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List of works by Louis M Havekes

6-mercaptopurine inhibits atherosclerosis in apolipoprotein e*3-leiden transgenic mice through atheroprotective actions on monocytes and macrophages

scientific article published on 22 April 2010

A Novel EPO Receptor Agonist Improves Glucose Tolerance via Glucose Uptake in Skeletal Muscle in a Mouse Model of Diabetes ⬇️

scientific article published on June 30, 2011

A low-fat diet has a higher potential than energy restriction to improve high-fat diet-induced insulin resistance in mice

scientific article published in June 2002

Acute central neuropeptide Y administration increases food intake but does not affect hepatic very low-density lipoprotein (VLDL) production in mice

scientific article

Acute hepatic steatosis in mice by blocking beta-oxidation does not reduce insulin sensitivity of very-low-density lipoprotein production

scientific article published on 7 April 2005

Acute inhibition of hepatic beta-oxidation in APOE*3Leiden mice does not affect hepatic VLDL secretion or insulin sensitivity

scientific article

An Extrahepatic Receptor-associated Protein-sensitive Mechanism Is Involved in the Metabolism of Triglyceride-rich Lipoproteins

scientific article published in Journal of Biological Chemistry

Anacetrapib reduces progression of atherosclerosis, mainly by reducing non-HDL-cholesterol, improves lesion stability and adds to the beneficial effects of atorvastatin

scientific article

Anti-atherosclerotic effect of amlodipine, alone and in combination with atorvastatin, in APOE*3-Leiden/hCRP transgenic mice

scientific article published in January 2006

Apo E Polymorphism in Relation to the Expression of Familial Dysbetalipoproteinemia

ApoAV reduces plasma triglycerides by inhibiting very low density lipoprotein-triglyceride (VLDL-TG) production and stimulating lipoprotein lipase-mediated VLDL-TG hydrolysis

scientific article

ApoC-III deficiency prevents hyperlipidemia induced by apoE overexpression

scientific article published in May 2005

ApoE plasma levels and risk of cardiovascular mortality in old age

scientific article published on 9 May 2006

ApoE2-associated hypertriglyceridemia is ameliorated by increased levels of apoA-V but unaffected by apoC-III deficiency

scientific article published on 10 February 2008

Apolipoprotein A5 deficiency aggravates high-fat diet-induced obesity due to impaired central regulation of food intake

scientific article published on 6 May 2013

Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification

scientific article

Apolipoprotein C3 deficiency results in diet-induced obesity and aggravated insulin resistance in mice

scientific article published in March 2005

Apolipoprotein CI inhibits scavenger receptor BI and increases plasma HDL levels in vivo

scientific article

Apolipoprotein CI overexpression is not a relevant strategy to block cholesteryl ester transfer protein (CETP) activity in CETP transgenic mice

scientific article published on January 2005

Apolipoprotein E Polymorphisms and the Genetic Heterogeneity of Familial Dysbetalipoproteinemia

Apolipoprotein E as a risk factor for coronary heart disease: a genetic and molecular biology approach.

scientific article

Apolipoprotein gene cluster on chromosome 19

article

Apolipoproteins modulate the inflammatory response to lipopolysaccharide

scientific article

Aspirin reduces hypertriglyceridemia by lowering VLDL-triglyceride production in mice fed a high-fat diet

scientific article

Bexarotene induces dyslipidemia by increased very low-density lipoprotein production and cholesteryl ester transfer protein-mediated reduction of high-density lipoprotein

scientific article published on 15 January 2009

Both transient and continuous corticosterone excess inhibit atherosclerotic plaque formation in APOE*3-leiden.CETP mice

scientific article

Brown adipose tissue takes up plasma triglycerides mostly after lipolysis

scientific article published on 28 October 2014

Brown adipose tissue volume in healthy lean south Asian adults compared with white Caucasians: a prospective, case-controlled observational study

scientific article published on 12 November 2013

CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice

scientific article published on 16 August 2003

CD36 is important for adipocyte recruitment and affects lipolysis

scientific article published on 29 May 2013

CETP does not affect triglyceride production or clearance in APOE*3-Leiden mice

scientific article published on January 2010

CETP expression reverses the reconstituted HDL-induced increase in VLDL.

