Search filters

List of works by Bryan Paul Morgan

''Homologous restriction'' in complement lysis: roles of membrane complement regulators.

scientific article

2-Chloroadenosine inhibits complement-induced reactive oxygen metabolite production and recovery of human polymorphonuclear leucocytes attacked by complement

scientific article published on 01 January 1985

A De Novo Deletion in the Regulators of Complement Activation Cluster Producing a Hybrid Complement Factor H/Complement Factor H-Related 3 Gene in Atypical Hemolytic Uremic Syndrome.

scientific article

A novel antibody against human factor B that blocks formation of the C3bB proconvertase and inhibits complement activation in disease models.

scientific article

A novel mutation in a patient with a deficiency of the eighth component of complement associated with recurrent meningococcal meningitis.

scientific article published on 12 May 2009

A protein toxin from the sea anemone Phyllodiscus semoni targets the kidney and causes a severe renal injury with predominant glomerular endothelial damage

scientific article published on 28 June 2007

A quantitative method for comparison of expression of alternatively spliced genes using different primer pairs

scientific article published on 09 December 2005

A rapid method for the isolation of analogues of human CD59 by preparative SDS-PAGE: application to pig CD59

scientific article published on 01 February 1995

A targeted complement-dependent strategy to improve the outcome of mAb therapy, and characterization in a murine model of metastatic cancer ⬇️

scientific article published on March 22, 2012

Absence of CD59 in Guinea Pigs: Analysis of the Cavia porcellus Genome Suggests the Evolution of a CD59 Pseudogene.

scientific article

Absence of the complement regulatory molecule CD59a leads to exacerbated neuropathology after traumatic brain injury in mice.

scientific article published on 8 January 2009

Adjuvant treatment with dexamethasone plus anti-C5 antibodies improves outcome of experimental pneumococcal meningitis: a randomized controlled trial

scientific article

Affinity purification of human factor H on polypeptides derived from streptococcal m protein: enrichment of the Y402 variant

scientific article

Age-related macular degeneration and modification of systemic complement factor H production through liver transplantation.

scientific article published on 4 April 2013

An abnormal but functionally active complement component C9 protein found in an Irish family with subtotal C9 deficiency.

scientific article published in March 2003

An anticomplement agent that homes to the damaged brain and promotes recovery after traumatic brain injury in mice

scientific article published on 2 November 2015

Anti-disialoside antibodies kill perisynaptic Schwann cells and damage motor nerve terminals via membrane attack complex in a murine model of neuropathy.

scientific article

Antibody-independent activation of the classical complement pathway by cytomegalovirus-infected fibroblasts

scientific article published on 01 December 1998

Antigen-presenting cell exosomes are protected from complement-mediated lysis by expression of CD55 and CD59.

scientific article published in February 2003

Antithyroid drugs and release of inflammatory mediators by complement-attacked thyroid cells

scientific article published on September 12, 1992

B cells from mice prematurely expressing human complement receptor type 2 are unresponsive to T-dependent antigens

scientific article published on 01 June 2005

Beyond lysis: how complement influences cell fate.

scientific article

Biological activity, membrane-targeting modification, and crystallization of soluble human decay accelerating factor expressed in E. coli.

scientific article published in September 2004

Blockade of the C5a receptor fails to protect against experimental autoimmune encephalomyelitis in rats

scientific article published on 01 December 2004

C3-dependent mechanism of microglial priming relevant to multiple sclerosis.

scientific article published on 4 January 2012

CD46 plays a key role in tailoring innate immune recognition of apoptotic and necrotic cells

scientific article published on 8 August 2005

CD55 Deficiency Protects against Atherosclerosis in ApoE-Deficient Mice via C3a Modulation of Lipid Metabolism ⬇️

scientific article published on August 2, 2011

CD55 in rat male reproductive tissue: differential expression in testis and expression of a unique truncated isoform on spermatozoa

scientific journal article

CD59 blockade enhances antigen-specific CD4+ T cell responses in humans: a new target for cancer immunotherapy?

