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List of works by Peter Tontonoz

2014 American Society for Clinical Investigation Presidential Address. Leading by example: pastors, mentors, physician-scientists, and the ASCI.

scientific article

A Novel Type 2 Diabetes Mouse Model of Combined Diabetic Kidney Disease and Atherosclerosis

scientific article published on 15 November 2017

A Nurr1 pathway for neuroprotection

scientific article published in April 2009

A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism

scientific article published in May 2018

A nuclear receptor corepressor-dependent pathway mediates suppression of cytokine-induced C-reactive protein gene expression by liver X receptor

scientific article published on 16 November 2006

A role for IRF3-dependent RXRalpha repression in hepatotoxicity associated with viral infections

scientific article

A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development

scientific article

Acknowledgment of Ad Hoc Reviewers

scientific article published on 20 November 2020

Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs

scientific article published on March 2013

Adopting new orphans into the family of metabolic regulators

scientific article published on 07 February 2008

An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway

scientific article published on 15 September 2011

An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers

scientific article

ApoE promotes the proteolytic degradation of Abeta

scientific article

Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.

scientific article published on 30 July 2009

Arginase I induction by modified lipoproteins in macrophages: a peroxisome proliferator-activated receptor-gamma/delta-mediated effect that links lipid metabolism and immunity

scientific article published on 6 March 2008

Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells

scientific article published on 13 September 2018

Aster proteins regulate the accessible cholesterol pool in the plasma membrane

scientific article published on 27 July 2020

Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake

scientific article published on 09 November 2023

Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors

scholarly article

Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia

scientific article published on 5 April 2017

Before they were fat: adipocyte progenitors

scientific article published on December 2008

Bone marrow NR4A expression is not a dominant factor in the development of atherosclerosis or macrophage polarization in mice

scientific article published on 3 January 2013

Chlamydia pneumoniae--induced macrophage foam cell formation is mediated by Toll-like receptor 2.

scientific article published on 04 December 2006

Cholesterol Accumulation in CD11c+ Immune Cells Is a Causal and Targetable Factor in Autoimmune Disease

scientific article

Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice

scientific article

Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target

scientific journal article

Coordinate regulation of neutrophil homeostasis by liver X receptors in mice

scientific article published on 12 December 2011

Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors

scientific article published on 07 September 2008

Critical Roles of the Histone Methyltransferase MLL4/KMT2D in Murine Hepatic Steatosis Directed by ABL1 and PPARγ2.

scientific article

Crosstalk between LXR and Toll-like Receptor Signaling Mediates Bacterial and Viral Antagonism of Cholesterol Metabolism ⬇️

scientific article published on October 1, 2003

Cultured macrophages transfer surplus cholesterol into adjacent cells in the absence of serum or high-density lipoproteins

scientific article published on 30 April 2020

Dietary cholesterol promotes adipocyte hypertrophy and adipose tissue inflammation in visceral, but not in subcutaneous, fat in monkeys

scientific article

Direct and Indirect Mechanisms for Regulation of Fatty Acid Synthase Gene Expression by Liver X Receptors ⬇️

scientific article (publication date: 29 March 2002)

ER phospholipid composition modulates lipogenesis during feeding and in obesity

scientific article published on 28 August 2017

Endocrine functions of adipose tissue

scientific article published on January 2007

Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis

scientific article

Enhanced thermogenesis in the blinc of an eye.

scientific article published in August 2014

Eosinophils in fat: pink is the new brown

scientific article published in June 2014

Estrogen receptor (ER)α-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression

scientific article

Estrogen receptor alpha protects pancreatic beta cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress

scientific article

FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors

scientific article published on 22 November 2011

Fat's loss is bone's gain

scientific article published on March 2004

Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis

scientific journal article

GPIHBP1, an endothelial cell transporter for lipoprotein lipase ⬇️

scientific article published on August 15, 2011

Genetic architecture of insulin resistance in the mouse

scientific article

Genome-Wide Association Studies Identify New Targets in Cardiovascular Disease ⬇️

scientific article published on September 8, 2010

HRASLS3 is a PPARgamma-selective target gene that promotes adipocyte differentiation

scientific article

High-resolution imaging and quantification of plasma membrane cholesterol by NanoSIMS.

scientific article published on 6 February 2017

Hormonal modulators of glial ABCA1 and apoE levels

scientific article published on 02 September 2013

Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.

