List of works - Dalia Barsyte-Lovejoy

(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells

scientific article

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases

scientific article published on 24 November 2015

A chemical biology toolbox to study protein methyltransferases and epigenetic signaling

scientific article published in Nature Communications

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

scientific article

A chemical tool for in vitro and in vivo precipitation of lysine methyltransferase G9a.

scientific article published on 17 January 2014

A combinatorial anticancer drug screen identifies off-target effects of epigenetic chemical probes

A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3)

scientific article

AT-21INTEGRATED (EPI)GENOMIC ANALYSES IDENTIFY SUB-GROUP SPECIFIC THERAPEUTIC TARGETS IN CNS RHABDOID TUMORS.

scientific article published on 30 May 2016

An Integrative Proteomic Approach Identifies Novel Cellular SMYD2 Substrates

scientific article published on 10 May 2016

An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1

scientific article

Analysis of Myc bound loci identified by CpG island arrays shows that Max is essential for Myc-dependent repression

scientific article

Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation

scientific article

Author Correction: Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

scientific article published on 26 May 2020

C-terminal processing of the teneurin proteins: Independent actions of a teneurin C-terminal associated peptide in hippocampal cells ⬇️

scientific article published on September 28, 2012

CUL7 is a novel antiapoptotic oncogene

scientific article

Cancer therapeutics: targeting the dark side of Myc.

scientific article

Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

scientific article

Characterization of a corticotropin-releasing factor (CRF)/diuretic hormone-like peptide from tunicates: insight into the origins of the vertebrate CRF family

scientific article published on 29 July 2009

Cloning and characterization of teneurin C-terminus associated peptide (TCAP)-3 from the hypothalamus of an adult rainbow trout (Oncorhynchus mykiss).

scientific article

Control of the hippo pathway by Set7-dependent methylation of Yap.

scientific article published on 11 July 2013

Discovery of a Dual PRMT5-PRMT7 Inhibitor

scientific article published on 2 March 2015

Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor

scientific article

Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening

scientific article

Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6.

scientific article published on September 2016

Discovery of a chemical probe for PRDM9

scientific article published on 17 December 2019

Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain

scientific article published on 6 January 2013

Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.

scientific article published on 31 October 2013

ERK5 is targeted to myocyte enhancer factor 2A (MEF2A) through a MAPK docking motif

scientific article

Erratum: A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

article

Erratum: Corrigendum: Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

scientific article published in Nature Communications

Erratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

scholarly article by Florian Grebien et al published October 2015 in Nature Chemical Biology

Erratum: The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex

scientific article published in July 2017

Evolution of complementary peptide systems: teneurin C-terminal-associated peptides and corticotropin-releasing factor superfamilies

scientific article published on April 2009

Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3

scientific article published on 08 July 2019

Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth

scientific article

Histone recognition and large-scale structural analysis of the human bromodomain family

scientific article

Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells

scientific article

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors

scientific article

Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells

scientific article

LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2.

scientific article published on 30 March 2015

MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin

scientific article published on 25 November 2015

Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines

scientific article

PRMT5 inhibition disrupts splicing and stemness in glioblastoma

scientific article published on 12 February 2021

PRMT5 regulates ATF4 transcript splicing and oxidative stress response

scientific article published on 11 March 2022

PRMT5 regulates ATF4 transcript splicing and oxidative stress response

preprint

Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

scientific article published on 14 May 2020

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

scientific article

Promoter-binding and repression of PDGFRB by c-Myc are separable activities

scientific article published on 29 June 2004

Protein arginine methylation: from enigmatic functions to therapeutic targeting

Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5

scientific article published on January 2013

Specificity determinants in MAPK signaling to transcription factors

scientific article published on 10 January 2002

Systems approaches to genomic and epigenetic inter-regulation of peptide hormones in stress and reproduction

scientific article published on 14 March 2013

TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma

scientific article published on 6 April 2018

Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells

scientific article published on 29 March 2019

Targeting human SET1/MLL family of proteins

scientific article

Teneurin C-Terminal Associated Peptide (TCAP)-1 and Latrophilin Interaction in HEK293 Cells: Evidence for Modulation of Intercellular Adhesion

