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List of works by John Kopchick

17α-Estradiol promotes ovarian aging in growth hormone receptor knockout mice, but not wild-type littermates

scientific article published on 04 November 2019

17α-estradiol modulates IGF1 and hepatic gene expression in a sex-specific manner

scientific article published on 28 August 2020

A Long-lived Mouse Lacking Both Growth Hormone and Growth Hormone Receptor: A New Animal Model for Aging Studies.

scientific article published on 29 September 2016

A dwarf mouse model with decreased GH/IGF-1 activity that does not experience life-span extension: potential impact of increased adiposity, leptin, and insulin with advancing age.

scientific article

A liver specific gene that is expressed in growth hormone transgenic mice and in normal female mice as a function of age.

scientific article published on 24 May 2006

A proteomic approach to obesity and type 2 diabetes

scientific article

A review of renal GH/IGF1 family gene expression in chronic kidney diseases

scientific article published on 16 July 2019

ALS blood expression profiling identifies new biomarkers, patient subgroups, and evidence for neutrophilia and hypoxia

scientific article published on 22 May 2019

Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects.

scientific article published on 21 April 2009

Adipocyte-Specific GH Receptor-Null (AdGHRKO) Mice Have Enhanced Insulin Sensitivity With Reduced Liver Triglycerides

scientific article published on 01 January 2019

Adiponectin in mice with altered GH action: links to insulin sensitivity and longevity?

scientific article published on 25 February 2013

Adiposity profile in the dwarf rat: an unusually lean model of profound growth hormone deficiency.

scientific article published on 30 January 2007

Age- and Sex-Associated Plasma Proteomic Changes in Growth Hormone Receptor Gene–Disrupted Mice ⬇️

scientific article published on December 7, 2011

Age-related alterations in pituitary and testicular functions in long-lived growth hormone receptor gene-disrupted mice

scientific article published on 13 September 2007

Age-related and depot-specific changes in white adipose tissue of growth hormone receptor-null mice

scientific article published on 20 July 2013

Age-related changes in body composition of bovine growth hormone transgenic mice

scientific article published on 23 October 2008

Analysis of mouse skin reveals proteins that are altered in a diet-induced diabetic state: a new method for detection of type 2 diabetes

scientific article published on 01 April 2007

CIDE-A gene expression is decreased in white adipose tissue of growth hormone receptor/binding protein gene disrupted mice and with high-fat feeding of normal mice

scientific article published on 4 June 2007

CIDE-A is expressed in liver of old mice and in type 2 diabetic mouse liver exhibiting steatosis

scientific article published on May 2007

Caloric restriction and growth hormone receptor knockout: effects on expression of genes involved in insulin action in the heart

scientific article

Cardiac-Specific Disruption of GH Receptor Alters Glucose Homeostasis While Maintaining Normal Cardiac Performance in Adult Male Mice

scientific article published on April 2016

Central leptin and insulin administration modulates serum cytokine- and lipoprotein-related markers.

scientific article

Characterization of an intestine-specific GH receptor knockout (IntGHRKO) mouse

scientific article published on 03 May 2019

Cholinergic neurons in the hypothalamus and dorsal motor nucleus of the vagus are directly responsive to growth hormone

scientific article published on 08 August 2020

Comment on: Kloting et al. (2008) Autocrine IGF-1 action in adipocytes controls systemic IGF-1 concentrations and growth: Diabetes 57:2074-2082.

scientific article

Comparing adiposity profiles in three mouse models with altered GH signaling

scientific article published in August 2004

Could calgranulins and advanced glycated end products potentiate acromegaly pathophysiology?

scientific article published on 20 April 2019

Crosstalk between the growth hormone/insulin-like growth factor-1 axis and the gut microbiome: A new frontier for microbial endocrinology

scientific article published on 18 July 2020

Daily energy balance in growth hormone receptor/binding protein (GHR -/-) gene-disrupted mice is achieved through an increase in dark-phase energy efficiency

scientific article

Deconstructing the Growth Hormone Receptor(GHR): Physical and Metabolic Phenotypes of Tissue-Specific GHR Gene-Disrupted Mice

scientific article published on 13 January 2016

Decreased insulin sensitivity and increased oxidative damage in wasting adipose tissue depots of wild-type mice

scientific article

Decreased levels of proapoptotic factors and increased key regulators of mitochondrial biogenesis constitute new potential beneficial features of long-lived growth hormone receptor gene-disrupted mice.

