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List of works by Hsing-Wen Sung

21. pH-sensitive chitosan-based nanoparticles for protein drug delivery: oral approaches: Original research article: a novel pH-sensitive hydrogel composed of carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery, 200

scientific article published in September 2014

A FRET-guided, NIR-responsive bubble-generating liposomal system for in vivo targeted therapy with spatially and temporally precise controlled release.

scientific article published on 31 March 2016

A dual-emission Förster resonance energy transfer nanoprobe for sensing/imaging pH changes in the biological environment.

scientific article published on 17 November 2010

A genetically-encoded KillerRed protein as an intrinsically generated photosensitizer for photodynamic therapy

scientific article published on 8 October 2013

A genipin-crosslinked gelatin membrane as wound-dressing material: in vitro and in vivo studies.

scientific article

A nanoscale drug-entrapment strategy for hydrogel-based systems for the delivery of poorly soluble drugs.

scientific article

A natural compound (reuterin) produced by Lactobacillus reuteri for biological-tissue fixation.

scientific article published in April 2003

A natural compound (reuterin) produced by Lactobacillus reuteri for hemoglobin polymerization as a blood substitute.

scientific article

A novel method for the synthesis of the PEG-crosslinked chitosan with a pH-independent swelling behavior

scientific article published on 01 October 2005

A novel pH-sensitive hydrogel composed of N,O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery.

scientific article

A pH-Responsive Carrier System that Generates NO Bubbles to Trigger Drug Release and Reverse P-Glycoprotein-Mediated Multidrug Resistance.

scientific article published in July 2015

A rapid drug release system with a NIR light-activated molecular switch for dual-modality photothermal/antibiotic treatments of subcutaneous abscesses.

scientific article published on 11 December 2014

A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery.

scientific article

A strategy for fabrication of a three-dimensional tissue construct containing uniformly distributed embryoid body-derived cells as a cardiac patch.

scientific article published on 26 May 2010

A thermoresponsive bubble-generating liposomal system for triggering localized extracellular drug delivery

scientific article published on 20 December 2012

A translational approach in using cell sheet fragments of autologous bone marrow-derived mesenchymal stem cells for cellular cardiomyoplasty in a porcine model

scientific article published on 23 March 2013

Acellular biological tissues containing inherent glycosaminoglycans for loading basic fibroblast growth factor promote angiogenesis and tissue regeneration.

scientific article published in September 2006

Acidity-triggered charge-convertible nanoparticles that can cause bacterium-specific aggregation in situ to enhance photothermal ablation of focal infection

scientific article

Advanced drug delivery systems for therapeutic applications

scientific article published on 01 August 2014

Aglycone geniposidic acid, a naturally occurring crosslinking agent, and its application for the fixation of collagenous tissues.

scientific article published in December 2007

An AS1411 aptamer-conjugated liposomal system containing a bubble-generating agent for tumor-specific chemotherapy that overcomes multidrug resistance.

scientific article published on 28 January 2015

An Implantable Depot That Can Generate Oxygen in Situ for Overcoming Hypoxia-Induced Resistance to Anticancer Drugs in Chemotherapy

scientific article published on 13 April 2016

An Intestinal "Transformers"-like Nanocarrier System for Enhancing the Oral Bioavailability of Poorly Water-Soluble Drugs

scientific article published on 06 June 2018

An In Situ Depot for Continuous Evolution of Gaseous H2 Mediated by a Magnesium Passivation/Activation Cycle for Treating Osteoarthritis

scientific article published on 06 July 2018

Anti-microbial activity and film characterization of thiazolidinone derivatives of chitosan.

scientific article published in June 2005

Bioengineered cardiac patch constructed from multilayered mesenchymal stem cells for myocardial repair.

scientific article

Biomimetic Engineering of a Scavenger-Free Nitric Oxide-Generating/Delivering System to Enhance Radiation Therapy

scientific article published on 04 May 2020

CD44-specific nanoparticles for redox-triggered reactive oxygen species production and doxorubicin release.

scientific article published on 4 February 2016

Calcium depletion-mediated protease inhibition and apical-junctional-complex disassembly via an EGTA-conjugated carrier for oral insulin delivery

scientific article published on 27 November 2012

Can cardiac catheterization accurately assess the severity of aortic stenosis? AnIn Vitro pulsatile flow study ⬇️

scientific article published on September 1, 1997

Cardiac repair with injectable cell sheet fragments of human amniotic fluid stem cells in an immune-suppressed rat model.

