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List of works by Nico van Rooijen

"In vivo" depletion of macrophages by liposome-mediated "suicide".

scientific article

5-azacytidine enhances the anti-leukemic activity of lintuzumab (SGN-33) in preclinical models of acute myeloid leukemia

scientific article

A Protective Role for Interleukin 18 in Interferon γ–Mediated Innate Immunity to Cryptosporidium parvum That Is Independent of Natural Killer Cells ⬇️

scientific article published on April 19, 2012

A Serotype 3 Pneumococcal Capsular Polysaccharide-Specific Monoclonal Antibody Requires Fcγ Receptor III and Macrophages To Mediate Protection against Pneumococcal Pneumonia in Mice ⬇️

scientific article published on January 30, 2012

A combination immunomodulatory treatment promotes neuroprotection and locomotor recovery after contusion SCI.

scientific article published on 23 March 2010

A conduit system distributes chemokines and small blood-borne molecules through the splenic white pulp

scientific article published on August 2003

A deficiency in the autophagy gene Atg16L1 enhances resistance to enteric bacterial infection

scientific article published on August 2013

A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis

scientific article

A novel animal model of Borrelia recurrentis louse-borne relapsing fever borreliosis using immunodeficient mice

scientific article published on 29 September 2009

A novel mechanism of complement-independent clearance of red cells deficient in glycosyl phosphatidylinositol-linked proteins

scientific article published on 26 November 2003

A novel model of demyelinating encephalomyelitis induced by monocytes and dendritic cells

scientific article published on 01 November 2006

A novel type I IFN-producing cell subset in murine lupus

scientific article published on April 2008

A protease-dependent mechanism for initiating T-dependent B cell responses to large particulate antigens

scientific article

A targeted complement-dependent strategy to improve the outcome of mAb therapy, and characterization in a murine model of metastatic cancer ⬇️

scientific article published on March 22, 2012

A1 adenosine receptors in microglia control glioblastoma-host interaction

scientific article published in September 2006

Activity of SHIP, Which Prevents Expression of Interleukin 1β, Is Reduced in Patients With Crohn's Disease.

scientific article published on 16 October 2015

Acute CD4+ T lymphocyte-dependent interleukin-1-driven arthritis selectively requires interleukin-2 and interleukin-4, joint macrophages, granulocyte-macrophage colony-stimulating factor, interleukin-6, and leukemia inhibitory factor

scientific article published in December 2005

Adenosine A1 receptors and microglial cells mediate CX3CL1-induced protection of hippocampal neurons against Glu-induced death

scientific article published on 3 March 2010

Adenovirus serotype 5 hexon mediates liver gene transfer

scientific article published in February 2008

Adhesion molecule expression in local-macrophage-depleted rats bearing orthotopic corneal allografts

scientific article published on 16 April 2003

Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B.

scientific article published on 08 August 2013

Alveolar macrophages are essential for protection from respiratory failure and associated morbidity following influenza virus infection

scientific article

Alveolar macrophages are indispensable for controlling influenza viruses in lungs of pigs

scientific article published on 20 February 2008

Alveolar macrophages are necessary for the systemic inflammation of acute alveolar hypoxia

scientific article published on 26 July 2007

Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia

scientific article published on 25 September 2002

An alpha5beta1 integrin inhibitor attenuates glioma growth

scientific article

An antigen-specific pathway for CD8 T cells across the blood-brain barrier

scientific article

An efficient and reproducible method for quantifying macrophages in different experimental models of central nervous system pathology

scientific article published on 23 April 2009

An innate immune system cell is a major determinant of species-related susceptibility differences to fungal pneumonia

scientific article published in September 2005

An innate response to allogeneic nonself mediated by monocytes

scientific article published in December 2009

An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells.

scientific article

Another barrier to regeneration in the CNS: activated macrophages induce extensive retraction of dystrophic axons through direct physical interactions

scientific article

Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels

scientific article

Arginase activity in alternatively activated macrophages protects PI3Kp110δ deficient mice from dextran sodium sulfate induced intestinal inflammation

scientific article published on 25 September 2014

Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses

scientific article published on 22 May 2012

Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors

scientific article

Block of death-receptor apoptosis protects mouse cytomegalovirus from macrophages and is a determinant of virulence in immunodeficient hosts

scientific article (publication date: 2012)

Blockade of tumor necrosis factor alpha signaling in tumor-associated macrophages as a radiosensitizing strategy

scientific article published on 9 February 2010

Blood flow-dependent arterial remodelling is facilitated by inflammation but directed by vascular tone

scientific article

Blood monocyte subsets differentially give rise to CD103+ and CD103- pulmonary dendritic cell populations

scientific article published on 01 March 2008

Bone fracture exacerbates murine ischemic cerebral injury

scientific article published on June 2013

Bone marrow B cell apoptosis during in vivo influenza virus infection requires TNF-alpha and lymphotoxin-alpha

scientific article published in December 2002

Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche

scientific article

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs.