scientific article

Deletion of growth hormone receptor in hypothalamic neurons affects the adaptation capacity to aerobic exercise: Central GH action regulates exercise performance

scientific article published on 15 October 2020

Depot-specific and GH-dependent regulation of IGF binding protein-4, pregnancy-associated plasma protein-A, and stanniocalcin-2 in murine adipose tissue

scientific article published on 2 February 2018

Development of pure prolactin receptor antagonists.

scientific article

Developmental aspects of adipose tissue in GH receptor and prolactin receptor gene disrupted mice: site-specific effects upon proliferation, differentiation and hormone sensitivity

scientific article published in October 2006

Developments in our understanding of the effects of growth hormone on white adipose tissue from mice: implications to the clinic

scientific article

Diet-induced weight loss is sufficient to reduce senescent cell number in white adipose tissue of weight-cycled mice.

scientific article

Differential Effects of Growth Hormone Versus Insulin-Like Growth Factor-I on the Mouse Plasma Proteome ⬇️

scientific article published on July 26, 2011

Differential effects of early-life nutrient restriction in long-lived GHR-KO and normal mice.

scientific article published on 18 May 2017

Differential gene signature in adipose tissue depots of growth hormone transgenic mice

scientific article published on 20 July 2020

Differentially expressed proteins in the pancreas of diet-induced diabetic mice

scientific article published on 16 June 2005

Direct and indirect effects of growth hormone receptor ablation on liver expression of xenobiotic metabolizing genes

scientific article published on 13 August 2013

Discovery and uses of pegvisomant: a growth hormone antagonist

scientific article

Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice

scientific article

Disruption of growth hormone receptor prevents calorie restriction from improving insulin action and longevity

scientific article

Disruption of the GH Receptor Gene in Adult Mice Increases Maximal Lifespan in Females

scientific article published on 12 October 2016

Disruption of the GH receptor gene in adult mice and in insulin sensitive tissues

scientific article published on 24 November 2017

Do altered energy metabolism or spontaneous locomotion 'mediate' decelerated senescence?

scientific article published on 26 February 2015

Effect of growth hormone on insulin signaling

scientific article published on 20 September 2020

Effect of growth hormone on susceptibility to diet-induced obesity

scientific article published on 23 March 2006

Effect of growth hormone receptor gene disruption and PMA treatment on the expression of genes involved in primordial follicle activation in mice ovaries.

scientific article

Effects of caloric restriction and growth hormone resistance on insulin-related intermediates in the skeletal muscle

scientific article published in January 2007

Effects of caloric restriction and growth hormone resistance on the expression level of peroxisome proliferator-activated receptors superfamily in liver of normal and long-lived growth hormone receptor/binding protein knockout mice

scientific article published on 01 November 2005

Effects of growth hormone and prolactin on adipose tissue development and function

scientific article published on September 2003

Effects of insulin-like growth factor 1 on glutathione S-transferases and thioredoxin in growth hormone receptor knockout mice

scientific article published on 8 July 2014

Effects of rapamycin on growth hormone receptor knockout mice.

scientific article

Effects of tissue-specific GH receptor knockouts in mice

scientific article published on 24 June 2020

Elevated systolic blood pressure in male GH transgenic mice is age dependent.

scientific article published on January 2013

Endocrine Parameters and Phenotypes of the Growth Hormone Receptor Gene Disrupted (GHR−/−) Mouse ⬇️

scientific article published on December 1, 2010

Endocrine regulation of heat shock protein mRNA levels in long-lived dwarf mice

scientific article published on 08 April 2009

Enhanced Cognition and Hypoglutamatergic Signaling in a Growth Hormone Receptor Knockout Mouse Model of Successful Aging.

