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List of works by José M Mato

1H-NMR-based urine metabolomics reveals signs of enhanced carbon and nitrogen recycling in prostate cancer

scientific article published on 07 May 2020

5'-methylthioadenosine modulates the inflammatory response to endotoxin in mice and in rat hepatocytes.

scientific article published on April 2004

A Metabolomics Signature Linked To Liver Fibrosis In The Serum Of Transplanted Hepatitis C Patients

scientific article published on 5 September 2017

A glycine N-methyltransferase knockout mouse model for humans with deficiency of this enzyme

scientific article published on June 2006

A morphological method for ammonia detection in liver

scientific article

A signature of six genes highlights defects on cell growth and specific metabolic pathways in murine and human hepatocellular carcinoma.

scientific article published on 12 May 2011

Abnormal concentration of porphyrins in serum from COVID-19 patients

scientific article published on 03 August 2020

Abnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis

scientific article published in January 2004

Acid sphingomyelinase-ceramide system in steatohepatitis: a novel target regulating multiple pathways

scientific article published on 02 October 2014

Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis ⬇️

scientific article published on November 1, 2010

Activation of a novel c-Myc-miR27-prohibitin 1 circuitry in cholestatic liver injury inhibits glutathione synthesis in mice.

scientific article

Alcohol, DNA methylation, and cancer

scientific article

Altered liver gene expression in CCl4-cirrhotic rats is partially normalized by insulin-like growth factor-I.

scientific article published in March 2002

Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation

scientific article published on 01 September 2020

Binding of S-methyl-5'-thioadenosine and S-adenosyl-L-methionine to protein MJ0100 triggers an open-to-closed conformational change in its CBS motif pair

scientific article

Biomarkers and subtypes of deranged lipid metabolism in non-alcoholic fatty liver disease

scientific article published on 01 June 2019

Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.

scientific article published on April 2010

Changes in S-adenosylmethionine and GSH homeostasis during endotoxemia in mice.

scientific article

Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes

scientific article published on December 2008

Correlation between gene expression and GO semantic similarity

scientific article published on October 2005

Corrigendum: mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

scientific article published on 17 January 2018

Depletion of mitochondrial methionine adenosyltransferase α1 triggers mitochondrial dysfunction in alcohol-associated liver disease

scientific article published on 28 January 2022

Deregulated methionine adenosyltransferase α1, c-Myc, and Maf proteins together promote cholangiocarcinoma growth in mice and humans(‡).

scientific article published on 11 March 2016

Deregulated neddylation in liver fibrosis

scientific article

Effect of hepatocyte growth factor on methionine adenosyltransferase genes and growth is cell density-dependent in HepG2 cells

scientific article published on March 2007

Effects of S-adenosylmethionine and methylthioadenosine on inflammation-induced colon cancer in mice

scientific article published on 9 December 2011

Evidence for LKB1/AMP-activated protein kinase/ endothelial nitric oxide synthase cascade regulated by hepatocyte growth factor, S-adenosylmethionine, and nitric oxide in hepatocyte proliferation.

scientific article published in February 2009

Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis

scientific article published on 14 August 2013

FRI-294-Mitochondrial GNMT-complex II is recovered by miR-873-5p targeting in NAFLD

scholarly article

Fatty liver and fibrosis in glycine N-methyltransferase knockout mice is prevented by nicotinamide

scientific article

Fine-tuning of SIRT1 expression is essential to protect the liver from cholestatic liver disease

scientific article published on 19 September 2018

Folding of dimeric methionine adenosyltransferase III: identification of two folding intermediates

scientific article

Functional proteomics of nonalcoholic steatohepatitis: mitochondrial proteins as targets of S-adenosylmethionine

scholarly article

GARBAN: genomic analysis and rapid biological annotation of cDNA microarray and proteomic data.

scientific article published in November 2003

Genetic polymorphisms in the methylenetetrahydrofolate reductase and thymidylate synthase genes and risk of hepatocellular carcinoma

scientific article published on September 2007

Glycine N-methyltransferase expression in the hippocampus and its role in neurogenesis and cognitive performance

scientific article published on 8 April 2014

Hepatic expression patterns of inflammatory and immune response genes associated with obesity and NASH in morbidly obese patients

scientific article (publication date: 22 October 2010)

Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1.

