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List of works by Mechthild Krause

"Radiobiology of Proton Therapy": Results of an international expert workshop

scientific article published on 01 June 2018

A Five-MicroRNA Signature Predicts Survival and Disease Control of Patients with Head and Neck Cancer Negative for HPV Infection

scientific article published on 31 August 2018

A Monte Carlo based radiation response modelling framework to assess variability of clinical RBE in proton therapy

scientific article published on 21 November 2019

A comparative study of machine learning methods for time-to-event survival data for radiomics risk modelling. ⬇️

scientific article published on 16 October 2017

A novel poly(ADP-ribose) polymerase inhibitor, ABT-888, radiosensitizes malignant human cell lines under hypoxia

scientific article

Adjuvant inhibition of the epidermal growth factor receptor after fractionated irradiation of FaDu human squamous cell carcinoma.

scientific article published in July 2004

Adoptive transfer of cytotoxic T-cells for treatment of residual disease after irradiation

scientific article published on November 2007

Advances in radiotherapy special feature.

scientific article published on 26 May 2015

Aldehyde Dehydrogenase Is Regulated by β-Catenin/TCF and Promotes Radioresistance in Prostate Cancer Progenitor Cells

scientific article

An Epigenetic Reprogramming Strategy to Resensitize Radioresistant Prostate Cancer Cells.

scientific article published on 16 March 2016

An optimized small animal tumour model for experimentation with low energy protons.

scientific article

Applying Tissue Slice Culture in Cancer Research-Insights from Preclinical Proton Radiotherapy

scientific article published on 16 June 2020

CD44: A Cancer Stem Cell–Related Biomarker with Predictive Potential for Radiotherapy ⬇️

scientific article published on September 22, 2010

CD8+ tumour-infiltrating lymphocytes in relation to HPV status and clinical outcome in patients with head and neck cancer after postoperative chemoradiotherapy: A multicentre study of the German cancer consortium radiation oncology group (DKTK-ROG).

scientific article

CT imaging during treatment improves radiomic models for patients with locally advanced head and neck cancer

scientific article published on 04 August 2018

Can Local Ablative Radiotherapy Revert Castration-resistant Prostate Cancer to an Earlier Stage of Disease?

scientific article published on 18 December 2018

Cancer stem cells and radiotherapy.

scientific article published on May 2009

Cancer stem cells at the crossroads of current cancer therapy failures--radiation oncology perspective

scientific article published on 26 February 2010

Cancer stem cells: Radioresistance, prediction of radiotherapy outcome and specific targets for combined treatments

scientific article

Cancer stem cells: targets and potential biomarkers for radiotherapy

scientific article

Cellular and tumor radiosensitivity is correlated to epidermal growth factor receptor protein expression level in tumors without EGFR amplification

scientific article published on 20 April 2011

Cetuximab attenuates its cytotoxic and radiosensitizing potential by inducing fibronectin biosynthesis

scientific article published on 15 August 2013

Characterization of a switchable chimeric antigen receptor platform in a pre-clinical solid tumor model.

scientific article published on 20 June 2017

Clinical Implementation of Dual-energy CT for Proton Treatment Planning on Pseudo-monoenergetic CT scans

scientific article published on 21 October 2016

Clinical biomarkers of kinase activity: examples from EGFR inhibition trials

scientific article published on September 2008

Clinical trials for personalized glioblastoma radiotherapy: Markers for efficacy and late toxicity but often delayed treatment - Does that matter?

scientific article published on 01 January 2016

Cognitive deficits following brain tumor radiation therapy

scientific article published on 20 September 2017

Combination of EGFR/HER2 tyrosine kinase inhibition by BIBW 2992 and BIBW 2669 with irradiation in FaDu human squamous cell carcinoma.

scientific article published on May 2007

Combined treatment of the immunoconjugate bivatuzumab mertansine and fractionated irradiation improves local tumour control in vivo.

scientific article

Combining precision radiotherapy with molecular targeting and immunomodulatory agents: a guideline by the American Society for Radiation Oncology

scientific article published on 01 May 2018

Comparative analysis of transcriptomics based hypoxia signatures in head- and neck squamous cell carcinoma

scientific article

Comparison of detection methods for HPV status as a prognostic marker for loco-regional control after radiochemotherapy in patients with HNSCC.