scientific article published in May 2009

CD59 or C3 are not requred for angiotensin II-dependent hypertension or hypertrophy in mice.

scientific article

CD59 protects rat kidney from complement mediated injury in collaboration with crry

scientific article published on 01 October 2000

CD59a deficient mice display reduced B cell activity and antibody production in response to T-dependent antigens.

scientific article published on 12 February 2007

CD59a is the primary regulator of membrane attack complex assembly in the mouse.

scientific article published in September 2004

CD93 regulates central nervous system inflammation in two mouse models of autoimmune encephalomyelitis

scientific article published on 11 July 2018

Characterization in vitro and in vivo of the pig analogue of human CD59 using new monoclonal antibodies

scientific article published on 01 November 1998

Characterization of a large genomic deletion in four Irish families with C7 deficiency.

scientific article published on 28 December 2011

Characterization of the mouse analogues of CD59 using novel monoclonal antibodies: tissue distribution and functional comparison ⬇️

scientific article published on May 1, 2003

Characterizing a pH-switch anti-C5 antibody as a tool for human and mouse complement C5 purification and cross-species inhibition of classical and reactive lysis

scientific article published on 30 July 2018

Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFNgamma-dependent iNOS expression in the vasculature of healthy mice.

scientific article published on 15 February 2008

Comparison of the suppressive effects of soluble CR1 and C5a receptor antagonist in acute arthritis induced in rats by blocking of CD59

scientific article published on 01 February 2000

Complement Biomarkers as Predictors of Disease Progression in Alzheimer's Disease

scientific article

Complement C3a receptors in the pituitary gland: a novel pathway by which an innate immune molecule releases hormones involved in the control of inflammation.

scientific article published on 16 October 2003

Complement UK--how and why it started

scientific article published on 05 May 2011

Complement activation and CD59 expression in the motor facial nucleus following intracranial transection of the facial nerve in the adult rat

scientific article published on 01 November 1998

Complement activation and expression during chronic relapsing experimental autoimmune encephalomyelitis in the Biozzi ABH mouse.

scientific article published on 24 April 2015

Complement activation in leprosy: a retrospective study shows elevated circulating terminal complement complex in reactional leprosy

scientific article

Complement activation in multiple sclerosis plaques: an immunohistochemical analysis

scientific article

Complement activation on human neuroblastoma cell lines in vitro: route of activation and expression of functional complement regulatory proteins.

scientific article published in May 1996

Complement and clusterin in the spinal cord dorsal horn and gracile nucleus following sciatic nerve injury in the adult rat

scientific article published on 01 September 1995

Complement and complement regulators in the male reproductive system

scientific article

Complement component C9 in Graves' disease

scientific article published on 01 December 1986

Complement dysregulation and disease: From genes and proteins to diagnostics and drugs ⬇️

scientific article published on November 1, 2012

Complement in multiple sclerosis: its role in disease and potential as a biomarker.

scientific article

Complement in the pathogenesis of Alzheimer's disease.

scientific article published on 13 November 2017

Complement is activated in progressive multiple sclerosis cortical grey matter lesions

scientific article published on 22 June 2016

Complement mediated cell death is associated with DNA fragmentation

scientific article published on 01 January 2000

Complement mediated signaling on pulmonary CD103(+) dendritic cells is critical for their migratory function in response to influenza infection.

scientific article

Complement membrane attack is required for endplate damage and clinical disease in passive experimental myasthenia gravis in Lewis rats

scientific article published on 01 November 2006

Complement regulation at the molecular level: The structure of decay-accelerating factor

scientific article

Complement regulation by Kaposi's sarcoma-associated herpesvirus ORF4 protein.

scientific article

Complement regulation in the rat glomerulus: Crry and CD59 regulate complement in glomerular mesangial and endothelial cells

scientific article published on 01 August 1995

Complement regulator CD59 deficiency fails to augment susceptibility to actively induced experimental autoimmune myasthenia gravis.

