List of works - John Kuriyan

A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1.

scientific article published on 27 September 2017

A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca2+/Calmodulin- Dependent Kinase II Holoenzyme

scientific article

A Ras-induced conformational switch in the Ras activator Son of sevenless

scientific article (publication date: 7 November 2006)

A Src-like inactive conformation in the abl tyrosine kinase domain

scientific article

A conserved protonation-dependent switch controls drug binding in the Abl kinase

scientific article

A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases

scientific article

A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS.

scientific article published on 7 March 2019

A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70

scientific article

A saturation-mutagenesis analysis of the interplay between stability and activation in Ras

scientific article published in 2022

A structural role for the PHP domain in E. coli DNA polymerase III

scientific article

Activation of tyrosine kinases by mutation of the gatekeeper threonine

scientific article

An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

scientific article

An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor.

scientific article published on 04 October 2016

Analysis of the role of PCNA-DNA contacts during clamp loading

scientific article

Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate

scientific article published on 20 February 2015

Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase

scientific article published on 09 September 2020

CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks

scientific article published on 10 June 2020

Clamp loader ATPases and the evolution of DNA replication machinery

scientific article

Clamp loaders and sliding clamps

scientific article

Comparative Analysis of Mutant Tyrosine Kinase Chemical Rescue † ‡

scientific article

Conformational coupling across the plasma membrane in activation of the EGF receptor

scientific article

Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases

scientific article published on 19 September 2019

Crystal Structure of a Ube2S-Ubiquitin Conjugate

scientific article

Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacterium

scientific article

Crystal structure of a tetradecameric assembly of the association domain of Ca2+/calmodulin-dependent kinase II

scientific article (publication date: May 2003)

Crystal structure of the chi:psi sub-assembly of the Escherichia coli DNA polymerase clamp-loader complex

scientific article

Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)

scientific article

Deconstruction of the Ras switching cycle through saturation mutagenesis

scientific article

Differences in flexibility underlie functional differences in the Ras activators son of sevenless and Ras guanine nucleotide releasing factor 1

scientific article (publication date: 14 January 2009)

Efficient semisynthesis of a tetraphosphorylated analogue of the Type I TGFbeta receptor

scientific article

Equally Potent Inhibition of c-Src and Abl by Compounds that Recognize Inactive Kinase Conformations

scientific article

Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen.

scientific article published on 16 March 2018

Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation

scientific article published on 09 March 2020

High yield bacterial expression of active c-Abl and c-Src tyrosine kinases

scientific article

How a DNA Polymerase Clamp Loader Opens a Sliding Clamp

scientific article

Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface

scientific article

Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation

scientific article

Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment

scientific article

Mechanism of proliferating cell nuclear antigen clamp opening by replication factor C

scientific article

Modulating Heme Redox Potential through Protein-Induced Porphyrin Distortion

scientific article

Molecular basis for multimerization in the activation of the epidermal growth factor receptor

scientific article published on 28 March 2016

Molecular mechanism of activation-triggered subunit exchange in Ca(2+)/calmodulin-dependent protein kinase II

scientific article published on 7 March 2016

Nucleotide-induced conformational changes in an isolated Escherichia coli DNA polymerase III clamp loader subunit

scientific article (publication date: March 2003)

Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization

scientific article

Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase

scientific article

Paul Sigler (1934-2000).

scientific article published in May 2000

Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS.

scientific article

Probing the Function of Heme Distortion in the H-NOX Family

scientific article

Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless

scientific article

Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker

scientific article

Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex

scientific article

Structural analysis of autoinhibition in the Ras activator Son of sevenless

scientific article

Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1

scientific article

Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3

scientific article

Structural basis for dimerization quality control

scientific article published on 19 August 2020

Structural basis for the autoinhibition of c-Abl tyrosine kinase

scientific article (publication date: 21 March 2003)

Structural basis for the inhibition of tyrosine kinase activity of ZAP-70

scientific article

Structural basis for the recognition of c-Src by its inactivator Csk

scientific article

Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS

scientific article

Structural insights into the molecular mechanism of H-NOX activation

scientific article

Structure of a Sliding Clamp on DNA

scientific article

Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp

scientific article

Tandem histone folds in the structure of the N-terminal segment of the ras activator Son of Sevenless

scientific article

The Src module: an ancient scaffold in the evolution of cytoplasmic tyrosine kinases

scientific article published on 05 September 2018

The conformational plasticity of protein kinases

scientific article (publication date: 3 May 2002)

