List of works - Clive Holmes

A double-blind placebo-controlled randomized trial of Melissa officinalis oil and donepezil for the treatment of agitation in Alzheimer's disease

scientific article published on 19 February 2011

A novel Alzheimer disease locus located near the gene encoding tau protein.

scientific article

A positive association between 5HT re-uptake binding sites and depression in dementia with Lewy bodies.

scientific article published in May 2002

A randomised placebo controlled study to assess the effects of cholinergic treatment on muscarinic receptors in Alzheimer's disease ⬇️

scientific article published on November 1, 2003

AD2000: design and conclusions.

scientific article published in October 2004

Alzheimer's disease polygenic risk score as a predictor of conversion from mild-cognitive impairment

scientific article published on 24 May 2019

Amyloid-β vaccination for Alzheimer's dementia – Authors' reply

scientific article published in The Lancet

Association between interleukin 1-beta promoter (-511) polymorphism and depressive symptoms in Alzheimer's disease.

scientific article published in January 2004

Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 01 September 2019

Aβ immunotherapy for Alzheimer's disease: effects on apoE and cerebral vasculopathy.

scientific article published on 7 September 2014

Brief psychosocial therapy for the treatment of agitation in Alzheimer disease (the CALM-AD trial).

scientific article

CAG/CTG repeat expansions at the Huntington's disease-like 2 locus are rare in Huntington's disease patients

scientific article

Clinical practice with anti-dementia drugs: A revised (third) consensus statement from the British Association for Psychopharmacology

scientific article

Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling

scientific article (publication date: August 2009)

Common polygenic variation enhances risk prediction for Alzheimer's disease

scientific article published on 21 October 2015

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

scientific article (publication date: May 2011)

Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease

scientific article

Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain.

scientific article

Core outcome measures for interventions to prevent or slow the progress of dementia for people living with mild to moderate dementia: Systematic review and consensus recommendations.

scientific article

Correction to: The Edinburgh Consensus: preparing for the advent of disease-modifying therapies for Alzheimer's disease.

scientific article published on 30 July 2018

Cost-effectiveness of donepezil and memantine in moderate to severe Alzheimer's disease (the DOMINO-AD trial).

scientific article published on 13 October 2016

DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCT

scientific article published on 24 July 2009

DOWNREGULATED APOPTOSIS AND AUTOPHAGY AFTER ANTI-Aβ IMMUNOTHERAPY IN ALZHEIMER'S DISEASE.

scientific article

Depression in Alzheimer's disease: the effect of serotonin receptor gene variation

scientific article published in May 2003

Development of a core outcome set for disease modification trials in mild to moderate dementia: a systematic review, patient and public consultation and consensus recommendations.

scientific article published in May 2017

Donepezil and memantine for moderate-to-severe Alzheimer's disease.

scientific article

Effect of active Aβ immunotherapy on neurons in human Alzheimer's disease

scientific article published on 7 January 2015

Effect of amyloid-β (Aβ) immunization on hyperphosphorylated tau: a potential role for glycogen synthase kinase (GSK)-3β.

scientific article published in June 2015

Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

scholarly article published in Nature Genetics

Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

article

Etanercept in Alzheimer disease: A randomized, placebo-controlled, double-blind, phase 2 trial

scientific article published on May 2015

Evaluating the effects of the novel GLP-1 analogue liraglutide in Alzheimer's disease: study protocol for a randomised controlled trial (ELAD study)

scientific article published on 03 April 2019

Examining for association between candidate gene polymorphisms in the dopamine pathway and attention-deficit hyperactivity disorder: a family-based study

scientific article published in July 2001

Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease

scientific article

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease

scientific article (publication date: 15 November 2010)

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 28 February 2019

Genetic variation in the 5-HT2A receptor and altered neocortical [3H] ketanserin binding in Alzheimer's disease.

scientific article

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

scientific article

Inflammation and dementia: Using rheumatoid arthritis as a model to develop treatments?

scientific article published on 10 July 2018

Inflammation in Alzheimer's disease: relevance to pathogenesis and therapy ⬇️

scientific article published on 22 January 2010

Inflammatory components in human Alzheimer's disease and after active amyloid-β42 immunization

scientific article published on 13 August 2013

Lavender oil as a treatment for agitated behaviour in severe dementia: a placebo controlled study.