scientific article published on 23 October 2006

Complement regulator factor H as a serum biomarker of multiple sclerosis disease state.

scientific article published on 25 April 2010

Complement regulator factor H in multiple sclerosis.

scientific article published in October 2011

Complement regulatory molecules: application to therapy and transplantation.

scientific article published on June 1995

Complement regulatory protein expression by a human oligodendrocyte cell line: cytokine regulation and comparison with astrocytes.

scientific article published on November 1996

Complement system activation contributes to the ependymal damage induced by microbial neuraminidase.

scientific article published on 21 May 2016

Complement system biomarkers in epilepsy

scientific article published on 24 May 2018

Complement system biomarkers in first episode psychosis

scientific article

Complement therapeutics; history and current progress.

scientific article

Complement upregulation and activation on motor neurons and neuromuscular junction in the SOD1 G93A mouse model of familial amyotrophic lateral sclerosis

scientific article published on 17 April 2011

Complement, a target for therapy in inflammatory and degenerative diseases.

scientific article

Complement, roles in renal disease and modulation for therapy.

scientific article

Complement-mediated lysis of pigeon erythrocyte ghosts analysed by flow cytometry. Evidence for the involvement of a 'threshold' phenomenon.

scientific article published on October 1983

Complement: central to innate immunity and bridging to adaptive responses.

scientific article

Complementing the inflammasome.

scientific article

Corrigendum to “Deletion of Crry, the murine ortholog of the sporadic Alzheimer's disease risk gene CR1, impacts tau phosphorylation and brain CFH” [Neurosci. Lett. 533 (2013) 96–99].

scientific article published in June 2013

Cross-linking of CD59 and of other glycosyl phosphatidylinositol-anchored molecules on neutrophils triggers cell activation via tyrosine kinase

scientific article published on 01 November 1993

Crry deficiency in complement sufficient mice: C3 consumption occurs without associated renal injury

scientific journal article

CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers

scientific article published in Nature Communications

Cutting edge: murine CD59a modulates antiviral CD4+ T cell activity in a complement-independent manner

scientific article published on December 2005

Cutting edge: the NLRP3 inflammasome links complement-mediated inflammation and IL-1β release.

scientific article published on July 2013

Cytokine-mediated up-regulation of CD55 and CD59 protects human hepatoma cells from complement attack.

scientific article published on August 2000

Decay-accelerating factor must bind both components of the complement alternative pathway C3 convertase to mediate efficient decay

scientific journal article

Deficiency of the complement regulator CD59a enhances disease severity, demyelination and axonal injury in murine acute experimental allergic encephalomyelitis

scientific article published on 01 January 2004

Deficiency of the complement regulator CD59a exacerbates Wallerian degeneration.

scientific article published on 26 February 2009

Deletion of Crry, the murine ortholog of the sporadic Alzheimer's disease risk gene CR1, impacts tau phosphorylation and brain CFH.

scientific article published on 12 November 2012

Deletion of the gene encoding CD59a in mice increases disease severity in a murine model of rheumatoid arthritis

scientific article published on 01 September 2004

Deletion of the membrane complement inhibitor CD59a drives age and gender-dependent alterations to bone phenotype in mice.

scientific article published on 22 December 2015

Development of a model for cytomegalovirus infection of oligodendrocytes.

scientific article published in December 1997

Dimerization of complement factor H-related proteins modulates complement activation in vivo

scientific article

Discovery of omecamtiv mecarbil the first, selective, small molecule activator of cardiac Myosin.

scientific article published on 20 August 2010

Distribution and determinants of circulating complement factor H concentration determined by a high-throughput immunonephelometric assay

scientific article

Distribution of membrane cofactor protein (MCP/CD46) on pig tissues. Relevance To xenotransplantation

scientific article published on 01 September 1999

Editorial

scientific article published on 20 February 2016

Effects of inhibition of complement activation using recombinant soluble complement receptor 1 on neutrophil CD11b/CD18 and L-selectin expression and release of interleukin-8 and elastase in simulated cardiopulmonary bypass

scientific article published on 01 February 1996

Efficient generation of monoclonal antibodies for specific protein domains using recombinant immunoglobulin fusion proteins: pitfalls and solutions.