scientific article

High-frequency ultrasound imaging for longitudinal evaluation of non-alcoholic fatty liver disease progression in mice.

scientific article

Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1

scientific article

Homocysteine, the bad thiol

scientific article

HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis

scientific journal article

Human antigen R contributes to hepatic stellate cell activation and liver fibrosis

scientific article published on 9 October 2012

Id2 leaves the chromatin of the E2F4-p130-controlled c-myc promoter during hepatocyte priming for liver regeneration

scientific journal article

Identification of a gene-pathway associated with non-alcoholic steatohepatitis

scientific article published on 30 November 2006

Impaired Function of Solute Carrier Family 19 Leads to Low Folate Levels and Lipid Droplet Accumulation in Hepatocytes

Impaired liver regeneration in mice lacking glycine N-methyltransferase.

scientific article published on August 2009

Impaired liver regeneration in mice lacking methionine adenosyltransferase 1A.

scientific article published on 19 March 2004

Importance of a deficiency in S-adenosyl-L-methionine synthesis in the pathogenesis of liver injury

scientific article

Inhibition of human betaine-homocysteine methyltransferase expression by S-adenosylmethionine and methylthioadenosine

scientific article published on January 2007

Inhibition of human methionine adenosyltransferase 1A transcription by coding region methylation

scientific article

Inhibition of lipopolysaccharide-stimulated TNF-alpha promoter activity by S-adenosylmethionine and 5'-methylthioadenosine

scientific article published on 2 April 2004

Inhibition of natural killer cells protects the liver against acute injury in the absence of glycine N-methyltransferase

scientific article

Insulin-like growth factor 1 activates methionine adenosyltransferase 2A transcription by multiple pathways in human colon cancer cells

scientific article published on June 2011

L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells: role of S-adenosylmethionine

scientific article published on 26 March 2003

Liquid chromatography-mass spectrometry-based parallel metabolic profiling of human and mouse model serum reveals putative biomarkers associated with the progression of nonalcoholic fatty liver disease

scientific article

Liver cancer-associated changes to the proteome: what deserves clinical focus?

scientific article published on 19 September 2018

Liver receptor homolog 1 and transmethylation fluxes in nonalcoholic steatohepatitis

scientific article published on 3 September 2015

Liver-specific deletion of prohibitin 1 results in spontaneous liver injury, fibrosis, and hepatocellular carcinoma in mice ⬇️

scientific article published on October 1, 2010

Lysine and Arginine Protein Post-translational Modifications by Enhanced DIA Libraries: Quantification in Murine Liver Disease

scientific article published on 23 September 2020

MAT2B-GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer

scientific article published on 14 May 2013

Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer

Metabolic Characterization of Advanced Liver Fibrosis in HCV Patients as Studied by Serum 1H-NMR Spectroscopy

scientific article

Metabolic landscape of the mouse liver by quantitative <sup>31</sup> P-NMR analysis of the phosphorome

scientific article published on 07 December 2020

Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis.

scientific article published on 26 January 2017

Metabolomics Discloses Potential Biomarkers for the Noninvasive Diagnosis of Idiopathic Portal Hypertension

scientific article published on 19 February 2013

Metabolomics as a diagnostic tool for idiopathic non-cirrhotic portal hypertension

scientific article published on 23 September 2015

Metabolomics discloses potential biomarkers to predict the acute HVPG response to propranolol in patients with cirrhosis

scientific article published on 10 February 2019

Metabolomic‐based noninvasive serum test to diagnose nonalcoholic steatohepatitis: Results from discovery and validation cohorts.

scientific article published on 4 May 2018

Methionine Adenosyltransferase α1 Is Targeted to the Mitochondrial Matrix and Interacts with Cytochrome P450 2E1 to Lower Its Expression

scientific article published on 25 June 2019

Methionine adenosyltransferase 1A gene deletion disrupts hepatic very low-density lipoprotein assembly in mice

scientific article published on December 2011

Methionine adenosyltransferase 2B, HuR, and sirtuin 1 protein cross-talk impacts on the effect of resveratrol on apoptosis and growth in liver cancer cells.

scientific article published in January 2014

Methionine adenosyltransferase 2B, HuR, and sirtuin 1 protein cross-talk impacts on the effect of resveratrol on apoptosis and growth in liver cancer cells.

