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List of works by Steven E Ealick

A Maize Thiamine Auxotroph Is Defective in Shoot Meristem Maintenance ⬇️

scientific article published on October 22, 2010

A Novel Function for the N-Terminal Nucleophile Hydrolase Fold Demonstrated by the Structure of an Archaeal Inosine Monophosphate Cyclohydrolase † , ‡

scientific article

A corrected space group forSulfolobus sulfataricus5′-deoxy-5′-methylthioadenosine phosphorylase II ⬇️

scientific article published on February 7, 2012

A localized specific interaction alters the unfolding pathways of structural homologues.

scientific article

A model for the Bacillus subtilis formylglycinamide ribonucleotide amidotransferase multiprotein complex

scientific article

A novel mechanism of sulfur transfer catalyzed byO-acetylhomoserine sulfhydrylase in the methionine-biosynthetic pathway ofWolinella succinogenes ⬇️

scientific article published on September 8, 2011

Acidophilic adaptations in the structure of Acetobacter aceti N5-carboxyaminoimidazole ribonucleotide mutase (PurE).

scientific article published on 23 September 2004

Active-site models for complexes of quinolinate synthase with substrates and intermediates

scientific article

Anaerobic 5-Hydroxybenzimidazole Formation from Aminoimidazole Ribotide: An Unanticipated Intersection of Thiamin and Vitamin B₁₂ Biosynthesis

scientific article published on 3 August 2015

Binding and inhibition of human spermidine synthase by decarboxylated S-adenosylhomocysteine ⬇️

scientific article published on September 15, 2011

Biochemical and Structural Characterization of a Ureidoglycine Aminotransferase in the Klebsiella pneumoniae Uric Acid Catabolic Pathway

scientific article

Biochemical and structural characterization of Klebsiella pneumoniae oxamate amidohydrolase in the uric acid degradation pathway

scientific article published on 25 May 2016

Biochemical characterization of the HpxO enzyme from Klebsiella pneumoniae, a novel FAD-dependent urate oxidase

scientific article

Biochemistry: molecular cannibalism.

scientific article

Biosynthesis of Thiamin Pyrophosphate

scientific article published on August 2009

Biosynthesis of the thiamin-thiazole in eukaryotes: identification of a thiazole tautomer intermediate

scientific article published on 25 July 2008

Biosynthesis of thiamin thiazole in eukaryotes: conversion of NAD to an advanced intermediate

scientific article published on 20 February 2007

Burkholderia glumae ToxA Is a Dual-Specificity Methyltransferase That Catalyzes the Last Two Steps of Toxoflavin Biosynthesis

scientific article published on 12 April 2016

Catalysis of a flavoenzyme-mediated amide hydrolysis

scientific article

Characterization of the Structure and Function of Klebsiella pneumoniae Allantoin Racemase ⬇️

scientific article published on May 17, 2011

Co-opting sulphur-carrier proteins from primary metabolic pathways for 2-thiosugar biosynthesis

scientific article

Cofactor biosynthesis--still yielding fascinating new biological chemistry

scientific article

Complexed Structures of Formylglycinamide Ribonucleotide Amidotransferase from Thermotoga maritima Describe a Novel ATP Binding Protein Superfamily † , ‡

scientific article

Complexes ofThermotoga maritimaS-adenosylmethionine decarboxylase provide insights into substrate specificity

scientific article

Construction of a thiamin sensor from the periplasmic thiamin binding protein ⬇️

scientific article published on December 2, 2010

Crystal Structure and Function of 5-Formaminoimidazole-4-carboxamide Ribonucleotide Synthetase from Methanocaldococcus jannaschii † , ‡

scientific article

Crystal Structure of a Sulfur Carrier Protein Complex Found in the Cysteine Biosynthetic Pathway of Mycobacterium tuberculosis † ‡

scientific article

Crystal Structures of the Iron-Sulfur Cluster-Dependent Quinolinate Synthase in Complex with Dihydroxyacetone Phosphate, Iminoaspartate Analogues, and Quinolinate

scientific article

Crystal structure and mechanism of tryptophan 2,3-dioxygenase, a heme enzyme involved in tryptophan catabolism and in quinolinate biosynthesis