scientific article

Enhanced complement susceptibility of avidin-biotin-treated human erythrocytes is a consequence of neutralization of the complement regulators CD59 and decay accelerating factor.

scientific article published on May 1995

Epitope mapping of 10 monoclonal antibodies against the pig analogue of human membrane cofactor protein (MCP)

scientific article published on 01 April 1999

Evidence for activation of the terminal pathway of complement and upregulation of sulfated glycoprotein (SGP)-2 in the hypoglossal nucleus following peripheral nerve injury

scientific article published on 01 January 1995

Exogenous glycosyl phosphatidylinositol-anchored CD59 associates with kinases in membrane clusters on U937 cells and becomes Ca(2+)-signaling competent ⬇️

scientific article published on November 1, 1995

Exploiting the nephrotoxic effects of venom from the sea anemone, Phyllodiscus semoni, to create a hemolytic uremic syndrome model in the rat

scientific article

Expression and function of membrane regulators of complement on rat astrocytes in culture

scientific article published on 01 May 1996

Expression of CD46 in developing rat spermatozoa: ultrastructural localization and utility as a marker of the various stages of the seminiferous tubuli

scientific journal article

Expression of human complement receptor type 2 (CD21) in mice during early B cell development results in a reduction in mature B cells and hypogammaglobulinemia.

scientific article

Expression of rat CD59: functional analysis confirms lack of species selectivity and reveals that glycosylation is not required for function

scientific article published on 01 April 1997

Expression of the glycosylphosphatidylinositol-linked complement-inhibiting protein CD59 antigen in insect cells using a baculovirus vector ⬇️

scientific article published on November 1, 1993

Extracting the barbs from complement assays: Identification and optimisation of a safe substitute for traditional buffers

scientific article published on 20 July 2018

Functional analysis of a complement polymorphism (rs17611) associated with rheumatoid arthritis

scientific article

Functional basis of protection against age-related macular degeneration conferred by a common polymorphism in complement factor B

scholarly article

Generation of a recombinant, membrane-targeted form of the complement regulator CD59: activity in vitro and in vivo.

scientific article published on 30 September 2003

Genetic analysis and functional characterization of novel mutations in a series of patients with atypical hemolytic uremic syndrome.

scientific article

Glomerular complement regulation is overwhelmed in passive Heymann nephritis

scientific article published on 01 September 2001

Glycation of CD59 impairs complement regulation on erythrocytes from diabetic subjects.

scientific article published in February 2005

Glycosylation and the complement system.

scientific article

Hereditary angioedema--therapies old and new.

scientific article published on August 2010

Hexamerization-enhanced CD20 antibody mediates complement-dependent cytotoxicity in serum genetically deficient in C9.

scientific article

High Levels of Soluble C5b-9 Complex in Dialysis Fluid May Predict Poor Prognosis in Peritonitis in Peritoneal Dialysis Patients

scientific article

High-resolution structures of bacterially expressed soluble human CD59

scientific article

Holding T cells in check--a new role for complement regulators?

scientific article

Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q

scientific article

Human cell-adhesion molecule CD2 binds CD58 (LFA-3) with a very low affinity and an extremely fast dissociation rate but does not bind CD48 or CD59

scientific article published on 01 August 1994

Human diffusely adhering Escherichia coli expressing Afa/Dr adhesins that use human CD55 (decay-accelerating factor) as a receptor does not bind the rodent and pig analogues of CD55

scientific article

Human factor H-related protein 5 (FHR-5). A new complement-associated protein

scientific article

Identification of an Astrocyte Cell Population from Human Brain that Expresses Perforin, a Cytotoxic Protein Implicated in Immune Defense ⬇️

scientific article published on February 16, 1998

Identification of factor H-like protein 1 as the predominant complement regulator in Bruch's membrane: implications for age-related macular degeneration.

