List of works - Alain Israel

A glycosphingolipid binding domain controls trafficking and activity of the mammalian notch ligand delta-like 1

scientific article

A hypermorphic IkappaBalpha mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency

scientific article

A hypermorphic IκBα mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency

A point mutation in NEMO associated with anhidrotic ectodermal dysplasia with immunodeficiency pathology results in destabilization of the oligomer and reduces lipopolysaccharide- and tumor necrosis factor-mediated NF-kappa B activation

scientific article published on 26 December 2005

A regulator branches out

scientific article published in Nature

AIP4/Itch regulates Notch receptor degradation in the absence of ligand

scientific article

Arachidonic acid differentially affects basal and lipopolysaccharide-induced sPLA(2)-IIA expression in alveolar macrophages through NF-kappaB and PPAR-gamma-dependent pathways

scientific article

Combined deficiency in I B and I B reveals a critical window of NF- B activity in natural killer cell differentiation

scientific article published on 05 February 2004

Correction

scientific article published in November 2004

DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding

scientific article

Erratum to: Flt3 receptor inhibition reduces constitutive NFκB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia

scientific article published on 01 December 2015

Flt3 receptor inhibition reduces constitutive NFkappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia

scientific article

Forebrain-specific neuronal inhibition of nuclear factor-kappaB activity leads to loss of neuroprotection.

scientific article published on October 2003

From calcium to NF-kappa B signaling pathways in neurons

scientific article

Generation and characterization of mutant cell lines defective in gamma-secretase processing of Notch and amyloid precursor protein

scientific article published on 15 June 2005

Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia

scientific article published on 25 May 2015

IKK Regulation and Human Genetics ⬇️

scientific article published on January 1, 2011

IKK connects autophagy to major stress pathways

scientific article published on January 2010

IkappaBalpha/IkappaBepsilon deficiency reveals that a critical NF-kappaB dosage is required for lymphocyte survival.

scientific article

Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency

scientific article

Induction of the NF-kappaB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor

scientific article published on 01 January 2003

Inhibition of NF-kappa B activation by peptides targeting NF-kappa B essential modulator (nemo) oligomerization

scientific article

Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains

scientific article

Listeriolysin O secreted by Listeria monocytogenes induces NF-kappaB signalling by activating the IkappaB kinase complex

scientific article

Mature T cells depend on signaling through the IKK complex.

scientific article published in September 2003

Molecular analysis of the genetic defect in a large cohort of IP patients and identification of novel NEMO mutations interfering with NF-kappaB activation

scientific article

Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor

scientific article published on July 2004

NEMO is a key component of NF-κB- and IRF-3-dependent TLR3-mediated immunity to herpes simplex virus.

scientific article

NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain

scientific article

NEMO trimerizes through its coiled-coil C-terminal domain

scientific article (publication date: 17 May 2002)

NF-kappaB activation: Nondegradative ubiquitination implicates NEMO

scientific article published on 18 July 2006

NF-kappaB is required for cell death induction by latent membrane protein 1 of Epstein-Barr virus

scientific article published in April 2003

NF-kappaB regulates spatial memory formation and synaptic plasticity through protein kinase A/CREB signaling

scientific article

NRP/Optineurin Cooperates with TAX1BP1 to potentiate the activation of NF-kappaB by human T-lymphotropic virus type 1 tax protein

scientific article

Negative feedback loop in T cell activation through IkappaB kinase-induced phosphorylation and degradation of Bcl10

scholarly article

New mechanism of X-linked anhidrotic ectodermal dysplasia with immunodeficiency: impairment of ubiquitin binding despite normal folding of NEMO protein

scientific article published on 26 May 2011

Osteopetrosis, lymphedema, anhidrotic ectodermal dysplasia, and immunodeficiency in a boy and incontinentia pigmenti in his mother

scientific article published in June 2002

Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection

scientific article

Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression

scientific article published in February 2012

Regrowing the adult brain: NF-κB controls functional circuit formation and tissue homeostasis in the dentate gyrus

scientific article

Reply to 'Alice Dautry' profile

scientific article

Sleep deprivation increases the activation of nuclear factor kappa B in lateral hypothalamic cells

scientific article published in April 2004

Super-resolution microscopy reveals a preformed NEMO lattice structure that is collapsed in incontinentia pigmenti

scientific article

T-cell-receptor- and B-cell-receptor-mediated activation of NF-kappaB in lymphocytes

scientific article published on June 2004

TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO-IKK supramolecular structures

scientific article

TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2

scientific article published in Nature

The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors

scientific article published on 21 October 2013

The IKK complex contributes to the induction of autophagy

scientific article

The IKK complex, a central regulator of NF-kappaB activation

scientific article

The NEMO mutation creating the most-upstream premature stop codon is hypomorphic because of a reinitiation of translation.

scientific article

The NF-kappaB signalling pathway in human diseases: from incontinentia pigmenti to ectodermal dysplasias and immune-deficiency syndromes

scientific article

The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase

scientific article

The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway

scientific article

The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity

scientific journal article

The notch ligand Delta1 recruits Dlg1 at cell-cell contacts and regulates cell migration.

scientific article

The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation

scientific article

The trimerization domain of NEMO is composed of the interacting C-terminal CC2 and LZ coiled-coil subdomains

scientific article published on 23 April 2004

The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

scientific article (publication date: 14 August 2003)

