List of works - Ulrich H Frey

A functional GNAQ promoter haplotype is associated with altered Gq expression and with insulin resistance and obesity in women with polycystic ovary syndrome.

scientific article published in August 2010

A novel aspect of GNAS imprinting: Higher maternal expression of Gαs in human lymphoblasts, peripheral blood mononuclear cells, mammary adipose tissue, and heart ⬇️

scientific article published on July 20, 2011

A novel functional haplotype in the human GNAS gene alters Galphas expression, responsiveness to beta-adrenoceptor stimulation, and peri-operative cardiac performance.

scientific article published on 10 January 2009

A novel promoter polymorphism in the human gene GNAS affects binding of transcription factor upstream stimulatory factor 1, Galphas protein expression and body weight regulation.

scientific article published on February 2008

A novel-1364A/C aquaporin 5 gene promoter polymorphism influences the responses to salt loading of the renin-angiotensin-aldosterone system and of blood pressure in young healthy men.

scientific article

ACE I/D but not AGT (-6)A/G polymorphism is a risk factor for mortality in ARDS

scientific article published on 15 November 2006

Alemtuzumab induces enhanced apoptosis in vitro in B-cells from patients with chronic lymphocytic leukemia by antibody-dependent cellular cytotoxicity.

scientific article published in May 2005

Amelogenin sex determination by pyrosequencing of short PCR products.

scientific article published on 20 March 2008

Aquaporin 1 and 5 expression evoked by the β2 adrenoreceptor agonist terbutaline and lipopolysaccharide in mice and in the human monocytic cell line THP-1 is differentially regulated.

scientific article published on November 2013

Aquaporin 5 Gene Promoter −1364A/C Polymorphism Associated with 30-day Survival in Severe Sepsis

article

Association of the GNB3 825T-allele with better survival in patients with glioblastoma multiforme.

scientific article

Association study of the G-protein beta3 subunit C825T polymorphism with disease progression an overall survival in patients with head and neck squamous cell carcinoma

scientific article published on 01 November 2008

Bax gene G(-248)A promoter polymorphism and chronic lymphocytic leukemia: lack of association with incidence, disease stage and progression-free survival

scientific article published on 01 April 2006

Better identification of patients who benefit from implantable cardioverter defibrillators by genotyping the G protein beta3 subunit (GNB3) C825T polymorphism.

scientific article published on 16 June 2006

CHRM3 rs2165870 polymorphism is independently associated with postoperative nausea and vomiting, but combined prophylaxis is effective

scientific article published on 04 April 2018

Can a brief psychological expectancy intervention improve postoperative pain? A randomized, controlled trial in patients with breast cancer

scientific article published on 01 July 2019

Characterization of the GNAQ promoter and association of increased Gq expression with cardiac hypertrophy in humans.

scientific article

Characterization of the PLCB1 promoter and regulation by early growth response transcription factor EGR-1.

scientific article published on September 2014

Circulating miR-192 is a prognostic marker in patients with ischemic cardiomyopathy

scientific article published on 21 June 2018

Cloning and characterization of the GNA11 promoter and its regulation by early growth response 1.

scientific article published on 19 July 2013

Comparison of mortality prediction models in acute respiratory distress syndrome undergoing extracorporeal membrane oxygenation and development of a novel prediction score: the PREdiction of Survival on ECMO Therapy-Score (PRESET-Score).

scientific article published on 12 December 2017

Comparison of thrombelastometry with procalcitonin, interleukin 6, and C-reactive protein as diagnostic tests for severe sepsis in critical ill adults ⬇️

scientific article published on October 7, 2010

Comparison of thrombelastometry with simplified acute physiology score II and sequential organ failure assessment scores for the prediction of 30-day survival: a cohort study

scientific article published on 01 April 2011

Cooperative effect of GNB3 825C>T and GPIIIa PI(A) polymorphisms in enhanced platelet aggregation.

scientific article

Darbepoetin alpha, a long-acting erythropoeitin derivate, does not alter LPS evoked myocardial depression and gene expression of Bax, Bcl-Xs, Bcl-XL, Bcl-2, and TNF-alpha

scientific article published on 01 January 2009

Decreased expression of miR-133a but not of miR-1 is associated with signs of heart failure in patients undergoing coronary bypass surgery.