scientific article published on 10 October 2014

Identification of the individual residues that determine human CD59 species selective activity

scientific article published on 01 April 1999

Immunization with autologous CD46 generates a strong autoantibody response in rats that targets spermatozoa.

scientific article published on 6 September 2006

Immunocytochemical localization of the terminal complement complex in multiple sclerosis.

scientific article published on July 1989

Immunoradiometric assay for human complement component C9 utilising monoclonal antibodies

scientific article published on 01 October 1983

Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina.

scientific article

Implication of Complement System and its Regulators in Alzheimer’s Disease

scientific article (publication date: March 2009)

In vivo characterization and therapeutic efficacy of a C5-specific inhibitor from the soft tick Ornithodoros moubata

scientific article published on 10 January 2007

Inhibition of complement-induced [14C]sucrose release by intracellular and extracellular monoclonal antibodies to C9: evidence that C9 is a transmembrane protein

scientific article published on 01 January 1984

Inhibition of coxsackie B virus infection by soluble forms of its receptors: binding affinities, altered particle formation, and competition with cellular receptors.

scientific article

Inhibition of the Membrane Attack Complex of the Complement System Reduces Secondary Neuroaxonal Loss and Promotes Neurologic Recovery after Traumatic Brain Injury in Mice

scientific article published on 31 January 2014

Interplay between REST and nucleolin transcription factors: a key mechanism in the overexpression of genes upon increased phosphorylation

scientific article published on 27 November 2013

Intervention in the complement system: a therapeutic strategy in inflammation.

scientific article published on February 1996

Into the third century of complement research

scientific article published on 01 December 2000

Intracellular Ca2+ and cell injury: a paradoxical role of Ca2+ in complement membrane attack.

scientific article

Introduction to complement in health and disease: novel aspects and insights

scientific article published on 8 January 2018

Isolation and characterization of a membrane protein from rat erythrocytes which inhibits lysis by the membrane attack complex of rat complement ⬇️

scientific article published on May 15, 1992

Isolation and characterization of a membrane-attack-complex-inhibiting protein present in human serum and other biological fluids

scientific article

Isolation and characterization of the complement-inhibiting protein CD59 antigen from platelet membranes ⬇️

scientific article published on March 1, 1992

Killing of cells by perforin. Resistance to killing is not due to diminished binding of perforin to the cell membrane ⬇️

scientific article published on November 15, 1991

Killing of rat glial cells by complement: deficiency of the rat analogue of CD59 is the cause of oligodendrocyte susceptibility to lysis

scientific article published on 01 November 1993

Lessons from functional and structural analyses of disease-associated genetic variants in the complement alternative pathway.

scientific article

Letter in response to A. Agrawal: 'CRP after 2004'

scientific article published on 01 February 2006

Local therapy with soluble complement receptor 1 (sCR1) suppresses inflammation in rat mono-articular arthritis

scientific article published on 01 October 1997

M. leprae components induce nerve damage by complement activation: identification of lipoarabinomannan as the dominant complement activator.

scientific article published on 15 March 2015

Mapping the regions of the complement inhibitor CD59 responsible for its species selective activity

scientific article published on 01 August 1997

Measurement of C9 concentrations using an immunochemiluminometric assay

Measurement of factor H variants in plasma using variant-specific monoclonal antibodies: application to assessing risk of age-related macular degeneration

scientific article

Measurement of soluble CD59 in CSF in demyelinating disease: Evidence for an intrathecal source of soluble CD59.

scientific article published in February 2018

Mechanisms of complement resistance induced by non-lethal complement attack and by growth arrest

scientific article published on 01 April 1997

Membrane attack complex formation on yeast as trigger of selective release of terminal complement proteins from human polymorphonuclear leukocytes

scientific article published on 01 May 2000

Membrane complement regulators protect against fibrin exudation increases in a severe peritoneal inflammation model in rats.

