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List of works by Patrick L Iversen

A hexameric phosphorothioate oligonucleotide telomerase inhibitor arrests growth of Burkitt's lymphoma cells in vitro and in vivo.

scientific article published on May 1997

A k-mer based transcriptomics approach for antisense drug discovery targeting the Ewing's family of tumors

scientific article published on 17 July 2018

A morpholino oligomer targeting highly conserved internal ribosome entry site sequence is able to inhibit multiple species of picornavirus.

scientific article

A novel antisense inhibitor of MMP-9 attenuates angiogenesis, human prostate cancer cell invasion and tumorigenicity.

scientific article

Active specific immunotherapy with a beta-human chorionic gonadotropin peptide vaccine in patients with metastatic colorectal cancer: antibody response is associated with improved survival

scientific article published on 01 July 2002

Advanced antisense therapies for postexposure protection against lethal filovirus infections.

scientific article

Advanced c-myc antisense (AVI-4126)-eluting phosphorylcholine-coated stent implantation is associated with complete vascular healing and reduced neointimal formation in the porcine coronary restenosis model

scientific article published in April 2004

Alternative Splicing in the Cytochrome P450 Superfamily Expands Protein Diversity to Augment Gene Function and Redirect Human Drug Metabolism.

scientific article published on 10 February 2017

Alternative Splicing in the Nuclear Receptor Superfamily Expands Gene Function to Refine Endo-Xenobiotic Metabolism

scientific article published on 24 January 2020

Alternative splice forms of CTLA-4 induced by antisense mediated splice-switching influences autoimmune diabetes susceptibility in NOD mice.

scientific article

Alternative splicing of the vitamin D receptor modulates target gene expression and promotes ligand-independent functions

scientific article published on 12 December 2018

An experimental model for interpreting percutaneous penetration of oligonucleotides that incorporates the role of keratinocytes

scientific article published on 01 December 1998

An in vitro model for endothelial permeability: assessment of monolayer integrity.

scientific article published in December 1995

Androgen receptor down-regulation in prostate cancer with phosphorodiamidate morpholino antisense oligomers.

scientific article published on September 2004

Antisense morpholino-oligomers directed against the 5' end of the genome inhibit coronavirus proliferation and growth

scientific article

Antisense oligonucleotide OL (1) p53 for in vitro purging of autologous bone marrow in acute myelogenous leukemia

scientific article published on 01 January 1994

Antisense oligonucleotide induced exon skipping and the dystrophin gene transcript: cocktails and chemistries

scientific article (publication date: 2 July 2007)

Antisense oligonucleotide of c-myc discriminates between zinc- and dexamethasone-induced synthesis of metallothionein

scientific article published on 01 February 1994

Antisense oligonucleotide-mediated inhibition of metallothionein protein synthesis in neuroblastoma IMR 32 and Chang liver cells in culture

scientific article published on March 1, 1992

Antisense phosphorodiamidate morpholino oligomer inhibits viability of Escherichia coli in pure culture and in mouse peritonitis.

scientific article published on 4 May 2005

Antisense phosphorodiamidate morpholino oligomer length and target position effects on gene-specific inhibition in Escherichia coli.

scientific article

Antisense phosphorodiamidate morpholino oligomers targeted to an essential gene inhibit Burkholderia cepacia complex.

scientific article

Antisense targeting of cFLIP sensitizes activated T cells to undergo apoptosis and desensitizes responses to contact dermatitis.

scientific article published on 19 February 2009

Antisense therapy for restenosis following percutaneous coronary intervention.

scientific article

Antiviral activity of morpholino oligomers designed to block various aspects of Equine arteritis virus amplification in cell culture.

scientific article published on November 2005

Arginine-rich cell penetrating peptides: design, structure-activity, and applications to alter pre-mRNA splicing by steric-block oligonucleotides.

scientific article published on April 2008

Arginine-rich cell-penetrating peptide dramatically enhances AMO-mediated ATM aberrant splicing correction and enables delivery to brain and cerebellum.