scientific article

CCR2 mediates homeostatic and inflammatory release of Gr1(high) monocytes from the bone marrow, but is dispensable for bladder infiltration in bacterial urinary tract infection

scientific journal article

CCR2 promotes hepatic fibrosis in mice

scientific article published on July 2009

CD11c(+)/CD11b(+) cells are critical for organic dust-elicited murine lung inflammation

scientific article

CD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes

scientific article

CD169⁺ macrophages provide a niche promoting erythropoiesis under homeostasis and stress

scientific article published on 17 March 2013

CD4+ T lymphocytes mediate in vivo clearance of plasmid DNA vaccine antigen expression and potentiate CD8+ T-cell immune responses

scientific article published on 10 September 2008

CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis

scientific article

CD68 acts as a major gateway for malaria sporozoite liver infection

scientific article published on 27 July 2015

CD8- dendritic cells and macrophages cross-present poly(D,L-lactate-co-glycolate) acid microsphere-encapsulated antigen in vivo.

scientific article published on 27 July 2011

CEACAM1+ myeloid cells control angiogenesis in inflammation

scientific article published on 9 March 2009

CSF-1-dependent red pulp macrophages regulate CD4 T cell responses

scientific article published on 14 January 2011

CXCL10/CXCR3 signaling in glia cells differentially affects NMDA-induced cell death in CA and DG neurons of the mouse hippocampus

scientific article published in February 2011

Cellular plasticity of inflammatory myeloid cells in the peritoneal foreign body response

scientific article

Chitin induces accumulation in tissue of innate immune cells associated with allergy

scientific article

Chlamydia psittaci Genetic Variants Differ in Virulence by Modulation of Host Immunity ⬇️

scientific article published on August 15, 2011

Chorionic gonadotropin alleviates thioglycollate-induced peritonitis by affecting macrophage function.

scientific article published on 4 May 2009

Clodronate Liposomes Improve Metabolic Profile and Reduce Visceral Adipose Macrophage Content in Diet-Induced Obese Mice ⬇️

scientific article published on September 12, 2011

Clodronate liposomes: perspectives in research and therapeutics

scientific article

Clodronate treatment significantly depletes macrophages in chickens

scientific article published on October 2014

Combination of cyclophosphamide, rituximab, and intratumoral CpG oligodeoxynucleotide successfully eradicates established B cell lymphoma

scientific article published in September 2012

Conjunctival macrophages act as antigen-presenting cells in the conjunctiva during the development of experimental allergic conjunctivitis ⬇️

scientific article published on July 10, 2010

Contrasting responses of Kupffer cells and inflammatory mononuclear phagocytes to biliary obstruction in a mouse model of cholestatic liver injury

scientific article published on 13 December 2012

Contribution of macrophages to angiogenesis induced by vascular endothelial growth factor receptor-3-specific ligands

scientific article published on October 2009

Correction of the nonlinear dose response improves the viability of adenoviral vectors for gene therapy of Fabry disease

scientific article published in May 2002

Critical Involvement of Macrophage Infiltration in the Development of Sjögren's Syndrome–Associated Dry Eye ⬇️

scientific article published on July 4, 2012

Critical Role of Macrophages and Their Activation via MyD88-NFκB Signaling in Lung Innate Immunity to Mycoplasma pneumoniae ⬇️

scientific article published on December 23, 2010

Critical role of airway macrophages in modulating disease severity during influenza virus infection of mice

scientific article

Critical role of effector macrophages in mediating CD4-dependent alloimmune injury of transplanted liver parenchymal cells

scientific article

Critical roles of macrophages in the formation of intracranial aneurysm

scientific article

Cross-activating invariant NKT cells and kupffer cells suppress cholestatic liver injury in a mouse model of biliary obstruction

scientific article

Demonstration of feasibility of in vivo gene therapy for Gaucher disease using a chemically induced mouse model

scientific article

Depletion and reconstitution of macrophages in mice

scientific article published on August 2012

Depletion of bone marrow-derived macrophages perturbs the innate immune response to surgery and reduces postoperative memory dysfunction

scientific article published on March 2013

Depletion of macrophages in mice results in higher dengue virus titers and highlights the role of macrophages for virus control

scientific article published on October 2009

Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses

scientific article

Dexamethasone promotes tolerance in vivo by enriching CD11clo CD40lo tolerogenic macrophages ⬇️

scientific article published on November 7, 2012

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

scientific article

Differential detection and distribution of microglial and hematogenous macrophage populations in the injured spinal cord of lys-EGFP-ki transgenic mice

scientific article published in March 2012

Differential requirements for CTL generation by novel immunostimulants: APC tropism, use of the TAP-independent processing pathway, and dependency on CD80/CD86 costimulation

scientific article published in September 2003

Disruption of SIRPα signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts

scientific article

Dual role for macrophagesin vivo in pathogenesis and control of murineSalmonella enterica var.Typhimurium infections

scholarly article by Odilia L C Wijburg et al published March 2000 in European Journal of Immunology

