List of works - David Sattelle

2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm

scientific article published on 11 July 2018

A Cys-loop mutation in the Caenorhabditis elegans nicotinic receptor subunit UNC-63 impairs but does not abolish channel function

scientific article

A novel Caenorhabditis elegans allele, smn-1(cb131), mimicking a mild form of spinal muscular atrophy, provides a convenient drug screening platform highlighting new and pre-approved compounds

scientific article

A quasi-elastic laser light scattering study of tubulin and microtubule protein from bovine brain

scientific article published on October 1982

A7DB: a relational database for mutational, physiological and pharmacological data related to the alpha7 nicotinic acetylcholine receptor

scientific article

Actions of agonists, fipronil and ivermectin on the predominant in vivo splice and edit variant (RDLbd, I/V) of the Drosophila GABA receptor expressed in Xenopus laevis oocytes

scientific article

Actions of snake neurotoxins on an insect nicotinic cholinergic synapse

scientific article

Alzheimer's disease: insights from Drosophila melanogaster models

scientific article

An L319F mutation in transmembrane region 3 (TM3) selectively reduces sensitivity to okaramine B of the Bombyx mori l-glutamate-gated chloride channel.

scientific article

An antagonist of the retinoid X receptor reduces the viability of Trichuris muris in vitro

scientific article

Anthelmintic drug discovery: target identification, screening methods and the role of open science

scientific article published on 02 June 2020

Automated phenotyping of mosquito larvae enables high-throughput screening for novel larvicides and offers potential for smartphone-based detection of larval insecticide resistance

scientific article published on 03 June 2021

Automated, high-throughput, motility analysis in Caenorhabditis elegans and parasitic nematodes: Applications in the search for new anthelmintics

scientific article

Caenorhabditis elegans in the study of SMN-interacting proteins: a role for SMI-1, an orthologue of human Gemin2 and the identification of novel components of the SMN complex

scientific article published on 9 September 2006

Chemistry-to-gene screens in Caenorhabditis elegans

scientific article

Cofactor-enabled functional expression of fruit fly, honeybee, and bumblebee nicotinic receptors reveals picomolar neonicotinoid actions

scientific article published on 01 July 2020

Crystal structures of Lymnaea stagnalis AChBP in complex with neonicotinoid insecticides imidacloprid and clothianidin

scientific article

Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo

scientific article

Effects of mutations of a glutamine residue in loop D of the alpha7 nicotinic acetylcholine receptor on agonist profiles for neonicotinoid insecticides and related ligands

scientific article

Exon 3 splicing and mutagenesis identify residues influencing cell surface density of heterologously expressed silkworm (Bombyx mori) glutamate-gated chloride channels

scientific article published on 26 September 2014

Exploring the pharmacological properties of insect nicotinic acetylcholine receptors

scientific article published on 6 December 2006

Fast, automated measurement of nematode swimming (thrashing) without morphometry

scientific article

Functional and evolutionary insights from the genomes of three parasitoid Nasonia species

scientific article

Functional characterisation of a nicotinic acetylcholine receptor α subunit from the brown dog tick, Rhipicephalus sanguineus

scientific article

Functional genomics of ionotropic acetylcholine receptors in Caenorhabditis elegans and Drosophila melanogaster

scientific article

Functional genomics of the nicotinic acetylcholine receptor gene family of the nematode, Caenorhabditis elegans

scientific article published on January 2004

Gene silencing of selected calcium-signalling molecules in a Drosophila cell line using double-stranded RNA interference

scientific article published in February 2004

Genome of the house fly, Musca domestica L., a global vector of diseases with adaptations to a septic environment

scientific article

Genomic insights into the Ixodes scapularis tick vector of Lyme disease

scientific article published on 9 February 2016

Glutamate-gated chloride channels of Haemonchus contortus restore drug sensitivity to ivermectin resistant Caenorhabditis elegans

scientific article

Insect nicotinic acetylcholine receptor gene families: from genetic model organism to vector, pest and beneficial species.

scientific article published on 11 January 2007

Invertebrate models of spinal muscular atrophy: insights into mechanisms and potential therapeutics

scientific article

Ion channels: molecular targets of neuroactive insecticides

scientific article

Is spinal muscular atrophy the result of defects in motor neuron processes?

scientific article

Laser-light scattering diffusion measurements on brain microtubule protein from dogfish (Squalus acanthus) and beef ⬇️

scientific article published on December 1, 1981

Loops D, E and G in the Drosophila Dα1 subunit contribute to high neonicotinoid sensitivity of Dα1-chicken β2 nicotinic acetylcholine receptor.

