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List of works by Zoltán Ivics

A Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes

scientific article

A highly soluble Sleeping Beauty transposase improves control of gene insertion

scientific article published on 04 November 2019

A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains.

scientific article

A single amino acid switch converts the Sleeping Beauty transposase into an efficient unidirectional excisionase with utility in stem cell reprogramming

scientific article published on 01 January 2020

A whole lotta jumpin' goin' on: new transposon tools for vertebrate functional genomics.

scientific article

Alterations in SCAI Expression during Cell Plasticity, Fibrosis and Cancer

scientific article published on 16 August 2017

Applying a "double-feature" promoter to identify cardiomyocytes differentiated from human embryonic stem cells following transposon-based gene delivery.

scientific article published on May 2009

Assessment of fecundity and germ line transmission in two transgenic pig lines produced by sleeping beauty transposition

scientific article published on 12 October 2012

Assessment of fetal cell chimerism in transgenic pig lines generated by Sleeping beauty transposition

scientific article

Author Correction: Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression

scientific article published on 01 August 2019

Author Correction: Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells

scientific article published in Nature Communications

Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery

scientific article

Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery

Brief report: impaired cell reprogramming in nonhomologous end joining deficient cells.

scientific article published in August 2013

CD30 Receptor-Targeted Lentiviral Vectors for Human Induced Pluripotent Stem Cell-Specific Gene Modification.

scientific article published on 09 March 2016

Cell division promotes efficient retrotransposition in a stable L1 reporter cell line

scientific article published on 6 March 2013

Common physical properties of DNA affecting target site selection of sleeping beauty and other Tc1/mariner transposable elements.

scientific article published in October 2002

Comparative analysis of transposable element vector systems in human cells

scientific article

Comparative genomic integration profiling of Sleeping Beauty transposons mobilized with high efficacy from integrase-defective lentiviral vectors in primary human cells

scientific article

Correction: Genomic Analysis of Sleeping Beauty Transposon Integration in Human Somatic Cells

scientific article published on 30 January 2020

Correction: Integration Profile and Safety of an Adenovirus Hybrid-Vector Utilizing Hyperactive Sleeping Beauty Transposase for Somatic Integration

scientific article published on 04 February 2020

Correction: Reliable transgene-independent method for determining sleeping beauty transposon copy numbers.

scientific article published on 15 March 2013

Correction: Suicidal Autointegration of Sleeping Beauty and piggyBac Transposons in Eukaryotic Cells

scientific article published on 23 September 2019

Corrigendum: Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites

scientific article published on 01 February 2020

Cytoplasmic injection of murine zygotes with Sleeping Beauty transposon plasmids and minicircles results in the efficient generation of germline transgenic mice

scientific article

Derivation and characterization of bovine induced pluripotent stem cells by transposon-mediated reprogramming.

scientific article

Derivation and characterization of sleeping beauty transposon-mediated porcine induced pluripotent stem cells.

scientific article published on 2 November 2012

Efficient Non-Viral T-Cell Engineering by Sleeping Beauty Minicircles Diminishing DNA Toxicity and miRNAs Silencing the Endogenous T-Cell Receptors

scientific article published on 21 March 2018

Efficient Non-viral Gene Delivery into Human Hematopoietic Stem Cells by Minicircle Sleeping Beauty Transposon Vectors.

scientific article published on 31 January 2018

Efficient conditional and promoter-specific in vivo expression of cDNAs of choice by taking advantage of recombinase-mediated cassette exchange using FlEx gene traps

scientific article

Efficient stable gene transfer into human cells by the Sleeping Beauty transposon vectors.

scientific article published on 15 July 2009

Emerging potential of transposons for gene therapy and generation of induced pluripotent stem cells

scientific article published on 26 May 2009

Engineered Sleeping Beauty transposase redirects transposon integration away from genes

scientific article published on 01 March 2022

Engineering of PEDF-Expressing Primary Pigment Epithelial Cells by the SB Transposon System Delivered by pFAR4 Plasmids

scientific article published on 10 February 2017

Establishment of cell-based transposon-mediated transgenesis in cattle

scientific article published on 29 December 2015

Evolution-guided evaluation of the inverted terminal repeats of the synthetic transposon Sleeping Beauty

scientific article published in Scientific Reports

Excision efficiency is not strongly coupled to transgenic rate: cell type-dependent transposition efficiency of sleeping beauty and piggyBac DNA transposons

scientific article

Expression of Active Fluorophore Proteins in the Milk of Transgenic Pigs Bypassing the Secretory Pathway

scientific article published on 18 April 2016

Frog Prince transposon-based RNAi vectors mediate efficient gene knockdown in human cells

scientific article published on 2 September 2005

Gateway-compatible transposon vector to genetically modify human embryonic kidney and adipose-derived stromal cells.