scientific article

Arginine-rich cell-penetrating peptides facilitate delivery of antisense oligomers into murine leukocytes and alter pre-mRNA splicing

scientific article published on 27 July 2007

Arginine-rich peptide conjugation to morpholino oligomers: effects on antisense activity and specificity.

scientific article

Bacterial resistance to antisense peptide phosphorodiamidate morpholino oligomers

scientific article

Benzimidazoisoquinolines: a new class of rapidly metabolized aryl hydrocarbon receptor (AhR) ligands that induce AhR-dependent Tregs and prevent murine graft-versus-host disease

scientific article

Binding of antisense phosphorothioate oligonucleotides to murine lymphocytes is lineage specific and inducible

scientific article published on January 1, 1992

By-passing the nonsense mutation in the 4 CV mouse model of muscular dystrophy by induced exon skipping

scientific article published on 01 January 2009

Cationic phosphorodiamidate morpholino oligomers efficiently prevent growth of Escherichia coli in vitro and in vivo.

scientific article published in January 2010

Cell-penetrating peptide-morpholino conjugates alter pre-mRNA splicing of DMD (Duchenne muscular dystrophy) and inhibit murine coronavirus replication in vivo.

scientific article published on August 2007

Cellular uptake and subcellular distribution of phosphorothioate oligonucleotides into cultured cells

scientific article published on January 1, 1992

Cellular uptake of antisense morpholino oligomers conjugated to arginine-rich peptides.

scientific article published on March 2004

Cellular uptake of neutral phosphorodiamidate morpholino oligomers.

scientific article

Characterization of Binding Sites, Extent of Binding, and Drug Interactions of Oligonucleotides with Albumin ⬇️

scientific article published on January 1, 1995

Characterization of a variety of standard collagen substrates: ultrastructure, uniformity, and capacity to bind and promote growth of neurons

scientific article published on 01 June 1981

Chromatographic and spectral investigations on the in vivo metabolites of 6-nitrobenzo[a]pyrene

scientific article published on 01 October 1988

Combination of antisense oligonucleotide and low-dose chemotherapy in hematological malignancies.

scientific article

Complete vascular healing and sustained suppression of neointimal thickening after local delivery of advanced c-myc antisense at six months follow-up in a rabbit balloon injury model

scientific article published in January 2002

Continuous infusion of antisense phosphorothioate therapeutics

scientific article published on 01 January 1996

Delayed Time-to-Treatment of an Antisense Morpholino Oligomer Is Effective against Lethal Marburg Virus Infection in Cynomolgus Macaques

scientific article (publication date: February 2016)

Delivery of steric block morpholino oligomers by (R-X-R)4 peptides: structure-activity studies.

scientific article published on 16 September 2008

Depleting regulatory T cells with arginine-rich, cell-penetrating, peptide-conjugated morpholino oligomer targeting FOXP3 inhibits regulatory T-cell function.

scientific article

Detection of vesicular exanthema of swine-like calicivirus in tissues from a naturally infected spontaneously aborted bovine fetus

scientific article published on 01 February 2002

Down-regulation of SNAIL suppresses MIN mouse tumorigenesis: modulation of apoptosis, proliferation, and fractal dimension.

scientific article

Effects of Size and Sequence on the lontophoretic Delivery of Oligonucleotidest ⬇️

scientific article published on January 1, 1998

Effects of millimeter-wave radiation on monolayer cell cultures. II. Scanning and transmission electron microscopy

scientific article published on 01 January 1981

Effects of systemic multiexon skipping with peptide-conjugated morpholinos in the heart of a dog model of Duchenne muscular dystrophy

scientific article

Evaluation of antisense mechanisms of action

scientific article published on 01 January 2000

Evidence of enhanced iron excretion during systemic phosphorothioate oligodeoxynucleotide treatment

scientific article published on 01 January 2000

Ex Vivo Treatment of Bone Marrow with Phosphorothioate Oligonucleotide OL(l)p53 for Autologous Transplantation in Acute Myelogenous Leukemia and Myelodysplastic Syndrome ⬇️

scientific article published on 01 October 1997

Expression and regulation of brain metallothionein ⬇️

scientific article published on July 1, 1995

First human experience with local delivery of novel antisense AVI-4126 with Infiltrator catheter in de novo native and restenotic coronary arteries: 6-month clinical and angiographic follow-up from AVAIL study

scientific article published in October 2007

Gene structure and nucleotide sequence for rat cytochrome P-450c.

