List of works - Mahtab Moayeri

A Bacillus anthracis strain deleted for six proteases serves as an effective host for production of recombinant proteins

scientific article

A Bacteriophage T4 Nanoparticle-Based Dual Vaccine against Anthrax and Plague ⬇️

scientific article

A Bivalent Anthrax-Plague Vaccine That Can Protect against Two Tier-1 Bioterror Pathogens, Bacillus anthracis and Yersinia pestis

scientific article published on 26 June 2017

A Diverse Set of Single-domain Antibodies (VHHs) against the Anthrax Toxin Lethal and Edema Factors Provides a Basis for Construction of a Bispecific Agent That Protects against Anthrax Infection

scientific article published on 18 August 2016

A heterodimer of a VHH (variable domains of camelid heavy chain-only) antibody that inhibits anthrax toxin cell binding linked to a VHH antibody that blocks oligomer formation is highly protective in an anthrax spore challenge model

scientific article

Adenoviral Expression of a Bispecific VHH-Based Neutralizing Agent That Targets Protective Antigen Provides Prophylactic Protection from Anthrax in Mice

scientific article published on 6 January 2016

Anthrax Pathogenesis

scientific article published on 16 July 2015

Anthrax Toxins

Anthrax and the inflammasome

scientific article published on 17 December 2011

Anthrax edema factor toxicity is strongly mediated by the N-end rule

scientific article

Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport

scientific article published on 25 September 2017

Anthrax edema toxin has cAMP-mediated stimulatory effects and high-dose lethal toxin has depressant effects in an isolated perfused rat heart model

scientific article

Anthrax edema toxin impairs clearance in mice

scientific article published on 21 November 2011

Anthrax edema toxin sensitizes DBA/2J mice to lethal toxin

scientific article published on 5 March 2007

Anthrax immune globulin improves hemodynamics and survival during B. anthracis toxin-induced shock in canines receiving titrated fluid and vasopressor support

scientific article published on 23 October 2017

Anthrax lethal and edema toxins in anthrax pathogenesis

scientific article

Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome

scientific article

Anthrax lethal factor cleaves mouse nlrp1b in both toxin-sensitive and toxin-resistant macrophages

scientific article

Anthrax lethal factor cleaves regulatory subunits of phosphoinositide-3 kinase to contribute to toxin lethality

scientific article published on 07 September 2020

Anthrax lethal factor represses glucocorticoid and progesterone receptor activity

scientific article

Anthrax lethal toxin activates the inflammasome in sensitive rat macrophages

scientific journal article

Anthrax lethal toxin downregulates claudin-5 expression in human endothelial tight junctions

scientific article

Anthrax lethal toxin induces ketotifen-sensitive intradermal vascular leakage in certain inbred mice

scientific article

Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome

scientific article published on 10 September 2007

Anthrax protective antigen cleavage and clearance from the blood of mice and rats

scientific article

Anthrax toxin targeting of myeloid cells through the CMG2 receptor is essential for establishment of Bacillus anthracis infections in mice

scientific article

Antidotes to anthrax lethal factor intoxication. Part 1: Discovery of potent lethal factor inhibitors with in vivo efficacy

scientific article

Antidotes to anthrax lethal factor intoxication. Part 2: structural modifications leading to improved in vivo efficacy

scientific article

Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain

scientific article

Arsenic trioxide and other arsenical compounds inhibit the NLRP1, NLRP3, and NAIP5/NLRC4 inflammasomes

scientific article published on 13 December 2013

Assessment of validity and reliability of Drug Hypersensitivity Quality of Life Questionnaire: The Dutch experience

scientific article published in May 2017

Auranofin protects against anthrax lethal toxin-induced activation of the Nlrp1b inflammasome

scientific article

B. anthracis Lethal Toxin but not Edema Toxin, Increases Pulmonary Artery Pressure and Permeability in Isolated Perfused Rat Lungs

