List of works - Bryan Paul Morgan

Complement, a target for therapy in inflammatory and degenerative diseases.

scientific article

Vesicular removal by oligodendrocytes of membrane attack complexes formed by activated complement

scientific article published in Nature

Dimerization of complement factor H-related proteins modulates complement activation in vivo

scientific article

Antigen-presenting cell exosomes are protected from complement-mediated lysis by expression of CD55 and CD59.

scientific article published in February 2003

Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain.

scientific article published in December 1997

Cutting edge: the NLRP3 inflammasome links complement-mediated inflammation and IL-1β release.

scientific article published on July 2013

Human cell-adhesion molecule CD2 binds CD58 (LFA-3) with a very low affinity and an extremely fast dissociation rate but does not bind CD48 or CD59

scientific article published on 01 August 1994

Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina.

scientific article

Physiologic relevance of the membrane attack complex inhibitory protein CD59 in human seminal plasma: CD59 is present on extracellular organelles (prostasomes), binds cell membranes, and inhibits complement-mediated lysis

scientific article

Complement: central to innate immunity and bridging to adaptive responses.

scientific article

The Glycosylation of the Complement Regulatory Protein, Human Erythrocyte CD59

scientific article published in Journal of Biological Chemistry

Immunocytochemical localization of the terminal complement complex in multiple sclerosis.

scientific article published on July 1989

The human complement fragment receptor, C5L2, is a recycling decoy receptor.

scientific article

Targeted deletion of the CD59 gene causes spontaneous intravascular hemolysis and hemoglobinuria

article

Anti-disialoside antibodies kill perisynaptic Schwann cells and damage motor nerve terminals via membrane attack complex in a murine model of neuropathy.

scientific article

Beyond lysis: how complement influences cell fate.

scientific article

CD46 plays a key role in tailoring innate immune recognition of apoptotic and necrotic cells

scientific article published on 8 August 2005

Structural basis of complement membrane attack complex formation.

scientific article

Exogenous glycosyl phosphatidylinositol-anchored CD59 associates with kinases in membrane clusters on U937 cells and becomes Ca(2+)-signaling competent

scientific article published on November 1, 1995

The Membrane Attack Complex of Complement Causes Severe Demyelination Associated with Acute Axonal Injury

scientific article published on 01 January 2002

Normal rat serum cytotoxicity against syngeneic oligodendrocytes. Complement activation and attack in the absence of anti-myelin antibodies.

scientific article published in February 1989

C3-dependent mechanism of microglial priming relevant to multiple sclerosis.

scientific article published on 4 January 2012

Complement therapeutics; history and current progress.

scientific article

Holding T cells in check--a new role for complement regulators?

scientific article

The role of complement in the pathogenesis of experimental allergic encephalomyelitis

scientific article published on 01 August 1989

Complement regulation by Kaposi's sarcoma-associated herpesvirus ORF4 protein.

scientific article

Miller Fisher anti-GQ1b antibodies: alpha-latrotoxin-like effects on motor end plates

scientific article published on 01 February 1999

Physiology and pathophysiology of complement: progress and trends.

scientific article published on January 1995

Functional basis of protection against age-related macular degeneration conferred by a common polymorphism in complement factor B

scholarly article

Complement dysregulation and disease: From genes and proteins to diagnostics and drugs

scientific article published on November 1, 2012

Soluble complement receptor 1 (sCR1) protects against experimental autoimmune myasthenia gravis

scientific article published on 01 December 1996

Complement regulation at the molecular level: The structure of decay-accelerating factor

scientific article

Systemic and local anti-C5 therapy reduces the disease severity in experimental autoimmune uveoretinitis.

scientific article published on 4 December 2009

Isolation and characterization of a membrane-attack-complex-inhibiting protein present in human serum and other biological fluids

scientific article

Measurement of factor H variants in plasma using variant-specific monoclonal antibodies: application to assessing risk of age-related macular degeneration

scientific article

Molecular dissection of interactions between components of the alternative pathway of complement and decay accelerating factor (CD55).

scientific article published on 9 November 2004

Complement activation in multiple sclerosis plaques: an immunohistochemical analysis

scientific article

Sphingomyelinases in the venom of the spider Loxosceles intermedia are responsible for both dermonecrosis and complement-dependent hemolysis

scientific article published on 01 October 1998

In vivo characterization and therapeutic efficacy of a C5-specific inhibitor from the soft tick Ornithodoros moubata

scientific article published on 10 January 2007

Roles of the complement system in human neurodegenerative disorders: pro-inflammatory and tissue remodeling activities.

scientific article

CD59a is the primary regulator of membrane attack complex assembly in the mouse.

scientific article published in September 2004

Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q

scientific article

Glycosylation and the complement system.

scientific article

Inhibition of the Membrane Attack Complex of the Complement System Reduces Secondary Neuroaxonal Loss and Promotes Neurologic Recovery after Traumatic Brain Injury in Mice

scientific article published on 31 January 2014

Myelin-oligodendrocyte glycoprotein (MOG) is a surface marker of oligodendrocyte maturation

scientific article published on 01 May 1989

Sensitive and specific assays for C3 nephritic factors clarify mechanisms underlying complement dysregulation

scientific article published on August 2012

Intracellular Ca2+ and cell injury: a paradoxical role of Ca2+ in complement membrane attack.

scientific article

The membrane attack complex as an inflammatory trigger

scientific article published on 30 April 2015

Complement regulator factor H as a serum biomarker of multiple sclerosis disease state.

scientific article published on 25 April 2010

Human factor H-related protein 5 (FHR-5). A new complement-associated protein

scientific article

List of works by Bryan Paul Morgan

Complement, a target for therapy in inflammatory and degenerative diseases.