scientific article published on 21 May 2016

Erratum to: Preservation of blood glucose homeostasis in slow-senescing somatotrophism-deficient mice subjected to intermittent fasting begun at middle or old age.

scientific article published on 9 August 2014

Evaluation of functional erythropoietin receptor status in skeletal muscle in vivo: acute and prolonged studies in healthy human subjects

scientific article

Evaluation of growth hormone (GH) action in mice: discovery of GH receptor antagonists and clinical indications

scientific article published on 11 September 2013

Expression of apoptosis-related genes in liver-specific growth hormone receptor gene-disrupted mice is sex dependent

scientific article

Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress.

scientific article published on 8 February 2005

Fibroblast growth factor 21, fibroblast growth factor receptor 1, and β-Klotho expression in bovine growth hormone transgenic and growth hormone receptor knockout mice.

scientific article published on 24 August 2016

GH Knockout Mice Have Increased Subcutaneous Adipose Tissue With Decreased Fibrosis and Enhanced Insulin Sensitivity

scientific article published on 01 July 2019

GH Receptor Plays a Major Role in Liver Regeneration through the Control of EGFR and ERK1/2 Activation

article

GH action influences adipogenesis of mouse adipose tissue-derived mesenchymal stem cells.

scientific article published on 5 May 2015

GHR-/- Mice are protected from obesity-related white adipose tissue inflammation

scientific article published on 12 April 2020

Gene expression of key regulators of mitochondrial biogenesis is sex dependent in mice with growth hormone receptor deletion in liver

scientific article

Gene expression patterns in calorically restricted mice: partial overlap with long-lived mutant mice

scientific article published in November 2002

Growth Hormone Deficiency and Excess Alter the Gut Microbiome in Adult Male Mice

scientific article published on 01 April 2020

Growth Hormone Discovery and Structure

scientific article published on 01 September 2018

Growth Hormone Influence on the Morphology and Size of the Mouse Meibomian Gland.

scientific article published on 14 February 2016

Growth Hormone Inhibits Hepatic De Novo Lipogenesis in Adult Mice

scientific article

Growth Hormone Receptor Antagonist Transgenic Mice Have Increased Subcutaneous Adipose Tissue Mass, Altered Glucose Homeostasis and No Change in White Adipose Tissue Cellular Senescence

scientific article published on 16 September 2015

Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence

scientific article published on 10 February 2016

Growth Hormone Receptor Deletion Reduces the Density of Axonal Projections from Hypothalamic Arcuate Nucleus Neurons

scientific article published on 27 March 2020

Growth Hormone Receptor Knockdown Sensitizes Human Melanoma Cells to Chemotherapy by Attenuating Expression of ABC Drug Efflux Pumps.

scientific article published on 14 March 2017

Growth Hormone Resistance-Special Focus on Inflammatory Bowel Disease.

scientific article

Growth Hormone Upregulates Mediators of Melanoma Drug Efflux and Epithelial-to-Mesenchymal Transition In Vitro and In Vivo

scientific article published on 04 December 2020

Growth Hormone Upregulates Melanocyte-Inducing Transcription Factor Expression and Activity via JAK2-STAT5 and SRC Signaling in GH Receptor-Positive Human Melanoma

scientific article published on 12 September 2019

Growth Hormone and the Epithelial-to-Mesenchymal Transition.

scientific article published on 4 August 2017

Growth hormone action in the developing neural retina: a proteomic analysis.

scientific article

Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice.

scientific article

Growth hormone activated STAT5 is required for induction of beige fat in vivo

scientific article published on 29 August 2018

Growth hormone acts along PPARγ-FSP27 axis to stimulate lipolysis in human adipocytes

scientific article published on 16 October 2018

Growth hormone and adipose tissue: beyond the adipocyte

scientific article

Growth hormone controls lipolysis by regulation of FSP27 expression

scientific article published on 01 December 2018

Growth hormone is required for ovarian follicular growth

scientific article published in October 2002

Growth hormone modulates hypothalamic inflammation in long-lived pituitary dwarf mice