scientific article published on 15 February 2012

Membrane complement regulators protect against the development of type II collagen-induced arthritis in rats

scientific article published on 01 October 2001

Mice expressing human CR1/CD35 have an enhanced humoral immune response to T-dependent antigens but fail to correct the effect of premature human CR2 expression ⬇️

scientific article published on June 25, 2011

Microbial Neuraminidase Induces a Moderate and Transient Myelin Vacuolation Independent of Complement System Activation

scientific article published on 7 March 2017

Miller Fisher anti-GQ1b antibodies: alpha-latrotoxin-like effects on motor end plates

scientific article published on 01 February 1999

Molecular and functional analysis of mouse decay accelerating factor (CD55)

scientific article published on August 1999

Molecular cell biology of complement membrane attack.

scientific article

Molecular cloning of the rat analogue of human CD59: structural comparison with human CD59 and identification of a putative active site

scientific journal article

Molecular cloning, expression and characterization of the rat analogue of human membrane cofactor protein (MCP/CD46)

scientific article published on 01 September 1999

Molecular dissection of interactions between components of the alternative pathway of complement and decay accelerating factor (CD55).

scientific article published on 9 November 2004

Molecular pathogenesis of human CD59 deficiency

scientific article published on 26 October 2018

Myasthenia gravis thymus: complement vulnerability of epithelial and myoid cells, complement attack on them, and correlations with autoantibody status.

scientific article

Myelin-oligodendrocyte glycoprotein (MOG) is a surface marker of oligodendrocyte maturation

scientific article published on 01 May 1989

Non-lethal doses of antibody and complement stimulate release of prostaglandin E2 from human amniotic cells in vitro

scientific article published on 01 August 1990

Normal rat serum cytotoxicity against syngeneic oligodendrocytes. Complement activation and attack in the absence of anti-myelin antibodies.

scientific article published in February 1989

Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain.

scientific article published in December 1997

Photoproteins as indicators of intracellular free Ca2+

scientific article published on 01 July 1989

Physiologic relevance of the membrane attack complex inhibitory protein CD59 in human seminal plasma: CD59 is present on extracellular organelles (prostasomes), binds cell membranes, and inhibits complement-mediated lysis

scientific article

Physiology and pathophysiology of complement: progress and trends.

scientific article published on January 1995

Plasma complement biomarkers distinguish multiple sclerosis and neuromyelitis optica spectrum disorder.

scientific article published on 9 September 2016

Presence and pathogenic relevance of antibodies to clustered acetylcholine receptor in ocular and generalized myasthenia gravis

scientific article published on 01 August 2012

Production and functional analysis of rat CD59 and chimeric CD59-Crry as active soluble proteins in Pichia pastoris

scientific article published on 01 January 2000

Production and functional characterization of a soluble recombinant form of mouse CD59

scientific article published on 01 February 2000

Protection of human breast cancer cells from complement-mediated lysis by expression of heterologous CD59.

scientific article published on January 1999

Rat T cells express neither CD55 nor CD59 and are dependent on Crry for protection from homologous complement

scientific article published on 01 February 2002

Rat membrane cofactor protein (MCP; CD46) is expressed only in the acrosome of developing and mature spermatozoa and mediates binding to immobilized activated C3

scientific journal article

Recombinant membrane-targeted form of CD59 inhibits the growth of choroidal neovascular complex in mice.

