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List of works by Jens C Brüning

A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding

scientific article published in August 2017

A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding

scientific article published in September 2017

A guide to analysis of mouse energy metabolism

scientific article published on 28 December 2011

A link between FTO, ghrelin, and impaired brain food-cue responsivity

scientific article

A microRNA screen reveals that elevated hepatic ectodysplasin A expression contributes to obesity-induced insulin resistance in skeletal muscle

scientific article

Activation of Stat3 signaling in AgRP neurons promotes locomotor activity

scientific article published in March 2008

Acute selective ablation of rat insulin promoter-expressing (RIPHER) neurons defines their orexigenic nature

scientific article

AgRP Innervation onto POMC Neurons Increases with Age and Is Accelerated with Chronic High-Fat Feeding in Male Mice ⬇️

scientific article published on November 16, 2012

AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue

scientific article published on March 2016

Agouti-related peptide-expressing neurons are mandatory for feeding

scientific article

Autocrine IGF-1 action in adipocytes controls systemic IGF-1 concentrations and growth

scientific article published on 28 April 2008

Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance

scholarly article by Carmen Guerra et al published 2 January 2019 in Journal of Clinical Investigation

CNS insulin signaling in the control of energy homeostasis and glucose metabolism – from embryo to old age ⬇️

scientific article published on December 19, 2012

CNS leptin and insulin action in the control of energy homeostasis ⬇️

scientific article published on November 11, 2010

CNS-targets in control of energy and glucose homeostasis

scientific article published on 31 October 2009

Central insulin action in energy and glucose homeostasis

scientific article

Central insulin action regulates peripheral glucose and fat metabolism in mice

scientific article published on June 2008

Central insulin signaling modulates hypothalamus-pituitary-adrenal axis responsiveness

scientific article

Ceramide synthase 4 regulates stem cell homeostasis and hair follicle cycling

scientific article published on 23 February 2015

Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance

scientific article (publication date: February 2004)

Contraction-induced interleukin-6 gene transcription in skeletal muscle is regulated by c-Jun terminal kinase/activator protein-1

scientific article

Control of energy homeostasis by insulin and leptin: targeting the arcuate nucleus and beyond

scientific article published on 05 April 2009

Cutting edge: Inhibition of IL-6 trans-signaling protects from malaria-induced lethality in mice

scientific article published on 30 March 2012

Delayed puberty but normal fertility in mice with selective deletion of insulin receptors from Kiss1 cells

scientific article

Dicer1-miR-328-Bace1 signalling controls brown adipose tissue differentiation and function

scientific article published on 22 February 2016

Diet-Induced Growth Is Regulated via Acquired Leptin Resistance and Engages a Pomc-Somatostatin-Growth Hormone Circuit.

scientific article published in May 2018

Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility

scientific article

Distinct Roles for JNK and IKK Activation in Agouti-Related Peptide Neurons in the Development of Obesity and Insulin Resistance.

scientific article published on 13 November 2014

Divergent roles of growth factors in the GnRH regulation of puberty in mice

scientific article

Dwarfism in Mice Lacking Collagen-binding Integrins α2β1 and α11β1 Is Caused by Severely Diminished IGF-1 Levels ⬇️

scientific article published on December 30, 2011

Elevated GH/IGF-I, due to somatotrope-specific loss of both IGF-I and insulin receptors, alters glucose homeostasis and insulin sensitivity in a diet-dependent manner

scientific article published on 11 October 2011

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity

scientific article

Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation

scientific article published on December 2007

Epidermal insulin/IGF-1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation

scientific article published on 24 July 2008

Estrogen receptor-alpha and Sp1 interact in the induction of the low density lipoprotein-receptor

scientific article published on August 2003

Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes

scientific article published on 08 December 2008

FOXO1 couples metabolic activity and growth state in the vascular endothelium

scientific article published on 06 January 2016

Fischer et al. reply

scientific article published in Nature

Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis ⬇️

scientific article published on November 3, 2010

Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intolerance

scientific article

Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis

scholarly article

Hepatic leptin receptor expression can partially compensate for IL-6Rα deficiency in DEN-induced hepatocellular carcinoma

scholarly article by Melanie J Mittenbühler published in September 2018

Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation

scientific article published in November 2010

High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons

scientific article

Hormone and glucose signalling in POMC and AgRP neurons.

scientific article

Hybrid embryonic stem cell-derived tetraploid mice show apparently normal morphological, physiological, and neurological characteristics

scientific article

Hypothalamic UDP Increases in Obesity and Promotes Feeding via P2Y6-Dependent Activation of AgRP Neurons

scientific article published in September 2015

Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism

scientific article

Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity

scientific article

Hypothalamic inflammation in obesity and metabolic disease ⬇️

scientific article published on 3 January 2017

IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development ⬇️

scientific article published on March 23, 2011

IGF-IR signaling attenuates the age-related decline of diastolic cardiac function

scientific article published on 15 May 2012

IL-6/Stat3-Dependent Induction of a Distinct, Obesity-Associated NK Cell Subpopulation Deteriorates Energy and Glucose Homeostasis

scientific article published in July 2017

IRS-2 branch of IGF-1 receptor signaling is essential for appropriate timing of myelination

scientific article published on 18 September 2008

Inactivation of the Fto gene protects from obesity

scientific article (publication date: 16 April 2009)

Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure

scientific article

Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production

scientific article

Insulin controls food intake and energy balance via NPY neurons

scientific article

Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition

scientific article

Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer’s disease ⬇️

scientific article published on November 6, 2011

Insulin signaling in the central nervous system is critical for the normal sympathoadrenal response to hypoglycemia

scientific article published in May 2005

Insulin-Dependent Activation of MCH Neurons Impairs Locomotor Activity and Insulin Sensitivity in Obesity

scientific article published in December 2016

Insulin-like growth factor-1 controls type 2 T cell-independent B cell response

scientific article

Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition

scientific article

Integrative neurobiology of energy homeostasis-neurocircuits, signals and mediators

scientific article published on September 2009

Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation

scientific article

Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action

scientific article published on September 2010

K(ATP)-channel-dependent regulation of catecholaminergic neurons controls BAT sympathetic nerve activity and energy homeostasis

scientific article published in September 2013

Mapping leptin's link to reproduction

scientific article published on 09 August 2012

Meta-analysis of global metabolomic data identifies metabolites associated with life-span extension

scientific article

Mutant Huntingtin Causes Metabolic Imbalance by Disruption of Hypothalamic Neurocircuits ⬇️

scientific article published on April 6, 2011

MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity

scientific article published on October 2009

Myeloid Cell-Restricted Insulin/IGF-1 Receptor Deficiency Protects against Skin Inflammation

scientific article published on 30 October 2015

Myeloid cell-restricted insulin receptor deficiency protects against obesity-induced inflammation and systemic insulin resistance

scientific article (publication date: May 2010)

Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis

scientific article

N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response

scientific article published in February 2018

NK cells link obesity-induced adipose stress to inflammation and insulin resistance

scientific article published on 2 March 2015

Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding

scientific article

Neurocircuits integrating hormone and nutrient signaling in control of glucose metabolism

scientific article published on 19 February 2008

Neuroendocrinology: Electromagnetogenetic Control over Feeding and Glucose Metabolism

scientific article published in June 2016

Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease.

scientific article published in June 2009

Neuronal control of peripheral insulin sensitivity and glucose metabolism

scientific article

Novel Approaches to the Pharmacotherapy of Obesity ⬇️

scientific article published on January 1, 2013

Novel roles for JNK1 in metabolism ⬇️

scientific article published on September 1, 2010

Obesity promotes liver carcinogenesis via Mcl-1 stabilization independent of IL-6Rα signaling

scientific article published on 15 August 2013

Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance

scientific article published in October 2014

Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism

scientific journal article

Obesity: The need to eat--overruling the homeostatic control of feeding

scientific article published on 26 November 2013

Overexpression of Fto leads to increased food intake and results in obesity

scientific article

PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response

scientific article published in April 2008

PLRG1 is an essential regulator of cell proliferation and apoptosis during vertebrate development and tissue homeostasis

scientific journal article

Perinatal programming of metabolic diseases: role of insulin in the development of hypothalamic neurocircuits

scientific article published on 13 December 2012

Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity

scientific article published on 12 April 2009

Phosphoinositide-dependent kinase 1 provides negative feedback inhibition to Toll-like receptor-mediated NF-kappaB activation in macrophages

scientific journal article

Rad GTPase deficiency leads to cardiac hypertrophy

scientific article

Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD

scientific article published on 8 October 2007

Regulation of metabolism by long, non-coding RNAs

scientific article published on 25 March 2014

Reversible gene knockdown in mice using a tight, inducible shRNA expression system

scientific article published on 21 March 2007

Riboflavin kinase couples TNF receptor 1 to NADPH oxidase

scientific article

Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis

scientific article

Role for neuronal insulin resistance in neurodegenerative diseases

scholarly article

Role of the fatty acid binding protein mal1 in obesity and insulin resistance

scientific journal article

Role of tyrosine kinase signaling in estrogen-induced LDL receptor gene expression in HepG2 cells

scientific article

Secondary consequences of beta cell inexcitability: identification and prevention in a murine model of K(ATP)-induced neonatal diabetes mellitus

scientific article published on February 2009

Selective Insulin and Leptin Resistance in Metabolic Disorders ⬇️

scientific article published on August 8, 2012

Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis

scientific article published on 12 June 2010

Signal-dependent control of gluconeogenic key enzyme genes through coactivator-associated arginine methyltransferase 1

scientific journal article

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

scientific article

Signaling through the adaptor molecule MyD88 in CD4+ T cells is required to overcome suppression by regulatory T cells

scientific article published on January 2014

Single copy shRNA configuration for ubiquitous gene knockdown in mice

scientific article

T cell-intrinsic role of IL-6 signaling in primary and memory responses

scientific article

Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus.

scientific article published on 28 June 2018

Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance

scientific article published on 3 May 2017

The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry

scientific article

The role of insulin receptor signaling in the brain

scientific article

Time-dependent assessment of stimulus-evoked regional dopamine release

scientific article published in Nature Communications

Toll-like receptors: linking inflammation to metabolism ⬇️

scientific article published on October 1, 2010

Versatile functions for IL-6 in metabolism and cancer

scientific article

Welcome to molecular metabolism!

scientific article published on 16 August 2012

gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor

scholarly article

p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling

scientific article

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