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List of works by Shunichi Takeda

A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models

scientific article

A chemical neurotoxin, MPTP induces Parkinson's disease like phenotype, movement disorders and persistent loss of dopamine neurons in medaka fish

scientific article published on 7 August 2009

A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination

scientific article

A mutated EGFR is sufficient to induce malignant melanoma with genetic background-dependent histopathologies.

scientific article published in January 2010

A naturally occurring genetic variant of human XRCC2 (R188H) confers increased resistance to cisplatin-induced DNA damage

scientific article published on 27 November 2006

A novel Rad18 function involved in protection of the vertebrate genome after exposure to camptothecin

scientific article published on 22 August 2006

A novel approach using DNA-repair-deficient chicken DT40 cell lines for screening and characterizing the genotoxicity of environmental contaminants

scientific article

A novel genotoxicity assay of carbon nanotubes using functional macrophage receptor with collagenous structure (MARCO)-expressing chicken B lymphocytes

scientific article published on 21 August 2013

ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair

scientific article published on 17 November 2017

ATF6α/β-mediated adjustment of ER chaperone levels is essential for development of the notochord in medaka fish

scientific article published on 27 February 2013

ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization When DSBs Form by Blocking HUWE1 to Allow Efficient γH2AX Foci Formation

scientific article published on 16 December 2015

ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons

scientific journal article

Accumulation of true single strand breaks and AP sites in base excision repair deficient cells

scientific article

Activation of Cdh1-dependent APC is required for G1 cell cycle arrest and DNA damage-induced G2 checkpoint in vertebrate cells

scientific article

Alleviation of Abeta-induced cognitive impairment by ultrasound-mediated gene transfer of HGF in a mouse model

scientific article published on 21 February 2008

Ammonium chloride and tunicamycin are novel toxins for dopaminergic neurons and induce Parkinson's disease-like phenotypes in medaka fish

scientific article published on 26 October 2010

An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63.

scientific article

An essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells

scientific article

Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways.

scientific article

Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics.

scientific article published on 19 December 2011

BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination

scientific article

BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes

article published in the Proceedings of the National Academy of Sciences of the United States of America

Berberine induces double-strand DNA breaks in Rev3 deficient cells

scientific article published on 28 February 2014

Bloom DNA helicase facilitates homologous recombination between diverged homologous sequences

scientific article

Bloom helicase is involved in DNA surveillance in early S phase in vertebrate cells.

scientific article published on March 2001

Cells deficient in PARP-1 show an accelerated accumulation of DNA single strand breaks, but not AP sites, over the PARP-1-proficient cells exposed to MMS.

scientific article published on 22 September 2009

Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM.

scientific article

Chicken DT40 cell line lacking DJ-1, the gene responsible for familial Parkinson's disease, displays mitochondrial dysfunction

scientific article published on 21 September 2013

Chromatin remodeler ALC1 prevents replication-fork collapse by slowing fork progression

scientific article published on 6 February 2018

Cohesin associates with spindle poles in a mitosis-specific manner and functions in spindle assembly in vertebrate cells

scientific article published on 30 December 2008

Collaborative roles of gammaH2AX and the Rad51 paralog Xrcc3 in homologous recombinational repair

scientific article published on 22 November 2006

Connecting the dots between septins and the DNA damage checkpoint.

scientific article published in September 2007

Conserved domains in the chicken homologue of BRCA2

scientific article published on 01 February 2002

Convenient, multi-well plate-based DNA damage response analysis using DT40 mutants is applicable to a high-throughput genotoxicity assay with characterization of modes of action

scientific article published on March 2011

Cooperative roles of vertebrate Fbh1 and Blm DNA helicases in avoidance of crossovers during recombination initiated by replication fork collapse

scientific article published on 5 February 2007

Corrigendum to “DNA damage response protein ASCIZ links base excision repair with immunoglobulin gene conversion” [Biochem. Biophys. Res. Commun. 371 (2008) 225–229]

article

CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1.

scientific article published on 17 November 2010

Ctp1/CtIP and the MRN complex collaborate in the initial steps of homologous recombination

scientific article published on November 2007

Cyclin-dependent kinases and cell-cycle transitions: does one fit all?

scientific article

Cytotoxicity of Tirapazamine (3-Amino-1,2,4-benzotriazine-1,4-dioxide)-Induced DNA Damage in Chicken DT40 Cells

scientific article published on 12 December 2016

DDB1 gene disruption causes a severe growth defect and apoptosis in chicken DT40 cells

scientific article published on 22 October 2007

DNA cross-link repair protein SNM1A interacts with PIAS1 in nuclear focus formation

scientific article

DNA damage induces Chk1-dependent threonine-160 phosphorylation and activation of Cdk2.