scientific article published on 7 March 2012

Gene Therapy with the Sleeping Beauty Transposon System

scientific article published on 27 September 2017

Generating knockout rats by transposon mutagenesis in spermatogonial stem cells

scientific article

Generation of an immortalized mesenchymal stem cell line producing a secreted biosensor protein for glucose monitoring

scientific article published on 26 September 2017

Genome-wide Profiling Reveals Remarkable Parallels Between Insertion Site Selection Properties of the MLV Retrovirus and the piggyBac Transposon in Primary Human CD4(+) T Cells.

scientific article published on 12 January 2016

Genomic analysis of Sleeping Beauty transposon integration in human somatic cells

scientific article

Genotype-independent transmission of transgenic fluorophore protein by boar spermatozoa

scientific article (publication date: 2011)

Germline transgenesis in pigs by cytoplasmic microinjection of Sleeping Beauty transposons.

scientific article published on 13 March 2014

Germline transgenesis in rabbits by pronuclear microinjection of Sleeping Beauty transposons.

scientific article published on 13 March 2014

Germline transgenesis in rodents by pronuclear microinjection of Sleeping Beauty transposons.

scientific article published on 13 March 2014

Germline transgenesis of the chordate Ciona intestinalis with hyperactive variants of sleeping beauty transposable element

scientific article published on 14 November 2012

Germline transgenic pigs by Sleeping Beauty transposition in porcine zygotes and targeted integration in the pig genome

scientific article (publication date: 2011)

Going non-viral: the Sleeping Beauty transposon system breaks on through to the clinical side

scientific article published on 12 April 2017

Herpes simplex virus/Sleeping Beauty vector-based embryonic gene transfer using the HSB5 mutant: loss of apparent transposition hyperactivity in vivo

scientific article

Human Genome Editing in the Clinic: New Challenges in Regulatory Benefit-Risk Assessment.

scientific article published in October 2017

Hungary's 'reforms' are threatening basic science

scientific article published in Nature

Hybrid lentivirus-transposon vectors with a random integration profile in human cells.

scientific article

Identification and re-addressing of a transcriptionally permissive locus in the porcine genome

scientific article published on 29 October 2015

Insertional engineering of chromosomes with Sleeping Beauty transposition: an overview

scientific article published on January 2011

Insertional mutagenesis of the mouse germline with Sleeping Beauty transposition

scientific article published in January 2008

Integration profile and safety of an adenovirus hybrid-vector utilizing hyperactive sleeping beauty transposase for somatic integration

scientific article published on 04 October 2013

Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression

scientific article published on 21 January 2016

Latest Advances for the Sleeping Beauty Transposon System: 23 Years of Insomnia but Prettier than Ever: Refinement and Recent Innovations of the Sleeping Beauty Transposon System Enabling Novel, Nonviral Genetic Engineering Applications

scientific article published on 16 September 2020

Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice

scientific article published on 04 November 2020

Long-Term PEDF Release in Rat Iris and Retinal Epithelial Cells after Sleeping Beauty Transposon-Mediated Gene Delivery.

scientific article published on 12 August 2017

Minicircle-Based Engineering of Chimeric Antigen Receptor (CAR) T Cells.

scientific article published on January 2016

Modulation of the functional association between the HIV-1 intasome and the nucleosome by histone amino-terminal tails.

scientific article published on 28 November 2017

Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates

scientific article (publication date: June 2009)

Non-viral reprogramming of fibroblasts into induced pluripotent stem cells by Sleeping Beauty and piggyBac transposons.

scientific article

Nonviral gene delivery with the sleeping beauty transposon system.

scientific article published on September 2011

Novel hyperactive transposons for genetic modification of induced pluripotent and adult stem cells: a nonviral paradigm for coaxed differentiation.

scientific article published on October 2010

Novel strong tissue specific promoter for gene expression in human germ cells.

scientific article

Nuclear inclusions of pathogenic ataxin-1 induce oxidative stress and perturb the protein synthesis machinery

scientific article published on 11 February 2020

One-step Multiplex Transgenesis via Sleeping Beauty Transposition in Cattle.

scientific article published on 24 February 2016

Potent CAR-T cells engineered with Sleeping Beauty transposon vectors display a central memory phenotype

scientific article published on 05 March 2020

Precision genetic engineering in large mammals ⬇️

scientific article published on April 20, 2012

Preclinical Evaluation of a Cell-Based Gene Therapy Using the Sleeping Beauty Transposon System in Choroidal Neovascularization

scientific article published on 09 November 2019

Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells

scientific article

Proceedings of the Frontiers of Retrovirology Conference 2016.