Dual roles for perivascular macrophages in immune-to-brain signaling

scientific article published on January 2010

Dynamic imaging reveals promiscuous crosspresentation of blood-borne antigens to naive CD8+ T cells in the bone marrow

scientific article

Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis

scientific article published on 3 April 2006

Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: crucial involvement of macrophage-derived cysteinyl-leukotrienes

scientific article

Effect of allyl alcohol on hepatic transporter expression: zonal patterns of expression and role of Kupffer cell function

scientific article

Effect of local macrophage depletion on cellular immunity and tolerance evoked by corneal allografts

scientific article

Effect of neutralizing sera on factor x-mediated adenovirus serotype 5 gene transfer

scientific article published on 22 October 2008

Effects of an immunomodulatory therapy and chondroitinase after spinal cord hemisection injury

scientific article published in October 2014

Effects of ischemia on lung macrophages

scientific article

Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus

scientific article

Engineered anti-CD70 antibody with multiple effector functions exhibits in vitro and in vivo antitumor activities

scientific article published on 12 October 2006

Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis

scientific journal article

Enterobacterial tumor colonization in mice depends on bacterial metabolism and macrophages but is independent of chemotaxis and motility

scientific article published on 23 May 2010

Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation

scientific article

Epilysin (MMP-28) restrains early macrophage recruitment in Pseudomonas aeruginosa pneumonia

scientific journal article

Essential role for neutrophils but not alveolar macrophages at early time points following Aspergillus fumigatus infection

scientific article published on August 2009

Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis

scientific article

Exercise promotes collateral artery growth mediated by monocytic nitric oxide

scientific article

Experimental infection of immunomodulated NOD/LtSz-SCID mice as a new model for Plasmodium falciparum erythrocytic stages

scientific article published on 10 December 2004

Extramedullary hematopoiesis generates Ly-6C(high) monocytes that infiltrate atherosclerotic lesions

scientific article published on 5 December 2011

F4/80+ Host Macrophages Are a Barrier to Murine Embryonic Stem Cell-Derived Hematopoietic Progenitor Engraftment In Vivo

scientific article

Fatty acid elongation in non-alcoholic steatohepatitis and hepatocellular carcinoma

scientific article published on 4 April 2014

Fungal iron availability during deep seated candidiasis is defined by a complex interplay involving systemic and local events

scientific article

Gamma interferon-independent effects of interleukin-12 on immunity to Salmonella enterica serovar Typhimurium

scientific article

Generation of a dual-functioning antitumor immune response in the peritoneal cavity

scientific article published on 08 August 2013

Gr1+ cells control growth of YopM-negative yersinia pestis during systemic plague

scientific article published on 06 July 2009

Gut ischemia/reperfusion induced acute lung injury is an alveolar macrophage dependent event

scientific article published in May 2008

Heart grafts tolerized through third-party multipotent adult progenitor cells can be retransplanted to secondary hosts with no immunosuppression

scientific article published on 08 July 2013

Helminth infection protects mice from anaphylaxis via IL-10-producing B cells.

scientific article published in November 2004

Helminth-modified pulmonary immune response protects mice from allergen-induced airway hyperresponsiveness

scientific article published in January 2006

Hematogenous macrophages express CD8 and distribute to regions of lesion cavitation after spinal cord injury

scientific article

Heme oxygenase-2 deletion impairs macrophage function: implication in wound healing

scientific article

Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function

scientific article published on 12 June 2008

Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2

scientific article

Hepatocyte cytoskeleton during ischemia and reperfusion--influence of ANP-mediated p38 MAPK activation

scientific article published in December 2005

Hepatocyte entry leads to degradation of autoreactive CD8 T cells

scientific article

Herpesvirus entry mediator regulates hypoxia-inducible factor-1α and erythropoiesis in mice

scientific article published on 14 November 2011

Highly Biased Type 1 Immune Responses in Mice Deficient in LFA-1 inListeria monocytogenesInfection Are Caused by Elevated IL-12 Production by Granulocytes ⬇️

scientific article published on October 15, 2003

Host genetics and Chlamydia disease: prediction and validation of disease severity mechanisms

scientific article

Human FcγRIIA induces anaphylactic and allergic reactions ⬇️

scientific article published on December 2, 2011

Human Lupus Serum Induces Neutrophil-Mediated Organ Damage in Mice That Is Enabled by Mac-1 Deficiency ⬇️

scientific article published on August 29, 2012

Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage

scientific article

IL-27 receptor signalling restricts the formation of pathogenic, terminally differentiated Th1 cells during malaria infection by repressing IL-12 dependent signals

scientific article

IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation

scientific article

IL-33 shifts macrophage polarization, promoting resistance against Pseudomonas aeruginosa keratitis

scientific article

Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer

scientific article published on 08 May 2009

IgA EGFR antibodies mediate tumour killing in vivo

scientific article published on August 2013

Imaging the modulation of adenoviral kinetics and biodistribution for cancer gene therapy