scientific article published on 24 May 2013

ESC Joint Working Groups on Cardiovascular Surgery and the Cellular Biology of the Heart Position Paper: Perioperative myocardial injury and infarction in patients undergoing coronary artery bypass graft surgery

scientific article published in August 2017

Easy-to-use strategy for reference gene selection in quantitative real-time PCR experiments.

scientific article

Effect of P6 acustimulation on post-operative nausea and vomiting in patients undergoing a laparoscopic cholecystectomy.

scientific article published on 13 August 2009

Erythropoietin treatment improves liver regeneration and survival in rat models of extended liver resection and living donor liver transplantation.

scientific article published on December 2008

Establishment of an easy and straight forward heparinase protocol to analyse circulating and myocardial tissue micro-RNA during coronary artery-bypass-graft surgery.

scientific article published on 22 January 2018

Extracellular vesicles isolated from patients undergoing remote ischemic preconditioning decrease hypoxia-evoked apoptosis of cardiomyoblasts after isoflurane but not propofol exposure

scientific article published on 14 February 2020

FCRL2 mRNA expression is inversely associated with clinical progression in chronic lymphocytic leukemia.

scientific article

Factor V Leiden mutation is associated with improved 30-day survival in patients with acute respiratory distress syndrome.

scientific article published in June 2008

GNAQ TT(-695/-694)GC Polymorphism Is Associated with Increased Gq Expression, Vascular Reactivity, and Myocardial Injury after Coronary Artery Bypass Surgery.

scientific article

GNAS1 T393C polymorphism and disease progression in patients with malignant melanoma ⬇️

scientific article published on October 25, 2010

GNAS1 T393C polymorphism and survival in patients with sporadic colorectal cancer

scientific article published on 01 July 2005

GNB3 C825T polymorphism and response to interferon-alfa/ribavirin treatment in patients with hepatitis C virus genotype 1 (HCV-1) infection

scientific article

GNB3 gene 825 TT variant predicts hard coronary events in the population-based Heinz Nixdorf Recall study

scientific article published on 28 August 2014

Gender-dependent association of the GNAS1 T393C polymorphism with early aseptic loosening after total hip arthroplasty.

scientific article published in December 2008

Genetic contribution to PONV risk

scientific article published on 08 May 2019

Genetic interactions in the β-adrenoceptor/G-protein signal transduction pathway and survival after coronary artery bypass grafting: a pilot study

scientific article published on 01 December 2011

Hydrocortisone fails to abolish NF-κB1 protein nuclear translocation in deletion allele carriers of the NFKB1 promoter polymorphism (-94ins/delATTG) and is associated with increased 30-day mortality in septic shock.

scientific article

Increased circulating microRNA-122 is a biomarker for discrimination and risk stratification in patients defined by sepsis-3 criteria.

scientific article

Increased circulating microRNA-122 is associated with mortality and acute liver injury in the acute respiratory distress syndrome.

scientific article published on 23 June 2018

Interdisciplinary Comparison of PADUA and R.E.N.A.L. Scoring Systems for Prediction of Conversion to Nephrectomy in Patients with Renal Mass Scheduled for Nephron Sparing Surgery

scientific article published on 09 October 2019

Methylenetetrahydrofolate reductase (MTHFR) gene 677C>T and 1298A>C polymorphisms are associated with differential apoptosis of leukemic B cells in vitro and disease progression in chronic lymphocytic leukemia.

scientific article published in November 2004

Modified implantation height of the Sapien3™ transcatheter heart valve

scientific article published on 23 April 2019

Myocardial protection by remote ischaemic pre-conditioning is abolished in sulphonylurea-treated diabetics undergoing coronary revascularisation

scientific article published on 18 February 2014

Overall and relapse-free survival in oropharyngeal and hypopharyngeal squamous cell carcinoma are associated with genotypes of T393C polymorphism of the GNAS1 gene.

scientific article

P6 acustimulation effectively decreases postoperative nausea and vomiting in high-risk patients.

scientific article published on 25 February 2009

Postoperative nausea and vomiting: The role of the dopamine D2 receptor TaqIA polymorphism.

scientific article published on 29 July 2015

Regulation of glycolysis by Raf protein serine/threonine kinases

scientific article

Relevance of the NOS3 T-786C and G894T variants for cholinergic and adrenergic coronary vasomotor responses in man.