Vesicular removal by oligodendrocytes of membrane attack complexes formed by activated complement

Dimerization of complement factor H-related proteins modulates complement activation in vivo

Antigen-presenting cell exosomes are protected from complement-mediated lysis by expression of CD55 and CD59.

Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain.

Cutting edge: the NLRP3 inflammasome links complement-mediated inflammation and IL-1β release.

Human cell-adhesion molecule CD2 binds CD58 (LFA-3) with a very low affinity and an extremely fast dissociation rate but does not bind CD48 or CD59

Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina.

Physiologic relevance of the membrane attack complex inhibitory protein CD59 in human seminal plasma: CD59 is present on extracellular organelles (prostasomes), binds cell membranes, and inhibits complement-mediated lysis

Complement: central to innate immunity and bridging to adaptive responses.

The Glycosylation of the Complement Regulatory Protein, Human Erythrocyte CD59

Immunocytochemical localization of the terminal complement complex in multiple sclerosis.

The human complement fragment receptor, C5L2, is a recycling decoy receptor.

Targeted deletion of the CD59 gene causes spontaneous intravascular hemolysis and hemoglobinuria

Anti-disialoside antibodies kill perisynaptic Schwann cells and damage motor nerve terminals via membrane attack complex in a murine model of neuropathy.

Beyond lysis: how complement influences cell fate.

CD46 plays a key role in tailoring innate immune recognition of apoptotic and necrotic cells

Structural basis of complement membrane attack complex formation.

Exogenous glycosyl phosphatidylinositol-anchored CD59 associates with kinases in membrane clusters on U937 cells and becomes Ca(2+)-signaling competent

The Membrane Attack Complex of Complement Causes Severe Demyelination Associated with Acute Axonal Injury

Normal rat serum cytotoxicity against syngeneic oligodendrocytes. Complement activation and attack in the absence of anti-myelin antibodies.

C3-dependent mechanism of microglial priming relevant to multiple sclerosis.

Complement therapeutics; history and current progress.

Holding T cells in check--a new role for complement regulators?

The role of complement in the pathogenesis of experimental allergic encephalomyelitis

Complement regulation by Kaposi's sarcoma-associated herpesvirus ORF4 protein.

Miller Fisher anti-GQ1b antibodies: alpha-latrotoxin-like effects on motor end plates

Physiology and pathophysiology of complement: progress and trends.

Functional basis of protection against age-related macular degeneration conferred by a common polymorphism in complement factor B

Complement dysregulation and disease: From genes and proteins to diagnostics and drugs

Soluble complement receptor 1 (sCR1) protects against experimental autoimmune myasthenia gravis

Complement regulation at the molecular level: The structure of decay-accelerating factor

Systemic and local anti-C5 therapy reduces the disease severity in experimental autoimmune uveoretinitis.

Isolation and characterization of a membrane-attack-complex-inhibiting protein present in human serum and other biological fluids

Measurement of factor H variants in plasma using variant-specific monoclonal antibodies: application to assessing risk of age-related macular degeneration

Molecular dissection of interactions between components of the alternative pathway of complement and decay accelerating factor (CD55).

Complement activation in multiple sclerosis plaques: an immunohistochemical analysis

Sphingomyelinases in the venom of the spider Loxosceles intermedia are responsible for both dermonecrosis and complement-dependent hemolysis

In vivo characterization and therapeutic efficacy of a C5-specific inhibitor from the soft tick Ornithodoros moubata

Roles of the complement system in human neurodegenerative disorders: pro-inflammatory and tissue remodeling activities.

CD59a is the primary regulator of membrane attack complex assembly in the mouse.

Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q

Glycosylation and the complement system.

Inhibition of the Membrane Attack Complex of the Complement System Reduces Secondary Neuroaxonal Loss and Promotes Neurologic Recovery after Traumatic Brain Injury in Mice

Myelin-oligodendrocyte glycoprotein (MOG) is a surface marker of oligodendrocyte maturation

Sensitive and specific assays for C3 nephritic factors clarify mechanisms underlying complement dysregulation

Intracellular Ca2+ and cell injury: a paradoxical role of Ca2+ in complement membrane attack.

The membrane attack complex as an inflammatory trigger

Complement regulator factor H as a serum biomarker of multiple sclerosis disease state.

Human factor H-related protein 5 (FHR-5). A new complement-associated protein