scientific article published on 30 December 2017

Comparison study of in vivo dose response to laser-driven versus conventional electron beam.

scientific article published on 20 January 2015

Concept for individualized patient allocation: ReCompare--remote comparison of particle and photon treatment plans

scientific article published on 18 February 2014

Corrigendum to “HPV16 DNA status is a strong prognosticator of loco-regional control after postoperative radiochemotherapy of locally advanced oropharyngeal carcinoma: Results from a multicentre explorative study of the German Cancer Consortium Rad

article

Creating a data exchange strategy for radiotherapy research: towards federated databases and anonymised public datasets

scientific article

DNA Damage Response Assessments in Human Tumor Samples Provide Functional Biomarkers of Radiosensitivity

scientific article

Decreased repopulation as well as increased reoxygenation contribute to the improvement in local control after targeting of the EGFR by C225 during fractionated irradiation

scientific article published on August 2005

Development and validation of NTCP models for acute side-effects resulting from proton beam therapy of brain tumours

scientific article published on 20 July 2018

Development and validation of a gene signature for patients with head and neck squamous cell carcinomas treated by postoperative radio(chemo)therapy.

scientific article published on 3 January 2018

Development of a genetic sensor that eliminates p53 deficient cells

scientific article published on 13 November 2017

Different classes of EGFR inhibitors may have different potential to improve local tumour control after fractionated irradiation: a study on C225 in FaDu hSCC.

scientific article published on 25 November 2004

Diverse effects of combined radiotherapy and EGFR inhibition with antibodies or TK inhibitors on local tumour control and correlation with EGFR gene expression

scientific article published on 12 June 2011

Does heterogeneity of pimonidazole labelling correspond to the heterogeneity of radiation-response of FaDu human squamous cell carcinoma?

scientific article published on August 2005

Dose-guided patient positioning in proton radiotherapy using multicriteria-optimization

scientific article published on 05 November 2018

EGF receptor inhibition radiosensitizes NSCLC cells by inducing senescence in cells sustaining DNA double-strand breaks

scientific article published on 18 August 2011

EGFR-TK inhibition before radiotherapy reduces tumour volume but does not improve local control: differential response of cancer stem cells and nontumourigenic cells?

scientific article published on 24 May 2007

EGFR-amplification plus gene expression profiling predicts response to combined radiotherapy with EGFR-inhibition: A preclinical trial in 10 HNSCC-tumour-xenograft models

scientific article published on 11 August 2017

EGFR-mediated chromatin condensation protects KRAS-mutant cancer cells against ionizing radiation

scientific article

EGFR-targeted anti-cancer drugs in radiotherapy: preclinical evaluation of mechanisms

scientific article published on 14 May 2007

ESTRO consensus guideline on target volume delineation for elective radiation therapy of early stage breast cancer

scientific article published on 24 January 2015

ESTRO consensus guideline on target volume delineation for elective radiation therapy of early stage breast cancer, version 1.1.

scientific article published on 18 January 2016

Early and late effects of radiochemotherapy on cerebral blood flow in glioblastoma patients measured with non-invasive perfusion MRI.

scientific article published on 30 December 2015

Effect of [(18)F]FMISO stratified dose-escalation on local control in FaDu hSCC in nude mice

scientific article published on 14 March 2014

Effect of cetuximab and fractionated irradiation on tumour micro-environment

scientific article published on November 2010

Effect of combined irradiation and EGFR/Erb-B inhibition with BIBW 2992 on proliferation and tumour cure in cell lines and xenografts.

scientific article

Effect of the hypoxic cell sensitizer isometronidazole on local control of two human squamous cell carcinomas after fractionated irradiation.

scientific article

Effects of lovastatin alone or combined with irradiation on tumor cells in vitro and in vivo

scientific article published on January 2008

Epidermal growth factor receptor inhibitors for radiotherapy: biological rationale and preclinical results.

scientific article

Epidermal growth factor receptor targeting and its role for individualisation in radiation oncology.