scientific article

Gene-silencing antisense oligomers inhibit acinetobacter growth in vitro and in vivo

scientific article published on 14 October 2013

Gene-specific countermeasures against Ebola virus based on antisense phosphorodiamidate morpholino oligomers.

scientific article

Gene-specific effects of antisense phosphorodiamidate morpholino oligomer-peptide conjugates on Escherichia coli and Salmonella enterica serovar typhimurium in pure culture and in tissue culture.

scientific article published on August 2006

HIV Tat peptide enhances cellular delivery of antisense morpholino oligomers.

scientific article published in February 2003

HIV-1 rev antisense phosphorothioate oligonucleotide binding to human mononuclear cells is cell type specific and inducible.

scientific article published on January 1994

INSERM/NIH Conference: antisense oligonucleotides and ribonucleases H, September, 1992

scientific article published on 01 January 1993

In vivo modulation of the rat cytochrome P450 1A1 by double-stranded phosphorothioate oligodeoxynucleotides

scientific article published on 01 December 1995

In vivo properties of an in situ forming gel for parenteral delivery of macromolecular drugs.

scientific article

Induced IL-10 splice altering approach to antiviral drug discovery.

scientific article published on 21 March 2014

Induction of cytochromes P450IA1 and P450IA2 as determined by solution hybridization ⬇️

scientific article published on June 1, 1991

Induction of revertant fibres in the mdx mouse using antisense oligonucleotides

scientific article

Inhibition and escape of SARS-CoV treated with antisense morpholino oligomers

scientific article published on January 2006

Inhibition of Gene Expression in Escherichia coli by Antisense Phosphorodiamidate Morpholino Oligomers ⬇️

scientific article published on October 1, 2003

Inhibition of HSV-1 ocular infection with morpholino oligomers targeting ICP0 and ICP27.

scientific article published on 7 August 2009

Inhibition of Vesivirus infections in mammalian tissue culture with antisense morpholino oligomers.

scientific article

Inhibition of carotid artery neointimal formation with intravenous microbubbles.

scientific article published in February 2001

Inhibition of coxsackievirus B3 in cell cultures and in mice by peptide-conjugated morpholino oligomers targeting the internal ribosome entry site.

scientific article

Inhibition of foot-and-mouth disease virus infections in cell cultures with antisense morpholino oligomers.

scientific article published on 29 August 2007

Inhibition of hepatitis E virus replication by peptide-conjugated morpholino oligomers.

scientific article published on 15 June 2015

Inhibition of human chorionic gonadotropin beta-subunit modulates the mitogenic effect of c-myc in human prostate cancer cells

scientific article published on 01 November 2002

Inhibition of infectious haematopoietic necrosis virus in cell cultures with peptide-conjugated morpholino oligomers.

scientific article

Inhibition of influenza A H3N8 virus infections in mice by morpholino oligomers

scientific article

Inhibition of measles virus infections in cell cultures by peptide-conjugated morpholino oligomers.

scientific article published on 6 January 2009

Inhibition of norovirus replication by morpholino oligomers targeting the 5'-end of the genome.

scientific article published on 09 September 2008

Inhibition of p53 expression by peptide-conjugated phosphorodiamidate morpholino oligomers sensitizes human cancer cells to chemotherapeutic drugs.