Teneurin carboxy (C)-terminal associated peptide-1 inhibits alkalosis-associated necrotic neuronal death by stimulating superoxide dismutase and catalase activity in immortalized mouse hypothalamic cells

scientific article

Teneurin proteins possess a carboxy terminal sequence with neuromodulatory activity.

scientific article published on February 2005

The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex

scientific article published on 30 January 2017

The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity

scientific article published on 23 January 2017

The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis

scientific article (publication date: 15 May 2006)

c-Myc represses the proximal promoters of GADD45a and GADD153 by a post-RNA polymerase II recruitment mechanism

scientific article published on April 2004

List of works by Dalia Barsyte-Lovejoy

(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases

A chemical biology toolbox to study protein methyltransferases and epigenetic signaling

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

A chemical tool for in vitro and in vivo precipitation of lysine methyltransferase G9a.

A combinatorial anticancer drug screen identifies off-target effects of epigenetic chemical probes

A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3)

AT-21INTEGRATED (EPI)GENOMIC ANALYSES IDENTIFY SUB-GROUP SPECIFIC THERAPEUTIC TARGETS IN CNS RHABDOID TUMORS.

An Integrative Proteomic Approach Identifies Novel Cellular SMYD2 Substrates

An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1

Analysis of Myc bound loci identified by CpG island arrays shows that Max is essential for Myc-dependent repression

Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation

Author Correction: Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

C-terminal processing of the teneurin proteins: Independent actions of a teneurin C-terminal associated peptide in hippocampal cells ⬇️

CUL7 is a novel antiapoptotic oncogene

Cancer therapeutics: targeting the dark side of Myc.

Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

Characterization of a corticotropin-releasing factor (CRF)/diuretic hormone-like peptide from tunicates: insight into the origins of the vertebrate CRF family

Cloning and characterization of teneurin C-terminus associated peptide (TCAP)-3 from the hypothalamus of an adult rainbow trout (Oncorhynchus mykiss).

Control of the hippo pathway by Set7-dependent methylation of Yap.

Discovery of a Dual PRMT5-PRMT7 Inhibitor

Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor

Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening

Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6.

Discovery of a chemical probe for PRDM9

Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain

Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.

ERK5 is targeted to myocyte enhancer factor 2A (MEF2A) through a MAPK docking motif

Erratum: A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

Erratum: Corrigendum: Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

Erratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

Erratum: The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex

Evolution of complementary peptide systems: teneurin C-terminal-associated peptides and corticotropin-releasing factor superfamilies

Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3

Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth

Histone recognition and large-scale structural analysis of the human bromodomain family

Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors

Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells

LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2.

MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin

Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines

PRMT5 inhibition disrupts splicing and stemness in glioblastoma

PRMT5 regulates ATF4 transcript splicing and oxidative stress response

PRMT5 regulates ATF4 transcript splicing and oxidative stress response

Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

Promoter-binding and repression of PDGFRB by c-Myc are separable activities

Protein arginine methylation: from enigmatic functions to therapeutic targeting

Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5

Specificity determinants in MAPK signaling to transcription factors

Systems approaches to genomic and epigenetic inter-regulation of peptide hormones in stress and reproduction

TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma

Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells

Targeting human SET1/MLL family of proteins

Teneurin C-Terminal Associated Peptide (TCAP)-1 and Latrophilin Interaction in HEK293 Cells: Evidence for Modulation of Intercellular Adhesion

Teneurin carboxy (C)-terminal associated peptide-1 inhibits alkalosis-associated necrotic neuronal death by stimulating superoxide dismutase and catalase activity in immortalized mouse hypothalamic cells

Teneurin proteins possess a carboxy terminal sequence with neuromodulatory activity.

The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex

The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity

The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis

c-Myc represses the proximal promoters of GADD45a and GADD153 by a post-RNA polymerase II recruitment mechanism