scientific article published on 28 June 2013

Methionine adenosyltransferase 2B-GIT1 complex serves as a scaffold to regulate Ras/Raf/MEK1/2 activity in human liver and colon cancer cells

scientific article

Methionine adenosyltransferase I/III deficiency: two Korean compound heterozygous siblings with a novel mutation ⬇️

scientific article published on December 1, 2002

Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma

scientific article published in April 2003

Methionine adenosyltransferase and S-adenosylmethionine in alcoholic liver disease.

scientific article published on October 2006

Methionine adenosyltransferase α2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells

scientific article

Methionine adenosyltransferases in liver cancer

scientific article published on 01 August 2019

Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis

scientific article published on 19 September 2015

Methylthioadenosine phosphorylase gene expression is impaired in human liver cirrhosis and hepatocarcinoma

scientific article

MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis

scientific article published on 20 September 2018

MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma

scientific article

Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis.

scientific article

Molecular profiling of hepatocellular carcinoma in mice with a chronic deficiency of hepatic s-adenosylmethionine: relevance in human liver diseases

scientific article

Multi-Omics Integration Highlights the Role of Ubiquitination in CCl<sub>4</sub>-Induced Liver Fibrosis

scientific article published on 27 November 2020

Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation

scientific article published in March 2012

NO sensitizes rat hepatocytes to proliferation by modifying S-adenosylmethionine levels

scientific article published in May 2002

Non-alcoholic steatohepatitis and animal models: understanding the human disease.

scientific article

Non-invasive detection of drug toxicity in rats by solid-phase extraction and MALDI-TOF analysis of urine samples.

scientific article

Obeticholic Acid Modulates Serum Metabolites and Gene Signatures Characteristic of Human NASH and Attenuates Inflammation and Fibrosis Progression in Ldlr-/-.Leiden Mice

scientific article published on 29 October 2018

Overview of extracellular microvesicles in drug metabolism.

scientific article published on May 2010

Oxidation of specific methionine and tryptophan residues of apolipoprotein A-I in hepatocarcinogenesis.

scientific article

PINE: An Automation Tool to Extract & Visualize Protein-Centric Functional Networks

scientific article published on 28 May 2020

PS-015-Role of methylation-controlled J-protein, endogenous repressor of the mitochondrial respiratory chain, in cholestatic liver disease

scholarly article

PS-034-MCJ: A therapeutic target in hepatic ischemia and reperfusion injury

scholarly article

Polyamine and methionine adenosyltransferase 2A crosstalk in human colon and liver cancer

scientific article published on 12 April 2013

Prohibitin 1 Acts As a Negative Regulator of Wingless/Integrated-Beta-Catenin Signaling in Murine Liver and Human Liver Cancer Cells

scientific article published on 27 September 2018

Prohibitin 1 Regulates the H19-Igf2 Axis and Proliferation in Hepatocytes

scientific article published on 29 September 2016

Prohibitin 1 suppresses liver cancer tumorigenesis in mice and human hepatocellular and cholangiocarcinoma cells

scientific article published on 16 December 2016

Proteomic analysis of human hepatoma cells expressing methionine adenosyltransferase I/III: Characterization of DDX3X as a target of S-adenosylmethionine

scientific article published on 16 January 2012

Proteomics analysis of human nonalcoholic fatty liver

scientific article

Quantitative proteomic analysis of hepatocyte-secreted extracellular vesicles reveals candidate markers for liver toxicity

scientific article published on 18 April 2014

Reciprocal Regulation Between Forkhead Box M1/NF-kB and Methionine Adenosyltransferase 1A Drives Liver Cancer

scientific article published on 21 February 2020

Regulation of mammalian liver methionine adenosyltransferase

scientific journal article

Repurposing ciclopirox as a pharmacological chaperone in a model of congenital erythropoietic porphyria

scientific article published on 01 September 2018

Role of AMP-activated protein kinase in the control of hepatocyte priming and proliferation during liver regeneration

scientific article published on 22 March 2011

Role of Aramchol in steatohepatitis and fibrosis in mice.