scientific article

CNTO736, a novel glucagon-like peptide-1 receptor agonist, ameliorates insulin resistance and inhibits very low-density lipoprotein production in high-fat-fed mice

scientific article published on 10 October 2008

Caspase-1 deficiency in mice reduces intestinal triglyceride absorption and hepatic triglyceride secretion

scientific article published on 17 November 2012

Characterisation and Mode of Inheritance of Apolipoprotein E3-Leiden

scientific article published on 01 January 1987

Cholesteryl ester transfer protein decreases high-density lipoprotein and severely aggravates atherosclerosis in APOE*3-Leiden mice

scientific article published on 31 August 2006

Circulating insulin stimulates fatty acid retention in white adipose tissue via KATP channel activation in the central nervous system only in insulin-sensitive mice

scientific article

Colestilan decreases weight gain by enhanced NEFA incorporation in biliary lipids and fecal lipid excretion ⬇️

scientific article published on February 22, 2013

Detrimental effects of constant light exposure and high‐fat diet on circadian energy metabolism and insulin sensitivity ⬇️

scientific article published on January 9, 2013

Development of atopic dermatitis in mice transgenic for human apolipoprotein C1.

scientific article published on 29 November 2007

Dietary sphingolipids lower plasma cholesterol and triacylglycerol and prevent liver steatosis in APOE*3Leiden mice.

scientific article

Differential effects of amlodipine and atorvastatin treatment and their combination on atherosclerosis in ApoE*3-Leiden transgenic mice

scientific article

Differential effects of pharmacological liver X receptor activation on hepatic and peripheral insulin sensitivity in lean and ob/ob mice

scientific article

Effect of plasma triglyceride metabolism on lipid storage in adipose tissue: studies using genetically engineered mouse models

scientific article published on 08 January 2009

Effects of amlodipine, atorvastatin and combination of both on advanced atherosclerotic plaque in APOE*3-Leiden transgenic mice

scientific article published in January 2003

Endogenous apoC-I increases hyperlipidemia in apoE-knockout mice by stimulating VLDL production and inhibiting LPL.

scientific article published on 14 March 2006

Endogenous interleukin-10 protects against hepatic steatosis but does not improve insulin sensitivity during high-fat feeding in mice

scientific article published on 18 May 2006

Establishment of a general NAFLD scoring system for rodent models and comparison to human liver pathology

scientific article

Estimation of Activity Related Energy Expenditure and Resting Metabolic Rate in Freely Moving Mice from Indirect Calorimetry Data ⬇️

scientific article (publication date: 2012)

Expression of type III hyperlipoproteinemia in apolipoprotein E2 (Arg158 --> Cys) homozygotes is associated with hyperinsulinemia

scientific article published in February 2002

Fenofibrate increases very low density lipoprotein triglyceride production despite reducing plasma triglyceride levels in APOE*3-Leiden.CETP mice

scientific article published on 25 May 2010

GLP-1 receptor activation inhibits VLDL production and reverses hepatic steatosis by decreasing hepatic lipogenesis in high-fat-fed APOE*3-Leiden mice

scientific article

Generation of a recombinant apolipoprotein E variant with improved biological functions: hydrophobic residues (LEU-261, TRP-264, PHE-265, LEU-268, VAL-269) of apoE can account for the apoE-induced hypertriglyceridemia

scientific article published on 2 December 2004

Genomic analysis of the response of mouse models to high-fat feeding shows a major role of nuclear receptors in the simultaneous regulation of lipid and inflammatory genes

scientific article published on 16 March 2005

Gut-brain axis

scientific article published on July 2008

HOE 402 lowers serum cholesterol levels by reducing VLDL-lipid production, and not by induction of the LDL receptor, and reduces atherosclerosis in wild-type and LDL receptor-deficient mice

scientific article

Hepatic low-density lipoprotein receptor-related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol

scientific article

Hepatocyte-specific IKK-β activation enhances VLDL-triglyceride production in APOE*3-Leiden mice

scientific article

Hepatocyte-specific IKKβ expression aggravates atherosclerosis development in APOE*3-Leiden mice

scientific article

High levels of dietary stearate promote adiposity and deteriorate hepatic insulin sensitivity

scientific article

High levels of whole-body energy expenditure are associated with a lower coupling of skeletal muscle mitochondria in C57Bl/6 mice

article published in 2010

High-fat diets rich in medium- versus long-chain fatty acids induce distinct patterns of tissue specific insulin resistance

scholarly article by Johan De Vogel-van den Bosch et al published April 2011 in Journal of Nutritional Biochemistry