scientific article

Cellular cardiomyoplasty with human amniotic fluid stem cells: in vitro and in vivo studies

scientific article published on 01 June 2010

Columnar mesophases of the complexes of DNA with low-generation poly(amido amine) dendrimers.

scientific article

Complete destruction of deep-tissue buried tumors via combination of gene silencing and gold nanoechinus-mediated photodynamic therapy.

scientific article published on 22 May 2015

Conductive Materials for Healing Wounds: Their Incorporation in Electroactive Wound Dressings, Characterization, and Perspectives

scientific article published on 04 December 2020

Construction of varying porous structures in acellular bovine pericardia as a tissue-engineering extracellular matrix.

scientific article published in May 2005

Controlled Release of an Anti-inflammatory Drug Using an Ultrasensitive ROS-Responsive Gas-Generating Carrier for Localized Inflammation Inhibition.

scientific article published on 22 September 2015

Core-shell cell bodies composed of human cbMSCs and HUVECs for functional vasculogenesis.

scientific article

Crosslinking characteristics and mechanical properties of a bovine pericardium fixed with a naturally occurring crosslinking agent

scientific article published on 01 November 1999

Crosslinking of biological tissues using genipin and/or carbodiimide.

scientific article

Direct intramyocardial injection of mesenchymal stem cell sheet fragments improves cardiac functions after infarction.

scientific article published on 19 October 2007

Effects of chitosan-nanoparticle-mediated tight junction opening on the oral absorption of endotoxins

scientific article published on 08 September 2011

Effects of crosslinking degree of an acellular biological tissue on its tissue regeneration pattern.

scientific article published in August 2004

Effects of incorporation of poly(gamma-glutamic acid) in chitosan/DNA complex nanoparticles on cellular uptake and transfection efficiency.

scientific article

Effects of pH on molecular mechanisms of chitosan-integrin interactions and resulting tight-junction disruptions.

scientific article published on 24 October 2012

Effects of the nanostructure of dendrimer/DNA complexes on their endocytosis and gene expression.

scientific article published on July 2010

Effects of various chemical sterilization methods on the crosslinking and enzymatic degradation characteristics of an epoxy-fixed biological tissue

scientific article published on 01 December 1997

Electrical coupling of isolated cardiomyocyte clusters grown on aligned conductive nanofibrous meshes for their synchronized beating.

scientific article

Elucidating the signaling mechanism of an epithelial tight-junction opening induced by chitosan.

scientific article published on 7 June 2012

Enhancement of cell adhesion, retention, and survival of HUVEC/cbMSC aggregates that are transplanted in ischemic tissues by concurrent delivery of an antioxidant for therapeutic angiogenesis.

scientific article published on 30 September 2015

Enhancement of efficiencies of the cellular uptake and gene silencing of chitosan/siRNA complexes via the inclusion of a negatively charged poly(γ-glutamic acid) ⬇️

scientific article published on August 25, 2010

Enhancement of efficiency of chitosan-based complexes for gene transfection with poly(γ-glutamic acid) by augmenting their cellular uptake and intracellular unpackage.

scientific article published on 26 April 2014

Enhancing the stiffness of electrospun nanofiber scaffolds with a controlled surface coating and mineralization.

scientific article

FRET-based dual-emission and pH-responsive nanocarriers for enhanced delivery of protein across intestinal epithelial cell barrier

scientific article published on 13 October 2014

Fabrication of chondroitin sulfate-chitosan composite artificial extracellular matrix for stabilization of fibroblast growth factor.

scientific article published in January 2006

Feasibility study using a natural compound (reuterin) produced by Lactobacillus reuteri in sterilizing and crosslinking biological tissues.

scientific article published on September 2002

Fixation of biological tissues with a naturally occurring crosslinking agent: fixation rate and effects of pH, temperature, and initial fixative concentration

scientific article published on 01 October 2000

Gelatin-derived bioadhesives for closing skin wounds: an in vivo study

scientific article published on 01 January 1999

Genipin‐crosslinked gelatin microspheres as a drug carrier for intramuscular administration: In vitro and in vivo studies ⬇️

scientific article published on May 1, 2003

H2O2-Depleting and O2-Generating Selenium Nanoparticles for Fluorescence Imaging and Photodynamic Treatment of Proinflammatory-Activated Macrophages.