scientific article

Crystal structure of 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase from Salmonella typhimurium at 2.3 A resolution

scientific article

Crystal structure of an aminoimidazole riboside kinase from Salmonella enterica: implications for the evolution of the ribokinase superfamily

scientific article published in October 2004

Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system

scientific article

Different polyamine pathways from bacteria have replaced eukaryotic spermidine biosynthesis in ciliates Tetrahymena thermophila and Paramecium tetaurelia

scientific article

Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme

scientific article

Domain Organization in Candida glabrata THI6, a Bifunctional Enzyme Required for Thiamin Biosynthesis in Eukaryotes, ⬇️

scientific article published on October 22, 2010

Domain organization of Salmonella typhimurium formylglycinamide ribonucleotide amidotransferase revealed by X-ray crystallography

scientific article published on August 2004

Enzymatic reactions involving novel mechanisms of carbanion stabilization

scientific article published in October 2004

Ethenoguanines undergo glycosylation by nucleoside 2'-deoxyribosyltransferases at non-natural sites

scientific article

Evolutionary links as revealed by the structure of Thermotoga maritima S-adenosylmethionine decarboxylase

scientific article

Flavogenomics--a genomic and structural view of flavin-dependent proteins

scientific article

Formylglycinamide Ribonucleotide Amidotransferase from Thermotoga maritima: Structural Insights into Complex Formation † ‡

scientific article

From Suicide Enzyme to Catalyst: The Iron-Dependent Sulfide Transfer in Methanococcus jannaschii Thiamin Thiazole Biosynthesis

scientific article

Gene Identification and Structural Characterization of the Pyridoxal 5‘-Phosphate Degradative Protein 3-Hydroxy-2-methylpyridine-4,5-dicarboxylate Decarboxylase from Mesorhizobium loti MAFF303099 † , ‡

scientific article

Glycal Formation in Crystals of Uridine Phosphorylase ,

scientific article

HMP Binding Protein ThiY and HMP-P Synthase THI5 Are Structural Homologues, ⬇️

scientific article published on October 19, 2010

High-Resolution Crystal Structures of Streptococcus pneumoniae Nicotinamidase with Trapped Intermediates Provide Insights into the Catalytic Mechanism and Inhibition by Aldehydes,

scientific article

Identification of a subversive substrate of Trichomonas vaginalis purine nucleoside phosphorylase and the crystal structure of the enzyme-substrate complex

scientific article published on 7 April 2005

Identification of the product of toxoflavin lyase: degradation via a Baeyer-Villiger oxidation

scientific article published on 9 March 2012

Implementation of a k/k0 Method to Identify Long-Range Structure in Transition States during Conformational Folding/Unfolding of Proteins

scientific article

In silico chemical library screening and experimental validation of a novel 9-aminoacridine based lead-inhibitor of human S-adenosylmethionine decarboxylase

scientific article

Mechanism of human S-adenosylmethionine decarboxylase proenzyme processing as revealed by the structure of the S68A mutant

scientific article (publication date: 4 March 2003)

Mechanistic understanding of Pyrococcus horikoshiiDph2, a [4Fe–4S] enzyme required for diphthamidebiosynthesis ⬇️

scientific article published on October 8, 2010

Molecular characterization of recombinant mouse adenosine kinase and evaluation as a target for protein phosphorylation

scientific article published in September 2004

Monomeric S-adenosylmethionine decarboxylase from plants provides an alternative to putrescine stimulation

scientific article

Mutagenesis studies on TenA: A thiamin salvage enzyme from Bacillus subtilis

scientific article

N 5 -CAIR Mutase:  Role of a CO 2 Binding Site and Substrate Movement in Catalysis † , ‡

scientific article

New Insights into the Design of Inhibitors of Human S -Adenosylmethionine Decarboxylase: Studies of Adenine C 8 Substitution in Structural Analogues of S -Adenosylmethionine †

scientific article

Non-canonical active site architecture of the radical SAM thiamin pyrimidine synthase

scientific article

Novel multisubstrate inhibitors of mammalian purine nucleoside phosphorylase

scientific article (publication date: November 2005)