scientific article published on 20 July 2005

Remote ischaemic preconditioning increases serum extracellular vesicle concentrations with altered micro-RNA signature in CABG patients

scientific article published on 11 December 2018

Reply by Authors

Role of the GNAS1 T393C polymorphism in patients with glioblastoma multiforme ⬇️

scientific article published on September 15, 2011

Successful amplification of extremely GC-rich promoter regions using a novel 'slowdown PCR' technique

scientific article published on 01 December 2003

The Arg16Gly-β2-adrenoceptor single nucleotide polymorphism: exercise capacity and survival in patients with end-stage heart failure ⬇️

scientific article published on August 29, 2010

The C allele of the GNB3 C825T polymorphism of the G protein beta3-subunit is associated with an increased risk for the development of oncocytic thyroid tumours

scientific article published on 01 January 2007

The CC genotype of the C825T polymorphism of the G protein beta3 gene (GNB3) is associated with a high relapse rate in patients with chronic lymphocytic leukaemia.

scientific article published in October 2003

The CC genotype of the GNAS T393C polymorphism is associated with obesity and insulin resistance in women with polycystic ovary syndrome.

scientific article

The G-Allele of the PSMA6-8C>G polymorphism is associated with poor outcome in multiple myeloma independently of circulating proteasome serum levels

scientific article published on 08 April 2010

The GNAS1 T393C polymorphism is associated with disease progression and survival in chronic lymphocytic leukemia

scientific article published in October 2006

The GNB3 C825T polymorphism influences platelet aggregation in human whole blood.

scientific article published in January 2012

The GRK2 Promoter Is Regulated by Early-Growth Response Transcription Factor EGR-1

scientific article published on 09 July 2018

The IKZF3 (Aiolos) transcription factor is highly upregulated and inversely correlated with clinical progression in chronic lymphocytic leukaemia

scientific article published on 11 November 2008

The NFKB1 promoter polymorphism (-94ins/delATTG) alters nuclear translocation of NF-κB1 in monocytes after lipopolysaccharide stimulation and is associated with increased mortality in sepsis.

scientific article

The T393C polymorphism in the gene GNAS1 of G protein is associated with survival of patients with invasive breast carcinoma.

scientific article published on 21 December 2006

The T393C polymorphism of the G alpha s gene (GNAS1) is a novel prognostic marker in bladder cancer

scientific article published on 01 April 2005

The functional Aquaporin 1 -783G/C-polymorphism is associated with survival in patients with glioblastoma multiforme.

scientific article

The human G protein beta4 subunit: gene structure, expression, Ggamma and effector interaction.

scientific article

The minimally invasive MitraClip™ procedure for mitral regurgitation under general anaesthesia: immediate effects on the pulmonary circulation and right ventricular function

scientific article published on 7 May 2014

Transfemoral aortic valve implantation under sedation and monitored anaesthetic care--a feasibility study.

scientific article published on 20 September 2011

True Lumen Stabilization to Overcome Malperfusion in Acute Type I Aortic Dissection

scientific article published on 08 December 2018

[How Much Alarm Can the Human Being Tolerate?]

scientific article published on 25 July 2017

[Point-of-Care Testing in Trauma Patients - Methods and Evidence]

scientific article published on 26 June 2018

β2-Adrenoceptor gene variants affect vasopressor requirements in patients after thoracic epidural anaesthesia.

scientific article published on 22 December 2013

List of works by Ulrich H Frey

A functional GNAQ promoter haplotype is associated with altered Gq expression and with insulin resistance and obesity in women with polycystic ovary syndrome.

A novel aspect of GNAS imprinting: Higher maternal expression of Gαs in human lymphoblasts, peripheral blood mononuclear cells, mammary adipose tissue, and heart ⬇️

A novel functional haplotype in the human GNAS gene alters Galphas expression, responsiveness to beta-adrenoceptor stimulation, and peri-operative cardiac performance.

A novel promoter polymorphism in the human gene GNAS affects binding of transcription factor upstream stimulatory factor 1, Galphas protein expression and body weight regulation.

A novel-1364A/C aquaporin 5 gene promoter polymorphism influences the responses to salt loading of the renin-angiotensin-aldosterone system and of blood pressure in young healthy men.

ACE I/D but not AGT (-6)A/G polymorphism is a risk factor for mortality in ARDS

Alemtuzumab induces enhanced apoptosis in vitro in B-cells from patients with chronic lymphocytic leukemia by antibody-dependent cellular cytotoxicity.