scientific article published on 19 October 2009

DNA damage response protein ASCIZ links base excision repair with immunoglobulin gene conversion

scientific article

DNA ligase IV-deficient cells are more resistant to ionizing radiation in the absence of Ku70: Implications for DNA double-strand break repair

scientific article

DNA-dependent protein kinase inhibits AID-induced antibody gene conversion

scientific article

Differential and collaborative actions of Rad51 paralog proteins in cellular response to DNA damage

scientific article

Differential micronucleus frequency in isogenic human cells deficient in DNA repair pathways is a valuable indicator for evaluating genotoxic agents and their genotoxic mechanisms

Differential usage of non-homologous end-joining and homologous recombination in double strand break repair

scientific article published on 27 June 2006

Disruption of the BLM gene in ATM-null DT40 cells does not exacerbate either phenotype

scientific article published on February 2004

Disruption of the HSF3 gene results in the severe reduction of heat shock gene expression and loss of thermotolerance.

scientific article published on March 1998

Distinct DNA Damage Spectra Induced by Ionizing Radiation in Normoxic and Hypoxic Cells

scientific article published on 2 October 2015

Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis

scientific article

Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2

scientific article (publication date: October 2003)

EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step

scientific article

Early expression of Ig μ chain from a transgene significantly reduces the duration of the pro-B stage but does not affect the small pre-B stage

scientific article published on 01 August 1996

Efficient rejoining of radiation-induced DNA double-strand breaks in vertebrate cells deficient in genes of the RAD52 epistasis group.

scientific article published in April 2001

Escherichia coli extract-catalyzed recombination in switch regions of mouse immunoglobulin genes.

scientific article published on May 1983

Evolution of pre-existing versus acquired resistance to platinum drugs and PARP inhibitors in BRCA-associated cancers

scientific article

Exploring the pathogenetic mechanisms underlying Parkinson's disease in medaka fish

scientific article published on January 2014

Extensive chromosomal breaks are induced by tamoxifen and estrogen in DNA repair-deficient cells

scientific article published on May 2004

FEN1 functions in long patch base excision repair under conditions of oxidative stress in vertebrate cells

scientific article

Fen-1 facilitates homologous recombination by removing divergent sequences at DNA break ends

scientific article published on August 2005

Fibroblast-dependent growth of mouse mast cells in vitro: duplication of mast cell depletion in mutant mice of W/Wv genotype.

scientific article published on January 1988

Forcible destruction of severely misfolded mammalian glycoproteins by the non-glycoprotein ERAD pathway

scientific article

GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination

scientific article

Generation and iterative affinity maturation of antibodies in vitro using hypermutating B-cell lines

scientific article published on 15 October 2002

Generation and phenotypic analysis of conditionally inactivated mutant cells

Generation of medaka gene knockout models by target-selected mutagenesis

scientific article

Genetic Evidence for Genotoxic Effect of Entecavir, an Anti-Hepatitis B Virus Nucleotide Analog

scientific article published on 22 January 2016

Genetic Evidence for the Involvement of Mismatch Repair Proteins, PMS2 and MLH3, in a Late Step of Homologous Recombination

scientific article published on 02 October 2020

Genetic analysis of the DNA-dependent protein kinase reveals an inhibitory role of Ku in late S-G2 phase DNA double-strand break repair

scientific article

Genetic dissection of vertebrate 53BP1: a major role in non-homologous end joining of DNA double strand breaks

scientific article published on 27 April 2006

Genetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig v in chicken B lymphocytes

scientific article

Genetic evidence that the non-homologous end-joining repair pathway is involved in LINE retrotransposition

scientific article

Genistein‐induced DNA damage is repaired by nonhomologous end joining and homologous recombination in TK6 cells

Genotoxic potentials and related mechanisms of bisphenol A and other bisphenol compounds: a comparison study employing chicken DT40 cells

scientific article published on 18 June 2013

Genotoxicity of several polybrominated diphenyl ethers (PBDEs) and hydroxylated PBDEs, and their mechanisms of toxicity

scientific article published on 5 May 2011

Histone H1 null vertebrate cells exhibit altered nucleosome architecture

scientific article

Histone H1 variant, H1R is involved in DNA damage response

scientific article published on 05 July 2007

Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity

scientific article published on 23 January 2014

Homologous DNA recombination in vertebrate cells

scientific article

Homologous Recombination and Translesion DNA Synthesis Play Critical Roles on Tolerating DNA Damage Caused by Trace Levels of Hexavalent Chromium

scientific article

Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells ⬇️

scientific article (publication date: 15 September 1998)