scientific article

Growth hormone promotes glomerular lipid accumulation in bGH mice

scientific article

Growth hormone promotes skeletal muscle cell fusion independent of insulin-like growth factor 1 up-regulation

scholarly article

Growth hormone receptor antagonist transgenic mice are protected from hyperinsulinemia and glucose intolerance despite obesity when placed on a HF diet

scientific article

Growth hormone receptor gene deficiency causes delayed insulin responsiveness in skeletal muscles without affecting compensatory islet cell overgrowth in obese mice

scientific article published on 18 April 2006

Growth hormone signaling is necessary for lifespan extension by dietary methionine

scientific article

Heterogeneity among white adipose tissue depots in male C57BL/6J mice

scientific article published on 21 July 2011

Human growth hormone expressed in tobacco cells as an arabinogalactan-protein fusion glycoprotein has a prolonged serum life

scientific article

Human metastatic melanoma cell lines express high levels of growth hormone receptor and respond to GH treatment

scientific article published on 14 October 2013

Hypothalamic growth hormone receptor (GHR) controls hepatic glucose production in nutrient-sensing leptin receptor (LepRb) expressing neurons

scientific article

Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production

scientific article

Hypothesis: Extra-hepatic acromegaly: a new paradigm?

scientific article published on 02 November 2010

Identification of new biomarkers of low-dose GH replacement therapy in GH-deficient patients.

scientific article

Identification of the glomerular podocyte as a target for growth hormone action

scientific article published on February 2007

Impact of Growth Hormone on Regulation of Adipose Tissue.

scientific article

Impact of growth hormone resistance on female reproductive function: new insights from growth hormone receptor knockout mice

scientific article published in October 2002

Increased class A scavenger receptor and glomerular lipid precede mesangial matrix expansion in the bGH mouse model

scientific article published on 25 June 2010

Increased fibrosis: A novel means by which GH influences white adipose tissue function

scientific article published on 20 December 2017

Increased metabolic flexibility and complexity in a long-lived growth hormone insensitive mouse model

scientific article published on 20 June 2013

Inflammatory and Glutamatergic Homeostasis Are Involved in Successful Aging

scientific article published on 22 February 2015

Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases.

scientific article published on 17 December 2010

Insulin, IGF-1, and GH Receptors Are Altered in an Adipose Tissue Depot-Specific Manner in Male Mice With Modified GH Action.

scientific article published on 27 February 2017

Interaction of growth hormone receptor/binding protein gene disruption and caloric restriction for insulin sensitivity and attenuated aging.

scientific article

Interventions to Slow Aging in Humans: Are We Ready?

scientific article

Jens Sandahl Christiansen, DMSci, FRCPI (1948-2015).

scientific article

Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles

scientific article published on 11 February 2014

Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism

scientific article published on 21 May 2009

Local over-expression of prolactin in differentiating mouse mammary gland induces functional defects and benign lesions, but no carcinoma.

scientific article

Local prolactin is a target to prevent expansion of basal/stem cells in prostate tumors

scientific article

MECHANISMS IN ENDOCRINOLOGY: Lessons from growth hormone receptor gene disrupted mice: Are there benefits of endocrine defects?

scientific article published on 19 February 2018

MON-473 Growth Hormone (GH) Impacts the Gut Microbial Profile: the Presence of Unique Bacterial Genera in Mouse Lines with Altered GH Action.

scientific article published on 30 April 2019

MON-476 Growth Hormone and the Glomerular Podocyte: Studies of Podocyte-Specific Growth Hormone Receptor Gene Deletion in Mice

MON-479 Gross and Microscopic Intestinal Morphology of Bovine Growth Hormone Transgenic Mice Longitudinally.

scientific article published on 30 April 2019

MON-480 Reduced Respiration Observed In Isolated Liver Mitochondria Of Long-lived GHR-/- Mice At Early Ages.

scientific article

MON-484 Adipocyte-Specific GH Receptor Knockout Mice (AdGHRKO) Have Enhanced Insulin Sensitivity with Reduced Liver Triglycerides and Depot Specific Analyses in These Mice Suggest that GH May Have a More Substantial Effect on Subcutaneous White Adip

scientific article

Male bovine GH transgenic mice have decreased adiposity with an adipose depot-specific increase in immune cell populations.