scientific article published on 13 March 2007

Immature monocytes acquire antigens from other cells in the bone marrow and present them to T cells after maturing in the periphery

scientific article

Immediate mineralocorticoid receptor blockade improves myocardial infarct healing by modulation of the inflammatory response

scientific article

Immune-to-brain signalling: the role of cerebral CD163-positive macrophages

scientific article

Immunoglobulin M antiplatelet autoantibodies from mice immunized with rat platelets induce thrombocytopenia and platelet function impairment

scientific article

Impact of PPAR-α induction on glucose homoeostasis in alcohol-fed mice

scientific article published in December 2013

Impact of macrophage and dendritic cell subset elimination on antiviral immunity, viral clearance and production of type 1 interferon

scientific article

Importance of bacterial replication and alveolar macrophage-independent clearance mechanisms during early lung infection with Streptococcus pneumoniae

scientific article

Improvement in middle cerebral artery structure and endothelial function in stroke-prone spontaneously hypertensive rats after macrophage depletion

scientific article

Increased intrinsic neuronal vulnerability and decreased beneficial reaction of macrophages on axonal regeneration in aged rats

scientific article published on 27 August 2008

Increased resistance of LFA-1-deficient mice to lipopolysaccharide-induced shock/liver injury in the presence of TNF-alpha and IL-12 is mediated by IL-10: a novel role for LFA-1 in the regulation of the proinflammatory and anti-inflammatory cytokine

scientific article published in July 2003

Infection-induced regulation of natural killer cells by macrophages and collagen at the lymph node subcapsular sinus

scientific article

Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis

scientific article (publication date: 14 May 2007)

Influenza virus-like particles containing M2 induce broadly cross protective immunity

scientific article (publication date: 18 January 2011)

Inhibition of recall responses through complementary therapies targeting CD8+ T-cell- and alloantibody-dependent allocytotoxicity in sensitized transplant recipients

scientific article published on 11 October 2012

Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection

scientific article

Interference with dendritic cell populations limits early antigen presentation in chronic γ-herpesvirus-68 infection

scientific article published on 18 August 2010

Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action

scientific article published on September 2010

Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis requires STAT3 but not SOCS3.

scientific article

Intrahepatic injection of adenovirus reduces inflammation and increases gene transfer and therapeutic effect in mice

scientific article published in September 2006

Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection

scientific article published on 14 April 2013

Intratumoral but not systemic delivery of CpG oligodeoxynucleotide augments the efficacy of anti-CD20 monoclonal antibody therapy against B cell lymphoma

scientific article

Intravenous treatment with liposome-encapsulated dichloromethylene bisphosphonate (C12MBP)suppresses nitric oxide production and reduces genetic resistance to Marek's disease ⬇️

scientific article published on April 1, 2003

Islet transplantation in the discordant tilapia-to-mouse model: a novel application of alginate microencapsulation in the study of xenograft rejection

scientific article published in March 2003

Kupffer Cells Influence Parenchymal Invasion and Phenotypic Orientation, but Not the Proliferation, of Liver Progenitor Cells in a Murine Model of Liver Injury ⬇️

scientific article published on August 18, 2011

Kupffer cell activation is a causal factor for hepatic insulin resistance

scientific article published on 29 October 2009

Kupffer cell and interleukin-12-dependent loss of natural killer T cells in hepatosteatosis

scientific article published on January 2010

Kupffer cell depletion with liposomal clodronate prevents suppression of Ntcp expression in endotoxin-treated rats

scientific article published in January 2005

Kupffer cell-monocyte communication is essential for initiating murine liver progenitor cell-mediated liver regeneration

scientific article published on 14 July 2015

Kupffer cells abrogate cholestatic liver injury in mice

scientific article

Kupffer cells are obligatory for Plasmodium yoelii sporozoite infection of the liver

scientific article published on 31 August 2006

Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis

scientific article (publication date: June 2011)

Kupffer cells modulate iron homeostasis in mice via regulation of hepcidin expression

scientific article

Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity

scientific article published in February 2010

LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression

scientific article

Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47null cells

scientific article

Lethality in an anti-angiogenic tumor gene therapy model upon constitutive but not inducible expression of the soluble vascular endothelial growth factor receptor 1.

scientific article

Liposomal clodronate as a novel agent for treating autoimmune hemolytic anemia in a mouse model

scientific article published on 29 August 2002

Liposomal clodronate selectively eliminates microglia from primary astrocyte cultures

scientific article

Liposomes for specific depletion of macrophages from organs and tissues

scientific article published in January 2010

Liposomes for targeting of antigens and drugs: immunoadjuvant activity and liposome-mediated depletion of macrophages

scientific article published in August 2008

Liver Kupffer cells control the magnitude of the inflammatory response in the injured brain and spinal cord

scientific article published on 12 July 2008

Liver inflammation abrogates immunological tolerance induced by Kupffer cells.