Homologous recombination, but not DNA repair, is reduced in vertebrate cells deficient in RAD52.

scientific article published on November 1998

Homologous-pairing activity of the human DNA-repair proteins Xrcc3.Rad51C

scientific article

Human replicative DNA polymerase δ can bypass T-T (6-4) ultraviolet photoproducts on template strands

scientific article published on 11 November 2010

Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform

scientific article

In vitro effects of recombinant interleukin 7 on growth and differentiation of bone marrow pro-B- and pro-T-lymphocyte clones and fetal thymocyte clones.

scientific article

In vivo evidence for translesion synthesis by the replicative DNA polymerase δ.

scientific article published on 16 May 2016

Incorporation of metabolic activation potentiates cyclophosphamide-induced DNA damage response in isogenic DT40 mutant cells

scientific article

Increased ratio of targeted to random integration after transfection of chicken B cell lines.

scientific article published on October 1991

Induction of the 2B9 antigen/dipeptidyl peptidase IV/CD26 on human natural killer cells by IL-2, IL-12 or IL-15.

scientific article published on May 1997

Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells.

scientific article

Interference in DNA replication can cause mitotic chromosomal breakage unassociated with double-strand breaks

scientific article

Introduction and Expression of the Interleukin 2 Receptor (Tac) Gene in Hematopoietic Stem Cells with Retrovirus Vectors

article

Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway

scientific article

Involvement of vertebrate Polkappa in translesion DNA synthesis across DNA monoalkylation damage

scientific article published on 23 November 2005

Involvement of vertebrate polkappa in Rad18-independent postreplication repair of UV damage

scientific article

KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents

scientific article

Ku70 prevents genome instability resulting from heterozygosity of the telomerase RNA component in a vertebrate tumour line

scientific article

Leptin receptor-deficient (knockout) medaka, Oryzias latipes, show chronical up-regulated levels of orexigenic neuropeptides, elevated food intake and stage specific effects on growth and fat allocation.

scientific article published on 25 October 2013

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

scientific article published on 01 September 1996

Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes.

scientific article published on November 2016

Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes.

scientific article published in December 2016

Multiple repair pathways mediate cellular tolerance to resveratrol-induced DNA damage

scientific article published on 18 April 2017

Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells

scientific article published in December 2005

Multiple roles of vertebrate REV genes in DNA repair and recombination

scientific article

Mutant cells defective in DNA repair pathways provide a sensitive high-throughput assay for genotoxicity

scientific article

Myostatin-deficient medaka exhibit a double-muscling phenotype with hyperplasia and hypertrophy, which occur sequentially during post-hatch development

scientific article published on 07 September 2011

Nucleotide sequence of mouse IL-2 receptor cDNA and its comparison with the human IL-2 receptor sequence.

scientific article published on March 1985

Oxidative stress at low levels can induce clustered DNA lesions leading to NHEJ mediated mutations

scientific article published on 23 March 2016

PARP-1 ensures regulation of replication fork progression by homologous recombination on damaged DNA.

scientific article published on 22 December 2008

PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates

scientific article

Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells

scientific article

Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase

scientific article published on 4 June 2007

Poor recognition of O6-isopropyl dG by MGMT triggers double strand break-mediated cell death and micronucleus induction in FANC-deficient cells

scientific article published on 29 July 2016

Post-replication repair in DT40 cells: translesion polymerases versus recombinases

scientific article published on February 2004

Potentials and mechanisms of genotoxicity of six pharmaceuticals frequently detected in freshwater environment

scientific article

Preclinical detection in Japanese families with myotonic dystrophy using polymorphic DNA markers

scientific article published on 01 September 1989

Production of Extrachromosomal MicroDNAs Is Linked to Mismatch Repair Pathways and Transcriptional Activity

scientific article

Proteasome inhibition in medaka brain induces the features of Parkinson's disease

scientific article published on 12 August 2010

Proteomics Analysis with a Nano Random Forest Approach Reveals Novel Functional Interactions Regulated by SMC Complexes on Mitotic Chromosomes

scientific article published on 26 May 2016

Purification of the human SMN-GEMIN2 complex and assessment of its stimulation of RAD51-mediated DNA recombination reactions

scientific article

RAD18 and RAD54 cooperatively contribute to maintenance of genomic stability in vertebrate cells

scientific article published on October 2002

RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors

scientific article

RAP80 acts independently of BRCA1 in repair of topoisomerase II poison-induced DNA damage

scientific article published on 19 October 2010

Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death

scientific article (publication date: 15 January 1998)