scientific article

Metabolic effects of intra-abdominal fat in GHRKO mice

scientific article published on 28 November 2011

Morphology of ovaries in laron dwarf mice, with low circulating plasma levels of insulin-like growth factor-1 (IGF-1), and in bovine GH-transgenic mice, with high circulating plasma levels of IGF-1

scientific article published on 2 July 2012

Mouse models of growth hormone action and aging: a proteomic perspective

scientific article

New insights of growth hormone (GH) actions from tissue-specific GH receptor knockouts in mice

scientific article published on 01 November 2019

Novel serum biomarkers for erythropoietin use in humans: a proteomic approach.

scientific article published on 21 October 2010

Novel serum protein biomarkers indicative of growth hormone doping in healthy human subjects

scientific article

Pancreatic islet-specific expression of an insulin-like growth factor-I transgene compensates islet cell growth in growth hormone receptor gene-deficient mice

scientific article published on 24 February 2005

Perspective: proteomic approach to detect biomarkers of human growth hormone

scientific article published on 04 June 2009

Perspective: proteomics--see "spots" run.

scientific article

Pharmacologic inhibition of ghrelin receptor signaling is insulin sparing and promotes insulin sensitivity

scientific article published on 20 July 2011

Phenotypical enrichment strategies for microarray data analysis applied in a type II diabetes study

scientific article

Plasma Protein Biomarkers Correlated with the Development of Diet-Induced Type 2 Diabetes in Mice

scientific article

Plasma biomarkers of mouse aging ⬇️

scientific article published on September 15, 2010

Plasma proteomic profiles of bovine growth hormone transgenic mice as they age ⬇️

scientific article published on March 2, 2011

Post‐transcriptional regulation of IGF1R by key microRNAs in long–lived mutant mice ⬇️

scientific article published on December 1, 2011

Preservation of blood glucose homeostasis in slow-senescing somatotrophism-deficient mice subjected to intermittent fasting begun at middle or old age.

scientific article

Primer: molecular tools used for the understanding of endocrinology.

scientific article published on April 2007

Prof. Jens Sandahl Christiansen

scientific article published on 11 January 2016

Proteomic analysis allows for early detection of potential markers of metabolic impairment in very young obese children

scientific article

Proteomic changes in the heart of diet-induced pre-diabetic mice ⬇️

scientific article published on February 24, 2011

Puberty is delayed in male growth hormone receptor gene-disrupted mice.

scientific article published in September 2002

Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice

scientific article published on 19 February 2009

Regulation of mTOR activity in Snell dwarf and GH receptor gene-disrupted mice

scientific article

Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR-/- mice

scientific article

Repression of GH signaling: one extended life to live!

scientific article published on October 2013

Reversal of experimental Laron Syndrome by xenotransplantation of microencapsulated porcine Sertoli cells

scientific article published on 03 September 2012

SAT-041 Bioinformatic Analysis of Human Cutaneous Melanomas Identifies Increased Mortality and Genetic Alterations in GH-responsive Tumors.

scientific article published on 30 April 2019

SAT-181 Characterization of Adult Growth Hormone Receptor Gene-Disrupted Mice

SAT-LB053 Investigating the Effects of Growth Hormone on Tumor-derived Exosome Output and Content.

scientific article published on 30 April 2019

SAT-LB054 Growth Hormone Receptor (GHR) Antagonism Suppresses Hepatocellular Carcinoma Growth in a Syngeneic Mouse Model

SUN-094 Altering Cycle Duration Of A Yoyo-diet Has No Effect On Mortality In Weight Cycled Mice

scientific article published on 30 April 2019

SUN-336 Autocrine / Paracrine Growth Hormone (GH) Drives Multimodal Therapy Resistance in Growth Hormone Receptor (GHR)-expressing Human Cancers.