scientific article published on 22 April 2015

Local delivery of polarized macrophages improves reperfusion recovery in a mouse hind limb ischemia model

scientific article

Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation

scientific article

Local proliferation dominates lesional macrophage accumulation in atherosclerosis

scientific article published on 11 August 2013

Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling

scientific article published on 20 August 2009

Ly6c+ "inflammatory monocytes" are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis

scientific article

MCP-1 expression in CNS-1 astrocytoma cells: implications for macrophage infiltration into tumors in vivo

scientific article published on January 2002

Macrophage IL-12p70 Signaling Prevents HSV-1–Induced CNS Autoimmunity Triggered by Autoaggressive CD4+Tregs ⬇️

scientific article published on April 8, 2011

Macrophage TNF-α mediates parathion-induced airway hyperreactivity in guinea pigs

scientific article

Macrophage depletion alters the blood-nerve barrier without affecting Schwann cell function after neural injury.

scientific article published in March 2007

Macrophage depletion attenuates chronic cyclosporine A nephrotoxicity

scientific article published in June 2010

Macrophage depletion following liposomal-encapsulated clodronate (LIP-CLOD) injection enhances megakaryocytopoietic and thrombopoietic activities in mice

scientific article

Macrophage depletion impairs wound healing and increases left ventricular remodeling after myocardial injury in mice

scientific article published on March 2007

Macrophage depletion in hypertensive rats accelerates development of cardiomyopathy

scientific article published on 22 January 2009

Macrophage depletion in the murine olfactory epithelium leads to increased neuronal death and decreased neurogenesis

scientific article

Macrophage depletion inhibits experimental choroidal neovascularization

scientific article

Macrophage depletion reduces cell proliferation and extracellular matrix accumulation but increases the ultimate tensile strength of injured Achilles tendons

scientific article published on 25 October 2013

Macrophage depletion reduces monocyte chemotactic protein-1 and transforming growth factor-beta1 in healing rat vein grafts

scientific article published in April 2004

Macrophage depletion suppresses sympathetic hyperinnervation following myocardial infarction

scientific article published on 13 May 2009

Macrophage-dependent regulation of neutrophil mobilization and chemotaxis during development of sterile peritonitis in the rat

scientific journal article

Macrophage-depletion induced impairment of experimental CNS remyelination is associated with a reduced oligodendrocyte progenitor cell response and altered growth factor expression

scientific article published in February 2005

Macrophage-derived osteopontin induces reactive astrocyte polarization and promotes re-establishment of the blood brain barrier after ischemic stroke

scientific article published on 7 July 2015

Macrophage-derived proinflammatory factors contribute to the development of arthritis and myositis after infection with an arthrogenic alphavirus

scientific article

Macrophage-independent T cell infiltration to the site of injury-induced brain inflammation

scientific article published in October 2008

Macrophage-mediated but gamma interferon-independent innate immune responses control the primary wave of Plasmodium yoelii parasitemia

scientific article

Macrophages Restrict Pseudomonas aeruginosa Growth, Regulate Polymorphonuclear Neutrophil Influx, and Balance Pro- and Anti-Inflammatory Cytokines in BALB/c Mice ⬇️

scientific article published on May 15, 2003

Macrophages Subvert Adaptive Immunity to Urinary Tract Infection

scientific article (publication date: July 2015)

Macrophages act as effectors of tissue damage in acute renal allograft rejection

scientific article published in October 2003

Macrophages are important determinants of acute ocular HSV-1 infection in immunized mice

scientific article published in December 2007

Macrophages are involved in hexachlorobenzene-induced adverse immune effects

scientific article published on November 2005

Macrophages are mediators of gastritis in acute Helicobacter pylori infection in C57BL/6 mice

scientific article published on 10 March 2008

Macrophages are vital in spontaneous intraocular tumor eradication

scientific article published on July 2006

Macrophages contribute to the antitumor activity of the anti-CD30 antibody SGN-30.

scientific article

Macrophages direct tumour histology and clinical outcome in a colon cancer model

scientific article published on October 2005

Macrophages in bone fracture healing: Their essential role in endochondral ossification

scientific article published on 31 October 2015

Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation.

scientific article published on March 2005

Macrophages play a dual role during pulmonary tuberculosis in mice

scientific article published on 29 November 2004

Macrophages play a key role in angiogenesis and adipogenesis in a mouse tissue engineering model

scientific article published on 21 August 2013

Macrophages play a key role in early blood brain barrier reformation after hypothermic brain injury ⬇️

scientific article published on July 18, 2011

Macrophages play a role in the early phase of corneal allograft rejection in rats

scientific article

Macrophages prevent hemorrhagic infarct transformation in murine stroke models

scientific article published on June 2012

Macrophages promote axon regeneration with concurrent neurotoxicity

scientific article

Macrophages promote polycystic kidney disease progression

scientific article

Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism

scientific article (publication date: May 2009)

Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen

scientific article published on 28 March 2011

Mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation

scientific article

Mechanism of microglia neuroprotection: Involvement of P2X7, TNFα, and valproic acid

scientific article published on 21 August 2015

Microenvironmental control of malignancy exerted by RNASET2, a widely conserved extracellular RNase

scientific article

Microglia and a functional type I IFN pathway are required to counter HSV-1-driven brain lateral ventricle enlargement and encephalitis

scientific article published on 4 February 2013

Microglia promote the death of developing Purkinje cells

scientific article published in February 2004

Microglia stimulate the invasiveness of glioma cells by increasing the activity of metalloprotease-2.

scientific article published on September 2005

Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes

scientific article published on 05 September 2013

Minocycline delays photoreceptor death in the rds mouse through a microglia-independent mechanism

scientific article published in June 2004

Mobilization and margination of bone marrow Gr-1high monocytes during subclinical endotoxemia predisposes the lungs toward acute injury

scientific article published on January 2009

Modulation of dendritic cell trafficking to and from the airways

scientific article published on 01 March 2006

Modulation of macrophage activation state protects tissue from necrosis during critical limb ischemia in thrombospondin-1-deficient mice

scientific article

Monocyte Chemoattractant Protein–1 Released from Alveolar Macrophages Mediates the Systemic Inflammation of Acute Alveolar Hypoxia ⬇️

scientific article published on September 2, 2010

Monocyte depletion increases local proliferation of macrophage subsets after skeletal muscle injury

scientific article published on 19 December 2013

Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques

scientific article

Monocyte/macrophages promote vasculogenesis in choroidal neovascularization in mice by stimulating SDF-1 expression in RPE cells ⬇️

scientific article published on June 8, 2011

Monocytes control natural killer cell differentiation to effector phenotypes

scientific article published on 9 March 2011

Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice

scientific article

Mononuclear phagocyte system depletion blocks interstitial tonicity-responsive enhancer binding protein/vascular endothelial growth factor C expression and induces salt-sensitive hypertension in rats

scientific article published on 8 February 2010

Murine Kupffer cells are protective in total hepatic ischemia/reperfusion injury with bowel congestion through IL-10.

scientific article

MyD88-dependent, superoxide-initiated inflammation is necessary for flow-mediated inward remodeling of conduit arteries

scientific article

Myofiber damage precedes macrophage infiltration after in vivo injury in dysferlin-deficient A/J mouse skeletal muscle

scientific article published on 25 April 2015

NADPH-oxidase but not inducible nitric oxide synthase contributes to resistance in a murine Staphylococcus aureus Newman pneumonia model ⬇️

scientific article published on May 27, 2011

NK cells suppress experimental cholestatic liver injury by an interleukin-6-mediated, Kupffer cell-dependent mechanism ⬇️

scientific article published on November 18, 2010

Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10.

scientific article published on 13 February 2012

Neuroprotective function for ramified microglia in hippocampal excitotoxicity

scientific article published on 31 January 2012

Neutrophil elastase activity compensates for a genetic lack of matrix metalloproteinase-9 (MMP-9) in leukocyte infiltration in a model of experimental peritonitis

scientific article

Niacin inhibits skin dendritic cell mobilization in a GPR109A independent manner but has no impact on monocyte trafficking in atherosclerosis

scientific article published on 30 May 2011

On the influence of neutrophils in corneas with necrotizing HSV-1 keratitis following amniotic membrane transplantation

scientific article published on 14 June 2007

On the pathogenic role of brain-sequestered alphabeta CD8+ T cells in experimental cerebral malaria

scientific article published in December 2002

Opposite roles of CCR2 and CX3CR1 macrophages in alkali-induced corneal neovascularization

scientific article published on June 2009

Oval cell response is attenuated by depletion of liver resident macrophages in the 2-AAF/partial hepatectomy rat.

scientific article

Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation

scientific article published on August 2006

Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice

scientific article

Peripheral macrophage depletion reduces central nervous system parasitism and damage in Trypanosoma cruzi-infected suckling rats

scientific article published in April 2004

Peritoneal macrophages are important for the early containment of Enterococcus faecium peritonitis in mice

scientific article published in February 2009

Perivascular Arrest of CD8+ T Cells Is a Signature of Experimental Cerebral Malaria

scientific article

Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension.

scientific article

Platelet-activating factor contributes to Bacillus anthracis lethal toxin-associated damage

scientific article published on 29 January 2014

Pravastatin prevents miscarriages in mice: role of tissue factor in placental and fetal injury

scientific article

Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation

scientific article

Prevention of Both Neutrophil and Monocyte Recruitment Promotes Recovery after Spinal Cord Injury ⬇️

scientific article published on August 8, 2011

Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages

scientific article

Prolonged antigen presentation is required for optimal CD8+ T cell responses against malaria liver stage parasites

scientific article

Protection against type 1 diabetes upon Coxsackievirus B4 infection and iNKT-cell stimulation: role of suppressive macrophages

scientific article published on 26 July 2013

Protection and mechanism of action of a novel human respiratory syncytial virus vaccine candidate based on the extracellular domain of small hydrophobic protein