scientific article published on 25 January 2017

Hemoglobin polymerized with a naturally occurring crosslinking agent as a blood substitute: in vitro and in vivo studies.

scientific article

Heparin-functionalized chitosan-alginate scaffolds for controlled release of growth factor.

scientific article

Heparinization on pericardial substitutes can reduce adhesion and epicardial inflammation in the dog

scientific article published on 01 May 1998

Heparinized chitosan/poly(γ-glutamic acid) nanoparticles for multi-functional delivery of fibroblast growth factor and heparin

scientific article published on 01 December 2010

Hyperthermia-mediated local drug delivery by a bubble-generating liposomal system for tumor-specific chemotherapy.

scientific article published on 21 April 2014

Hypoxia-induced therapeutic neovascularization in a mouse model of an ischemic limb using cell aggregates composed of HUVECs and cbMSCs.

scientific article

In Situ Nanoreactor for Photosynthesizing H2 Gas To Mitigate Oxidative Stress in Tissue Inflammation.

scientific article

In Situ Self-Assembling Micellar Depots that Can Actively Trap and Passively Release NO with Long-Lasting Activity to Reverse Osteoporosis

scientific article published on 17 April 2018

In situ depot comprising phase-change materials that can sustainably release a gasotransmitter H2S to treat diabetic wounds

scientific article

In situ self-spray coating system that can uniformly disperse a poorly water-soluble H2S donor on the colorectal surface to treat inflammatory bowel diseases

scientific article published on 16 August 2018

In vitro evaluation of the genotoxicity of a naturally occurring crosslinking agent (genipin) for biologic tissue fixation

scientific article published on 01 October 2000

In vitro study of enzymatic degradation of biological tissues fixed by glutaraldehyde or epoxy compound

scientific article published on 01 January 1997

In vitro surface characterization of a biological patch fixed with a naturally occurring crosslinking agent.

scientific article published on July 2000

In vivo evaluation of cellular and acellular bovine pericardia fixed with a naturally occurring crosslinking agent (genipin).

scientific article published in June 2002

In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery

scientific article published on 26 January 2009

Inflammation-induced drug release by using a pH-responsive gas-generating hollow-microsphere system for the treatment of osteomyelitis.

scientific article published on 2 May 2014

Injectable PLGA porous beads cellularized by hAFSCs for cellular cardiomyoplasty

scientific article published on 03 March 2012

Injectable cell constructs fabricated via culture on a thermoresponsive methylcellulose hydrogel system for the treatment of ischemic diseases

scientific article published on 27 January 2014

Injectable microbeads with a thermo-responsive shell and a pH-responsive core as a dual-switch-controlled release system.

scientific article published on 30 June 2014

Intracellularly monitoring/imaging the release of doxorubicin from pH-responsive nanoparticles using Förster resonance energy transfer.

scientific article published on 19 January 2011

Loading of a novel angiogenic agent, ginsenoside Rg1 in an acellular biological tissue for tissue regeneration.

scientific article published in May 2005

Localized sequence-specific release of a chemopreventive agent and an anticancer drug in a time-controllable manner to enhance therapeutic efficacy.

scientific article published on 4 June 2016

Magnetically directed self-assembly of electrospun superparamagnetic fibrous bundles to form three-dimensional tissues with a highly ordered architecture.

scientific article published on 12 April 2011

Mechanical properties of a porcine aortic valve fixed with a naturally occurring crosslinking agent

scientific article published on 01 October 1999

Mechanism and consequence of chitosan-mediated reversible epithelial tight junction opening.

scientific article published on September 2011

Mechanisms of cellular uptake and intracellular trafficking with chitosan/DNA/poly(γ-glutamic acid) complexes as a gene delivery vector.

scientific article published on January 2011

Mechanistic study of transfection of chitosan/DNA complexes coated by anionic poly(γ-glutamic acid).

