List of works - Piotr Kosson

6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid mimics active conformation of tyrosine in opioid peptides.

scientific article published in May 2005

A new structural motif for mu-opioid antagonists.

scientific article published in May 2005

Affinity of fentanyl and its derivatives for the σ1-receptor

scientific article published on 13 June 2019

Antinociceptive and Cytotoxic Activity of Opioid Peptides with Hydrazone and Hydrazide Moieties at the C-Terminus

scientific article published on 28 July 2020

Antinociceptive effect induced by a combination of opioid and neurotensin moieties vs. their hybrid peptide [Ile(9)]PK20 in an acute pain treatment in rodents.

scientific article

Bifunctional Peptide-Based Opioid Agonist-Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain

scientific article published on April 2016

Binding of the new morphiceptin analogs to human MCF-7 breast cancer cells and their effect on growth.

scientific article published on August 2004

Biological properties of a new fluorescent biphalin fragment analogue

scientific article published in January 2002

Biphalin analogs containing β(3)-homo-amino acids at the 4,4' positions: Synthesis and opioid activity profiles

scientific article published on 20 February 2015

Blood-brain barrier penetration by two dermorphin tetrapeptide analogues: role of lipophilicity vs structural flexibility.

scientific article published on 28 March 2008

Blood-brain barrier permeability differentiates Sadowski mouse lines of high and low stress-induced analgesia: electron microscopy analysis.

scientific article

Can Keratin Scaffolds be used for Creating Three-dimensional Cell Cultures?

scientific article published on 03 April 2020

Characterization of antinociceptive activity of novel endomorphin-2 and morphiceptin analogs modified in the third position.

scientific article published in January 2005

Codon optimization of antigen coding sequences improves the immune potential of DNA vaccines against avian influenza virus H5N1 in mice and chickens

scientific article

Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics

scientific article published on 31 October 2015

Endomorphins interact with tachykinin receptors

scientific article

Enzymatic degradation studies of endomorphin-2 and its analogs containing N-methylated amino acids.

scientific article published on 8 August 2005

Expression, purification and characterization of glycosylated influenza H5N1 hemagglutinin produced in Pichia pastoris.

scientific article

Fentanyl Family at the Mu-Opioid Receptor: Uniform Assessment of Binding and Computational Analysis

scientific article published on 19 February 2019

High-Titre Neutralizing Antibodies to H1N1 Influenza Virus after Mouse Immunization with Yeast Expressed H1 Antigen: A Promising Influenza Vaccine Candidate

scientific article published on 08 January 2019

Hydrazone Linker as a Useful Tool for Preparing Chimeric Peptide/Nonpeptide Bifunctional Compounds.

scientific article published in November 2016

Identification of Dmt-D-Lys-Phe-Phe-OH as a highly antinociceptive tetrapeptide metabolite of the opioid-neurotensin hybrid peptide PK20.

scientific article

Immunogenicity of DNA Vaccine against H5N1 Containing Extended Kappa B Site: In Vivo Study in Mice and Chickens.

scientific article published on 24 August 2017

In Vivo, In Vitro and In Silico Studies of the Hybrid Compound AA3266, an Opioid Agonist/NK1R Antagonist with Selective Cytotoxicity

scientific article published on 19 October 2020

In vivo antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist-neurokinin 1 receptor antagonist chimera

scientific article published on 30 January 2012

Intrathecal antinociceptive interaction between the NMDA antagonist ketamine and the opioids, morphine and biphalin

scientific article published on 20 February 2008

Novel endomorphin-2 analogs with mu-opioid receptor antagonist activity.

scientific article published in September 2005

Novel peptide inhibitor of dipeptidyl peptidase IV (Tyr-Pro-D-Ala-NH2) with anti-inflammatory activity in the mouse models of colitis

scientific article published on 01 September 2018

Opioid Tripeptides Hybridized with trans-1-Cinnamylpiperazine as Proliferation Inhibitors of Pancreatic Cancer Cells in Two- and Three-Dimensional in vitro Models.