scientific article published in September 2013

Establishment and Characterisation of Heterotopic Patient-Derived Xenografts for Glioblastoma

scientific article published on 03 April 2020

Establishment of a small animal tumour model for in vivo studies with low energy laser accelerated particles

scientific article

Experimental evaluation of functional imaging for radiotherapy

scientific article

Exploring the role of cancer stem cells in radioresistance

scientific article

FDG uptake in normal tissues assessed by PET during treatment has prognostic value for treatment results in head and neck squamous cell carcinomas undergoing radiochemotherapy.

scientific article published on 17 February 2017

FMISO-PET-based lymph node hypoxia adds to the prognostic value of tumor only hypoxia in HNSCC patients

article

Final results of the prospective biomarker trial PETra: [<sup>11</sup>C]-MET-accumulation in postoperative PET/MRI predicts outcome after radiochemotherapy in glioblastoma

scientific article published on 29 December 2020

Final results of the randomized phase III CHARTWEL-trial (ARO 97-1) comparing hyperfractionated-accelerated versus conventionally fractionated radiotherapy in non-small cell lung cancer (NSCLC)

scientific article published on 13 July 2011

GTV differentially impacts locoregional control of non-small cell lung cancer (NSCLC) after different fractionation schedules: subgroup analysis of the prospective randomized CHARTWEL trial

scientific article

Genehmigungsverfahren klinischer Studien im Bereich der Radioonkologie

scientific article published on 01 December 2015

German Cancer Consortium (DKTK) - A national consortium for translational cancer research

article

Glioblastoma multiforme: emerging treatments and stratification markers beyond new drugs

scientific article

HPV status, cancer stem cell marker expression, hypoxia gene signatures and tumour volume identify good prognosis subgroups in patients with HNSCC after primary radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Rad

scientific article published on 29 November 2016

HPV16 DNA status is a strong prognosticator of loco-regional control after postoperative radiochemotherapy of locally advanced oropharyngeal carcinoma: results from a multicentre explorative study of the German Cancer Consortium Radiation Oncology G

scientific article published on 2 December 2014

Haploidentical bone marrow transplantation with post-grafting cyclophosphamide: multicenter experience with an alternative salvage strategy

scientific article published on 11 February 2011

Heat shock protein 70 and tumor-infiltrating NK cells as prognostic indicators for patients with squamous cell carcinoma of the head and neck after radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Radiation Oncolo

scientific article published on 13 December 2017

Heterogeneity of tumour response to combined radiotherapy and EGFR inhibitors: differences between antibodies and TK inhibitors

scientific article

Heterogeneity of γH2AX Foci Increases in Ex Vivo Biopsies Relative to In Vivo Tumors

scientific article published on 04 September 2018

Human gastric cancer modelling using organoids

scientific article published on 27 April 2018

IF-RT alone remains gold standard for stage IA nodular lymphocyte-predominant Hodgkin lymphoma

scientific article published on 18 May 2016

Identification of Patient Benefit From Proton Therapy for Advanced Head and Neck Cancer Patients Based on Individual and Subgroup Normal Tissue Complication Probability Analysis

scientific article published on 23 April 2015

Impact of adjuvant inhibition of vascular endothelial growth factor receptor tyrosine kinases on tumor growth delay and local tumor control after fractionated irradiation in human squamous cell carcinomas in nude mice

scientific article published in March 2005

Impact of increased cell loss on the repopulation rate during fractionated irradiation in human FaDu squamous cell carcinoma growing in nude mice

scientific article published on 01 July 2003

Impact of pre- and early per-treatment FDG-PET based dose-escalation on local tumour control in fractionated irradiated FaDu xenograft tumours.

scientific article published on 17 August 2016

Impact of the adaptor protein GIPC1/Synectin on radioresistance and survival after irradiation of prostate cancer ⬇️

scientific article published on November 7, 2012

Impact of waiting time after surgery and overall time of postoperative radiochemotherapy on treatment outcome in glioblastoma multiforme

scientific article

Implementation of a software for REmote COMparison of PARticlE and photon treatment plans: ReCompare.