scientific article

IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor

scientific article

IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure

scientific article published on 8 December 2017

Identification and characterization of two alternatively spliced transcript variants of human liver X receptor alpha

scientific article published on 16 September 2005

Identification of macrophage liver X receptors as inhibitors of atherosclerosis

scientific article

Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli

scientific article

Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1

scientific journal article

Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP.

scientific article published on 25 October 2017

Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77.

scientific article published on 09 September 2009

Integration of metabolism and inflammation by lipid-activated nuclear receptors

scientific article published on July 2008

Inter-organ cross-talk in metabolic syndrome

scientific article published on 09 December 2019

Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins

scientific article published on 08 June 2020

Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet

scientific article published on 27 January 2016

LXR deficiency confers increased protection against visceral Leishmania infection in mice

scientific article

LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression

scientific article

LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor

scientific article

LXR-dependent gene expression is important for macrophage survival and the innate immune response

scientific article

LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling

scientific article published on 14 July 2015

LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition

scientific article

LXRs: new therapeutic targets in atherosclerosis?

scientific article

LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice ⬇️

scientific article published on March 26, 2012

Licensing PPARγ to work in macrophages

scientific article

Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE

scientific journal article

Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis

scientific article published on 03 December 2018

Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling

scientific article

Liver X Receptor Signaling Is a Determinant of Stellate Cell Activation and Susceptibility to Fibrotic Liver Disease ⬇️

scientific article published on December 4, 2010

Liver X Receptor Signaling Pathways in Cardiovascular Disease ⬇️

scientific article published on April 10, 2003

Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages

scientific article published on 16 January 2003

Liver X receptors are regulators of adipocyte gene expression but not differentiation: identification of apoD as a direct target

scientific article published on January 2004

Liver X receptors as integrators of metabolic and inflammatory signaling

scientific article

Liver X receptors at the intersection of lipid metabolism and atherogenesis

scientific article

Liver X receptors in lipid metabolism: opportunities for drug discovery

scientific article published on 16 May 2014

Liver X receptors in lipid signalling and membrane homeostasis

scientific article published on 01 August 2018

Liver x receptor signaling pathways and atherosclerosis

scientific article

Long Noncoding RNA Discovery in Cardiovascular Disease: Decoding Form to Function

scientific article published in January 2018

Long Noncoding RNA Facilitated Gene Therapy Reduces Atherosclerosis in a Murine Model of Familial Hypercholesterolemia

scientific article published in August 2017

Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism

scientific article published on 23 May 2019

Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion

scientific article

Macrophages release plasma membrane-derived particles rich in accessible cholesterol

scientific article published on 20 August 2018

MafB promotes atherosclerosis by inhibiting foam-cell apoptosis

scientific article

Metabolism: Drug discovery goes for a swim

scientific article published in February 2013

NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism

scientific article

NanoSIMS Analysis of Intravascular Lipolysis and Lipid Movement across Capillaries and into Cardiomyocytes

NanoSIMS imaging reveals unexpected heterogeneity in nutrient uptake by brown adipocytes

scientific article published on 15 September 2018

Negative regulation of Hedgehog signaling by liver X receptors

scientific article published on 16 July 2009

Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia

scientific article

Nuclear receptors in macrophage biology: at the crossroads of lipid metabolism and inflammation

scientific article published in January 2004

Nur77 coordinately regulates expression of genes linked to glucose metabolism in skeletal muscle

scientific article published on 05 June 2007

Orphan nuclear receptors find a home in the arterial wall

scientific article

PON2 Deficiency Leads to Increased Susceptibility to Diet-Induced Obesity

PPARadigms and PPARadoxes: expanding roles for PPARgamma in the control of lipid metabolism.

scientific article

PPARs in atherosclerosis: the clot thickens

scientific article

Palmoplantar Keratoderma in Slurp2-Deficient Mice

scientific article

Palmoplantar keratoderma along with neuromuscular and metabolic phenotypes in Slurp1-deficient mice

scientific article

Peroxisome proliferator-activated receptor alpha (PPARalpha) influences substrate utilization for hepatic glucose production

scientific article published on 9 August 2002

Peroxisome proliferator-activated receptor gamma dances with different partners in macrophage and adipocytes

scientific article published on 22 February 2010

Phenamil, an amiloride derivative, restricts long bone growth and alters keeled-sternum bone architecture in growing chickens

