published in November 2007

Platelet antigen-induced regulation in ITP

scientific article published on 01 March 2009

Platelet immunobiology: platelets as prey and predator

scholarly article by R. Kapur & John W. Semple published 3 October 2017 in ISBT Science Series

Platelet-bound lipopolysaccharide enhances Fc receptor-mediated phagocytosis of IgG-opsonized platelets

scientific article

Platelet-surface glycoproteins in healthy and preeclamptic mothers and their newborn infants

scientific article

Platelets and innate immunity

scientific article published on 18 December 2009

Platelets and the immune continuum ⬇️

scientific article published on April 1, 2011

Platelets as immune-sensing cells

article

Platelets deliver small packages of genetic function

scientific article published in July 2013

Platelets give us many messages

scientific article published on 01 October 2003

Platelets play a direct role in sepsis-associated endothelial cell death

scientific article published on 01 February 2008

Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation

scientific article

Preanalytical requirements for flow cytometric evaluation of platelet activation: choice of anticoagulant

scientific article published on 01 June 1999

Processed platelet HPA1a peptides au naturel

scientific article published on 01 August 2009

Processing and presentation of insulin. II. Evidence for intracellular, plasma membrane-associated and extracellular degradation of human insulin by antigen-presenting B cells

scientific article published on June 1989

Processing and presentation of insulin. III. Insulin degrading enzyme: a neutral metalloendoproteinase that is non-homologous to classical endoproteinases mediates the processing of insulin epitopes for helper T cells ⬇️

scientific article (publication date: October 1992)

Quality of thrombin produced from the patient's own plasma using the TPD, a new Thrombin-processing Device.

scientific article published in June 2005

Quantification of platelet activation status by analyzing P-selectin expression

scientific article published on 01 July 2000

Rapid separation of CD4+ and CD19+ lymphocyte populations from human peripheral blood by a magnetic activated cell sorter (MACS)

scientific article published on 01 November 1993

Recent progress in understanding the pathogenesis of immune thrombocytopenia

scientific article

Recipient T lymphocytes modulate the severity of antibody-mediated transfusion-related acute lung injury

scientific article published on 08 July 2010

Recipient antigen-processing pathways of allogeneic platelet antigens: essential mediators of immunity

scientific article

Recipient humoral immunity against leukoreduced allogeneic platelets is suppressed by aminoguanidine, a selective inhibitor of inducible nitric oxide synthase

scientific article published on 01 October 1996

Single nucleotide polymorphism (SNP) analysis demonstrates a significant association of tumour necrosis factor-alpha (TNFA) with primary immune thrombocytopenia among Caucasian adults

scientific article

Splenic lymphocyte subtypes in immune thrombocytopenia: increased presence of a subtype of B-regulatory cells

scientific article published on 24 June 2015

Sulfated beef insulin treatment elicits CD8+ T cells that may abrogate immunologic insulin resistance in type I diabetes

scientific article

Suppressed natural killer cell activity in patients with chronic autoimmune thrombocytopenic purpura ⬇️

scientific article published on August 1, 1991

T cell and cytokine abnormalities in patients with autoimmune thrombocytopenic purpura ⬇️

scientific article published on June 1, 2003

T granules in human platelets function in TLR9 organization and signaling ⬇️

scientific article published on August 20, 2012

T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10.

scientific article published on 15 February 2017

Targeting Transfusion-Related Acute Lung Injury: The Journey From Basic Science to Novel Therapies.

scientific article published on 30 January 2018

The Immune Nature of Platelets Revisited

scientific article published on 19 September 2020

The Pathogenic Involvement of Neutrophils in Acute Respiratory Distress Syndrome and Transfusion-Related Acute Lung Injury

scientific article published on 21 September 2018

The Role of Complement in Transfusion-Related Acute Lung Injury

scientific article published on 18 October 2019

The Ultimate Murine Model of Immune Thrombocytopaenia

scientific article published on 06 February 2019

The cellular immunology associated with autoimmune thrombocytopenic purpura: an update.

scientific article

The contribution of recipient platelets in TRALI: has the jury reached a verdict?

scientific article published on 01 May 2020

The immunopathogenesis of immune thrombocytopenia: T cells still take center-stage

scientific article

The nonhemostatic immune functions of platelets.

scientific article

The spleen dictates platelet destruction, anti-platelet antibody production, and lymphocyte distribution patterns in a murine model of immune thrombocytopenia

scientific article

The tyrosine kinase receptor Tyro3 enhances lifespan and neuropeptide Y (Npy) neuron survival in the mouse anorexia (anx) mutation

scientific article

Thrombopoietin receptor agonist (TPO-RA) treatment raises platelet counts and reduces anti-platelet antibody levels in mice with immune thrombocytopenia (ITP)

scientific article published on 30 May 2019

Thymic retention of CD4+CD25+FoxP3+ T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia

scientific article

Thymic-derived tolerizing dendritic cells are upregulated in the spleen upon treatment with intravenous immunoglobulin in a murine model of immune thrombocytopenia

scientific article

Transfusion of antibody-opsonized red blood cells results in a shift in the immune response from the red blood cell to the antibody in a murine model.

scientific article published in September 2010

Transfusion-associated circulatory overload (TACO): Time to shed light on the pathophysiology

Transfusion-associated circulatory overload and transfusion-related acute lung injury

scientific article published on 26 February 2019

Transfusion-related Acute Lung Injury in the Perioperative Patient

scientific article published on 01 September 2019

Transfusion-related immunomodulation by platelets is dependent on their expression of MHC Class I molecules and is independent of white cells

scientific article published on 02 June 2008

Treating murine inflammatory diseases with an anti-erythrocyte antibody

scientific article published on 01 August 2019

Unique processing pathways within recipient antigen-presenting cells determine IgG immunity against donor platelet MHC antigens

scientific article published on March 2000

Update on the pathophysiology of transfusion-related acute lung injury

scientific article published on 29 August 2020

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