scientific article

Intracellular delivery strategies for antisense phosphorodiamidate morpholino oligomers

scientific article published on 01 August 2000

Intramural coronary delivery of advanced antisense oligonucleotides reduces neointimal formation in the porcine stent restenosis model

scientific article

Involvement of cytochrome P450 2E1-like isoform in the activation of N-nitrosobis(2-oxopropyl)amine in the rat nasal mucosa

scientific article published on 01 May 1994

Involvement of vacuolar protein sorting pathway in Ebola virus release independent of TSG101 interaction

scientific article

Iontophoretic delivery of a telomeric oligonucleotide

scientific article published on 01 June 1996

Isolation and characterization of a new Vesivirus from rabbits.

scientific article published on July 2005

Local application of antisense for prevention of restenosis

scientific article published in January 2005

Local delivery of c-myc neutrally charged antisense oligonucleotides with transport catheter inhibits myointimal hyperplasia and positively affects vascular remodeling in the rabbit balloon injury model.

scientific article

Lymphocytic choriomeningitis virus infection in FVB mouse produces hemorrhagic disease

scientific article

Manipulation of metallothionein expression in the regenerating rat liver using antisense oligonucleotides.

scientific article

Metallothionein in carcinogenesis and cancer chemotherapy.

scientific article

Microsomal cytochrome P-450 "handprints": five fractions from anion-exchange high-pressure liquid chromatography provide a rapid preliminary screen for selectivity in the induction and destruction of rat hepatic cytochrome P-450 subpopulations

scientific article published in March 1985

Monoclonal antibodies to two epitopes of beta-human chorionic gonadotropin for the treatment of cancer.

scientific article

Morpholino oligomer-mediated exon skipping averts the onset of dystrophic pathology in the mdx mouse

scientific article published on 19 June 2007

Neutrally charged phosphorodiamidate morpholino antisense oligomers: uptake, efficacy and pharmacokinetics.

scientific article

Novel site-specific systemic delivery of Rapamycin with perfluorobutane gas microbubble carrier reduced neointimal formation in a porcine coronary restenosis model

scientific article published in March 2005

Oligonucleotides in the treatment of leukemia.

scientific article published on January 1994

Peptide conjugated phosphorodiamidate morpholino oligomers increase survival of mice challenged with Ames Bacillus anthracis.

scientific article

Pharmacokinetics and biodistribution of phosphorodiamidate morpholino antisense oligomers.

scientific article

Pharmacokinetics and in vivo effects of a six-base phosphorothioate oligodeoxynucleotide with anticancer and hematopoietic activities in swine

scientific article published on 01 April 2000

Pharmacokinetics of a synthetic, chemically modified hammerhead ribozyme against the rat cytochrome P-450 3A2 mRNA after single intravenous injections.

scientific article

Pharmacokinetics, biodistribution, stability and toxicity of a cell-penetrating peptide-morpholino oligomer conjugate.

scientific article

Phase I trial of an antisense oligonucleotide OL(1)p53 in hematologic malignancies

scientific article published on 01 April 1996

Photoactivation of vascular iNOS and elevation of cGMP in vivo: possible mechanism for photovasorelaxation and inhibition of restenosis in an atherosclerotic rabbit models.

scientific article

Prenatal and presymptomatic diagnosis of the Marfan syndrome using fluorescence PCR and an automated sequencer

scientific article published on 01 June 1995

Preparation of 35S-labeled polyphosphorothioate oligodeoxyribonucleotides by use of hydrogen phosphonate chemistry

scientific article published on 01 July 1990

Qualitative and quantitative measurements of oligonucleotides in gene therapy: Part I. In vitro models.

scientific article published on April 1997

Qualitative and quantitative measurements of oligonucleotides in gene therapy: Part II in vivo models ⬇️

scientific article published on May 1, 1997

RNA-based therapeutics--from design to the clinic

scientific article published on 01 April 2009

Reaction between metabolically activated acetaminophen and phosphorothioate oligonucleotides

scientific article published on 01 July 1995

Review of in vivo pharmacokinetics and toxicology of phosphorothioate oligonucleotides.