O-phospho-L-serine and the thiocarboxylated sulfur carrier protein CysO-COSH are substrates for CysM, a cysteine synthase from Mycobacterium tuberculosis

scientific article published on 09 October 2008

Observation of time-resolved structural changes by linear interpolation of highly redundant X-ray diffraction data

scientific article

PNP anticancer gene therapy

scientific article

Polyketide Ring Expansion Mediated by a Thioesterase, Chain Elongation and Cyclization Domain, in Azinomycin Biosynthesis: Characterization of AziB and AziG.

scientific article published on 5 January 2016

Preliminary investigation of the three-dimensional structure of Salmonella typhimurium uridine phosphorylase in the crystalline state

scientific article

Pseudouridine Monophosphate Glycosidase: A New Glycosidase Mechanism ⬇️

scientific article published on October 30, 2012

Purification, crystallization and preliminary X-ray analysis of uridine phosphorylase from Salmonella typhimurium

scientific article published on 23 March 2004

Pyridoxal phosphate: Biosynthesis and catabolism ⬇️

scientific article published on 08 July 2011

Pyruvoyl-Dependent Arginine Decarboxylase from Methanococcus jannaschii

article

Pyruvoyl-dependent arginine decarboxylase from Methanococcus jannaschii: crystal structures of the self-cleaved and S53A proenzyme forms

scientific article (publication date: March 2003)

Radical S-adenosylmethionine (SAM) enzymes in cofactor biosynthesis: a treasure trove of complex organic radical rearrangement reactions

scientific article

Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily

scientific article

Reversal of the Substrate Specificity of CMP N -Glycosidase to dCMP

scientific article

Reverse structural genomics: an unusual flavin-binding site in a putative protease from Bacteroides thetaiotaomicron

scientific article published on 20 June 2012

Role of the Sulfonium Center in Determining the Ligand Specificity of Human S -Adenosylmethionine Decarboxylase

scientific article

Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase ⬇️

scientific article published on October 26, 2011

Structural Basis for Iron-Mediated Sulfur Transfer in Archael and Yeast Thiazole Synthases

scientific article published on 26 February 2016

Structural Basis for Putrescine Activation of Human S -Adenosylmethionine Decarboxylase † ‡

scientific article

Structural analyses reveal two distinct families of nucleoside phosphorylases

scientific article

Structural and Mechanistic Studies of HpxO, a Novel Flavin Adenine Dinucleotide-Dependent Urate Oxidase from Klebsiella pneumoniae ⬇️

scientific article published on January 9, 2013

Structural and Mechanistic Studies on Klebsiella pneumoniae 2-Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline Decarboxylase ⬇️

scientific article published on September 8, 2010

Structural and kinetic insights into the mechanism of 5-hydroxyisourate hydrolase from Klebsiella pneumoniae ⬇️

scientific article published on July 12, 2011

Structural and mechanistic studies on ThiO, a glycine oxidase essential for thiamin biosynthesis in Bacillus subtilis

scientific article (publication date: 18 March 2003)

Structural basis for inhibition of Escherichia coli uridine phosphorylase by 5-substituted acyclouridines

scientific article published on 24 June 2005

Structural basis for substrate specificity of Escherichia coli purine nucleoside phosphorylase

scientific article

Structural basis of the substrate specificity ofBacillus cereusadenosine phosphorylase ⬇️

scientific article published on February 14, 2012

Structural biology of S-adenosylmethionine decarboxylase

scientific article

Structural biology of enzymes of the thiamin biosynthesis pathway

scientific article published on December 2003

Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II.