scientific article published on 15 February 2019

Bacillus anthracis Edema Toxin Inhibits Hypoxic Pulmonary Vasoconstrictionvia Edema Factor and cAMP Mediated Mechanisms in Isolated Perfused Rat Lungs

scientific article published on 16 October 2020

Bacillus anthracis edema and lethal toxin have different hemodynamic effects but function together to worsen shock and outcome in a rat model

scientific article published on 03 January 2007

Bacillus anthracis edema toxin causes extensive tissue lesions and rapid lethality in mice

scientific article

Bacillus anthracis lethal toxin induces TNF-alpha-independent hypoxia-mediated toxicity in mice

scientific article published on September 2003

Bacillus anthracis lethal toxin induces TNF-α–independent hypoxia-mediated toxicity in mice

article

Bacillus anthracis toxins ⬇️

academic chapter published in The Comprehensive Sourcebook of Bacterial Protein Toxins, 4th edition

Bacterial Exotoxins and the Inflammasome

scientific article

Battling against host phagocytes: the wherefore of the RTX family of toxins?

scientific article published on December 1995

Blocking anthrax lethal toxin at the protective antigen channel by using structure-inspired drug design

scientific article

CA-074Me protection against anthrax lethal toxin

scientific article published on 27 July 2009

Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo

scientific article

Cellular and systemic effects of anthrax lethal toxin and edema toxin

scientific article published on 26 July 2009

Characterization of the NLRP1 inflammasome response in bovine species

scientific article published on 11 November 2019

Cisplatin inhibition of anthrax lethal toxin

scientific article

Delayed treatment with W1-mAb, a chimpanzee-derived monoclonal antibody against protective antigen, reduces mortality from challenges with anthrax edema or lethal toxin in rats and with anthrax spores in mice

scientific article

Detection of anthrax toxin by an ultrasensitive immunoassay using europium nanoparticles

scientific article

Dual role for inflammasome sensors NLRP1 and NLRP3 in murine resistance to Toxoplasma gondii

scientific article published on 18 February 2014

Effects of temperature, time, and toxin concentration on lesion formation by the Escherichia coli hemolysin.

scientific article published on October 1994

Efficient neutralization of anthrax toxin by chimpanzee monoclonal antibodies against protective antigen

scientific article published on 2 February 2006

Endocrine perturbation increases susceptibility of mice to anthrax lethal toxin

scientific article

Engineering anthrax toxin variants that exclusively form octamers and their application to targeting tumors

scientific article

Fluid support worsens outcome and negates the benefit of protective antigen-directed monoclonal antibody in a lethal toxin-infused rat Bacillus anthracis shock model.

scientific article published in June 2007

Frontline Science: Anthrax lethal toxin-induced, NLRP1-mediated IL-1β release is a neutrophil and PAD4-dependent event

scientific article published on 18 May 2020

Heat shock inhibits caspase-1 activity while also preventing its inflammasome-mediated activation by anthrax lethal toxin

scientific article published on 28 August 2008

Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis

scientific article

Hijacking multivesicular bodies enables long-term and exosome-mediated long-distance action of anthrax toxin

scientific article

Imaging of anthrax intoxication in mice reveals shared and individual functions of surface receptors CMG-2 and TEM-8 in cellular toxin entry

scientific article published on 04 December 2021

In vivo characterization of an Hfq protein encoded by the Bacillus anthracis virulence plasmid pXO1 ⬇️

scientific article

In vivo efficacy of beta-cyclodextrin derivatives against anthrax lethal toxin

scientific article published on 31 March 2008

Inflammasome sensor NLRP1 controls rat macrophage susceptibility to Toxoplasma gondii

scientific article

Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment

scientific article

Inflammasomes in livestock and wildlife: Insights into the intersection of pathogens and natural host species

scholarly article by Catherine E Vrentas et al published July 2018 in Veterinary Immunology and Immunopathology