scientific article published on 24 February 2015

Improving external beam radiotherapy by combination with internal irradiation

scientific article

In regard to Solomon et al.: EGFR blockade with ZD1839 ("Iressa") potentiates the antitumor effects of single and multiple fractions of ionizing radiation in human A431 squamous cell carcinoma. IJROBP 2003;55:713-723

scientific article published on 01 September 2003

In vivo studies of the PARP inhibitor, AZD-2281, in combination with fractionated radiotherapy: An exploration of the therapeutic ratio

scientific article published on 12 August 2015

Increase in Tumor Control and Normal Tissue Complication Probabilities in Advanced Head-and-Neck Cancer for Dose-Escalated Intensity-Modulated Photon and Proton Therapy

scientific article

Increased FDG uptake on late-treatment PET in non-tumour-affected oesophagus is prognostic for pathological complete response and disease recurrence in patients undergoing neoadjuvant radiochemotherapy

Independent validation of a new reirradiation risk score (RRRS) for glioma patients predicting post-recurrence survival: A multicenter DKTK/ROG analysis

scientific article published on 9 February 2018

Independent validation of the prognostic value of cancer stem cell marker expression and hypoxia-induced gene expression for patients with locally advanced HNSCC after postoperative radiotherapy.

scientific article

Independent validation of tumour volume, cancer stem cell markers and hypoxia-associated gene expressions for HNSCC after primary radiochemotherapy

article

Individualization of cancer treatment from radiotherapy perspective

scientific article published on 09 February 2012

Internal and external validation of an ESTRO delineation guideline - dependent automated segmentation tool for loco-regional radiation therapy of early breast cancer

scientific article

Intratumoral heterogeneity and TERT promoter mutations in progressive/higher-grade meningiomas

scientific article

Kinetics of EGFR expression during fractionated irradiation varies between different human squamous cell carcinoma lines in nude mice

scientific article published on August 2005

Late onset Li-Fraumeni Syndrome with bilateral breast cancer and other malignancies: case report and review of the literature

scientific article

Long-term efficacy of reduced-intensity versus myeloablative conditioning before allogeneic haemopoietic cell transplantation in patients with acute myeloid leukaemia in first complete remission: retrospective follow-up of an open-label, randomised

scientific article published on 14 March 2018

Long-term quality of life in inoperable non-small cell lung cancer patients treated with conventionally fractionated compared to hyperfractionated accelerated radiotherapy - Results of the randomized CHARTWEL trial

scientific article published on 19 December 2017

Low Cancer Stem Cell Marker Expression and Low Hypoxia Identify Good Prognosis Subgroups in HPV(-) HNSCC after Postoperative Radiochemotherapy: A Multicenter Study of the DKTK-ROG.

scientific article published on 11 January 2016

Low-dose hyperradiosensitivity of human glioblastoma cell lines in vitro does not translate into improved outcome of ultrafractionated radiotherapy in vivo

scientific article published in October 2005

Modeling in vivo relative biological effectiveness in particle therapy for clinically relevant endpoints

scientific article published on 29 August 2017

Modeling tumor control probability for spatially inhomogeneous risk of failure based on clinical outcome data

scientific article

Molecular targeting in radiotherapy of lung cancer.

scientific article

NTCP reduction for advanced head and neck cancer patients using proton therapy for complete or sequential boost treatment versus photon therapy

scientific article published on 4 September 2015

Neoadjuvant Radiochemotherapy Significantly Alters the Phenotype of Plasmacytoid Dendritic Cells and 6-Sulfo LacNAc Monocytes in Rectal Cancer

Neoadjuvant radiochemotherapy decreases the total amount of tumor infiltrating lymphocytes, but increases the number of CD8+/Granzyme B+ (GrzB) cytotoxic T-cells in rectal cancer

scientific article published on 07 November 2017

PORTAF - postoperative radiotherapy of non-small cell lung cancer: accelerated versus conventional fractionation - study protocol for a randomized controlled trial.