scientific article

Structural comparison of MTA phosphorylase and MTA/AdoHcy nucleosidase explains substrate preferences and identifies regions exploitable for inhibitor design

scientific article

Structural insights into the mechanism of the PLP synthase holoenzyme from Thermotoga maritima

scientific article

Structural similarities between thiamin-binding protein and thiaminase-I suggest a common ancestor

scientific article

Structural studies of thiamin monophosphate kinase in complex with substrates and products

scientific article

Structural studies of viperin, an antiviral radical SAM enzyme

scientific article

Structural studies on 3-hydroxyanthranilate-3,4-dioxygenase: the catalytic mechanism of a complex oxidation involved in NAD biosynthesis

scientific article

Structure Determination and Characterization of the Vitamin B 6 Degradative Enzyme ( E )-2-(Acetamidomethylene)succinate Hydrolase ,

scientific article

Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids

scientific article

Structure of Escherichia coli AMP nucleosidase reveals similarity to nucleoside phosphorylases

scientific article

Structure of Toxoplasma gondii adenosine kinase in complex with an ATP analog at 1.1 angstroms resolution

scientific article published on 18 January 2006

Structure of a Clostridium botulinum C143S Thiaminase I/Thiamin Complex Reveals Active Site Architecture,

scientific article

Structure of grouper iridovirus purine nucleoside phosphorylase

scientific article

Structure of human desArg-C5a

scientific article

Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution

scientific article

Structure of oxalate decarboxylase from Bacillus subtilis at 1.75 A resolution

scientific article

Structure of the Escherichia coli ThiS-ThiF complex, a key component of the sulfur transfer system in thiamin biosynthesis

scientific article

Structure of the PLP Degradative Enzyme 2-Methyl-3-hydroxypyridine-5-carboxylic Acid Oxygenase from Mesorhizobium loti MAFF303099 and Its Mechanistic Implications

scientific article

Structure of trifunctional THI20 from yeast ⬇️

scientific article published on August 9, 2011

Structure of variant 2 scorpion toxin from Centruroides sculpturatus Ewing

scientific article

Structures of human deoxycytidine kinase product complexes

scientific article

Structures of purine 2'-deoxyribosyltransferase, substrate complexes, and the ribosylated enzyme intermediate at 2.0 A resolution

scientific article published in March 2004

Structures of the N47A and E109Q mutant proteins of pyruvoyl-dependent arginine decarboxylase fromMethanococcus jannaschii

scientific article

Substrate analogs induce an intermediate conformational change in Toxoplasma gondii adenosine kinase

scientific article

The Leishmania donovani UMP Synthase Is Essential for Promastigote Viability and Has an Unusual Tetrameric Structure That Exhibits Substrate-controlled Oligomerization ⬇️

scientific article published on April 19, 2011

The crystal structure of 5'-deoxy-5'-methylthioadenosine phosphorylase II from Sulfolobus solfataricus, a thermophilic enzyme stabilized by intramolecular disulfide bonds

scientific article published on 27 December 2005

The crystal structure of Streptococcus pyogenes uridine phosphorylase reveals a distinct subfamily of nucleoside phosphorylases ⬇️

scientific article published on July 8, 2011

The formylglycinamide ribonucleotide amidotransferase complex from Bacillus subtilis: metabolite-mediated complex formation

scientific journal article

The mechanism of inactivation of 3-hydroxyanthranilate-3,4-dioxygenase by 4-chloro-3-hydroxyanthranilate

scientific article published in May 2005

The structural and biochemical foundations of thiamin biosynthesis

scientific article published on January 2009

The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation

scientific article published on 18 January 2006

Thiamin Pyrimidine Biosynthesis in Candida albicans: A Remarkable Reaction between Histidine and Pyridoxal Phosphate

scientific article

Thiamin biosynthesis in Bacillus subtilis: structure of the thiazole synthase/sulfur carrier protein complex

scientific article

Thiamin biosynthesis in eukaryotes: characterization of the enzyme-bound product of thiazole synthase from Saccharomyces cerevisiae and its implications in thiazole biosynthesis

scientific article published in June 2006

Thiamin phosphate synthase: the rate of pyrimidine carbocation formation

scientific article published on 28 March 2007

Three-dimensional Structure of YaaE from Bacillus subtilis, a Glutaminase Implicated in Pyridoxal-5′-phosphate Biosynthesis ⬇️

scientific article published on October 28, 2003

Toxoflavin Lyase Requires a Novel 1-His-2-Carboxylate Facial Triad, ⬇️

scientific article published on January 20, 2011

Unusual space-group pseudosymmetry in crystals of human phosphopantothenoylcysteine decarboxylase ⬇️

scientific article published on September 19, 2003

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