scientific article published on 18 August 2017

Opioid receptor binding and in vivo antinociceptive activity of position 3-substituted morphiceptin analogs

scientific article

PK20, a new opioid-neurotensin hybrid peptide that exhibits central and peripheral antinociceptive effects

scientific article

Physicochemical properties and in vitro cytotoxicity of iron oxide-based nanoparticles modified with antiangiogenic and antitumor peptide A7R.

scientific article

Pramipexole and Fingolimod exert neuroprotection in a mouse model of Parkinson's disease by activation of sphingosine kinase 1 and Akt kinase.

scientific article published on 23 February 2018

Role of the blood-brain barrier in differential response to opioid peptides and morphine in mouse lines divergently bred for high and low swim stress-induced analgesia

scientific article

Superpotent [Dmt¹] dermorphin tetrapeptides containing the 4-aminotetrahydro-2-benzazepin-3-one scaffold with mixed μ/δ opioid receptor agonistic properties.

scientific article published on 20 October 2011

Synthesis and biological activity of N-methylated analogs of endomorphin-2

scientific article published on 06 September 2005

Synthesis and biological evaluation of constrained analogues of the opioid peptide H-Tyr-D-Ala-Phe-Gly-NH2 using the 4-amino-2-benzazepin-3-one scaffold.

scientific article published in November 2005

Synthesis and pharmacological properties of a new fluorescent opioid peptide analog.

scientific article published in July 2009

Synthesis and receptor binding of opioid peptide analogues containing beta3-homo-amino acids

scientific article published in November 2009

Synthesis, binding affinities and metabolic stability of dimeric dermorphin analogs modified with β3-homo-amino acids

scientific article published on 01 April 2016

TAPP analogs containing β3 -homo-amino acids: synthesis and receptor binding

scientific article published on 12 July 2012

The Length of N-Glycans of Recombinant H5N1 Hemagglutinin Influences the Oligomerization and Immunogenicity of Vaccine Antigen

scientific article

The analgesic hybrid of dermorphin/substance P and analog of enkephalin improve wound healing in streptozotocin-induced diabetic rats

scientific article published on 19 November 2019

The impact of β-azido(or 1-piperidinyl)methylamino acids in position 2 or 3 on biological activity and conformation of dermorphin analogues

scientific article published in August 2016

The role of allogenic keratin-derived dressing in wound healing in a mouse model.

scientific article published on 20 December 2016

[(35)S]GTPgammaS binding stimulated by endomorphin-2 and morphiceptin analogs

scientific article published on 27 April 2006

β2-Homo-Amino Acid Scan of µ-Selective Opioid Tetrapeptide TAPP

scientific article published on 25 May 2020

List of works by Piotr Kosson

6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid mimics active conformation of tyrosine in opioid peptides.

A new structural motif for mu-opioid antagonists.

Affinity of fentanyl and its derivatives for the σ1-receptor

Antinociceptive and Cytotoxic Activity of Opioid Peptides with Hydrazone and Hydrazide Moieties at the C-Terminus

Antinociceptive effect induced by a combination of opioid and neurotensin moieties vs. their hybrid peptide [Ile(9)]PK20 in an acute pain treatment in rodents.

Bifunctional Peptide-Based Opioid Agonist-Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain

Binding of the new morphiceptin analogs to human MCF-7 breast cancer cells and their effect on growth.

Biological properties of a new fluorescent biphalin fragment analogue

Biphalin analogs containing β(3)-homo-amino acids at the 4,4' positions: Synthesis and opioid activity profiles

Blood-brain barrier penetration by two dermorphin tetrapeptide analogues: role of lipophilicity vs structural flexibility.

Blood-brain barrier permeability differentiates Sadowski mouse lines of high and low stress-induced analgesia: electron microscopy analysis.

Can Keratin Scaffolds be used for Creating Three-dimensional Cell Cultures?

Characterization of antinociceptive activity of novel endomorphin-2 and morphiceptin analogs modified in the third position.

Codon optimization of antigen coding sequences improves the immune potential of DNA vaccines against avian influenza virus H5N1 in mice and chickens

Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics

Endomorphins interact with tachykinin receptors

Enzymatic degradation studies of endomorphin-2 and its analogs containing N-methylated amino acids.

Expression, purification and characterization of glycosylated influenza H5N1 hemagglutinin produced in Pichia pastoris.

Fentanyl Family at the Mu-Opioid Receptor: Uniform Assessment of Binding and Computational Analysis

High-Titre Neutralizing Antibodies to H1N1 Influenza Virus after Mouse Immunization with Yeast Expressed H1 Antigen: A Promising Influenza Vaccine Candidate

Hydrazone Linker as a Useful Tool for Preparing Chimeric Peptide/Nonpeptide Bifunctional Compounds.

Identification of Dmt-D-Lys-Phe-Phe-OH as a highly antinociceptive tetrapeptide metabolite of the opioid-neurotensin hybrid peptide PK20.

Immunogenicity of DNA Vaccine against H5N1 Containing Extended Kappa B Site: In Vivo Study in Mice and Chickens.

In Vivo, In Vitro and In Silico Studies of the Hybrid Compound AA3266, an Opioid Agonist/NK1R Antagonist with Selective Cytotoxicity

In vivo antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist-neurokinin 1 receptor antagonist chimera

Intrathecal antinociceptive interaction between the NMDA antagonist ketamine and the opioids, morphine and biphalin

Novel endomorphin-2 analogs with mu-opioid receptor antagonist activity.

Novel peptide inhibitor of dipeptidyl peptidase IV (Tyr-Pro-D-Ala-NH2) with anti-inflammatory activity in the mouse models of colitis

Opioid Tripeptides Hybridized with trans-1-Cinnamylpiperazine as Proliferation Inhibitors of Pancreatic Cancer Cells in Two- and Three-Dimensional in vitro Models.

Opioid receptor binding and in vivo antinociceptive activity of position 3-substituted morphiceptin analogs

PK20, a new opioid-neurotensin hybrid peptide that exhibits central and peripheral antinociceptive effects

Physicochemical properties and in vitro cytotoxicity of iron oxide-based nanoparticles modified with antiangiogenic and antitumor peptide A7R.

Pramipexole and Fingolimod exert neuroprotection in a mouse model of Parkinson's disease by activation of sphingosine kinase 1 and Akt kinase.

Role of the blood-brain barrier in differential response to opioid peptides and morphine in mouse lines divergently bred for high and low swim stress-induced analgesia

Superpotent [Dmt¹] dermorphin tetrapeptides containing the 4-aminotetrahydro-2-benzazepin-3-one scaffold with mixed μ/δ opioid receptor agonistic properties.

Synthesis and biological activity of N-methylated analogs of endomorphin-2

Synthesis and biological evaluation of constrained analogues of the opioid peptide H-Tyr-D-Ala-Phe-Gly-NH2 using the 4-amino-2-benzazepin-3-one scaffold.

Synthesis and pharmacological properties of a new fluorescent opioid peptide analog.

Synthesis and receptor binding of opioid peptide analogues containing beta3-homo-amino acids

Synthesis, binding affinities and metabolic stability of dimeric dermorphin analogs modified with β3-homo-amino acids

TAPP analogs containing β3 -homo-amino acids: synthesis and receptor binding

The Length of N-Glycans of Recombinant H5N1 Hemagglutinin Influences the Oligomerization and Immunogenicity of Vaccine Antigen

The analgesic hybrid of dermorphin/substance P and analog of enkephalin improve wound healing in streptozotocin-induced diabetic rats

The impact of β-azido(or 1-piperidinyl)methylamino acids in position 2 or 3 on biological activity and conformation of dermorphin analogues

The role of allogenic keratin-derived dressing in wound healing in a mouse model.

[(35)S]GTPgammaS binding stimulated by endomorphin-2 and morphiceptin analogs

β2-Homo-Amino Acid Scan of µ-Selective Opioid Tetrapeptide TAPP