scientific article published on 26 January 2012

Mesothelium regeneration on acellular bovine pericardia loaded with an angiogenic agent (ginsenoside Rg1) successfully reduces postsurgical pericardial adhesions

scientific article published on 01 October 2006

Multi-ion-crosslinked nanoparticles with pH-responsive characteristics for oral delivery of protein drugs.

scientific article published on 9 September 2008

Multidrug release based on microneedle arrays filled with pH-responsive PLGA hollow microspheres.

scientific article published on 7 April 2012

Multimodality noninvasive imaging for assessing therapeutic effects of exogenously transplanted cell aggregates capable of angiogenesis on acute myocardial infarction

scientific article published on 11 September 2015

Nanomedicine for diabetes treatment

scientific article published on 01 October 2011

Nanoparticle- and biomaterials-mediated oral delivery for drug, gene, and immunotherapy.

scientific article published on 19 February 2013

Nanoparticle-induced tight-junction opening for the transport of an anti-angiogenic sulfated polysaccharide across Caco-2 cell monolayers.

scientific article

Nanoparticles with dual responses to oxidative stress and reduced ph for drug release and anti-inflammatory applications

scientific article published on 13 January 2014

Natural antimicrobial agent (reuterin) produced by lactobacillus reuteri for sanitization of biological tissues inoculated with pseudomonas aeruginosa.

scientific article published on October 2003

Noninvasive imaging oral absorption of insulin delivered by nanoparticles and its stimulated glucose utilization in controlling postprandial hyperglycemia during OGTT in diabetic rats.

scientific article published on 21 May 2013

Novel method using a temperature-sensitive polymer (methylcellulose) to thermally gel aqueous alginate as a pH-sensitive hydrogel.

scientific article published in September 2004

Opening of epithelial tight junctions and enhancement of paracellular permeation by chitosan: microscopic, ultrastructural, and computed-tomographic observations

scientific article published on 13 April 2012

Oral Nonviral Gene Delivery for Chronic Protein Replacement Therapy

scientific article published in August 2018

Oral delivery of peptide drugs using nanoparticles self-assembled by poly(gamma-glutamic acid) and a chitosan derivative functionalized by trimethylation

scientific article published on 03 June 2008

Paclitaxel-loaded poly(gamma-glutamic acid)-poly(lactide) nanoparticles as a targeted drug delivery system against cultured HepG2 cells.

scientific article published on March 2006

Photosynthesis-inspired H2 generation using a chlorophyll-loaded liposomal nanoplatform to detect and scavenge excess ROS

scientific article published on 27 January 2020

Photothermal tumor ablation in mice with repeated therapy sessions using NIR-absorbing micellar hydrogels formed in situ

scientific article published on 15 April 2015

Physicochemical, antimicrobial, and cytotoxic characteristics of a chitosan film cross-linked by a naturally occurring cross-linking agent, aglycone geniposidic acid.

scientific article

Polypyrrole-chitosan conductive biomaterial synchronizes cardiomyocyte contraction and improves myocardial electrical impulse propagation.

scientific article

Pore-filling nanoporous templates from degradable block copolymers for nanoscale drug delivery.

scientific article published in September 2009

Porous acellular bovine pericardia seeded with mesenchymal stem cells as a patch to repair a myocardial defect in a syngeneic rat model.

scientific article published on 17 July 2006

Preparation of nanoparticles composed of chitosan/poly-gamma-glutamic acid and evaluation of their permeability through Caco-2 cells

scientific article published in March 2005

Preservation of conductive propagation after surgical repair of cardiac defects with a bio-engineered conductive patch

scientific article published on 20 December 2017

Protease inhibition and absorption enhancement by functional nanoparticles for effective oral insulin delivery.

scientific article published on 11 January 2012

Pulsatile drug release from PLGA hollow microspheres by controlling the permeability of their walls with a magnetic field

scientific article published on 15 August 2012

Rapidly self-expandable polymeric stents with a shape-memory property.

scientific article published on 4 August 2007

Real-time visualization of pH-responsive PLGA hollow particles containing a gas-generating agent targeted for acidic organelles for overcoming multi-drug resistance

scientific article published on 06 October 2012

Recent advances in CO2 bubble-generating carrier systems for localized controlled release

scientific article

Response to Comment on "A Liposomal System Capable of Generating CO2 Bubbles to Induce Transient Cavitation, Lysosomal Rupturing and Cell Necrosis".