Amelogenin sex determination by pyrosequencing of short PCR products.

Aquaporin 1 and 5 expression evoked by the β2 adrenoreceptor agonist terbutaline and lipopolysaccharide in mice and in the human monocytic cell line THP-1 is differentially regulated.

Aquaporin 5 Gene Promoter −1364A/C Polymorphism Associated with 30-day Survival in Severe Sepsis

Association of the GNB3 825T-allele with better survival in patients with glioblastoma multiforme.

Association study of the G-protein beta3 subunit C825T polymorphism with disease progression an overall survival in patients with head and neck squamous cell carcinoma

Bax gene G(-248)A promoter polymorphism and chronic lymphocytic leukemia: lack of association with incidence, disease stage and progression-free survival

Better identification of patients who benefit from implantable cardioverter defibrillators by genotyping the G protein beta3 subunit (GNB3) C825T polymorphism.

CHRM3 rs2165870 polymorphism is independently associated with postoperative nausea and vomiting, but combined prophylaxis is effective

Can a brief psychological expectancy intervention improve postoperative pain? A randomized, controlled trial in patients with breast cancer

Characterization of the GNAQ promoter and association of increased Gq expression with cardiac hypertrophy in humans.

Characterization of the PLCB1 promoter and regulation by early growth response transcription factor EGR-1.

Circulating miR-192 is a prognostic marker in patients with ischemic cardiomyopathy

Cloning and characterization of the GNA11 promoter and its regulation by early growth response 1.

Comparison of mortality prediction models in acute respiratory distress syndrome undergoing extracorporeal membrane oxygenation and development of a novel prediction score: the PREdiction of Survival on ECMO Therapy-Score (PRESET-Score).

Comparison of thrombelastometry with procalcitonin, interleukin 6, and C-reactive protein as diagnostic tests for severe sepsis in critical ill adults ⬇️

Comparison of thrombelastometry with simplified acute physiology score II and sequential organ failure assessment scores for the prediction of 30-day survival: a cohort study

Cooperative effect of GNB3 825C>T and GPIIIa PI(A) polymorphisms in enhanced platelet aggregation.

Darbepoetin alpha, a long-acting erythropoeitin derivate, does not alter LPS evoked myocardial depression and gene expression of Bax, Bcl-Xs, Bcl-XL, Bcl-2, and TNF-alpha

Decreased expression of miR-133a but not of miR-1 is associated with signs of heart failure in patients undergoing coronary bypass surgery.

ESC Joint Working Groups on Cardiovascular Surgery and the Cellular Biology of the Heart Position Paper: Perioperative myocardial injury and infarction in patients undergoing coronary artery bypass graft surgery

Easy-to-use strategy for reference gene selection in quantitative real-time PCR experiments.

Effect of P6 acustimulation on post-operative nausea and vomiting in patients undergoing a laparoscopic cholecystectomy.

Erythropoietin treatment improves liver regeneration and survival in rat models of extended liver resection and living donor liver transplantation.

Establishment of an easy and straight forward heparinase protocol to analyse circulating and myocardial tissue micro-RNA during coronary artery-bypass-graft surgery.

Extracellular vesicles isolated from patients undergoing remote ischemic preconditioning decrease hypoxia-evoked apoptosis of cardiomyoblasts after isoflurane but not propofol exposure

FCRL2 mRNA expression is inversely associated with clinical progression in chronic lymphocytic leukemia.

Factor V Leiden mutation is associated with improved 30-day survival in patients with acute respiratory distress syndrome.

GNAQ TT(-695/-694)GC Polymorphism Is Associated with Increased Gq Expression, Vascular Reactivity, and Myocardial Injury after Coronary Artery Bypass Surgery.

GNAS1 T393C polymorphism and disease progression in patients with malignant melanoma ⬇️

GNAS1 T393C polymorphism and survival in patients with sporadic colorectal cancer

GNB3 C825T polymorphism and response to interferon-alfa/ribavirin treatment in patients with hepatitis C virus genotype 1 (HCV-1) infection

GNB3 gene 825 TT variant predicts hard coronary events in the population-based Heinz Nixdorf Recall study

Gender-dependent association of the GNAS1 T393C polymorphism with early aseptic loosening after total hip arthroplasty.

Genetic contribution to PONV risk

Genetic interactions in the β-adrenoceptor/G-protein signal transduction pathway and survival after coronary artery bypass grafting: a pilot study

Hydrocortisone fails to abolish NF-κB1 protein nuclear translocation in deletion allele carriers of the NFKB1 promoter polymorphism (-94ins/delATTG) and is associated with increased 30-day mortality in septic shock.

Increased circulating microRNA-122 is a biomarker for discrimination and risk stratification in patients defined by sepsis-3 criteria.

Increased circulating microRNA-122 is associated with mortality and acute liver injury in the acute respiratory distress syndrome.

Interdisciplinary Comparison of PADUA and R.E.N.A.L. Scoring Systems for Prediction of Conversion to Nephrectomy in Patients with Renal Mass Scheduled for Nephron Sparing Surgery

Methylenetetrahydrofolate reductase (MTHFR) gene 677C>T and 1298A>C polymorphisms are associated with differential apoptosis of leukemic B cells in vitro and disease progression in chronic lymphocytic leukemia.

Modified implantation height of the Sapien3™ transcatheter heart valve

Myocardial protection by remote ischaemic pre-conditioning is abolished in sulphonylurea-treated diabetics undergoing coronary revascularisation

Overall and relapse-free survival in oropharyngeal and hypopharyngeal squamous cell carcinoma are associated with genotypes of T393C polymorphism of the GNAS1 gene.

P6 acustimulation effectively decreases postoperative nausea and vomiting in high-risk patients.

Postoperative nausea and vomiting: The role of the dopamine D2 receptor TaqIA polymorphism.

Regulation of glycolysis by Raf protein serine/threonine kinases

Relevance of the NOS3 T-786C and G894T variants for cholinergic and adrenergic coronary vasomotor responses in man.

Remote ischaemic preconditioning increases serum extracellular vesicle concentrations with altered micro-RNA signature in CABG patients

Reply by Authors

Role of the GNAS1 T393C polymorphism in patients with glioblastoma multiforme ⬇️

Successful amplification of extremely GC-rich promoter regions using a novel 'slowdown PCR' technique

The Arg16Gly-β2-adrenoceptor single nucleotide polymorphism: exercise capacity and survival in patients with end-stage heart failure ⬇️

The C allele of the GNB3 C825T polymorphism of the G protein beta3-subunit is associated with an increased risk for the development of oncocytic thyroid tumours

The CC genotype of the C825T polymorphism of the G protein beta3 gene (GNB3) is associated with a high relapse rate in patients with chronic lymphocytic leukaemia.

The CC genotype of the GNAS T393C polymorphism is associated with obesity and insulin resistance in women with polycystic ovary syndrome.

The G-Allele of the PSMA6-8C>G polymorphism is associated with poor outcome in multiple myeloma independently of circulating proteasome serum levels

The GNAS1 T393C polymorphism is associated with disease progression and survival in chronic lymphocytic leukemia

The GNB3 C825T polymorphism influences platelet aggregation in human whole blood.

The GRK2 Promoter Is Regulated by Early-Growth Response Transcription Factor EGR-1

The IKZF3 (Aiolos) transcription factor is highly upregulated and inversely correlated with clinical progression in chronic lymphocytic leukaemia

The NFKB1 promoter polymorphism (-94ins/delATTG) alters nuclear translocation of NF-κB1 in monocytes after lipopolysaccharide stimulation and is associated with increased mortality in sepsis.

The T393C polymorphism in the gene GNAS1 of G protein is associated with survival of patients with invasive breast carcinoma.

The T393C polymorphism of the G alpha s gene (GNAS1) is a novel prognostic marker in bladder cancer

The functional Aquaporin 1 -783G/C-polymorphism is associated with survival in patients with glioblastoma multiforme.

The human G protein beta4 subunit: gene structure, expression, Ggamma and effector interaction.

The minimally invasive MitraClip™ procedure for mitral regurgitation under general anaesthesia: immediate effects on the pulmonary circulation and right ventricular function

Transfemoral aortic valve implantation under sedation and monitored anaesthetic care--a feasibility study.

True Lumen Stabilization to Overcome Malperfusion in Acute Type I Aortic Dissection

[How Much Alarm Can the Human Being Tolerate?]

[Point-of-Care Testing in Trauma Patients - Methods and Evidence]

β2-Adrenoceptor gene variants affect vasopressor requirements in patients after thoracic epidural anaesthesia.