Key tissue targets responsible for anthrax-toxin-induced lethality

scientific article

Killing of macrophages by anthrax lethal toxin: involvement of the N-end rule pathway ⬇️

scientific article published on 5 February 2008

Late treatment with a protective antigen-directed monoclonal antibody improves hemodynamic function and survival in a lethal toxin-infused rat model of anthrax sepsis

scientific article published on 22 December 2004

Lethality during continuous anthrax lethal toxin infusion is associated with circulatory shock but not inflammatory cytokine or nitric oxide release in rats

scientific article published on 8 January 2004

Lipoprotein biosynthesis by prolipoprotein diacylglyceryl transferase is required for efficient spore germination and full virulence of Bacillus anthracis

scientific article published on 22 November 2011

Lysosomal Cathepsin Release Is Required for NLRP3-Inflammasome Activation by Mycobacterium tuberculosis in Infected Macrophages.

scientific article

Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature

scientific article published on November 2007

Monoclonal antibody therapies against anthrax

scientific article

Mouse monoclonal antibodies to anthrax edema factor protect against infection

scientific article published on 12 September 2011

Mouse susceptibility to anthrax lethal toxin is influenced by genetic factors in addition to those controlling macrophage sensitivity

scientific article

MyD88-dependent signaling protects against anthrax lethal toxin-induced impairment of intestinal barrier function

scientific article

NLRP1a expression in Srebp-1a-deficient mice

scientific article published in March 2014

Nitric oxide production contributes to Bacillus anthracis edema toxin-associated arterial hypotension and lethality: ex vivo and in vivo studies in the rat.

scientific article published on 22 July 2016

Norepinephrine increases blood pressure but not survival with anthrax lethal toxin in rats

scientific article

Novel chimpanzee/human monoclonal antibodies that neutralize anthrax lethal factor, and evidence for possible synergy with anti-protective antigen antibody

scientific article published on 15 June 2009

Novel repression of the glucocorticoid receptor by anthrax lethal toxin

scientific article published in June 2004

Oxidized ATP protection against anthrax lethal toxin

scientific article

Pathogenicity of an Enterotoxigenic Escherichia coli Hemolysin ( hlyA ) Mutant in Gnotobiotic Piglets ⬇️

scientific article published on October 1, 1998

Phase 1 study of a recombinant mutant protective antigen of Bacillus anthracis

scientific article

Plant-based vaccine: mice immunized with chloroplast-derived anthrax protective antigen survive anthrax lethal toxin challenge

scientific article

Potent neutralization of anthrax edema toxin by a humanized monoclonal antibody that competes with calmodulin for edema factor binding

scientific article published on 27 July 2009

Prelytic and lytic conformations of erythrocyte-associated Escherichia coli hemolysin.

scientific article

Quickening the pace of anthrax research: three advances point towards possible therapies

scientific article

Rapid induction of inflammatory lipid mediators by the inflammasome in vivo

scientific article

Raxibacumab augments hemodynamic support and improves outcomes during shock with B. anthracis edema toxin alone or together with lethal toxin in canines

scientific article published on February 2015

Role of N-terminal amino acids in the potency of anthrax lethal factor

scientific article

Shock and lethality with anthrax edema toxin in rats are associated with reduced arterial responsiveness to phenylephrine and are reversed with adefovir.

scientific article published on 8 September 2017

Simian immunodeficiency virus lentivector corrects human X-linked chronic granulomatous disease in the NOD/SCID mouse xenograft

scientific article published on 30 August 2007

Small molecule inhibitors of anthrax edema factor

scientific article

Small-molecule inhibitors of lethal factor protease activity protect against anthrax infection

scientific article published on 17 June 2013

Spatial localization of bacteria controls coagulation of human blood by 'quorum acting'

scientific article published on December 2008

Sublethal doses of Bacillus anthracis lethal toxin inhibit inflammation with lipopolysaccharide and Escherichia coli challenge but have opposite effects on survival

scientific article published on 9 February 2006

Sulforaphane inhibits multiple inflammasomes through an Nrf2-independent mechanism

scientific article

Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1

scientific article

The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes

scientific article

The heart is an early target of anthrax lethal toxin in mice: a protective role for neuronal nitric oxide synthase (nNOS).

scientific article

The roles of anthrax toxin in pathogenesis

scientific article published on February 2004

Transcriptional analysis of the three Nlrp1 paralogs in mice

scientific article

List of works by Mahtab Moayeri

A Bacillus anthracis strain deleted for six proteases serves as an effective host for production of recombinant proteins

A Bacteriophage T4 Nanoparticle-Based Dual Vaccine against Anthrax and Plague ⬇️

A Bivalent Anthrax-Plague Vaccine That Can Protect against Two Tier-1 Bioterror Pathogens, Bacillus anthracis and Yersinia pestis

A Diverse Set of Single-domain Antibodies (VHHs) against the Anthrax Toxin Lethal and Edema Factors Provides a Basis for Construction of a Bispecific Agent That Protects against Anthrax Infection

A heterodimer of a VHH (variable domains of camelid heavy chain-only) antibody that inhibits anthrax toxin cell binding linked to a VHH antibody that blocks oligomer formation is highly protective in an anthrax spore challenge model

Adenoviral Expression of a Bispecific VHH-Based Neutralizing Agent That Targets Protective Antigen Provides Prophylactic Protection from Anthrax in Mice

Anthrax Pathogenesis

Anthrax Toxins

Anthrax and the inflammasome

Anthrax edema factor toxicity is strongly mediated by the N-end rule

Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport

Anthrax edema toxin has cAMP-mediated stimulatory effects and high-dose lethal toxin has depressant effects in an isolated perfused rat heart model

Anthrax edema toxin impairs clearance in mice

Anthrax edema toxin sensitizes DBA/2J mice to lethal toxin

Anthrax immune globulin improves hemodynamics and survival during B. anthracis toxin-induced shock in canines receiving titrated fluid and vasopressor support

Anthrax lethal and edema toxins in anthrax pathogenesis

Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome

Anthrax lethal factor cleaves mouse nlrp1b in both toxin-sensitive and toxin-resistant macrophages

Anthrax lethal factor cleaves regulatory subunits of phosphoinositide-3 kinase to contribute to toxin lethality

Anthrax lethal factor represses glucocorticoid and progesterone receptor activity

Anthrax lethal toxin activates the inflammasome in sensitive rat macrophages

Anthrax lethal toxin downregulates claudin-5 expression in human endothelial tight junctions

Anthrax lethal toxin induces ketotifen-sensitive intradermal vascular leakage in certain inbred mice

Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome

Anthrax protective antigen cleavage and clearance from the blood of mice and rats

Anthrax toxin targeting of myeloid cells through the CMG2 receptor is essential for establishment of Bacillus anthracis infections in mice

Antidotes to anthrax lethal factor intoxication. Part 1: Discovery of potent lethal factor inhibitors with in vivo efficacy

Antidotes to anthrax lethal factor intoxication. Part 2: structural modifications leading to improved in vivo efficacy

Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain

Arsenic trioxide and other arsenical compounds inhibit the NLRP1, NLRP3, and NAIP5/NLRC4 inflammasomes

Assessment of validity and reliability of Drug Hypersensitivity Quality of Life Questionnaire: The Dutch experience

Auranofin protects against anthrax lethal toxin-induced activation of the Nlrp1b inflammasome

B. anthracis Lethal Toxin but not Edema Toxin, Increases Pulmonary Artery Pressure and Permeability in Isolated Perfused Rat Lungs

Bacillus anthracis Edema Toxin Inhibits Hypoxic Pulmonary Vasoconstrictionvia Edema Factor and cAMP Mediated Mechanisms in Isolated Perfused Rat Lungs

Bacillus anthracis edema and lethal toxin have different hemodynamic effects but function together to worsen shock and outcome in a rat model

Bacillus anthracis edema toxin causes extensive tissue lesions and rapid lethality in mice

Bacillus anthracis lethal toxin induces TNF-alpha-independent hypoxia-mediated toxicity in mice

Bacillus anthracis lethal toxin induces TNF-α–independent hypoxia-mediated toxicity in mice

Bacillus anthracis toxins ⬇️

Bacterial Exotoxins and the Inflammasome

Battling against host phagocytes: the wherefore of the RTX family of toxins?