scientific article published on 26 September 2016

RNA-guided retargeting of Sleeping Beauty transposition in human cells

scientific article published on 06 March 2020

Regulated complex assembly safeguards the fidelity of Sleeping Beauty transposition.

scientific article published on December 2016

Regulation of DNA transposition by CpG methylation and chromatin structure in human cells

scientific article published on 15 May 2013

Reliable transgene-independent method for determining Sleeping Beauty transposon copy numbers ⬇️

scientific article published on March 3, 2011

Repetitive elements and genome instability

scientific article published on 01 August 2010

Reprogramming of Human Fibroblasts to Induced Pluripotent Stem Cells with Sleeping Beauty Transposon-Based Stable Gene Delivery

scientific article

Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells

scientific article published on 8 January 2016

Retargeting sleeping beauty transposon insertions by engineered zinc finger DNA-binding domains

scientific article

Retargeting transposon insertions by the adeno-associated virus Rep protein.

scientific article

Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites

scientific article published on 20 May 2015

Self-assembled peptide-poloxamine nanoparticles enable in vitro and in vivo genome restoration for cystic fibrosis

scientific article published on 28 January 2019

Sleeping Beauty Transposition.

scientific article published on April 2015

Sleeping Beauty transposase modulates cell-cycle progression through interaction with Miz-1.

scholarly article

Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering.

scientific article published on 30 March 2016

Sleeping Beauty transposition: from biology to applications.

scientific article

Sleeping Beauty transposon mutagenesis in rat spermatogonial stem cells ⬇️

scientific article published on September 8, 2011

Sleeping Beauty transposon mutagenesis of the rat genome in spermatogonial stem cells

scientific article

Sleeping Beauty transposon-based system for cellular reprogramming and targeted gene insertion in induced pluripotent stem cells.

scientific article published on 28 December 2012

Sleeping beauty transposition: biology and applications for molecular therapy

scientific article

Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system

scientific article

Structural Determinants of Sleeping Beauty Transposase Activity

scientific article published on 12 July 2016

Suicidal autointegration of sleeping beauty and piggyBac transposons in eukaryotic cells

scientific article

Sustained and regulated gene expression by Tet-inducible "all-in-one" retroviral vectors containing the HNRPA2B1-CBX3 UCOE®

scientific article published on 24 November 2018

Targeted Sleeping Beauty transposition in human cells

scientific article published on 10 April 2007

Targeted gene insertion for molecular medicine

scientific article published on 08 July 2008

Technology transfer from worms and flies to vertebrates: transposition-based genome manipulations and their future perspectives

scientific article

The Antibiotic-free pFAR4 Vector Paired with the Sleeping Beauty Transposon System Mediates Efficient Transgene Delivery in Human Cells.

scientific article

The Frog Prince: a reconstructed transposon from Rana pipiens with high transpositional activity in vertebrate cells

scientific article published on December 2003

The Sleeping Beauty transposable element: evolution, regulation and genetic applications

scientific article published on January 2004

The Sleeping Beauty transposon toolbox.

scientific article published on January 2012

The ancient mariner sails again: transposition of the human Hsmar1 element by a reconstructed transposase and activities of the SETMAR protein on transposon ends

scientific article

The expanding universe of transposon technologies for gene and cell engineering.

scientific article published on 07 December 2010

The impact of transposable element activity on therapeutically relevant human stem cells

scientific article published on 09 March 2019

Transcriptional activities of the Sleeping Beauty transposon and shielding its genetic cargo with insulators.

scientific article published on 11 December 2007

Transposable elements as plasmid-based vectors for long-term gene transfer into tumors.

scientific article

Transposable elements for transgenesis and insertional mutagenesis in vertebrates: a contemporary review of experimental strategies

scientific article

Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes

scientific article

Transposition of the bamboo Mariner-like element Ppmar1 in yeast.

scientific article published on 8 February 2017

Transposon-Based Reporter Marking Provides Functional Evidence for Intercellular Bridges in the Male Germline of Rabbits

scientific article

Transposon-mediated genome manipulation in vertebrates

scientific article

Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits.

scientific article published on 29 November 2012

Transposons As Tools for Functional Genomics in Vertebrate Models

scientific article published on 6 September 2017

Wide Awake and Ready to Move: 20 Years of Non-Viral Therapeutic Genome Engineering with the Sleeping Beauty Transposon System

scientific article published on 4 September 2017

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