scientific article published on 16 August 2017

Safety and efficacy of self-assembling bubble carriers stabilized with sodium dodecyl sulfate for oral delivery of therapeutic proteins.

scientific article published on 19 December 2016

Self-assembling bubble carriers for oral protein delivery

scientific article

Shell-crosslinked Pluronic L121 micelles as a drug delivery vehicle.

scientific article published on 19 October 2006

Smart multifunctional hollow microspheres for the quick release of drugs in intracellular lysosomal compartments.

scientific article published on 12 July 2011

Spherically symmetric mesenchymal stromal cell bodies inherent with endogenous extracellular matrices for cellular cardiomyoplasty

scientific article published on 01 March 2009

Stability of a biological tissue fixed with a naturally occurring crosslinking agent (genipin).

scientific article

Stability of angiogenic agents, ginsenoside Rg1 and Re, isolated from Panax ginseng: in vitro and in vivo studies.

scientific article published on 18 August 2006

Stimuli-Responsive Materials for Controlled Release of Theranostic Agents.

scientific article

Strategies for improving diabetic therapy via alternative administration routes that involve stimuli-responsive insulin-delivering systems

scientific article published on 06 December 2018

Synergistic antibacterial effects of localized heat and oxidative stress caused by hydroxyl radicals mediated by graphene/iron oxide-based nanocomposites

scientific article published on 19 December 2015

Targeted nanoparticles for drug delivery through the blood-brain barrier for Alzheimer's disease.

scientific article

The characteristics and in vivo suppression of neointimal formation with sirolimus-eluting polymeric stents.

scientific article published on 5 October 2008

The characteristics, biodistribution and bioavailability of a chitosan-based nanoparticulate system for the oral delivery of heparin

scientific article published on 19 September 2009

The characteristics, biodistribution, magnetic resonance imaging and biodegradability of superparamagnetic core-shell nanoparticles

scientific article

The effect of galectin 1 on 3T3 cell proliferation on chitosan membranes.

scientific article published on August 2004

The glucose-lowering potential of exendin-4 orally delivered via a pH-sensitive nanoparticle vehicle and effects on subsequent insulin secretion in vivo.

scientific article published on 21 January 2011

The use of MMP2 antibody-conjugated cationic microbubble to target the ischemic myocardium, enhance Timp3 gene transfection and improve cardiac function.

scientific article published on 26 October 2013

The use of cationic microbubbles to improve ultrasound-targeted gene delivery to the ischemic myocardium

scientific article published on 11 December 2012

The use of injectable spherically symmetric cell aggregates self-assembled in a thermo-responsive hydrogel for enhanced cell transplantation

scientific article published on 25 July 2009

Three-dimensional cell aggregates composed of HUVECs and cbMSCs for therapeutic neovascularization in a mouse model of hindlimb ischemia

scientific article published on 12 December 2012

Tissue regeneration observed in a basic fibroblast growth factor-loaded porous acellular bovine pericardium populated with mesenchymal stem cells.

scientific article published in July 2007

Tissue regeneration observed in a porous acellular bovine pericardium used to repair a myocardial defect in the right ventricle of a rat model.

scientific article

Treatment of chemotherapy-induced neutropenia in a rat model by using multiple daily doses of oral administration of G-CSF-containing nanoparticles.

scientific article published on 27 January 2014

Two-dimensional velocity measurements in a pulsatile flow model of the normal abdominal aorta simulating different hemodynamic conditions

scientific article published on 01 October 1993

Ultrasound-targeted HSVtk and Timp3 gene delivery for synergistically enhanced antitumor effects in hepatoma.

scientific article published on 19 April 2013

Vascularization and restoration of heart function in rat myocardial infarction using transplantation of human cbMSC/HUVEC core-shell bodies

scientific article published on 12 December 2011

XTT-colorimetric assay as a marker of viability in cryoprocessed cardiac valve

scientific article published on 01 April 1997

pH-Responsive Nanoparticles Shelled with Chitosan for Oral Delivery of Insulin: From Mechanism to Therapeutic Applications ⬇️

scientific article published on January 11, 2012

pH-triggered injectable hydrogels prepared from aqueous N-palmitoyl chitosan: in vitro characteristics and in vivo biocompatibility.

scientific article published on 13 June 2009

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