scientific article published on 4 October 2017

Role of S-adenosyl-L-methionine in liver health and injury

scientific article published on May 2007

Role of S-adenosylmethionine in two experimental models of pancreatitis

scientific article published in November 2002

Role of abnormal methionine metabolism in alcoholic liver injury

scientific article

Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer

scientific article

Role of methionine adenosyltransferase genes in hepatocarcinogenesis

scientific article published on 24 March 2011

S-Adenosylmethionine Negatively Regulates the Mitochondrial Respiratory Chain Repressor MCJ in the Liver

scholarly article

S-Adenosylmethionine and methylthioadenosine inhibit cellular FLICE inhibitory protein expression and induce apoptosis in colon cancer cells

scientific article published on 16 April 2009

S-Adenosylmethionine and methylthioadenosine inhibit β-catenin signaling by multiple mechanisms in liver and colon cancer

scientific article

S-Adenosylmethionine increases circulating very-low density lipoprotein clearance in non-alcoholic fatty liver disease.

scientific article

S-Adenosylmethionine revisited: its essential role in the regulation of liver function

scientific article

S-Adenosylmethionine: a control switch that regulates liver function.

scientific article

S-adenosyl methionine regulates ubiquitin-conjugating enzyme 9 protein expression and sumoylation in murine liver and human cancers

scientific article

S-adenosylmethionine and its metabolite induce apoptosis in HepG2 cells: Role of protein phosphatase 1 and Bcl-x(S).

scientific article published in July 2004

S-adenosylmethionine and proliferation: new pathways, new targets

scientific article

S-adenosylmethionine in Liver Health, Injury, and Cancer ⬇️

scientific article published on October 1, 2012

S-adenosylmethionine inhibits lipopolysaccharide-induced gene expression via modulation of histone methylation

scientific article published on May 2008

S-adenosylmethionine levels regulate the schwann cell DNA methylome.

scientific article published on March 2014

S-adenosylmethionine metabolism and liver disease.

scientific article published on March 2013

S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase

scientific article published on 01 July 2006

SARS-CoV-2 infection dysregulates the metabolomic and lipidomic profiles of serum

scientific article published on 05 October 2020

SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling.

scientific article published on 31 March 2014

SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer

scientific article published on 26 December 2018

Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves.

scientific article published in July 2015

Sensitive detection of SARS-CoV-2 seroconversion by flow cytometry reveals the presence of nucleoprotein-reactive antibodies in unexposed individuals

scientific article

Serum UPLC-MS/MS metabolic profiling in an experimental model for acute-liver injury reveals potential biomarkers for hepatotoxicity

scientific article

Solute carrier family 2 member 1 is involved in the development of nonalcoholic fatty liver disease

scientific article

Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A.

scientific article published on 07 June 2002

Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer

scientific article

Sub‐proteome approach to the knowledge of liver ⬇️

scientific article published on 03 February 2010

Surfing transcriptomic landscapes. A step beyond the annotation of chromosome 16 proteome.

scientific article published on 5 November 2013

Systems biology for hepatologists

scientific article

TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency

scientific article

Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly

scientific article published on 21 February 2020

The 2006 Human Liver Proteome Project (HLPP) Workshops ⬇️

scientific article published on April 19, 2007

The 2009 Human Liver Proteome Project (HLPP) Workshop 26 September 2009, Toronto, Canada ⬇️

scientific article published on 01 September 2010

The 2011 Human Liver Proteome Project (HLPP) Workshop September 5, 2011, Geneva, Switzerland.

scientific article published on 29 November 2011

The Hepatocarcinogenic Effect of Methionine and Choline Deficient Diets: An Adaptation to the Warburg Effect? ⬇️

scientific article published on February 1, 2011

The L-α-lysophosphatidylinositol/GPR55 system induces the development of non-alcoholic steatosis and steatohepatitis

scientific article published on 23 April 2020

The RNA-binding protein human antigen R controls global changes in gene expression during Schwann cell development.

scientific article published in April 2012

The mitochondrial chaperone Prohibitin 1 negatively regulates interleukin-8 in human liver cancers

scientific article published on 06 December 2018

The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury.

scientific article

WITHDRAWN: Silencing of human methionine adenosyltransferase 1A expression by methylation of the coding region

retracted scientific article published in December 2004

Where are we in the search for noninvasive nonalcoholic steatohepatitis biomarkers? ⬇️

scientific article published on October 1, 2011

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.

scientific article published on 28 June 2017

miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease

scientific article published on 16 August 2019

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