scientific article

Rapid host defense against Aspergillus fumigatus involves alveolar macrophages with a predominance of alternatively activated phenotype

scientific article

Rapid induction of inflammatory lipid mediators by the inflammasome in vivo

scientific article

Rapid recovery of platelet count following administration of liposome-encapsulated clodronate in a mouse model of immune thrombocytopenia

scientific article

Reduced expression of CD47 during murine red blood cell (RBC) senescence and its role in RBC clearance from the circulation

scientific article published in September 2007

Redundant and synergistic mechanisms control the sequestration of blood-born adenovirus in the liver

scientific article

Regulatory T cells suppress natural killer cells during plasmid DNA vaccination in mice, blunting the CD8+ T cell immune response by the cytokine TGFbeta

scientific article

Requirements for receptor engagement during infection by adenovirus complexed with blood coagulation factor X

scientific article

Resident alveolar macrophages suppress, whereas recruited monocytes promote, allergic lung inflammation in murine models of asthma

scientific article

Resident macrophages influence stem cell activity in the mammary gland

scientific article published on 26 August 2009

Resident peritoneal macrophages and mast cells are important cellular sites of COX-1 and COX-2 activity during acute peritoneal inflammation

scientific article published on 3 November 2009

Resistance and susceptibility to Marek's disease: nitric oxide synthase/arginase activity balance

scientific article published on May 2002

Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP.

scientific article published on 8 September 2008

Respiratory infection with Francisella novicida induces rapid dystrophic cardiac calcinosis (DCC)

scientific article published on 9 April 2008

Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes

scientific article published on 8 November 2004

Role of TNF receptor 2 expression on leukocytes in experimental T cell-dependent liver injury in mice

Role of inducible nitric oxide synthase and NADPH oxidase in early control of Burkholderia pseudomallei infection in mice

scientific article

Role of lung-marginated monocytes in an in vivo mouse model of ventilator-induced lung injury

scientific article published on 12 February 2009

Role of macrophages in the altered epithelial function during a type 2 immune response induced by enteric nematode infection

scientific article published on 23 January 2014

Roles for phagocytic cells and complement in controlling relapsing fever infection

scientific article

Roles of PI3K and JAK pathways in viability of retinal ganglion cells after acute elevation of intraocular pressure in rats with different autoimmune backgrounds

scientific article

Roles of macrophages in flow-induced outward vascular remodeling

scientific article published on 12 November 2008

S-3

scholarly article by Marcus O. Muench

SDF-1/CXCR4 contributes to the activation of tip cells and microglia in retinal angiogenesis

scientific article published on 24 February 2010

SHIP-deficient, alternatively activated macrophages protect mice during DSS-induced colitis

scientific article published on 17 June 2011

SIGNR1-negative red pulp macrophages protect against acute streptococcal sepsis after Leishmania donovani-induced loss of marginal zone macrophages

scientific article published on 30 July 2009

Secondary intracerebral hemorrhage due to early initiation of oral anticoagulation after ischemic stroke: an experimental study in mice

scientific article published in November 2012

Selective depletion of alveolar macrophages in polymicrobial sepsis increases lung injury, bacterial load and mortality but does not affect cytokine release

scientific article published on 2 October 2008

Selective depletion or blockade of Kupffer cells leads to enhanced and prolonged hepatic transgene expression using high-capacity adenoviral vectors

scientific article

Selective role for tumor necrosis factor-α, but not interleukin-1 or Kupffer cells, in down-regulation of CYP3A11 and CYP3A25 in livers of mice infected with a noninvasive intestinal pathogen

scientific article

Sensitizing protective tumor microenvironments to antibody-mediated therapy

scientific article published on January 2014

Severe malarial anemia of low parasite burden in rodent models results from accelerated clearance of uninfected erythrocytes

scientific article

Simultaneous targeting of toll- and nod-like receptors induces effective tumor-specific immune responses

scientific article published on February 2012

Small artery remodeling and erythrocyte deformability in L-NAME-induced hypertension: role of transglutaminases

scientific article published on 26 September 2007

Sources of alveolar soluble TNF receptors during acute lung injury of different etiologies ⬇️

scientific article published on April 21, 2011

Specific depletion of Ly6C(hi) inflammatory monocytes prevents immunopathology in experimental cerebral malaria

scientific article (publication date: 2015)

Splenic phagocytes promote responses to nucleosomes in (NZB x NZW) F1 mice

scientific article published on October 2008

Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells

scientific article

Subcapsular sinus macrophages limit dissemination of West Nile virus particles after inoculation but are not essential for the development of West Nile virus-specific T cell responses

scientific article published on 10 January 2014

Subcapsular sinus macrophages promote NK cell accumulation and activation in response to lymph-borne viral particles

scientific article published on 12 October 2012

Substance P delays apoptosis, enhancing keratitis after Pseudomonas aeruginosa infection.

scientific article published on 19 June 2008

Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe-/- mice during disease regression

scientific article

Suppression of experimental colitis by intestinal mononuclear phagocytes.