Rad52 partially substitutes for the Rad51 paralog XRCC3 in maintaining chromosomal integrity in vertebrate cells

scientific article

Rapid assessment of two major repair activities against DNA double-strand breaks in vertebrate cells

scientific article published on 17 November 2005

Rapid generation of specific antibodies by enhanced homologous recombination

scientific article published on 29 May 2005

Rationale for poly(ADP-ribose) polymerase (PARP) inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition

scientific article

Re-evaluation of the probabilities for productive rearrangements on the κ andλloci

scientific article published on 01 January 1996

Regulation of the Fanconi anemia pathway by a SUMO-like delivery network

scientific article

Relative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double-strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell lines

scientific article

Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides

scientific article published on 26 May 2016

Reverse genetic studies of the DNA damage response in the chicken B lymphocyte line DT40.

scientific article published in August 2004

SPARTAN promotes genetic diversification of the immunoglobulin-variable gene locus in avian DT40 cells

SUMO-targeted ubiquitin ligase RNF4 plays a critical role in preventing chromosome loss

scientific article published on 10 September 2014

Selective cytotoxicity of the anti-diabetic drug, metformin, in glucose-deprived chicken DT40 cells

scientific article published on 19 September 2017

Similar effects of Brca2 truncation and Rad51 paralog deficiency on immunoglobulin V gene diversification in DT40 cells support an early role for Rad51 paralogs in homologous recombination

scientific article

Simultaneous disruption of two DNA polymerases, Polη and Polζ, in Avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions

scientific article

Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells

scientific article

Split Dose Recovery Studies using Homologous Recombination Deficient Gene Knockout Chicken B Lymphocyte Cells

article

Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib

scientific article published on 19 December 2013

TDP1 is critical for the repair of DNA breaks induced by sapacitabine, a nucleoside also targeting ATM- and BRCA-deficient tumors

scientific article

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.

scientific article

Targeted disruption of an H3-IV/H3-V gene pair causes increased expression of the remaining H3 genes in the chicken DT40 cell line.

scientific article published on July 1995

The 9-1-1 DNA clamp is required for immunoglobulin gene conversion

scientific article

The BRCT domain of PARP-1 is required for immunoglobulin gene conversion ⬇️

scientific article

The POLD3 subunit of DNA polymerase δ can promote translesion synthesis independently of DNA polymerase ζ.

scientific article

The SUMO protease SENP1 is required for cohesion maintenance and mitotic arrest following spindle poison treatment

scientific article published on 27 August 2012

The USP1/UAF1 complex promotes double-strand break repair through homologous recombination

scientific article published on 11 April 2011

The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination

scientific article

The essential functions of human Rad51 are independent of ATP hydrolysis

scientific article

The histone chaperone facilitates chromatin transcription (FACT) protein maintains normal replication fork rates

scientific article published on 07 July 2011

The role of HERC2 and RNF8 ubiquitin E3 ligases in the promotion of translesion DNA synthesis in the chicken DT40 cell line

scientific article published on 02 March 2016

The unfolded protein response transducer ATF6 represents a novel transmembrane-type endoplasmic reticulum-associated degradation substrate requiring both mannose trimming and SEL1L protein

scientific article published on 16 September 2013

The vital link between the ubiquitin-proteasome pathway and DNA repair: impact on cancer therapy

scientific article published on 06 February 2009

Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis

scientific article

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

scientific article

Tumor suppressor RecQL5 controls recombination induced by DNA crosslinking agents

scientific article

Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells

scientific article published on 27 February 2012

Ubiquitin-binding motifs in REV1 protein are required for its role in the tolerance of DNA damage

scientific article published on 18 September 2006

Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage

scientific article published on October 2006

Vertebrate unfolded protein response: mammalian signaling pathways are conserved in Medaka fish

scientific article

Viable neuronopathic Gaucher disease model in Medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein

scientific article (publication date: April 2015)

Werner and Bloom helicases are involved in DNA repair in a complementary fashion

scientific article published on January 2002

XRCC3 and Rad51 modulate replication fork progression on damaged vertebrate chromosomes

scientific article published in April 2003

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