scientific article published on 14 June 2017

Mechanisms of action, resistance and toxicity of insecticides targeting GABA receptors.

scientific article published on 12 June 2017

Modes of action, resistance and toxicity of insecticides targeting nicotinic acetylcholine receptors.

scientific article

Motility of bovine spermatozoa studied by laser light scattering

scientific article

Neonicotinoids show selective and diverse actions on their nicotinic receptor targets: electrophysiology, molecular biology, and receptor modeling studies.

scientific article

Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection.

scientific article

Nicotinic acetylcholine receptors as drug/chemical targets, contributions from comparative genomics, forward and reverse genetics.

scientific article published on January 2007

Novel animal-health drug targets from ligand-gated chloride channels.

scientific article

Proteins interacting with nicotinic acetylcholine receptors: expanding functional and therapeutic horizons.

scientific article published on 30 July 2010

RNA interference: from model organisms towards therapy for neural and neuromuscular disorders

scientific article published in October 2004

Spectrometer for laser-light scattering measurements of macromolecular and subcellular particle motions

scientific article published on January 1982

Strategies for automated analysis of C. elegans locomotion

scientific article published on 08 August 2008

Structure and function of two-pore-domain K+ channels: contributions from genetic model organisms

scientific article

Studies on an acetylcholine binding protein identify a basic residue in loop G on the β1 strand as a new structural determinant of neonicotinoid actions

scientific article

Subtype-specific actions of beta-amyloid peptides on recombinant human neuronal nicotinic acetylcholine receptors (alpha7, alpha4beta2, alpha3beta4) expressed in Xenopus laevis oocytes

scientific article published on December 2005

The TRiC/CCT chaperone is implicated in Alzheimer's disease based on patient GWAS and an RNAi screen in Aβ-expressing Caenorhabditis elegans.

scientific article

The cys-loop ligand-gated ion channel gene superfamily of the red flour beetle, Tribolium castaneum

scientific article

The genome of the model beetle and pest Tribolium castaneum

scientific article

The nicotinic acetylcholine receptor gene family of the honey bee, Apis mellifera.

scientific article

The nicotinic acetylcholine receptor gene family of the nematode Caenorhabditis elegans: an update on nomenclature

scientific article

The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits

scientific article

Thymol, a constituent of thyme essential oil, is a positive allosteric modulator of human GABA(A) receptors and a homo-oligomeric GABA receptor from Drosophila melanogaster

scientific article

Tick Genome Assembled: New Opportunities for Research on Tick-Host-Pathogen Interactions

scientific article

Turning a Drug Target into a Drug Candidate: A New Paradigm for Neurological Drug Discovery?

scientific article published on 09 August 2020

Xenopus laevis RIC-3 enhances the functional expression of the C. elegans homomeric nicotinic receptor, ACR-16, in Xenopus oocytes.

scientific article

List of works by David Sattelle

2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm

A Cys-loop mutation in the Caenorhabditis elegans nicotinic receptor subunit UNC-63 impairs but does not abolish channel function

A novel Caenorhabditis elegans allele, smn-1(cb131), mimicking a mild form of spinal muscular atrophy, provides a convenient drug screening platform highlighting new and pre-approved compounds

A quasi-elastic laser light scattering study of tubulin and microtubule protein from bovine brain

A7DB: a relational database for mutational, physiological and pharmacological data related to the alpha7 nicotinic acetylcholine receptor

Actions of agonists, fipronil and ivermectin on the predominant in vivo splice and edit variant (RDLbd, I/V) of the Drosophila GABA receptor expressed in Xenopus laevis oocytes

Actions of snake neurotoxins on an insect nicotinic cholinergic synapse

Alzheimer's disease: insights from Drosophila melanogaster models

An L319F mutation in transmembrane region 3 (TM3) selectively reduces sensitivity to okaramine B of the Bombyx mori l-glutamate-gated chloride channel.