scientific article published on 20 December 2017

PRONTOX - proton therapy to reduce acute normal tissue toxicity in locally advanced non-small-cell lung carcinomas (NSCLC): study protocol for a randomised controlled trial

scientific article

Personalized Radiation Oncology: Epidermal Growth Factor Receptor and Other Receptor Tyrosine Kinase Inhibitors

scientific article published on January 2016

Photon vs. proton radiochemotherapy: Effects on brain tissue volume and perfusion.

scientific article

Pimonidazole labelling and response to fractionated irradiation of five human squamous cell carcinoma (hSCC) lines in nude mice: the need for a multivariate approach in biomarker studies.

scientific article published on 7 September 2006

Potential clinical predictors of outcome after postoperative radiotherapy of non-small cell lung cancer

scientific article published on 12 January 2014

Pre-clinical imaging for establishment and comparison of orthotopic non-small cell lung carcinoma: in search for models reflecting clinical scenarios

scientific article published on 11 October 2018

Pre-clinical research in small animals using radiotherapy technology--a bidirectional translational approach

scientific article

Precise image-guided irradiation of small animals: a flexible non-profit platform

scientific article published on 23 March 2016

Preclinical evaluation of molecular-targeted anticancer agents for radiotherapy.

scientific article published on 17 August 2006

Predicting late magnetic resonance image changes in glioma patients after proton therapy

scientific article published on 15 July 2019

Prediction of clonogenic cell survival curves based on the number of residual DNA double strand breaks measured by gammaH2AX staining

scientific article

Profile of European proton and carbon ion therapy centers assessed by the EORTC facility questionnaire

scientific article

Proliferation and micromilieu during fractionated irradiation of human FaDu squamous cell carcinoma in nude mice ⬇️

scientific article published on July 1, 2003

Proton radiography for inline treatment planning and positioning verification of small animals.

scientific article

Quality assessment of delineation and dose planning of early breast cancer patients included in the randomized Skagen Trial 1.

scientific article

Radiation Resistance in KRAS-Mutated Lung Cancer Is Enabled by Stem-like Properties Mediated by an Osteopontin-EGFR Pathway

scientific article published on 15 February 2017

Radiation oncology in the era of precision medicine.

scientific article published on 18 March 2016

Radio-chemotherapy improves survival in IDH-mutant, 1p/19q non-codeleted secondary high-grade astrocytoma patients.

scientific article

Radiolabeled Cetuximab Conjugates for EGFR Targeted Cancer Diagnostics and Therapy

scientific article published on 05 March 2014

Radiolabeled anti-EGFR-antibody improves local tumor control after external beam radiotherapy and offers theragnostic potential

scientific article published on 16 January 2014

Radiosensitization of NSCLC cells by EGFR inhibition is the result of an enhanced p53-dependent G1 arrest

scientific article

Radiotherapy and "new" drugs-new side effects?

scientific article

Re-irradiation of recurrent gliomas: pooled analysis and validation of an established prognostic score-report of the Radiation Oncology Group (ROG) of the German Cancer Consortium (DKTK).

scientific article published on 23 March 2018

Recovery from sublethal damage during fractionated irradiation of human FaDu SCC

scientific article published on 01 March 2005

Regional radiotherapy in high-risk breast cancer: is the issue solved?

scientific article

Relative biological effectiveness in proton beam therapy - Current knowledge and future challenges.

scientific article published in February 2018

Repeat FMISO-PET imaging weakly correlates with hypoxia-associated gene expressions for locally advanced HNSCC treated by primary radiochemotherapy

scientific article published on 09 March 2019

Repopulation during fractionated radiotherapy: much has been learned, even more is open.

scientific article

Repopulation of FaDu human squamous cell carcinoma during fractionated radiotherapy correlates with reoxygenation.

scientific article

Residual DNA double strand breaks in perfused but not in unperfused areas determine different radiosensitivity of tumours

scientific article

Residual gammaH2AX foci in head and neck squamous cell carcinomas as predictors for tumour radiosensitivity: Evaluation in pre-clinical xenograft models and clinical specimens

scientific article published on 29 April 2019

Residual tumour hypoxia in head-and-neck cancer patients undergoing primary radiochemotherapy, final results of a prospective trial on repeat FMISO-PET imaging.