scientific article published in April 2002

Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

scientific article

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

scientific article

Microglial alterations in human Alzheimer's disease following Aβ42 immunization.

scientific article published in August 2011

Microglial priming in neurodegenerative disease

scientific article published on 18 March 2014

Neuropathology after active Abeta42 immunotherapy: implications for Alzheimer's disease pathogenesis.

scientific article published on 15 July 2010

Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

scientific article published on 17 March 2003

Neuropsychiatric syndromes in dementia. Results from the European Alzheimer Disease Consortium: part I.

scientific article published on 7 November 2007

No association between CHRNA7 microsatellite markers and attention-deficit hyperactivity disorder

scientific article published in December 2001

Nursing home placement in the Donepezil and Memantine in Moderate to Severe Alzheimer's Disease (DOMINO-AD) trial: secondary and post-hoc analyses.

scientific article published on 26 October 2015

Periodontitis and Cognitive Decline in Alzheimer's Disease.

scientific article

Pharmacological profile of an essential oil derived from Melissa officinalis with anti-agitation properties: focus on ligand-gated channels.

scientific article

Pharmacological profile of essential oils derived from Lavandula angustifolia and Melissa officinalis with anti-agitation properties: focus on ligand-gated channels

scientific article published in November 2008

Phase 3 trial of flutemetamol labeled with radioactive fluorine 18 imaging and neuritic plaque density.

scientific article published in March 2015

Proinflammatory cytokines and the clinical features of dementia with lewy bodies.

scientific article published in January 2015

Proinflammatory cytokines, sickness behavior, and Alzheimer disease ⬇️

scientific article published on July 13, 2011

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

scientific article

Rate of progression of cognitive decline in Alzheimer's disease: effect of butyrylcholinesterase K gene variation

scientific article

Reduction of aggregated Tau in neuronal processes but not in the cell bodies after Abeta42 immunisation in Alzheimer's disease

scientific article

Risperidone and rivastigmine and agitated behaviour in severe Alzheimer's disease: a randomised double blind placebo controlled study.

scientific article published in April 2007

SCA12 is a rare locus for autosomal dominant cerebellar ataxia: a study of an Indian family

scientific article

Selective loss of dopamine D2 receptors in temporal cortex in dementia with Lewy bodies, association with cognitive decline.

scientific article published in November 2007

Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study

scientific article published in April 2007

Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial

scientific article published on 19 July 2011

Study of the use of antidepressants for depression in dementia: the HTA-SADD trial--a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine.

scientific article

Systemic infection modifies the neuroinflammatory response in late stage Alzheimer's disease

article

Systemic infection, interleukin 1beta, and cognitive decline in Alzheimer's disease.

scientific article

Targeting innate immunity for neurodegenerative disorders of the central nervous system

scientific article

The clinical phenotype of familial and sporadic late onset Alzheimer's disease

scientific article

The influence of TNF inhibitors on dementia incidence in patients with rheumatoid arthritis; an analysis from the BSRBR-RA.

scientific article published in March 2018

The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease

scientific article

Visual hallucinations are associated with lower alpha bungarotoxin binding in dementia with Lewy bodies

scientific article published in December 2001

List of works by Clive Holmes

A double-blind placebo-controlled randomized trial of Melissa officinalis oil and donepezil for the treatment of agitation in Alzheimer's disease

A novel Alzheimer disease locus located near the gene encoding tau protein.

A positive association between 5HT re-uptake binding sites and depression in dementia with Lewy bodies.

A randomised placebo controlled study to assess the effects of cholinergic treatment on muscarinic receptors in Alzheimer's disease ⬇️

AD2000: design and conclusions.

Alzheimer's disease polygenic risk score as a predictor of conversion from mild-cognitive impairment

Amyloid-β vaccination for Alzheimer's dementia – Authors' reply

Association between interleukin 1-beta promoter (-511) polymorphism and depressive symptoms in Alzheimer's disease.

Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Aβ immunotherapy for Alzheimer's disease: effects on apoE and cerebral vasculopathy.

Brief psychosocial therapy for the treatment of agitation in Alzheimer disease (the CALM-AD trial).

CAG/CTG repeat expansions at the Huntington's disease-like 2 locus are rare in Huntington's disease patients

Clinical practice with anti-dementia drugs: A revised (third) consensus statement from the British Association for Psychopharmacology

Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling

Common polygenic variation enhances risk prediction for Alzheimer's disease

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease

Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain.