An antagonist of the retinoid X receptor reduces the viability of Trichuris muris in vitro

Anthelmintic drug discovery: target identification, screening methods and the role of open science

Automated phenotyping of mosquito larvae enables high-throughput screening for novel larvicides and offers potential for smartphone-based detection of larval insecticide resistance

Automated, high-throughput, motility analysis in Caenorhabditis elegans and parasitic nematodes: Applications in the search for new anthelmintics

Caenorhabditis elegans in the study of SMN-interacting proteins: a role for SMI-1, an orthologue of human Gemin2 and the identification of novel components of the SMN complex

Chemistry-to-gene screens in Caenorhabditis elegans

Cofactor-enabled functional expression of fruit fly, honeybee, and bumblebee nicotinic receptors reveals picomolar neonicotinoid actions

Crystal structures of Lymnaea stagnalis AChBP in complex with neonicotinoid insecticides imidacloprid and clothianidin

Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo

Effects of mutations of a glutamine residue in loop D of the alpha7 nicotinic acetylcholine receptor on agonist profiles for neonicotinoid insecticides and related ligands

Exon 3 splicing and mutagenesis identify residues influencing cell surface density of heterologously expressed silkworm (Bombyx mori) glutamate-gated chloride channels

Exploring the pharmacological properties of insect nicotinic acetylcholine receptors

Fast, automated measurement of nematode swimming (thrashing) without morphometry

Functional and evolutionary insights from the genomes of three parasitoid Nasonia species

Functional characterisation of a nicotinic acetylcholine receptor α subunit from the brown dog tick, Rhipicephalus sanguineus

Functional genomics of ionotropic acetylcholine receptors in Caenorhabditis elegans and Drosophila melanogaster

Functional genomics of the nicotinic acetylcholine receptor gene family of the nematode, Caenorhabditis elegans

Gene silencing of selected calcium-signalling molecules in a Drosophila cell line using double-stranded RNA interference

Genome of the house fly, Musca domestica L., a global vector of diseases with adaptations to a septic environment

Genomic insights into the Ixodes scapularis tick vector of Lyme disease

Glutamate-gated chloride channels of Haemonchus contortus restore drug sensitivity to ivermectin resistant Caenorhabditis elegans

Insect nicotinic acetylcholine receptor gene families: from genetic model organism to vector, pest and beneficial species.

Invertebrate models of spinal muscular atrophy: insights into mechanisms and potential therapeutics

Ion channels: molecular targets of neuroactive insecticides

Is spinal muscular atrophy the result of defects in motor neuron processes?

Laser-light scattering diffusion measurements on brain microtubule protein from dogfish (Squalus acanthus) and beef ⬇️

Loops D, E and G in the Drosophila Dα1 subunit contribute to high neonicotinoid sensitivity of Dα1-chicken β2 nicotinic acetylcholine receptor.

Mechanisms of action, resistance and toxicity of insecticides targeting GABA receptors.

Modes of action, resistance and toxicity of insecticides targeting nicotinic acetylcholine receptors.

Motility of bovine spermatozoa studied by laser light scattering

Neonicotinoids show selective and diverse actions on their nicotinic receptor targets: electrophysiology, molecular biology, and receptor modeling studies.

Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection.

Nicotinic acetylcholine receptors as drug/chemical targets, contributions from comparative genomics, forward and reverse genetics.

Novel animal-health drug targets from ligand-gated chloride channels.

Proteins interacting with nicotinic acetylcholine receptors: expanding functional and therapeutic horizons.

RNA interference: from model organisms towards therapy for neural and neuromuscular disorders

Spectrometer for laser-light scattering measurements of macromolecular and subcellular particle motions

Strategies for automated analysis of C. elegans locomotion

Structure and function of two-pore-domain K+ channels: contributions from genetic model organisms

Studies on an acetylcholine binding protein identify a basic residue in loop G on the β1 strand as a new structural determinant of neonicotinoid actions

Subtype-specific actions of beta-amyloid peptides on recombinant human neuronal nicotinic acetylcholine receptors (alpha7, alpha4beta2, alpha3beta4) expressed in Xenopus laevis oocytes

The TRiC/CCT chaperone is implicated in Alzheimer's disease based on patient GWAS and an RNAi screen in Aβ-expressing Caenorhabditis elegans.

The cys-loop ligand-gated ion channel gene superfamily of the red flour beetle, Tribolium castaneum

The genome of the model beetle and pest Tribolium castaneum

The nicotinic acetylcholine receptor gene family of the honey bee, Apis mellifera.

The nicotinic acetylcholine receptor gene family of the nematode Caenorhabditis elegans: an update on nomenclature

The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits

Thymol, a constituent of thyme essential oil, is a positive allosteric modulator of human GABA(A) receptors and a homo-oligomeric GABA receptor from Drosophila melanogaster

Tick Genome Assembled: New Opportunities for Research on Tick-Host-Pathogen Interactions

Turning a Drug Target into a Drug Candidate: A New Paradigm for Neurological Drug Discovery?

Xenopus laevis RIC-3 enhances the functional expression of the C. elegans homomeric nicotinic receptor, ACR-16, in Xenopus oocytes.