scientific article

Respective roles of decay-accelerating factor and CD59 in circumventing glomerular injury in acute nephrotoxic serum nephritis

scientific article published on 01 February 2004

Response to Comment on "Functional Analysis of a Complement Polymorphism (rs17611) Associated with Rheumatoid Arthritis"

scientific article published on 01 July 2015

Retinal ganglion cell degeneration correlates with hippocampal spine loss in experimental Alzheimer's disease

scientific article published on 07 December 2020

Retraction notice to "The mouse complement regulator CD59b is significantly expressed only in testis and plays roles in sperm acrosome activation and motility" [Mol. Immunol. 45 (2008) 534-542]

article published in 2014

Retraction: Targeting Neural-Restrictive Silencer Factor Sensitizes Tumor Cells to Antibody-Based Cancer Immunotherapy In Vitro via Multiple Mechanisms

scientific article published on 01 December 2011

Role and regulation of pig CD59 and membrane cofactor protein/CD46 expressed on pig aortic endothelial cells

scientific article published on 01 August 2000

Role of CD59 in experimental glomerulonephritis in rats

scientific article published on 01 July 1994

Role of complement in the aetiology of Pick's disease?

scientific article published on 01 May 1996

Role of complement regulatory membrane proteins in ischaemia-reperfusion injury of rat gastric mucosa

scientific article published on 01 October 1999

Role of the Complement Pathway in Inflammatory Skin Diseases: A Focus on Hidradenitis Suppurativa

scientific article published on 20 December 2019

Roles for glycosylation in the anti-inflammatory molecule CD59.

scientific article published on November 1997

Roles of the complement system in human neurodegenerative disorders: pro-inflammatory and tissue remodeling activities.

scientific article

Sensitive and specific assays for C3 nephritic factors clarify mechanisms underlying complement dysregulation

scientific article published on August 2012

Signalling through neutrophil Fc gamma RIII, Fc gamma RII, and CD59 is not impaired in active rheumatoid arthritis.

scientific article published on May 1996

Soluble complement receptor 1 (sCR1) protects against experimental autoimmune myasthenia gravis

scientific article published on 01 December 1996

Soluble complement receptor 1 protects the peripheral nerve from early axon loss after injury.

scientific article published on 18 March 2008

Soluble complement receptor one (sCR1) inhibits the development and progression of rat collagen-induced arthritis

scientific article published on 01 January 2000

Specific Inhibition of Complement Activation Significantly Ameliorates Autoimmune Blistering Disease in Mice

scientific article published on 16 March 2018

Specific collaboration between rat membrane complement regulators Crry and CD59 protects peritoneum from damage by autologous complement activation

scientific article published on 22 November 2010

Spermatogenic cells distal to the blood-testis barrier in rats lack C3 convertase regulators and may be at risk of complement-mediated injury.

scientific article published on 27 December 2005

Sphingomyelinases in the venom of the spider Loxosceles intermedia are responsible for both dermonecrosis and complement-dependent hemolysis

scientific article published on 01 October 1998

Structural basis of complement membrane attack complex formation.

scientific article

Structures of the rat complement regulator CrrY

scientific article

Sub-lytic C5b-9 induces functional changes in retinal pigment epithelial cells consistent with age-related macular degeneration.

scientific article published on 20 May 2011

Suppression of complement activation by recombinant Crry inhibits experimental autoimmune anterior uveitis (EAAU).

scientific article published on 16 September 2010

Systemic and local anti-C5 therapy reduces the disease severity in experimental autoimmune uveoretinitis.

scientific article published on 4 December 2009

Systemic complement profiling in multiple sclerosis as a biomarker of disease state.

scientific article published on 21 February 2012

Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitis.

scientific article

Target-sensitive immunoerythrocytes: interaction of biotinylated red blood cells with immobilized avidin induces their lysis by complement

scientific article published on 01 March 1996

Targeted deletion of the CD59 gene causes spontaneous intravascular hemolysis and hemoglobinuria

article

Terminal complexes of the complement system: new structural insights and their relevance to function.

scientific article

Terminal component of complement (C9) in cerebrospinal fluid of patients with multiple sclerosis

scientific article published on 01 August 1984

The Glycosylation of the Complement Regulatory Protein, Human Erythrocyte CD59

scientific article published in Journal of Biological Chemistry

The Membrane Attack Complex of Complement Causes Severe Demyelination Associated with Acute Axonal Injury

scientific article published on 01 January 2002

The Membrane Attack Complex of the Complement System Is Essential for Rapid Wallerian Degeneration

scientific article published on 01 July 2007

The administration of complement component C9 enhances the survival of neonatal rats with Escherichia coli sepsis.