The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase

scientific article

The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2

scientific article

The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2)

scientific article

The tyrosine kinase Csk dimerizes through Its SH3 domain

scientific article

Tuning a Three-Component Reaction For Trapping Kinase Substrate Complexes

scientific article

Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain

scientific article

Understanding molecular mechanisms in cell signaling through natural and artificial sequence variation

scientific article published on 31 December 2018

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia

scientific article

Variation in assembly stoichiometry in non-metazoan homologs of the hub domain of Ca2+ /calmodulin-dependent protein kinase II

scientific article published on 17 April 2019

c-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermodynamic penalty

scientific article

List of works by John Kuriyan

A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1.

A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca2+/Calmodulin- Dependent Kinase II Holoenzyme

A Ras-induced conformational switch in the Ras activator Son of sevenless

A Src-like inactive conformation in the abl tyrosine kinase domain

A conserved protonation-dependent switch controls drug binding in the Abl kinase

A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases

A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS.

A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70

A saturation-mutagenesis analysis of the interplay between stability and activation in Ras

A structural role for the PHP domain in E. coli DNA polymerase III

Activation of tyrosine kinases by mutation of the gatekeeper threonine

An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor.

Analysis of the role of PCNA-DNA contacts during clamp loading

Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate

Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase

CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks

Clamp loader ATPases and the evolution of DNA replication machinery

Clamp loaders and sliding clamps

Comparative Analysis of Mutant Tyrosine Kinase Chemical Rescue † ‡

Conformational coupling across the plasma membrane in activation of the EGF receptor

Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases

Crystal Structure of a Ube2S-Ubiquitin Conjugate

Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacterium

Crystal structure of a tetradecameric assembly of the association domain of Ca2+/calmodulin-dependent kinase II

Crystal structure of the chi:psi sub-assembly of the Escherichia coli DNA polymerase clamp-loader complex

Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)

Deconstruction of the Ras switching cycle through saturation mutagenesis

Differences in flexibility underlie functional differences in the Ras activators son of sevenless and Ras guanine nucleotide releasing factor 1

Efficient semisynthesis of a tetraphosphorylated analogue of the Type I TGFbeta receptor

Equally Potent Inhibition of c-Src and Abl by Compounds that Recognize Inactive Kinase Conformations

Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen.

Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation

High yield bacterial expression of active c-Abl and c-Src tyrosine kinases

How a DNA Polymerase Clamp Loader Opens a Sliding Clamp

Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface

Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation

Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment

Mechanism of proliferating cell nuclear antigen clamp opening by replication factor C

Modulating Heme Redox Potential through Protein-Induced Porphyrin Distortion

Molecular basis for multimerization in the activation of the epidermal growth factor receptor

Molecular mechanism of activation-triggered subunit exchange in Ca(2+)/calmodulin-dependent protein kinase II

Nucleotide-induced conformational changes in an isolated Escherichia coli DNA polymerase III clamp loader subunit

Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization

Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase

Paul Sigler (1934-2000).

Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS.

Probing the Function of Heme Distortion in the H-NOX Family

Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless

Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker

Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex

Structural analysis of autoinhibition in the Ras activator Son of sevenless

Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1

Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3

Structural basis for dimerization quality control

Structural basis for the autoinhibition of c-Abl tyrosine kinase

Structural basis for the inhibition of tyrosine kinase activity of ZAP-70

Structural basis for the recognition of c-Src by its inactivator Csk

Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS

Structural insights into the molecular mechanism of H-NOX activation

Structure of a Sliding Clamp on DNA

Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp

Tandem histone folds in the structure of the N-terminal segment of the ras activator Son of Sevenless

The Src module: an ancient scaffold in the evolution of cytoplasmic tyrosine kinases

The conformational plasticity of protein kinases

The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase

The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2

The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2)

The tyrosine kinase Csk dimerizes through Its SH3 domain

Tuning a Three-Component Reaction For Trapping Kinase Substrate Complexes

Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain

Understanding molecular mechanisms in cell signaling through natural and artificial sequence variation

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia

Variation in assembly stoichiometry in non-metazoan homologs of the hub domain of Ca2+ /calmodulin-dependent protein kinase II

c-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermodynamic penalty