scientific article published on 23 August 2017

Residual γH2AX foci predict local tumour control after radiotherapy.

scientific article published on 25 July 2013

Response of U87 glioma xenografts treated with concurrent rapamycin and fractionated radiotherapy: possible role for thrombosis

scientific article published on 11 December 2006

Retrospective investigation of the prognostic value of the β1 integrin expression in patients with head and neck squamous cell carcinoma receiving primary radio(chemo)therapy

scientific article published in PLoS ONE

SDF-1/CXCR4 expression in head and neck cancer and outcome after postoperative radiochemotherapy

scientific article published on 14 July 2017

SDF-1/CXCR4 expression is an independent negative prognostic biomarker in patients with head and neck cancer after primary radiochemotherapy

scientific article published on 20 October 2017

Selective inhibition of the epidermal growth factor receptor tyrosine kinase by BIBX1382BS and the improvement of growth delay, but not local control, after fractionated irradiation in human FaDu squamous cell carcinoma in the nude mouse ⬇️

scientific article published on July 1, 2003

Simultaneous PLK1 inhibition improves local tumour control after fractionated irradiation

scientific article published on 25 July 2013

Simultaneous β1 integrin-EGFR targeting and radiosensitization of human head and neck cancer

scientific article

Spatial distribution of FMISO in head and neck squamous cell carcinomas during radio-chemotherapy and its correlation to pattern of failure.

scientific article published on 23 September 2015

Specific requirements for translation of biological research into clinical radiation oncology

scientific article published on 16 March 2020

TCP and NTCP in preclinical and clinical research in Europe.

scientific article

Targeted next-generation sequencing of locally advanced squamous cell carcinomas of the head and neck reveals druggable targets for improving adjuvant chemoradiation.

scientific article

Targeting of β1 integrins impairs DNA repair for radiosensitization of head and neck cancer cells.

scientific article published on 15 June 2015

Targeting the epidermal growth factor receptor in radiotherapy: radiobiological mechanisms, preclinical and clinical results

scientific article published in September 2004

The CD98 Heavy Chain Is a Marker and Regulator of Head and Neck Squamous Cell Carcinoma Radiosensitivity

scientific article published on 22 January 2019

The HIV protease and PI3K/Akt inhibitor nelfinavir does not improve the curative effect of fractionated irradiation in PC-3 prostate cancer in vitro and in vivo

scientific article

The PD-1/PD-L1 axis and human papilloma virus in patients with head and neck cancer after adjuvant chemoradiotherapy: A multicentre study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG).

scientific article published on 08 May 2017

The extreme radiosensitivity of the squamous cell carcinoma SKX is due to a defect in double-strand break repair

scientific article

Three-dimensional cell growth confers radioresistance by chromatin density modification

scientific article

Tumor heterogeneity determined with a γH2AX foci assay: A study in human head and neck squamous cell carcinoma (hHNSCC) models.

scientific article published on 21 July 2017

Ultrafractionation does not improve the results of radiotherapy in radioresistant murine DDL1 lymphoma

scientific article published on 01 August 2005

Ultrafractionation in A7 human malignant glioma in nude mice.

scientific article published in June 2003

Ultrafractionation in human malignant glioma xenografts.

scientific article

[Experimental tumor therapy].

scientific article

[Low molecular weight heparin decreases thrombosis risk in patients receiving chemotherapy for cancer]

scientific article published on 01 June 2013

[Management of immunological adverse events in patients treated with immune checkpoint inhibitors: ASCO clinical practice guideline summary]

scientific article published on 01 April 2019

[No evidence for reduced late toxicity with dose reduction in the elective lymph node region in primary radiochemotherapy of head and neck tumors]

scientific article published on 01 July 2018

[Reduced acute toxicity for adults with medulloblastoma treated with proton beam craniospinal irradiation].

scientific article

[Stereotactic radiosurgery for brainstem metastases : In experienced hands a good treatment option with excellent risk-benefit ratio]

scientific article published on 01 April 2017

β₁Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy

scientific article

γH2AX assay in ex vivo irradiated tumour specimens: A novel method to determine tumour radiation sensitivity in patient-derived material.

scientific article

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