The ubiquitin-specific protease 12 (USP12) is a negative regulator of notch signaling acting on notch receptor trafficking toward degradation.

scientific article

Two NEMO-like Ubiquitin-Binding Domains in CEP55 Differently Regulate Cytokinesis

scientific article published on 25 September 2019

Visualization of lymphatic vessels through NF- B activity

scientific article published on 22 July 2004

X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production

scientific article

[Human pathologies associated with NF-kappaB defects]

scientific article published on 01 January 2004

Α-arrestin 1 (ARRDC1) and β-arrestins cooperate to mediate Notch degradation in mammals.

scientific article published on 25 July 2013

List of works by Alain Israel

A glycosphingolipid binding domain controls trafficking and activity of the mammalian notch ligand delta-like 1

A hypermorphic IkappaBalpha mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency

A hypermorphic IκBα mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency

A point mutation in NEMO associated with anhidrotic ectodermal dysplasia with immunodeficiency pathology results in destabilization of the oligomer and reduces lipopolysaccharide- and tumor necrosis factor-mediated NF-kappa B activation

A regulator branches out

AIP4/Itch regulates Notch receptor degradation in the absence of ligand

Arachidonic acid differentially affects basal and lipopolysaccharide-induced sPLA(2)-IIA expression in alveolar macrophages through NF-kappaB and PPAR-gamma-dependent pathways

Combined deficiency in I B and I B reveals a critical window of NF- B activity in natural killer cell differentiation

Correction

DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding

Erratum to: Flt3 receptor inhibition reduces constitutive NFκB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia

Flt3 receptor inhibition reduces constitutive NFkappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia

Forebrain-specific neuronal inhibition of nuclear factor-kappaB activity leads to loss of neuroprotection.

From calcium to NF-kappa B signaling pathways in neurons

Generation and characterization of mutant cell lines defective in gamma-secretase processing of Notch and amyloid precursor protein

Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia

IKK Regulation and Human Genetics ⬇️

IKK connects autophagy to major stress pathways

IkappaBalpha/IkappaBepsilon deficiency reveals that a critical NF-kappaB dosage is required for lymphocyte survival.

Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency

Induction of the NF-kappaB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor

Inhibition of NF-kappa B activation by peptides targeting NF-kappa B essential modulator (nemo) oligomerization

Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains

Listeriolysin O secreted by Listeria monocytogenes induces NF-kappaB signalling by activating the IkappaB kinase complex

Mature T cells depend on signaling through the IKK complex.

Molecular analysis of the genetic defect in a large cohort of IP patients and identification of novel NEMO mutations interfering with NF-kappaB activation

Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor

NEMO is a key component of NF-κB- and IRF-3-dependent TLR3-mediated immunity to herpes simplex virus.

NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain

NEMO trimerizes through its coiled-coil C-terminal domain

NF-kappaB activation: Nondegradative ubiquitination implicates NEMO

NF-kappaB is required for cell death induction by latent membrane protein 1 of Epstein-Barr virus

NF-kappaB regulates spatial memory formation and synaptic plasticity through protein kinase A/CREB signaling

NRP/Optineurin Cooperates with TAX1BP1 to potentiate the activation of NF-kappaB by human T-lymphotropic virus type 1 tax protein

Negative feedback loop in T cell activation through IkappaB kinase-induced phosphorylation and degradation of Bcl10

New mechanism of X-linked anhidrotic ectodermal dysplasia with immunodeficiency: impairment of ubiquitin binding despite normal folding of NEMO protein

Osteopetrosis, lymphedema, anhidrotic ectodermal dysplasia, and immunodeficiency in a boy and incontinentia pigmenti in his mother

Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection

Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression

Regrowing the adult brain: NF-κB controls functional circuit formation and tissue homeostasis in the dentate gyrus

Reply to 'Alice Dautry' profile

Sleep deprivation increases the activation of nuclear factor kappa B in lateral hypothalamic cells

Super-resolution microscopy reveals a preformed NEMO lattice structure that is collapsed in incontinentia pigmenti

T-cell-receptor- and B-cell-receptor-mediated activation of NF-kappaB in lymphocytes

TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO-IKK supramolecular structures

TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2

The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors

The IKK complex contributes to the induction of autophagy

The IKK complex, a central regulator of NF-kappaB activation

The NEMO mutation creating the most-upstream premature stop codon is hypomorphic because of a reinitiation of translation.

The NF-kappaB signalling pathway in human diseases: from incontinentia pigmenti to ectodermal dysplasias and immune-deficiency syndromes

The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase

The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway

The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity

The notch ligand Delta1 recruits Dlg1 at cell-cell contacts and regulates cell migration.

The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation

The trimerization domain of NEMO is composed of the interacting C-terminal CC2 and LZ coiled-coil subdomains

The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

The ubiquitin-specific protease 12 (USP12) is a negative regulator of notch signaling acting on notch receptor trafficking toward degradation.

Two NEMO-like Ubiquitin-Binding Domains in CEP55 Differently Regulate Cytokinesis

Visualization of lymphatic vessels through NF- B activity

X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production

[Human pathologies associated with NF-kappaB defects]

Α-arrestin 1 (ARRDC1) and β-arrestins cooperate to mediate Notch degradation in mammals.