scientific article

Suppression of macrophage infiltration into the conjunctiva by clodronate liposomes in experimental immune-mediated blepharoconjunctivitis

scientific article published in April 2005

Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis

scientific article

Systemic analysis of PPARγ in mouse macrophage populations reveals marked diversity in expression with critical roles in resolution of inflammation and airway immunity

scientific article published on August 2012

T cell-activated macrophages are capable of both recognition and rejection of pancreatic islet xenografts

scientific article published in March 2003

TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P.

scientific article

TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence

scientific article published on 01 August 2018

TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus

scientific article published on December 2008

TLR7/9-mediated monocytosis and maturation of Gr-1hi inflammatory monocytes towards Gr-1lo resting monocytes implicated in murine lupus

TNF-Induced Target Cell Killing by CTL Activated through Cross-Presentation

article by Dirk Wohlleber et al published September 2012 in Cell Reports

Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activation

scientific article published on 22 April 2013

Targeting Macrophages Sensitizes Chronic Lymphocytic Leukemia to Apoptosis and Inhibits Disease Progression

scientific article published on 10 February 2016

Targeting of adenovirus vectors to the LRP receptor family with the high-affinity ligand RAP via combined genetic and chemical modification of the pIX capsomere

scientific article

Targeting tumor-associated macrophages and inhibition of MCP-1 reduce angiogenesis and tumor growth in a human melanoma xenograft

scientific article published on 26 April 2007

Th2 cytokine-induced alterations in intestinal smooth muscle function depend on alternatively activated macrophages

scientific article

The Roles of Vitreal Macrophages and Circulating Leukocytes in Retinal Neovascularization ⬇️

scientific article published on March 14, 2011

The efficacy of pneumococcal capsular polysaccharide-specific antibodies to serotype 3 Streptococcus pneumoniae requires macrophages ⬇️

scientific article published on August 26, 2010

The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity

scientific article published on December 2010

The influence of macrophage depletion on ligament healing ⬇️

scientific article published on November 30, 2010

The location of splenic NKT cells favours their rapid activation by blood-borne antigen

scientific article

The mechanism of anti-CD20-mediated B cell depletion revealed by intravital imaging

scientific article

The reactive D-glucopyranose moiety of streptozotocin is responsible for activation of macrophages and subsequent stimulation of CD8+ T cells

scientific article published in May 2005

The role of CD1d-restricted NKT cells in the clearance of Pseudomonas aeruginosa from the lung is dependent on the host genetic background

scientific article published on 13 April 2015

The role of complement in the therapeutic activity of rituximab in a murine B lymphoma model homing in lymph nodes

scientific article published on February 2006

The role of macrophages in the induction and regulation of immunity elicited by exogenous antigens

scientific article published on 01 February 1998

The role of perivascular and meningeal macrophages in experimental allergic encephalomyelitis

scientific article published in January 2002

The use of a model of in vivo macrophage depletion to study the role of macrophages during infection with Bacillus anthracis spores

scientific article published in October 2004

Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells

scientific article published on 08 December 2013

Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells

scientific article published on October 2013

Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes

scientific article

Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice

scientific article published on February 2013

Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis

scientific article

Tropism ablation and stealthing of oncolytic adenovirus enhances systemic delivery to tumors and improves virotherapy of cancer

scientific article published on 18 June 2012

Tumor Necrosis Factor-Mediated Survival of CD169+ Cells Promotes Immune Activation during Vesicular Stomatitis Virus Infection

scientific article published on 15 November 2017

Tumor formation initiated by nondividing epidermal cells via an inflammatory infiltrate

scientific article

Tumor necrosis factor (TNF) protects resistant C57BL/6 mice against herpes simplex virus-induced encephalitis independently of signaling via TNF receptor 1 or 2.

scientific article published on 15 November 2006

Tumor transition zone: a putative new morphological and functional hallmark of tumor aggressiveness

scientific article

Tumour necrosis factor α secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice

scientific article published on 5 April 2012

Twist1 induces CCL2 and recruits macrophages to promote angiogenesis

scientific article published on January 2013

Type 1 IFN deficiency in the absence of normal splenic architecture during lymphocytic choriomeningitis virus infection

scientific article published in September 2006

Type I interferon modulates monocyte recruitment and maturation in chronic inflammation

scientific article published on October 2009

Unique requirements for reactivation of virus-specific memory B lymphocytes

scientific article published on 25 August 2010

Use of tissue-specific microRNA to control pathology of wild-type adenovirus without attenuation of its ability to kill cancer cells

scientific article

Vaccination inducing broad and improved cross protection against multiple subtypes of influenza A virus

scientific article

Vascular endothelial growth factor‐induced skin carcinogenesis depends on recruitment and alternative activation of macrophages ⬇️

scientific article published on March 19, 2012

Vesicular stomatitis virus genomic RNA persists in vivo in the absence of viral replication

scientific article published on 23 December 2009

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