Blocking anthrax lethal toxin at the protective antigen channel by using structure-inspired drug design

CA-074Me protection against anthrax lethal toxin

Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo

Cellular and systemic effects of anthrax lethal toxin and edema toxin

Characterization of the NLRP1 inflammasome response in bovine species

Cisplatin inhibition of anthrax lethal toxin

Delayed treatment with W1-mAb, a chimpanzee-derived monoclonal antibody against protective antigen, reduces mortality from challenges with anthrax edema or lethal toxin in rats and with anthrax spores in mice

Detection of anthrax toxin by an ultrasensitive immunoassay using europium nanoparticles

Dual role for inflammasome sensors NLRP1 and NLRP3 in murine resistance to Toxoplasma gondii

Effects of temperature, time, and toxin concentration on lesion formation by the Escherichia coli hemolysin.

Efficient neutralization of anthrax toxin by chimpanzee monoclonal antibodies against protective antigen

Endocrine perturbation increases susceptibility of mice to anthrax lethal toxin

Engineering anthrax toxin variants that exclusively form octamers and their application to targeting tumors

Fluid support worsens outcome and negates the benefit of protective antigen-directed monoclonal antibody in a lethal toxin-infused rat Bacillus anthracis shock model.

Frontline Science: Anthrax lethal toxin-induced, NLRP1-mediated IL-1β release is a neutrophil and PAD4-dependent event

Heat shock inhibits caspase-1 activity while also preventing its inflammasome-mediated activation by anthrax lethal toxin

Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis

Hijacking multivesicular bodies enables long-term and exosome-mediated long-distance action of anthrax toxin

Imaging of anthrax intoxication in mice reveals shared and individual functions of surface receptors CMG-2 and TEM-8 in cellular toxin entry

In vivo characterization of an Hfq protein encoded by the Bacillus anthracis virulence plasmid pXO1 ⬇️

In vivo efficacy of beta-cyclodextrin derivatives against anthrax lethal toxin

Inflammasome sensor NLRP1 controls rat macrophage susceptibility to Toxoplasma gondii

Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment

Inflammasomes in livestock and wildlife: Insights into the intersection of pathogens and natural host species

Key tissue targets responsible for anthrax-toxin-induced lethality

Killing of macrophages by anthrax lethal toxin: involvement of the N-end rule pathway ⬇️

Late treatment with a protective antigen-directed monoclonal antibody improves hemodynamic function and survival in a lethal toxin-infused rat model of anthrax sepsis

Lethality during continuous anthrax lethal toxin infusion is associated with circulatory shock but not inflammatory cytokine or nitric oxide release in rats

Lipoprotein biosynthesis by prolipoprotein diacylglyceryl transferase is required for efficient spore germination and full virulence of Bacillus anthracis

Lysosomal Cathepsin Release Is Required for NLRP3-Inflammasome Activation by Mycobacterium tuberculosis in Infected Macrophages.

Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature

Monoclonal antibody therapies against anthrax

Mouse monoclonal antibodies to anthrax edema factor protect against infection

Mouse susceptibility to anthrax lethal toxin is influenced by genetic factors in addition to those controlling macrophage sensitivity

MyD88-dependent signaling protects against anthrax lethal toxin-induced impairment of intestinal barrier function

NLRP1a expression in Srebp-1a-deficient mice

Nitric oxide production contributes to Bacillus anthracis edema toxin-associated arterial hypotension and lethality: ex vivo and in vivo studies in the rat.

Norepinephrine increases blood pressure but not survival with anthrax lethal toxin in rats