scientific article published in July 1997

The alternative and terminal pathways of complement mediate post-traumatic spinal cord inflammation and injury

scientific article

The complement-inhibiting protein, Protectin (CD59 antigen), is present and functionally active on glomerular epithelial cells ⬇️

scientific article published on February 1, 1991

The distribution of inflammatory demyelinated lesions in the central nervous system of rats with antibody-augmented demyelinating experimental allergic encephalomyelitis.

scientific article published on October 1994

The effect of soluble complement receptor 1 (sCR1) and human thyroid antibodies on the course of experimental autoimmune thyroiditis in rats

scientific article published on 01 January 1996

The expression of complement regulatory proteins by adult human oligodendrocytes

scientific article published on 01 April 1998

The human complement fragment receptor, C5L2, is a recycling decoy receptor.

scientific article

The lipopolysaccharide co-receptor CD14 is present and functional in seminal plasma and expressed on spermatozoa

scientific article published on 01 November 2001

The membrane attack complex as an inflammatory trigger

scientific article published on 30 April 2015

The membrane attack complex of complement drives the progression of atherosclerosis in apolipoprotein E knockout mice

scientific article

The membrane attack pathway of complement drives pathology in passively induced experimental autoimmune myasthenia gravis in mice

scientific article published on 01 November 2006

The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome.

scientific article

The mouse complement regulator CD59b is significantly expressed only in testis and plays roles in sperm acrosome activation and motility.

scientific article published on 26 June 2007

The pig analogue of CD59 protects transgenic mouse hearts from injury by human complement

scientific article published on 01 September 2000

The possibilities and pitfalls for anti-complement therapies in inflammatory diseases.

scientific article published on March 2004

The role of calcium in rat oligodendrocyte injury and repair

scientific article published on 01 January 1992

The role of complement and complement regulators in mediating motor nerve terminal injury in murine models of Guillain-Barré syndrome.

scientific article published on 29 July 2008

The role of complement in disorders of the nervous system ⬇️

scientific article published on December 1, 1997

The role of complement in neurological and neuropsychiatric diseases.

scientific article published on October 2015

The role of complement in the pathogenesis of experimental allergic encephalomyelitis

scientific article published on 01 August 1989

Thrombomodulin enhances complement regulation through strong affinity interactions with factor H and C3b-Factor H complex

scientific article published on 2 August 2016

Tissue microarray methodology identifies complement pathway activation and dysregulation in progressive multiple sclerosis

scientific article published on 14 July 2017

Transfected CD59 protects mesangial cells from injury induced by antibody and complement

scientific article published on 01 July 1996

Transience of membrane channels induced by perforin and by the membrane attack complex

scientific article published on 01 August 1990

Tubulointerstitial injury induced in rats by a monoclonal antibody that inhibits function of a membrane inhibitor of complement ⬇️

scientific article published on November 1, 1995

Tumour cell killing using chemically engineered antibody constructs specific for tumour cells and the complement inhibitor CD59

scientific article published on 01 February 1997

Upregulating CD59: a new strategy for protection of neurons from complement-mediated degeneration

scientific article published on 03 November 2009

Vaccination against meningococcus in complement-deficient individuals.

scientific article published in December 1998

Variation in complement component C1 inhibitor in age-related macular degeneration

scientific article published on 23 July 2011

Vesicular removal by oligodendrocytes of membrane attack complexes formed by activated complement

scientific article published in Nature

Zymosan, but not lipopolysaccharide, triggers severe and progressive peritoneal injury accompanied by complement activation in a rat peritonitis model.

scientific article published on 24 June 2009

p53 regulates cellular resistance to complement lysis through enhanced expression of CD59

scientific article published on 01 February 2006

Paulina is supported by:

About Paulina

Help