scientific article

Selective inner retinal dysfunction in growth hormone transgenic mice

scientific article

Serum proteome changes in acromegalic patients following transsphenoidal surgery: novel biomarkers of disease activity.

scientific article

Serum proteomic changes after randomized prolonged erythropoietin treatment and/or endurance training: detection of novel biomarkers.

scientific article published on 13 February 2015

Significance of the disulphide bonds of human growth hormone

scientific article published on January 2013

Specific suppression of insulin sensitivity in growth hormone receptor gene-disrupted (GHR-KO) mice attenuates phenotypic features of slow aging

scientific article

Standardizing protocols dealing with growth hormone receptor gene disruption in mice using the Cre-lox system

scientific article published on 29 August 2018

Targeting growth hormone receptor in human melanoma cells attenuates tumor progression and epithelial mesenchymal transition via suppression of multiple oncogenic pathways

scientific article published on 16 February 2017

Temporal patterns of lipolytic regulators in adipose tissue after acute growth hormone exposure in human subjects: A randomized controlled crossover trial

scientific article published on 20 August 2019

The GH/IGF-1 axis in ageing and longevity ⬇️

scientific article published on April 16, 2013

The absence of GH signaling affects the susceptibility to high-fat diet-induced hypothalamic inflammation in male mice

scientific article published on 19 September 2014

The acute effects of growth hormone in adipose tissue is associated with suppression of antilipolytic signals

scientific article published on 01 February 2020

The cardiovascular phenotype of a mouse model of acromegaly

scientific article published on 9 March 2009

The effect of calorie restriction on the presence of apoptotic ovarian cells in normal wild type mice and low-plasma-IGF-1 Laron dwarf mice

scientific article published on 24 September 2013

The effect of low and high plasma levels of insulin-like growth factor-1 (IGF-1) on the morphology of major organs: studies of Laron dwarf and bovine growth hormone transgenic (bGHTg) mice.

scientific article published on 24 April 2013

The effects of 20-kDa human placental GH in male and female GH deficient mice: an improved human GH?

scientific article published on 18 June 2020

The effects of growth hormone on adipose tissue: old observations, new mechanisms

scientific article published on 28 November 2019

The enigmatic role of growth hormone in age-related diseases, cognition, and longevity

scientific article published on 04 September 2019

The forgotten lactogenic activity of growth hormone: important implications for rodent studies

scientific article

The impact of growth hormone on proteomic profiles: a review of mouse and adult human studies.

scientific article

The negative effect of prolonged somatotrophic/insulin signaling on an adult bone marrow-residing population of pluripotent very small embryonic-like stem cells (VSELs).

scientific article published on 5 January 2012

The role of GH in adipose tissue: lessons from adipose-specific GH receptor gene-disrupted mice

scientific article published on 24 January 2013

The role of prolactin and growth hormone in mammary gland development

scientific article

The role of transplanted visceral fat from the long-lived growth hormone receptor knockout mice on insulin signaling.

scientific article

The slow-aging growth hormone receptor/binding protein gene-disrupted (GHR-KO) mouse is protected from aging-resultant neuromusculoskeletal frailty

scientific article published on 04 July 2013

The somatotropic axis and aging: Benefits of endocrine defects.

scientific article published on 16 February 2016

Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging

scientific article

Tissue-specific disruption of the growth hormone receptor (GHR) in mice: An update

scientific article published on 24 December 2019

Transcriptional profiling identifies strain-specific effects of caloric restriction and opposite responses in human and mouse white adipose tissue.

scientific article

Transcriptome profiling of insulin sensitive tissues from GH deficient mice following GH treatment

scientific article published on 12 January 2021

Transcriptome profiling reveals divergent expression shifts in brown and white adipose tissue from long-lived GHRKO mice

scientific article

Two-year body composition analyses of long-lived GHR null mice

scientific article

Tyrosine hydroxylase neurons regulate growth hormone secretion via short-loop negative feedback

scientific article published on 14 April 2020

Upregulation of the angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas receptor axis in the heart and the kidney of growth hormone receptor knock-out mice.

scientific article published on 02 September 2012

Young at Heart

scientific article published on 01 January 2016

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