Core outcome measures for interventions to prevent or slow the progress of dementia for people living with mild to moderate dementia: Systematic review and consensus recommendations.

Correction to: The Edinburgh Consensus: preparing for the advent of disease-modifying therapies for Alzheimer's disease.

Cost-effectiveness of donepezil and memantine in moderate to severe Alzheimer's disease (the DOMINO-AD trial).

DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCT

DOWNREGULATED APOPTOSIS AND AUTOPHAGY AFTER ANTI-Aβ IMMUNOTHERAPY IN ALZHEIMER'S DISEASE.

Depression in Alzheimer's disease: the effect of serotonin receptor gene variation

Development of a core outcome set for disease modification trials in mild to moderate dementia: a systematic review, patient and public consultation and consensus recommendations.

Donepezil and memantine for moderate-to-severe Alzheimer's disease.

Effect of active Aβ immunotherapy on neurons in human Alzheimer's disease

Effect of amyloid-β (Aβ) immunization on hyperphosphorylated tau: a potential role for glycogen synthase kinase (GSK)-3β.

Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

Etanercept in Alzheimer disease: A randomized, placebo-controlled, double-blind, phase 2 trial

Evaluating the effects of the novel GLP-1 analogue liraglutide in Alzheimer's disease: study protocol for a randomised controlled trial (ELAD study)

Examining for association between candidate gene polymorphisms in the dopamine pathway and attention-deficit hyperactivity disorder: a family-based study

Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Genetic variation in the 5-HT2A receptor and altered neocortical [3H] ketanserin binding in Alzheimer's disease.

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

Inflammation and dementia: Using rheumatoid arthritis as a model to develop treatments?

Inflammation in Alzheimer's disease: relevance to pathogenesis and therapy ⬇️

Inflammatory components in human Alzheimer's disease and after active amyloid-β42 immunization

Lavender oil as a treatment for agitated behaviour in severe dementia: a placebo controlled study.

Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Microglial alterations in human Alzheimer's disease following Aβ42 immunization.

Microglial priming in neurodegenerative disease

Neuropathology after active Abeta42 immunotherapy: implications for Alzheimer's disease pathogenesis.

Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

Neuropsychiatric syndromes in dementia. Results from the European Alzheimer Disease Consortium: part I.

No association between CHRNA7 microsatellite markers and attention-deficit hyperactivity disorder

Nursing home placement in the Donepezil and Memantine in Moderate to Severe Alzheimer's Disease (DOMINO-AD) trial: secondary and post-hoc analyses.

Periodontitis and Cognitive Decline in Alzheimer's Disease.

Pharmacological profile of an essential oil derived from Melissa officinalis with anti-agitation properties: focus on ligand-gated channels.

Pharmacological profile of essential oils derived from Lavandula angustifolia and Melissa officinalis with anti-agitation properties: focus on ligand-gated channels

Phase 3 trial of flutemetamol labeled with radioactive fluorine 18 imaging and neuritic plaque density.

Proinflammatory cytokines and the clinical features of dementia with lewy bodies.

Proinflammatory cytokines, sickness behavior, and Alzheimer disease ⬇️

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Rate of progression of cognitive decline in Alzheimer's disease: effect of butyrylcholinesterase K gene variation

Reduction of aggregated Tau in neuronal processes but not in the cell bodies after Abeta42 immunisation in Alzheimer's disease

Risperidone and rivastigmine and agitated behaviour in severe Alzheimer's disease: a randomised double blind placebo controlled study.

SCA12 is a rare locus for autosomal dominant cerebellar ataxia: a study of an Indian family

Selective loss of dopamine D2 receptors in temporal cortex in dementia with Lewy bodies, association with cognitive decline.

Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study

Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial

Study of the use of antidepressants for depression in dementia: the HTA-SADD trial--a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine.

Systemic infection modifies the neuroinflammatory response in late stage Alzheimer's disease

Systemic infection, interleukin 1beta, and cognitive decline in Alzheimer's disease.

Targeting innate immunity for neurodegenerative disorders of the central nervous system

The clinical phenotype of familial and sporadic late onset Alzheimer's disease

The influence of TNF inhibitors on dementia incidence in patients with rheumatoid arthritis; an analysis from the BSRBR-RA.

The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease

Visual hallucinations are associated with lower alpha bungarotoxin binding in dementia with Lewy bodies