scientific article

Safety and pharmacokinetic profiles of phosphorodiamidate morpholino oligomers with activity against ebola virus and marburg virus: results of two single-ascending-dose studies

scientific article

Safety, tolerability, and pharmacokinetics of radavirsen (AVI-7100), an antisense oligonucleotide targeting influenza a M1/M2 translation

scientific article published on 20 September 2017

Selective changes in cytochrome P-450 and UDP-glucuronosyltransferase subpopulations following partial hepatectomy in rats

scientific article published on 01 March 1985

Selective cytotoxicity to human leukemic myeloblasts produced by oligodeoxyribonucleotide phosphorothioates complementary to p53 nucleotide sequences.

scientific article published on January 1994

Selective inhibition of alpha1B-adrenergic receptor expression and function using a phosphorothioate antisense oligodeoxynucleotide.

scientific article published on June 1998

Stability of cell-penetrating peptide-morpholino oligomer conjugates in human serum and in cells.

scientific article

Structural details of the human cytochrome P-450c gene

scientific article published on 01 July 1987

Suppression of porcine reproductive and respiratory syndrome virus replication by morpholino antisense oligomers.

scientific article published on 12 July 2006

Sustained dystrophin expression induced by peptide-conjugated morpholino oligomers in the muscles of mdx mice.

scientific article published on 10 June 2008

Synergy of phenobarbital and 3-methylcholanthrene in "superinduction" of cytochrome P-450c mRNA but not enzyme activity

scientific article published on 01 October 1987

Synthetic antisense oligonucleotide probes the essentiality of metallothionein gene

scientific article published on November 1, 1992

Systemic administration of a phosphorothioate oligonucleotide with a sequence complementary to p53 for acute myelogenous leukemia and myelodysplastic syndrome: initial results of a phase I trial

scientific article published on 01 January 1993

Systemic human antisense therapy begins

scientific article published on 01 January 1992

Systemic targeted delivery of antisense with perflourobutane gas microbubble carrier reduced neointimal formation in the porcine coronary restenosis model

scientific article published in July 2003

The cytotoxic effects of single-stranded telomere mimics on OMA-BL1 cells

scientific article published on 01 October 1999

The molecular biology of the polycyclic aromatic hydrocarbon inducible cytochrome P-450; the past is prologue

scientific article published on 01 January 1986

The role of primer recognition proteins in DNA replication: inhibition of cellular proliferation by antisense oligodeoxyribonucleotides

scientific article published on January 1, 1992

The turnover of tRNAs microinjected into animal cells ⬇️

scientific article published on October 1, 1978

Transdermal delivery of antisense oligonucleotides can induce changes in gene expression in vivo.

scientific article published in February 2001

Transdermal delivery of antisense oligonucleotides.

scientific article published in January 2005

Transdermal delivery of phosphorodiamidate Morpholino oligomers across hairless mouse skin.

scientific article published in May 2004

Transdermal use of phosphorodiamidate morpholino oligomer AVI-4472 inhibits cytochrome P450 3A2 activity in male rats.

scientific article published in October 2002

Treatment of AG129 mice with antisense morpholino oligomers increases survival time following challenge with dengue 2 virus.

scientific article

Treatment of highly pathogenic filovirus infections using advanced antisense technology

Tumor cell growth is inhibited by suppressing metallothionein-I synthesis

scientific article published on 01 June 1997

Variations in amino acid composition of antisense peptide-phosphorodiamidate morpholino oligomer affect potency against Escherichia coli in vitro and in vivo.

scientific article published on 17 November 2008

Vectorization of morpholino oligomers by the (R-Ahx-R)4 peptide allows efficient splicing correction in the absence of endosomolytic agents.

scientific article

Vesivirus viremia and seroprevalence in humans.

scientific article

Viral diversity and clonal evolution from unphased genomic data.

scientific article

Virus-specific antiviral treatment for controlling severe and fatal outbreaks of feline calicivirus infection.

scientific article published in January 2008

c-MYC antisense phosphosphorodiamidate morpholino oligomer inhibits lung metastasis in a murine tumor model.

scientific article published on 21 December 2007

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