scientific article published on 3 March 2017

Phospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis

scientific article published in February 2018

Phospholipid Remodeling in Physiology and Disease

scientific article published on 31 October 2018

Phosphorylation of the liver X receptors

scientific article published on 4 August 2006

Pioneering EBF2 remodels the brown fat chromatin landscape

scientific article published on April 2017

Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARgamma-/-, PPARdelta-/-, PPARgammadelta-/-, or LXRalphabeta-/- bone marrow

scientific article published on 04 September 2008

Progesterone receptor in the vascular endothelium triggers physiological uterine permeability preimplantation

scientific article published on January 2014

RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs

scientific article published on 13 February 2017

Reciprocal Regulation of Hepatic and Adipose Lipogenesis by Liver X Receptors in Obesity and Insulin Resistance ⬇️

scientific article published on July 2, 2013

Reciprocal metabolic perturbations in the adipose tissue and liver of GPIHBP1-deficient mice.

scientific article published on 15 December 2011

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

scientific article (publication date: February 2003)

Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor ⬇️

scientific article published on November 12, 2001

Regulation of macrophage inflammatory gene expression by the orphan nuclear receptor Nur77.

scientific article

Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia

scientific article published on 05 September 2019

Resistance to diet-induced obesity in mice with synthetic glyoxylate shunt

scientific article

Retinoid X receptor α attenuates host antiviral response by suppressing type I interferon

scientific article

STAMPing out Inflammation

scientific article published in May 2007

SUMOylation and PPARgamma: wrestling with inflammatory signaling

scientific article published in November 2005

SUMOylation places LRH-1 in PROXimity to lipid metabolism

scientific article

Setting fat on fire ⬇️

scientific article published on November 1, 2003

Single cell analysis reveals immune cell-adipocyte crosstalk regulating the transcription of thermogenic adipocytes

scientific article published on 23 October 2019

Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization

scientific article

Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females

scientific article published on April 2016

Small Molecule-Induced Complement Factor D (Adipsin) Promotes Lipid Accumulation and Adipocyte Differentiation

scientific article

Synthetic LXR ligand inhibits the development of atherosclerosis in mice

scientific article

T0901317, an LXR agonist, augments PKA-induced vascular cell calcification

scientific article published on 25 March 2009

TLE3 is a dual-function transcriptional coregulator of adipogenesis

scientific article published on April 2011

TLR/MyD88 and liver X receptor alpha signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosis

scientific article

Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists

scientific article

The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2.

scientific article

The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning

scientific article published on 11 September 2017

The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries

scientific article published on 10 April 2014

The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor

scientific article

The LXR-Idol axis differentially regulates plasma LDL levels in primates and mice

scientific article

The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans

scientific article

The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance

scientific article published on 14 January 2015

The arginase II gene is an anti-inflammatory target of liver X receptor in macrophages

scientific article published on 30 August 2006

The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma

scientific article published on 11 September 2008

The macrophage LBP gene is an LXR target that promotes macrophage survival and atherosclerosis

scientific article

The nuclear receptor LXRα controls the functional specialization of splenic macrophages ⬇️

scientific article published on June 16, 2013

The number of x chromosomes causes sex differences in adiposity in mice

scientific article

The orphan nuclear receptor Nur77 is a determinant of myofiber size and muscle mass in mice

scientific article

The peroxisome proliferator-activated receptor N-terminal domain controls isotype-selective gene expression and adipogenesis

scientific article published on 23 March 2006

The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions

scientific article

The small molecule phenamil induces osteoblast differentiation and mineralization

scientific article

The small molecule phenamil is a modulator of adipocyte differentiation and PPARgamma expression

scientific article

Thermoneutral Housing Accelerates Metabolic Inflammation to Potentiate Atherosclerosis but Not Insulin Resistance

scientific article published on 4 November 2015

Thioredoxin-interacting protein deficiency disrupts the fasting-feeding metabolic transition

scientific article published in November 2004

Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors

scientific article (publication date: 12 March 2004)

Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR ⬇️

scientific article published on March 14, 2012

Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA.

scientific article published on 12 February 2018

Transgenic expression of dominant-active IDOL in liver causes diet-induced hypercholesterolemia and atherosclerosis in mice

scientific article

Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-β and cholesterol 25-hydroxylase in jejunum

scientific article published on 7 June 2017

Vestigial-like 3 is an inhibitor of adipocyte differentiation

scientific article

sLRP1ng Up Glucose: LRP1 Regulates Hepatic Insulin Responses

scientific article published on 19 May 2016

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