Human CETP aggravates atherosclerosis by increasing VLDL-cholesterol rather than by decreasing HDL-cholesterol in APOE*3-Leiden mice

scientific article

Improved cholesterol phenotype analysis by a model relating lipoprotein life cycle processes to particle size

scientific article published on 10 June 2009

Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice

scientific article

Induction of atherosclerotic plaque rupture in apolipoprotein E-/- mice after adenovirus-mediated transfer of p53.

scientific article published in April 2002

Inhibition of the central melanocortin system decreases brown adipose tissue activity

scientific article

Integrative biological analysis of the APOE*3-leiden transgenic mouse

scientific article

Interactions between inflammation and lipid metabolism: Relevance for efficacy of anti-inflammatory drugs in the treatment of atherosclerosis ⬇️

scientific article published on March 1, 2013

Intracerebroventricular administration of neuropeptide Y induces hepatic insulin resistance via sympathetic innervation

scientific article published on 10 June 2008

Intracerebroventricular neuropeptide Y infusion precludes inhibition of glucose and VLDL production by insulin

scientific article published in October 2004

Intrauterine exposure to maternal atherosclerotic risk factors increases the susceptibility to atherosclerosis in adult life

scientific article published on 26 July 2007

LDL receptor deficiency results in decreased cell proliferation and presynaptic bouton density in the murine hippocampus

scientific article published on 17 July 2007

Lipidomics reveals multiple pathway effects of a multi-components preparation on lipid biochemistry in ApoE*3Leiden.CETP mice

scientific article (publication date: 2012)

Local Cre-mediated gene recombination in vascular smooth muscle cells in mice

scientific article published in February 2006

Local perivascular delivery of anti-restenotic agents from a drug-eluting poly(epsilon-caprolactone) stent cuff

scientific article published in September 2005

Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus

scientific article published in June 2004

META060 protects against diet-induced obesity and insulin resistance in a high-fat–diet fed mouse ⬇️

scientific article published on September 15, 2012

Macrophage p53 controls macrophage death in atherosclerotic lesions of apolipoprotein E deficient mice.

scientific article published on 18 June 2009

Macrophage-specific inhibition of NF-kappaB activation reduces foam-cell formation

scientific article

Maternal transmission of risk for atherosclerosis

scientific article published on August 2008

Metabolomics in the context of systems biology: bridging traditional Chinese medicine and molecular pharmacology

scientific article

Molecular mechanisms of type III hyperlipoproteinemia: The contribution of the carboxy-terminal domain of ApoE can account for the dyslipidemia that is associated with the E2/E2 phenotype

scientific article published in August 2003

Olmesartan and pravastatin additively reduce development of atherosclerosis in APOE*3Leiden transgenic mice

scientific article published in December 2007

Overexpression of APOC1 in obob mice leads to hepatic steatosis and severe hepatic insulin resistance

scientific article published in October 2003

Oxyntomodulin ameliorates glucose intolerance in mice fed a high-fat diet

scientific article published on 30 October 2007

PXR agonism decreases plasma HDL levels in ApoE3-Leiden.CETP mice

scientific article published on 25 December 2008

PYY3-36 reinforces insulin action on glucose disposal in mice fed a high-fat diet

scientific article

Perfluoroalkyl sulfonates cause alkyl chain length-dependent hepatic steatosis and hypolipidemia mainly by impairing lipoprotein production in APOE*3-Leiden CETP mice

scientific article published on 24 June 2011

Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity

scientific article published on 25 August 2014

Phenotype characterisation using integrated gene transcript, protein and metabolite profiling

scientific article published in January 2004

Plasma and liver lipidomics response to an intervention of rimonabant in ApoE*3Leiden.CETP transgenic mice

scientific article (publication date: 2011)

Plasma apolipoprotein CI correlates with increased survival in patients with severe sepsis

scientific article published on 30 January 2008

Plasma cholesteryl ester transfer protein is predominantly derived from Kupffer cells

scientific article published on 14 July 2015

Prenatal exposure to apoE deficiency and postnatal hypercholesterolemia are associated with altered cell-specific lysine methyltransferase and histone methylation patterns in the vasculature

scientific article

Preoperative apolipoprotein CI levels correlate positively with the proinflammatory response in patients experiencing endotoxemia following elective cardiac surgery

scientific article published on 12 April 2008

Raman spectroscopic investigation of atorvastatin, amlodipine, and both on atherosclerotic plaque development in APOE*3 Leiden transgenic mice

scientific article

Rare mutations in the APOE gene associated with dominant mode of inheritance of Familial Dysbetalipoproteinemia (FD)

article

Response of apolipoprotein E*3-Leiden transgenic mice to dietary fatty acids: combining liver proteomics with physiological data

scientific article

Ritonavir impairs lipoprotein lipase-mediated lipolysis and decreases uptake of fatty acids in adipose tissue

scientific article published on 3 November 2005

Ritonavir protects against the development of atherosclerosis in APOE*3-Leiden mice

scientific article published in December 2009

Rosiglitazone improves muscle insulin sensitivity, irrespective of increased triglyceride content, in ob/ob mice

scientific article published in August 2003

Rosuvastatin reduces atherosclerosis development beyond and independent of its plasma cholesterol-lowering effect in APOE*3-Leiden transgenic mice: evidence for antiinflammatory effects of rosuvastatin

scientific article published on 25 August 2003

Rosuvastatin reduces plasma lipids by inhibiting VLDL production and enhancing hepatobiliary lipid excretion in ApoE*3-leiden mice

scientific article published in January 2005

Selective parasympathetic innervation of subcutaneous and intra-abdominal fat--functional implications

scientific article

Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL

scientific article

Sixteen hours of fasting differentially affects hepatic and muscle insulin sensitivity in mice

scientific article published in December 2004

Specific and efficient targeting of adenovirus vectors to macrophages: application of a fusion protein between an adenovirus-binding fragment and avidin, linked to a biotinylated oligonucleotide

scientific article published on June 2006

Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles

scientific article published on 3 July 2002

Stimulatory effect of insulin on glucose uptake by muscle involves the central nervous system in insulin-sensitive mice

scientific article published on 25 October 2011

Sympathetic nervous system control of triglyceride metabolism: novel concepts derived from recent studies

scientific article

The VLDL receptor plays a major role in chylomicron metabolism by enhancing LPL-mediated triglyceride hydrolysis

scientific article

The effect of PPE-induced emphysema and chronic LPS-induced pulmonary inflammation on atherosclerosis development in APOE*3-LEIDEN mice

scientific article

The effects of high fat diet on the basal activity of the hypothalamus-pituitary-adrenal axis in mice

scientific article published on 22 May 2012

The expression of type III hyperlipoproteinemia: involvement of lipolysis genes

scientific article

The role and mode of action of apolipoproteins CIII and AV: synergistic actors in triglyceride metabolism?

scientific article

The transport of triglycerides through the secretory pathway of hepatocytes is impaired in apolipoprotein E deficient mice

scientific article published in April 2004

Torcetrapib does not reduce atherosclerosis beyond atorvastatin and induces more proinflammatory lesions than atorvastatin

scientific article published on 5 May 2008

Triglyceride-rich lipoprotein metabolism in unique VLDL receptor, LDL receptor, and LRP triple-deficient mice

scientific article

Tumor necrosis factor-alpha plays an important role in restenosis development

scientific article published in December 2005

Tumor necrosis factor-alpha promotes atherosclerotic lesion progression in APOE*3-Leiden transgenic mice

scientific article

VLDL receptor deficiency enhances intimal thickening after vascular injury but does not affect atherosclerotic lesion area

scientific article

Well-characterized garlic-derived materials are not hypolipidemic in APOE*3-Leiden transgenic mice

scientific article published in June 2004

Znf202 affects high density lipoprotein cholesterol levels and promotes hepatosteatosis in hyperlipidemic mice

scientific article

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