List of works - John Anthony Hardy

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

scientific article

Alzheimer's disease: the amyloid cascade hypothesis

scientific article published on 10 April 1992

alpha-Synuclein locus triplication causes Parkinson's disease

scientific article

Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium

scientific article (publication date: 27 December 2005)

Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment

scientific article published in September 2004

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

scientific article

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

scientific article

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

scientific article

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

scientific article

TREM2 Variants in Alzheimer's Disease

scientific article published on November 14, 2012

Genome-wide association study reveals genetic risk underlying Parkinson's disease

scientific article

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

scientific article

The amyloid hypothesis of Alzheimer's disease at 25 years

scientific article

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

scientific article (publication date: May 2011)

Amyloid deposition as the central event in the aetiology of Alzheimer's disease

scientific article (publication date: October 1991)

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

scientific article (publication date: September 2014)

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

scientific article published on January 1, 1998

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

scientific article

Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study

scientific article

Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

scientific article (publication date: 31 October 1991)

Genome-wide SNP assay reveals structural genomic variation, extended homozygosity and cell-line induced alterations in normal individuals

scientific article published on 20 November 2006

Toxic proteins in neurodegenerative disease

scientific article

Identification of common variants associated with human hippocampal and intracranial volumes

scientific article published on 15 April 2012

A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder

scientific article

Common genetic variants influence human subcortical brain structures

scientific article

Association of an extended haplotype in the tau gene with progressive supranuclear palsy

scientific article published in April 1999

A survey of genetic human cortical gene expression

article

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

scientific article published on 14 March 2012

Genomewide association studies and human disease

scientific article

The amyloid hypothesis for Alzheimer's disease: a critical reappraisal

scientific article published on 18 May 2009

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

scientific article (publication date: April 2004)

Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria

scientific article published on December 2009

Genetic variability in the regulation of gene expression in ten regions of the human brain

scientific article

Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database

scientific article

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

scientific article

Abeta42 is essential for parenchymal and vascular amyloid deposition in mice

scientific article

GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers

scientific article

Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease

scientific article

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

scientific article

DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers

scientific article published on March 2007

Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives

scientific article published on July 2010

The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

scientific article

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

scientific article

Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy

scientific article

Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data

scientific journal article

Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice.

scientific article published in September 2005

Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma

scientific article published on 15 August 2003

Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus

scientific article published on 23 August 2011

Lewy bodies and parkinsonism in families with parkin mutations

scientific article (publication date: September 2001)

A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease

scientific article

List of works by John Anthony Hardy

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

Alzheimer's disease: the amyloid cascade hypothesis

alpha-Synuclein locus triplication causes Parkinson's disease

Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium

Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

TREM2 Variants in Alzheimer's Disease

Genome-wide association study reveals genetic risk underlying Parkinson's disease

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

The amyloid hypothesis of Alzheimer's disease at 25 years

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

Amyloid deposition as the central event in the aetiology of Alzheimer's disease

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study

Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

Genome-wide SNP assay reveals structural genomic variation, extended homozygosity and cell-line induced alterations in normal individuals

Toxic proteins in neurodegenerative disease

Identification of common variants associated with human hippocampal and intracranial volumes

A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder

Common genetic variants influence human subcortical brain structures

Association of an extended haplotype in the tau gene with progressive supranuclear palsy

A survey of genetic human cortical gene expression

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

Genomewide association studies and human disease

The amyloid hypothesis for Alzheimer's disease: a critical reappraisal

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria

Genetic variability in the regulation of gene expression in ten regions of the human brain

Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

Abeta42 is essential for parenchymal and vascular amyloid deposition in mice

GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers

Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers

Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives

The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy

Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data

Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice.

Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma

Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus

Lewy bodies and parkinsonism in families with parkin mutations

A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease