List of works by John D. Lambris

'Stealth' corporate innovation: an emerging threat for therapeutic drug development

scientific article published on 01 November 2019

A 'rule of 3' to revive Greek science, research and innovation.

scientific article published on November 2015

A Phase-Variable Surface Layer from the Gut Symbiont Bacteroides thetaiotaomicron

scientific article

A Structurally Dynamic N-terminal Helix Is a Key Functional Determinant in Staphylococcal Complement Inhibitor (SCIN) Proteins

scientific article

A complement receptor C5a antagonist regulates epithelial to mesenchymal transition and crystallin expression after lens cataract surgery in mice

scientific article

A complement-IL-4 regulatory circuit controls liver regeneration

scientific article published on 19 December 2011

A flow-through optical sensor system for label-free detection of proteins and DNA

A functional C5a anaphylatoxin receptor in a teleost species

scientific article published on 01 January 2004

A high-fat diet impairs liver regeneration in C57BL/6 mice through overexpression of the NF-kappaB inhibitor, IkappaBalpha.

scientific article published in November 2005

A method for analysing lymphocyte surface antigens

scientific article published on 01 January 1980

A molecular insight into complement evasion by the staphylococcal complement inhibitor protein family

scientific article

A murine RP1 missense mutation causes protein mislocalization and slowly progressive photoreceptor degeneration

scientific article

A novel C5a receptor-tissue factor cross-talk in neutrophils links innate immunity to coagulation pathways.

scientific article

A novel C5aR-tissue factor crosstalk in neutrophils links innate immunity to coagulation pathways

A novel role of complement: mice deficient in the fifth component of complement (C5) exhibit impaired liver regeneration.

scientific article

A protective role for the fifth complement component (c5) in allergic airway disease

scientific article published on 26 January 2006

A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma

scientific article

A role for Lys-His-Gly-NH2 in avian and murine B cell development

scientific article published on September 1989

A simple, yet highly accurate, QSAR model captures the complement inhibitory activity of compstatin

scientific article

A structural basis for complement inhibition by Staphylococcus aureus

scientific article

A sweet spot to control complement-induced inflammation

scientific article published on 01 September 2012

Absence of mannose-binding lectin prevents hyperglycemic cardiovascular complications

scientific article published on 8 November 2011

Accumulation of viruslike particles in a yeast mutant lacking a mitochondrial pore protein

scientific article published on March 1989

Activation of polymorphonuclear leukocytes by candidate biomaterials for an implantable glucose sensor

scientific article published on November 2011

Acute antibody-mediated complement activation mediates lysis of pancreatic islets cells and may cause tissue loss in clinical islet transplantation

scientific article published on April 2008

Acute lung injury and fibrosis in a baboon model of Escherichia coli sepsis.

scientific article published on February 2014

Advances in understanding the structure, function, and mechanism of the SCIN and Efb families of Staphylococcal immune evasion proteins

scientific article published on January 2012

Aegean reflections on innate immunity

scientific article published in October 2013

Air Bubbles Activate Complement and Trigger Hemostasis and C3-Dependent Cytokine Release Ex Vivo in Human Whole Blood

scientific article published on 03 November 2021

Alginate microbeads are coagulation compatible, while alginate microcapsules activate coagulation secondary to complement or directly through FXII.

scientific article published on 30 May 2017

Allosteric inhibition of complement function by a staphylococcal immune evasion protein

scientific article

An ex vivo loop system models the toxicity and efficacy of PEGylated and unmodified adenovirus serotype 5 in whole human blood

scientific article published on 11 March 2010

Anaphylatoxin C5a creates a favorable microenvironment for lung cancer progression.

scientific article

Ancient origin of the complement system: emerging invertebrate models.

scientific article published on January 2007

Anti-inflammatory effects of C1-Inhibitor in porcine and human whole blood are independent of its protease inhibition activity

scientific article published on 26 August 2009

Antibodies against the extracellular enveloped virus B5R protein are mainly responsible for the EEV neutralizing capacity of vaccinia immune globulin

scientific article

Application of the C3 inhibitor compstatin in a human whole blood model designed for complement research – 20 years of experience and future perspectives

scientific article published in 2022

Applying complement therapeutics to rare diseases.

scientific article

Artificial surface-induced inflammation relies on complement factor 5: proof from a deficient person

scientific article

Attenuation of Staphylococcus aureus-Induced Bacteremia by Human Mini-Antibodies Targeting the Complement Inhibitory Protein Efb

scientific article published on 4 September 2015

Author Correction: 'Stealth' corporate innovation: an emerging threat for therapeutic drug development

scientific article published on 01 November 2019

Author Correction: Complement as a target in COVID-19?

scientific article published on 12 June 2020

Autoregulation of thromboinflammation on biomaterial surfaces by a multicomponent therapeutic coating

scientific article

Binding of C3 fragments on top of adsorbed plasma proteins during complement activation on a model biomaterial surface

article

Blood protein-polymer adsorption: implications for understanding complement-mediated hemoincompatibility

scientific article

C1-inhibitor efficiently inhibits Escherichia coli-induced tissue factor mRNA up-regulation, monocyte tissue factor expression and coagulation activation in human whole blood

scientific article published in August 2013

C3 glomerulopathy - understanding a rare complement-driven renal disease

scientific article published on 01 March 2019

C3 promotes expansion of CD8+ and CD4+ T cells in a Listeria monocytogenes infection

scientific article published on 31 July 2009

C3a and C3b activation products of the third component of complement (C3) are critical for normal liver recovery after toxic injury

scientific article published in July 2004

C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ishemia/reperfusion

scientific article published on 01 February 2007

C3a receptor antagonist attenuates brain injury after intracerebral hemorrhage

scientific article published on 27 August 2008

C5L2 receptor disruption enhances the development of diet-induced insulin resistance in mice.

scientific article published on 21 April 2012

C5a and TNF-alpha up-regulate the expression of tissue factor in intra-alveolar neutrophils of patients with the acute respiratory distress syndrome

scientific article published on June 2008

C5a causes limited, polymorphonuclear cell-independent, mesenteric ischemia/reperfusion-induced injury☆,☆☆

scientific article published on 01 September 2003

C5a promotes development of experimental lupus nephritis which can be blocked with a specific receptor antagonist

scientific article published in August 2005

C5a receptor-dependent cell activation by physiological concentrations of desarginated C5a: insights from a novel label-free cellular assay

scientific article

C5aR-antagonist significantly reduces the deleterious effect of a blunt chest trauma on fracture healing

scientific article published on 15 September 2011

CD14 inhibition improves survival and attenuates thrombo-inflammation and cardiopulmonary dysfunction in a baboon model of Escherichia coli sepsis

scientific article published on 10 November 2020

CD59 efficiently protects human NT2-N neurons against complement-mediated damage

scientific article

CMAP: Complement Map Database

scientific article published on 09 May 2013

Can cells and biomaterials in therapeutic medicine be shielded from innate immune recognition?

scientific article

Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD

scientific article

Characterization of Ehp, a secreted complement inhibitory protein from Staphylococcus aureus

scientific article

Cholesterol Crystals Induce Coagulation Activation through Complement-Dependent Expression of Monocytic Tissue Factor

scientific article published on 03 July 2019

Cholesterol crystals induce complement-dependent inflammasome activation and cytokine release

scientific article published on 19 February 2014

CiC3-1a-mediated chemotaxis in the deuterostome invertebrate Ciona intestinalis (Urochordata).

scientific article

Clinical promise of next-generation complement therapeutics

scientific article published on 19 July 2019

Cloning and structure of three rainbow trout C3 molecules: a plausible explanation for their functional diversity

scientific article published in January 2001

Cloning of three trout C3 isoforms: structural, functional, and phylogenetic analysis

Coarse-Grained Conformational Sampling of Protein Structure Improves the Fit to Experimental Hydrogen-Exchange Data.

scientific article

Combined Inhibition of Complement and CD14 Attenuates Bacteria-Induced Inflammation in Human Whole Blood More Efficiently Than Antagonizing the Toll-like Receptor 4-MD2 Complex.

scientific article published on 14 March 2016

Comparative Analysis of Novel Complement-Targeted Inhibitors, MiniFH, and the Natural Regulators Factor H and Factor H-like Protein 1 Reveal Functional Determinants of Complement Regulation.

scientific article

Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression.

scientific article

Complement C3 and C5 play critical roles in traumatic brain cryoinjury: blocking effects on neutrophil extravasation by C5a receptor antagonist.

scientific article

Complement C3 inhibition by compstatin Cp40 prevents intra- and extravascular hemolysis of red blood cells

scientific article published on 31 January 2020

Complement C3 inhibitor Cp40 attenuates xenoreactions in pig hearts perfused with human blood.

scientific article published on 27 September 2016

Complement C3 vs C5 inhibition in severe COVID-19: Early clinical findings reveal differential biological efficacy

scientific article published on 19 September 2020

Complement C3-Targeted Therapy: Replacing Long-Held Assertions with Evidence-Based Discovery.

scientific article

Complement C3a and C5a modulate osteoclast formation and inflammatory response of osteoblasts in synergism with IL-1β.

scientific article

Complement C3dg-mediated erythrophagocytosis: implications for paroxysmal nocturnal hemoglobinuria.

scientific article

Complement C5a Functions as a Master Switch for the pH Balance in Neutrophils Exerting Fundamental Immunometabolic Effects

scientific article published on 10 May 2017

Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis

scientific article published in March 2022

Complement C5a receptor is essential for the optimal generation of antiviral CD8+ T cell responses

scientific article published in August 2004

Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome

scientific article

Complement C5a-Induced Changes in Neutrophil Morphology During Inflammation

scientific article

Complement C5a-Mediated TAM-ing of Antitumor Immunity Drives Squamous Carcinogenesis

scientific article published on 01 October 2018

Complement Involvement in Periodontitis: Molecular Mechanisms and Rational Therapeutic Approaches

scientific article

Complement Receptors (CR) and Cytotoxic Responses: Monoclonal Antibodies Directed Against CR1 AMD CR3 Inhibit the Generation of Human Allospecific and Virus Specific Cytotoxic Cells in Vitro

article

Complement activation by CpG in a human whole blood loop system: mechanisms and immunomodulatory effects

scientific article

Complement activation is critical to airway hyperresponsiveness after acute ozone exposure

scientific article

Complement activation on neutrophils initiates endothelial adhesion and extravasation

scientific article published on 19 September 2019

Complement activation promoted by the lectin pathway mediates C3aR-dependent sarcoma progression and immunosuppression

scientific article published on 18 February 2021

Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration

scientific article published on January 2013

Complement anaphylatoxin C5a contributes to hemodialysis-associated thrombosis

scientific article

Complement and Neutrophil Function Changes After Liver Resection in Humans

scientific article published on 01 December 2009

Complement and coagulation: strangers or partners in crime?

scientific article published on March 2007

Complement and dysbiosis in periodontal disease

scientific article

Complement and innate immunity.

scientific article published in August 2000

Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis

scientific article published on 06 August 2020

Complement as a target in COVID-19?

scientific article published on 23 April 2020

Complement component 3 is required for optimal expansion of CD8 T cells during a systemic viral infection

scientific article published on 01 January 2003

Complement component C3 - The "Swiss Army Knife" of innate immunity and host defense ⬇️

scientific article

Complement component C3 binds to activated normal platelets without preceding proteolytic activation and promotes binding to complement receptor 1

scientific article

Complement component C3aR constitutes a novel regulator for chick eye morphogenesis.

scientific article published on 30 May 2017

Complement component C5a mediates hemorrhage-induced intestinal damage

scientific article published on 13 March 2008

Complement component c5a is integral to the febrile response of mice to lipopolysaccharide

scientific article published on January 2005

Complement deficiency promotes cutaneous wound healing in mice

scientific article

Complement deposits on ocular tissues adjacent to sites of inflammation

scientific article published in November 2007

Complement diversity: a mechanism for generating immune diversity?

scientific article

Complement evasion by human pathogens

scientific article

Complement fragment C3a controls mutual cell attraction during collective cell migration

scientific article published on 24 November 2011

Complement in Action: An Analysis of Patent Trends from 1976 Through 2011.

scientific article published on January 2013

Complement in cancer: untangling an intricate relationship.

scientific article published on 18 September 2017

Complement in disease: a defence system turning offensive

scientific article

Complement in immune and inflammatory disorders: pathophysiological mechanisms

scientific article published on April 2013

Complement in immune and inflammatory disorders: therapeutic interventions

scientific article published on April 2013

Complement in inflammatory tissue damage and disease

article

Complement in paroxysmal nocturnal hemoglobinuria: exploiting our current knowledge to improve the treatment landscape

scientific article

Complement in urochordates: cloning and characterization of two C3-like genes in the ascidian Ciona intestinalis

scientific article published on 8 February 2002

Complement inhibition decreases early fibrogenic events in the lung of septic baboons

scientific article

Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis

scientific article

Complement inhibition enables tumor delivery of LCMV glycoprotein pseudotyped viruses in the presence of antiviral antibodies.

scientific article

Complement inhibition in a xenogeneic model of interactions between human whole blood and porcine endothelium

scientific article

Complement inhibition in cancer therapy

scientific article published on February 2013

Complement inhibition in pre-clinical models of periodontitis and prospects for clinical application

scientific article published on 24 March 2016

Complement inhibition prevents oncolytic vaccinia virus neutralization in immune humans and cynomolgus macaques

scientific article published on 25 March 2015

Complement modulates the cutaneous microbiome and inflammatory milieu

scientific article

Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of age-related macular degeneration by restoring lysosomal function

scientific article published on 20 August 2020

Complement receptors C5aR1 and C5aR2 act differentially during the early immune response after bone fracture but are similarly involved in bone repair

scientific article published on 25 October 2017

Complement therapeutics

scientific article published on 01 June 2016

Complement therapeutics in inflammatory diseases: promising drug candidates for C3-targeted intervention

scientific article published on 29 August 2015

Complement-Dependent Mechanisms and Interventions in Periodontal Disease

scientific article published on 12 March 2019

Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4.

scientific article published on 26 September 2017

Complement-dependent neutrophil recruitment is critical for the development of elastase-induced abdominal aortic aneurysm

scientific article published on 23 March 2009

Complement-mediated clearance of erythrocytes: mechanism and delineation of the regulatory roles of Crry and DAF

scientific article published on 01 August 2002

Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis

scientific article

Complement-targeted therapeutics

scientific article

Complement-targeted therapeutics in periodontitis

scientific article

Complement-triggered pathways orchestrate regenerative responses throughout phylogenesis

scientific article published on February 2013

Complement: More than killing

scholarly article by John D. Lambris published February 2013 in Seminars in Immunology

Complement: an inflammatory pathway fulfilling multiple roles at the interface of innate immunity and development.

scientific article

Complement: more than a 'guard' against invading pathogens?

scientific article

Complement: structure, functions, evolution, and viral molecular mimicry

scientific article

Complementary Tolls in the periodontium: how periodontal bacteria modify complement and Toll-like receptor responses to prevail in the host

scientific article published on February 2010

Complementing the Cancer-Immunity Cycle

Complexity of complement activation in sepsis

scientific article published on December 2008

Compstatin Cp40 blocks hematin-mediated deposition of C3b fragments on erythrocytes: Implications for treatment of malarial anemia

scientific article

Compstatin analog Cp40 inhibits complement dysregulation in vitro in C3 glomerulopathy

scientific article published on 5 May 2015

Compstatin inhibits complement activation by binding to the beta-chain of complement factor 3.

scientific article

Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts

article

Compstatin, a peptide inhibitor of complement, exhibits species-specific binding to complement component C3.

scientific article published in January 2003

Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention

scientific article

Compstatin: a complement inhibitor on its way to clinical application

scientific article

Conformational analysis of compstatin analogues with molecular dynamics simulations in explicit water

scientific article

Conformational differences between surface-bound and fluid-phase complement-component-C3 fragments. Epitope mapping by cDNA expression ⬇️

scientific article published on March 15, 1992

Conformational interconversion in compstatin probed with molecular dynamics simulations

scientific article published in October 2003

Conjugation to albumin-binding molecule tags as a strategy to improve both efficacy and pharmacokinetic properties of the complement inhibitor compstatin

scientific article

Contact activation of C3 enables tethering between activated platelets and polymorphonuclear leukocytes via CD11b/CD18.

scientific article published on 13 August 2015

Contribution of chondroitin sulfate A to the binding of complement proteins to activated platelets

scientific article

Contribution of the Innate Immune System to Autoimmune Diabetes: A Role for the CR1/CR2 Complement Receptors

Control of the collective migration of enteric neural crest cells by the Complement anaphylatoxin C3a and N-cadherin

scientific article (publication date: June 2016)

Corrigendum: Targeting Complement Pathways in Polytrauma- and Sepsis-Induced Multiple-Organ Dysfunction

scientific article published on 03 May 2019

Coupling of C3b to erythrocytes by disulfide bond formation: Preparation of EC3b for hemolytic and complement receptor assays

scientific article published on 01 December 1983

Cross-disciplinary research stirs new challenges into the study of the structure, function and systems biology of complement.

scientific article published on January 2006

Crosstalk between the coagulation and complement systems in sepsis

scientific article

Crosstalk pathways between Toll-like receptors and the complement system

scientific article published on 10 February 2010

Crystallization of human complement component C3b in the presence of a staphylococcal complement-inhibitor protein (SCIN).

scientific article published on 24 April 2009

Current understanding of periodontal disease pathogenesis and targets for host-modulation therapy

scientific article published on 01 October 2020

Cutting edge: members of the Staphylococcus aureus extracellular fibrinogen-binding protein family inhibit the interaction of C3d with complement receptor 2.

scientific article published on December 2008

Cytokine secretion depends on Galalpha(1,3)Gal expression in a pig-to-human whole blood model

scientific article published on May 2008

DAF/Crry double deficiency in mice exacerbates nephrotoxic serum-induced proteinuria despite markedly reduced systemic complement activity.

scientific article published on 2 August 2006

Design and NMR characterization of active analogues of compstatin containing non-natural amino acids

scientific article published in January 2005

Development of a new pharmacophore model that discriminates active compstatin analogs

scientific article published on October 2008

Diet-induced hepatocellular carcinoma in genetically predisposed mice

scientific article published on 19 May 2009

Differential capacity for complement receptor-mediated immune evasion by Porphyromonas gingivalis depending on the type of innate leukocyte

scientific article

Differential effect of heparin coating and complement inhibition on artificial surface-induced eicosanoid production

scientific article published in March 2005

Differential effect of inhibiting MD-2 and CD14 on LPS- versus whole E. coli bacteria-induced cytokine responses in human blood

scientific article published on January 2012

Differentiation-dependent changes in human trophoblast expression of decay-accelerating factor are modulated by 3?,5? cyclic adenosine monophosphate

scientific article published on 01 January 1997

Dissecting the instant blood-mediated inflammatory reaction in islet xenotransplantation

scientific article published in July 2008

Diversity in the C3b Convertase Contact Residues and Tertiary Structures of the Staphylococcal Complement Inhibitor (SCIN) Protein Family

scientific article

Diversity in the C3b contact residues and tertiary structures of the staphylococcal complement inhibitor (SCIN) protein family

scientific article published in Journal of Biological Chemistry

Diversity of the third form of complement, C3, in fish: functional characterization of five forms of C3 in the diploid fish Sparus aurata

scientific article published on September 1997

Do cryopreserved mesenchymal stromal cells display impaired immunomodulatory and therapeutic properties?

scientific article

Does complement play a role in bone development and regeneration?

scientific article published on 02 February 2012

Drusen complement components C3a and C5a promote choroidal neovascularization

scientific article

Dynamic structural changes during complement C3 activation analyzed by hydrogen/deuterium exchange mass spectrometry

scientific article

Early post-operative measurement of cytokine plasma levels combined with pre-operative bilirubin levels identify high-risk patients after liver resection

scientific article

Editorial: Therapeutic Modulation of the Complement System: Clinical Indications and Emerging Drug Leads

scientific article published on 01 January 2019

Effect of a putative B cell superantigen on complement

scientific article published on 01 September 1995

Effect of complement inhibition and heparin coating on artificial surface-induced leukocyte and platelet activation

scientific article published in March 2004

Effect of supraphysiologic levels of C1-inhibitor on the classical, lectin and alternative pathways of complement

scientific article published on 13 November 2006

Electrostatic contributions drive the interaction betweenStaphylococcus aureusprotein Efb-C and its complement target C3d

scientific article

Electrostatic modeling predicts the activities of orthopoxvirus complement control proteins

scientific article

Epitope Mapping Using the X-Ray Crystallographic Structure of Complement Receptor Type 2 (CR2)/CD21: Identification of a Highly Inhibitory Monoclonal Antibody That Directly Recognizes the CR2-C3d Interface

scientific article published on 01 November 2001

Erythrocytes Reveal Complement Activation in Patients with COVID-19

scientific article published on 22 May 2020

Escherichia coli-induced coagulation activation and pentraxin 3 release is highly dependent on complement and CD14

scientific article published in 2012

Essential role of the C5a receptor in E coli-induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation

scientific article published in September 2002

Evidence for multiple sites of interaction in C3 for complement receptor type 2 (C3d/EBV receptor, CD21)

scientific article published on 01 November 1991

Evolution and diversity of the complement system of poikilothermic vertebrates

scientific article published in December 1998

Expanding Complement Therapeutics for the Treatment of Paroxysmal Nocturnal Hemoglobinuria

scientific article published on 14 February 2018

Exploring the complement interaction network using surface plasmon resonance.

scientific article published on January 2007

Expression and function of C5a receptor in mouse microvascular endothelial cells

scientific article published on 01 November 2002

Expression of CR2/EBV receptors on human thymocytes detected by monoclonal antibodies

scientific article published on 01 August 1988

Expression of EBV/C3d receptors on T cells: biological significance

scientific article

Expression of complement 3 and complement 5 in newt limb and lens regeneration.

scientific article

Expression of compstatin in Escherichia coli: incorporation of unnatural amino acids enhances its activity

scientific article published on 15 December 2005

Factor H C-Terminal Domains Are Critical for Regulation of Platelet/Granulocyte Aggregate Formation.

scientific article published on 23 November 2017

Factor H interferes with the adhesion of sickle red cells to vascular endothelium: a novel disease-modulating molecule

scientific article published on 10 January 2019

Factor H-IgG Chimeric Proteins as a Therapeutic Approach against the Gram-Positive Bacterial Pathogen Streptococcus pyogenes

scientific article published on 30 October 2017

Fluorescent labelling of proteins of lymphocyte plasma membranes

scientific article published on May 1979

From orphan drugs to adopted therapies: Advancing C3-targeted intervention to the clinical stage.

scientific article published on 16 June 2016

Functional Relevance of the Anaphylatoxin Receptor C3aR for Platelet Function and Arterial Thrombus Formation Marks an Intersection Point Between Innate Immunity and Thrombosis

scientific article published on 01 October 2018

Functional maturation of murine B lymphocyte precursors—III. Soluble factors involved in the regulation of growth and differentiation

scientific article published on 01 November 1988

Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1

scientific article (publication date: 15 May 2003)

G protein coupled receptor specificity for C3a and compound 48/80-induced degranulation in human mast cells: roles of Mas-related genes MrgX1 and MrgX2.

scientific article

Generation of C5a in the absence of C3: a new complement activation pathway

article

Generation of a monoclonal antibody to mouse C5 application in an ELISA assay for detection of anti-CS antibodies

scientific article published on 01 June 1987

Generation of analogues of the clinical complement inhibitor compstatin with improved potency and pharmacokinetics

scientific article

Generation of three different fragments of bound C3 with purified factor I or serum. II. Location of binding sites in the C3 Fragments for Factors B and H, complement receptors , and bovine conglutinin ⬇️

scientific article published on August 1, 1983

Genetic and intervention studies implicating complement C3 as a major target for the treatment of periodontitis

scientific article

Genetic and pharmacologic inhibition of complement impairs endothelial cell function and ablates ovarian cancer neovascularization

scientific article

Gingival Exudatome Dynamics Implicate Inhibition of the Alternative Complement Pathway in the Protective Action of the C3 Inhibitor Cp40 in Nonhuman Primate Periodontitis

scientific article published on 29 August 2018

H1 10:00 Phylogeny and diversity of the third complement component C3

scholarly article

H7 11:45 Structural and functional characterization of B/C2 complement molecules in teleost fish ⬇️

scholarly article

Herpes simplex virus type 1 evades the effects of antibody and complement in vivo

scientific article

High-Fat Diet-Induced Complement Activation Mediates Intestinal Inflammation and Neoplasia, Independent of Obesity

scientific article published on 17 August 2016

Hormonal regulation of complement factor B in human endometrium

scientific article published on 01 September 1993

Human genetic deficiencies reveal the roles of complement in the inflammatory network: lessons from nature

scholarly article

Hydrogen/deuterium exchange mass spectrometry: potential for investigating innate immunity proteins

scientific article published on January 2007

Hydrophobic Effect and Hydrogen Bonds Account for the Improved Activity of a Complement Inhibitor, Compstatin

article

Hypoxia and reoxygenation of primary human hepatocytes induce proteome changes of glucose metabolism, oxidative protection and peroxisomal function ⬇️

scientific article published on October 1, 2010

Identification of a C3bi-specific membrane complement receptor that is expressed on lymphocytes, monocytes, neutrophils, and erythrocytes.

scientific article

Illuminating the latest advances in innate immunity on the island of the sun god ⬇️

scientific article published on 01 November 2010

Immune competence of the Ciona intestinalis pharynx: Complement system-mediated activity

scientific article published on 05 September 2012

Immune evasion of Moraxella catarrhalis involves ubiquitous surface protein A-dependent C3d binding.

scientific article

Impaired ability of complement activation via the alternative pathway C3 convertase caused by a single-point mutation in the beta chain of C3

scientific article

Importance of Factors H and I for the Adherence of C3b-Coated Erythrocytes to Cells

scientific article published on 01 August 1983

In vivo significance of ITK-SLP-76 interaction in cytokine production

scientific article

Incomplete inhibition by eculizumab: mechanistic evidence for residual C5 activity during strong complement activation

scientific article

Increased C5a receptor expression in sepsis

scientific article

Increased C5a receptor expression in sepsis

Inducing and characterizing liver regeneration in mice: Reliable models, essential "readouts" and critical perspectives

scientific article published on October 2013

Induction of complement C3a receptor responses by kallikrein-related peptidase 14.

scientific article published on 06 September 2013

Inhibition of Heparin/Protamine Complex-Induced Complement Activation by Compstatin in Baboons

scientific article published on 01 September 2000

Inhibition of biomaterial-induced complement activation attenuates the inflammatory host response to implantation

scientific article published on 04 April 2013

Inhibition of pre-existing natural periodontitis in non-human primates by a locally administered peptide inhibitor of complement C3

scientific article published on 5 January 2016

Inhibition of the alternative complement pathway preserves photoreceptors after retinal injury.

scientific article published on July 2015

Innate immune responses to trauma.

scientific article published on 5 March 2018

Innate immunity activation on biomaterial surfaces: a mechanistic model and coping strategies

scientific article

Innate immunity in the Aegean: ancient pathways for today's survival

scientific article published in April 2002

Innate immunity mechanisms

scientific article published on 01 January 2012

Integrated Computational and Experimental Approach for Lead Optimization and Design of Compstatin Variants with Improved Activity

article

Interaction between Epstein-Barr virus and a T cell line (HSB-2) via a receptor phenotypically distinct from complement receptor type 2

scientific article published on May 1, 1992

Interaction between the coagulation and complement system

scientific article published on January 2008

Interaction of Streptococcus pyogenes with extracellular matrix components resulting in immunomodulation and bacterial eradication

scientific article published in May 2020

Interactions between coagulation and complement--their role in inflammation

scientific article

Interlaboratory Comparison of Hydrogen-Deuterium Exchange Mass Spectrometry Measurements of the Fab Fragment of NISTmAb

scientific article published on 14 May 2019

Invited commentary

Iron oxide nanoparticles induce cytokine secretion in a complement-dependent manner in a human whole blood model

scientific article

Is complement good or bad for cancer patients? A new perspective on an old dilemma

scientific article published on 08 May 2009

Isolation and characterization of the third complement component of axolotl (Ambystoma mexicanum)

scientific article published on 01 January 1990

Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) open reading frame 4 protein (kaposica) is a functional homolog of complement control proteins

scientific article

Key role of complement receptor 1 in the initial binding of Escherichia coli and Neisseria meningitidis to erythrocytes in human whole blood

scientific article published in 2009

Key role of complement receptor 1 in the initial binding of Escherichia coli and Neisseria meningitidis to erythrocytes in human whole blood

scientific article published in 2008

Kinetic analysis of glycoprotein C of herpes simplex virus types 1 and 2 binding to heparin, heparan sulfate, and complement component C3b.

scientific article published in March 2002

Kinetic analysis of the interactions of complement receptor 2 (CR2, CD21) with its ligands C3d, iC3b, and the EBV glycoprotein gp350/220.

scientific article published in August 2001

Liver inflammation and regeneration: two distinct biological phenomena or parallel pathophysiologic processes?

scientific article

Liver regeneration: a link to inflammation through complement.

scientific article published on January 2006

Local complement-targeted intervention in periodontitis: proof-of-concept using a C5a receptor (CD88) antagonist

scientific article

Local endothelial complement activation reverses endothelial quiescence, enabling t-cell homing, and tumor control during t-cell immunotherapy.

scientific article

Localization of the complement-component-C3b-binding site and the cofactor activity for factor I in the 38kDa tryptic fragment of factor H ⬇️

scientific article published on December 1, 1984

Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement

scientific article

Lymphocyte mitogenesis induced by monoclonal antibodies to the T3 complex. Differential modulation by human IgG

scientific article published on 01 November 1984

Mass spectrometric analyses of the activation products of the third component of complement

article

Mechanisms of action of differentiation inducers: detection of inducer binding protein(s) in murine erythroleukemia cells.

scientific article

Mediation of a non-proteolytic activation of complement component C3 by phospholipid vesicles.

scientific article

Membranoproliferative glomerulonephritis type II (dense deposit disease): an update

scientific article

Mesenchymal stromal cells engage complement and complement receptor bearing innate effector cells to modulate immune responses

scientific article

Method development and validation for the quantitation of the complement inhibitor Cp40 in human and cynomolgus monkey plasma by UPLC-ESI-MS.

scientific article published on 6 December 2016

Microbial hijacking of complement-toll-like receptor crosstalk

scientific article published on 16 February 2010

Microbial manipulation of receptor crosstalk in innate immunity

scientific article

Modulation of fluid-phase complement activation inhibits hyperacute rejection in a porcine-to-human xenograft model

article

Modulation of the antitumor immune response by complement

scientific article

Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b

scientific article

Molecular cloning of the beta subunit of complement component eight of rainbow trout

scientific article

Molecular intercommunication between the complement and coagulation systems

scientific article

More than complementing Tolls: complement-Toll-like receptor synergy and crosstalk in innate immunity and inflammation

scientific article

Mouse genetics and proteomic analyses demonstrate a critical role for complement in a model of DHRD/ML, an inherited macular degeneration

scientific article published on 13 August 2013

Multi-scale characterization of the energy landscape of proteins with application to the C3D/Efb-C complex

scientific article

Multiple forms of complement C3 in trout that differ in binding to complement activators

scientific article published on August 1996

Murine visceral leishmaniasis: IgM and polyclonal B-cell activation lead to disease exacerbation

scientific article

Native State of Complement Protein C3d Analysed via Hydrogen Exchange and Conformational Sampling

scientific article published on 24 March 2018

Neisseria meningitidis and Escherichia coli are protected from leukocyte phagocytosis by binding to erythrocyte complement receptor 1 in human blood

scientific article

Neoantigens in complement component C3 as detected by monoclonal antibodies. Mapping of the recognized epitopes by synthetic peptides.

scientific article published on May 1990

Neutrophil homeostasis and inflammation: novel paradigms from studying periodontitis

scientific article

New Analogs of the Complement C3 Inhibitor Compstatin with Increased Solubility and Improved Pharmacokinetic Profile

scientific article published on 03 July 2018

New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties

scientific article

New approaches to the treatment of dense deposit disease

scientific article published on 5 August 2007

New insights into the immune functions of complement

scientific article published on 01 August 2019

New milestones ahead in complement-targeted therapy

scientific article

Novel Complement Modulators for Paroxysmal Nocturnal Hemoglobinuria: Peptide and Protein Inhibitors of C3 Convertase Prevent Both Surface C3 Deposition and Subsequent Hemolysis of Affected Erythrocytes in Vitro ⬇️

scholarly article

Novel Immunoassay for Complement Activation by PF4/Heparin Complexes

scientific article published on 30 June 2018

Novel analogues of the therapeutic complement inhibitor compstatin with significantly improved affinity and potency

scientific article

Novel biological networks modulated by complement

scientific article

Novel mechanism of antibody-independent complement neutralization of herpes simplex virus type 1.

scientific article published on October 2000

Novel mechanisms and functions of complement.

scientific article published in November 2017

Novel monoclonal antibodies against mouse C3 interfering with complement activation: description of fine specificity and applications to various immunoassays

scientific article

Ornithodoros moubata complement inhibitor is an equally effective C5 inhibitor in pigs and humans

scientific article

Overexpression, purification, and characterization of third component of complement

scientific article published on November 1994

PMX-53 as a dual CD88 antagonist and an agonist for Mas-related gene 2 (MrgX2) in human mast cells

scientific article

PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer

scientific article

Partial hepatectomy induced liver proteome changes in mice

scientific article

Pathogenesis of B-cell superantigen-induced immune complex-mediated inflammation

scientific article

Pathogenic microbes and community service through manipulation of innate immunity

scientific article published on January 2012

Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

scientific article published on 04 February 2014

Peptides of myelin basic protein stimulate T lymphocytes from patients with multiple sclerosis

scientific article published in March 1989

Pericytes and immune cells contribute to complement activation in tubulointerstitial fibrosis

scientific article

Phagocytosis of Escherichia coli in human whole blood: Early complement dependency is succeeded by late CD14 dependency over time

scientific article published in 2012

Phylogenetic aspects of the complement system.

scientific article

Phylogeny of the third complement component, C3, and conservation of C3-ligand interactions

scientific article published on 01 April 1994

Phylogeny of the third component of complement, C3: Analysis of the conservation of human CR1, CR2, H, and B binding sites, concanavalin A binding sites, and thiolester bond in the C3 from different species

scientific article published on 01 January 1992

Physical methods for structure, dynamics and binding in immunological research.

scientific article

Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis

scientific article

Porphyromonas gingivalis disturbs host-commensal homeostasis by changing complement function

scientific article published on 30 June 2017

Porphyromonas gingivalis manipulates complement and TLR signaling to uncouple bacterial clearance from inflammation and promote dysbiosis

scientific article

Post challenge inhibition of C3 and CD14 attenuates Escherichia coli-induced inflammation in human whole blood

scientific article

Preclinical Development and In Vivo Evaluation Of Next-Generation Compstatin Analogs With Improved Systemic Profiles: A Novel Option For The Treatment Of Paroxysmal Nocturnal Hemoglobinuria ⬇️

scholarly article

Preclinical evaluation of innate immunity to baculovirus gene therapy vectors in whole human blood

scientific article published on 08 August 2009

Preformed mediators of defense-Gatekeepers enter the spotlight

scientific article published in November 2016

Progress and Trends in Complement Therapeutics

scientific article

Prolongation of ex vivo–perfused pig xenograft survival by the complement inhibitor compstatin

scientific article published on 01 February 1999

Prolonged intraocular residence and retinal tissue distribution of a fourth-generation compstatin-based C3 inhibitor in non-human primates

scientific article published on 27 March 2020

Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice

scientific article

Properdin-Mediated C5a Production Enhances Stable Binding of Platelets to Granulocytes in Human Whole Blood

scientific article published on 25 April 2016

Protection of host cells by complement regulators.

scientific article published in November 2016

Protection of innate immunity by C5aR antagonist in septic mice

article

Protection of nonself surfaces from complement attack by factor H-binding peptides: implications for therapeutic medicine

scientific article

Protective Effects of the Complement Inhibitor Compstatin CP40 in Hemorrhagic Shock

Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression

scientific article published on 01 January 2003

Rare loss-of-function mutation in complement component C3 provides insight into molecular and pathophysiological determinants of complement activity

scientific article

Rational engineering of a minimized immune inhibitor with unique triple-targeting properties

scientific article published on 24 April 2013

Real-time label-free detection of complement activation products in human serum by white light reflectance spectroscopy

scientific article published on 03 May 2009

Recent developments in low molecular weight complement inhibitors

scientific article published on 02 October 2009

Reduced Terminal Complement Complex Formation in Mice Manifests in Low Bone Mass and Impaired Fracture Healing

scientific article published on 17 October 2018

Regulation of Human Cytotoxic Responses by Complement: C3, C3b and C3d Preparations Enhance Human Allogeneic Cytotoxic Responses

article

Regulation of Instant Blood Mediated Inflammatory Reaction (IBMIR) in Pancreatic Islet Xeno-Transplantation: Points for Therapeutic Interventions

scientific article published on January 2015

Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo

scientific article published on 15 March 2007

Regulation of immune responsiveness in vivo by disrupting an early T-cell signaling event using a cell-permeable peptide

scientific article published on 7 May 2013

Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses

scientific article

Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode.

scientific article published on 24 March 2016

Restoration of complement-enhanced neutralization of vaccinia virus virions by novel monoclonal antibodies raised against the vaccinia virus complement control protein

scientific article

Role of complement in host-microbe homeostasis of the periodontium

scientific article

Role of decay-accelerating factor in regulating complement activation on the erythrocyte surface as revealed by gene targeting

scientific journal article

Safety and Efficacy of the Complement Inhibitor AMY-101 in a Natural Model of Periodontitis in Non-human Primates.

scientific article published on 18 August 2017

Safety profile after prolonged C3 inhibition

scientific article published on 10 October 2018

Segment spanning residues 727-768 of the complement C3 sequence contains a neoantigenic site and accommodates the binding of CR1, factor H, and factor B

scientific article published on 01 February 1992

Selective inhibition of TNF-alpha or IL-1 beta does not affect E. coli-induced inflammation in human whole blood

scientific article published on 23 March 2010

Selectivity of C3-opsonin targeted complement inhibitors: A distinct advantage in the protection of erythrocytes from paroxysmal nocturnal hemoglobinuria patients.

scientific article published on 6 January 2016

Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus

scientific article published on 18 June 2021

Short Leucine-Rich Proteoglycans Modulate Complement Activity and Increase Killing of the Respiratory Pathogen

scientific article published on 28 September 2018

Similarities between a conserved sequence element of homoeo boxes and other genes.

scientific article published in January 1986

Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement

scientific article published on 10 September 2020

Solution insights into the structure of the Efb/C3 complement inhibitory complex as revealed by lysine acetylation and mass spectrometry

scientific article

Solvent accessibility of native and hydrolyzed human complement protein 3 analyzed by hydrogen/deuterium exchange and mass spectrometry.

scientific article

Stages of meningococcal sepsis simulated in vitro, with emphasis on complement and Toll-like receptor activation

scientific article published on 30 June 2008

Structural Implications for the Formation and Function of the Complement Effector Protein iC3b.

scientific article

Structural and functional analysis of the complement component factor H with the use of different enzymes and monoclonal antibodies to factor H.

scientific article published on December 1985

Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor

scientific article

Structural change in alpha-chymotrypsin induced by complexation with alpha 1-antichymotrypsin as seen by enhanced sensitivity to proteolysis.

scientific article

Structure and biology of complement protein C3, a connecting link between innate and acquired immunity

scientific article (publication date: April 2001)

Structure of C3b reveals conformational changes that underlie complement activity

scientific article

Structure of complement fragment C3b-factor H and implications for host protection by complement regulators

scientific article

Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition

scientific article

Structure-kinetic relationship analysis of the therapeutic complement inhibitor compstatin

scientific article

Structures of C3b in complex with factors B and D give insight into complement convertase formation

scientific article

Studies of structure-activity relations of complement inhibitor compstatin.

scientific article

Suppression of drusen formation by compstatin, a peptide inhibitor of complement C3 activation, on cynomolgus monkey with early-onset macular degeneration

scientific article

Synergistic neuroprotective effects of C3a and C5a receptor blockade following intracerebral hemorrhage

scientific article published on 4 May 2009

Synthesis and activity of thioether-containing analogues of the complement inhibitor compstatin

scientific article

Systems Analysis of the Complement-Induced Priming Phase of Liver Regeneration.

scientific article published on 10 August 2016

T cell-derived interleukin (IL)-21 promotes brain injury following stroke in mice

scientific article

Taming hemodialysis-induced inflammation: Are complement C3 inhibitors a viable option?

scientific article published on 22 November 2018

Targeted complement inhibition as a promising strategy for preventing inflammatory complications in hemodialysis

scientific article

Targeting Complement Pathways in Polytrauma- and Sepsis-Induced Multiple-Organ Dysfunction

Targeting complement components C3 and C5 for the retina: Key concepts and lingering questions

scientific article published on 12 December 2020

The C-terminus of complement factor H is essential for host cell protection

scientific article published on 17 January 2007

The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss

scientific article

The Challenges and Promise of Complement Therapeutics for Ocular Diseases.

scientific article

The Complement System Is Critical in Maintaining Retinal Integrity during Aging.

scientific article published on 15 February 2018

The XXIV International Complement Workshop (ICW) on October 10-15, 2012. Preface.

scientific article published in November 2012

The alternative complement pathway regulates pathological angiogenesis in the retina

scientific article

The anaphylatoxin receptor C5aR is present during fracture healing in rats and mediates osteoblast migration in vitro

scientific article

The artificial surface-induced whole blood inflammatory reaction revealed by increases in a series of chemokines and growth factors is largely complement dependent

scientific article published on October 2008

The classical complement cascade mediates CNS synapse elimination

scientific article

The complement anaphylatoxin C5a receptor contributes to obese adipose tissue inflammation and insulin resistance

scientific article published on 16 September 2013

The complement inhibitory protein DAF (CD55) suppresses T cell immunity in vivo

scientific article

The complement system in teleosts

scientific article

The effects of selective complement and CD14 inhibition on the E. coli-induced tissue factor mRNA upregulation, monocyte tissue factor expression, and tissue factor functional activity in human whole blood

scientific article published in January 2013

The electrostatic nature of C3d-complement receptor 2 association.

scientific article published in June 2004

The evolution and appearance of C3 duplications in fish originate an exclusive teleost c3 gene form with anti-inflammatory activity

scientific article

The evolution, structure, biology and pathophysiology of complement

article

The extracellular adherence protein from Staphylococcus aureus inhibits the classical and lectin pathways of complement by blocking formation of the C3 proconvertase

scientific article

The first case of COVID-19 treated with the complement C3 inhibitor AMY-101

scientific article published on 29 April 2020

The induction of cytokines by polycation containing microspheres by a complement dependent mechanism

scientific article

The interaction of glycoprotein C of herpes simplex virus types 1 and 2 with the alternative complement pathway

scientific article published in September 1994

The multifunctional role of C3, the third component of complement

scientific article published on December 1988

The multifunctional role of C3: Structural analysis of its interactions with physiological ligands

article

The proinflammatory mediators C3a and C5a are essential for liver regeneration

scientific article

The regulation of liver cell survival by complement

scientific article published on May 2009

The renaissance of complement therapeutics.

scientific article published on 4 December 2017

The role of complement in biomaterial-induced inflammation

scientific article published on 14 August 2006

The role of complement in inflammatory diseases from behind the scenes into the spotlight

scientific article

The role of complement in tumor growth

scientific article

The role of properdin in zymosan- and Escherichia coli-induced complement activation

scientific article published on 30 July 2012

The role of properdin in zymosan- and Escherichia coli-induced complement activation

scientific article published in 2012

The role of the complement system in metabolic organs and metabolic diseases

scientific article published on February 2013

The role of third complement component (C3) in homing of hematopoietic stem/progenitor cells into bone marrow.

scientific article published on January 2006

The structural basis of compstatin activity examined by structure-function-based design of peptide analogs and NMR.

scientific article

The third component of Xenopus complement: cDNA cloning, structural and functional analysis, and evidence for an alternate C3 transcript.

scientific article published on February 1995

The three HveA receptor ligands, gD, LT-alpha and LIGHT bind to distinct sites on HveA.

scientific article published in August 2000

Therapeutic C3 inhibitor Cp40 abrogates complement activation induced by modern hemodialysis filters

scientific article

Therapeutic control of complement activation at the level of the central component C3.

scientific article

Therapeutic targeting of the complement system

scientific article published on 09 December 2019

Thermodynamic studies on the interaction of the third complement component and its inhibitor, compstatin

scientific article published on 15 October 2004

Thirty-Eight-Negative Kinase 1 Is a Mediator of Acute Kidney Injury in Experimental and Clinical Traumatic Hemorrhagic Shock

scientific article published on 26 August 2020

To regeneration...with complement

scientific article published on January 2006

Unwelcome complement

scientific article published on 04 August 2009

Using an in vitro xenoantibody-mediated complement-dependent cytotoxicity model to evaluate the complement inhibitory activity of the peptidic C3 inhibitor Cp40.

scientific article published on 5 November 2015

ciCD94-1, an ascidian multipurpose C-type lectin-like receptor expressed in Ciona intestinalis hemocytes and larval neural structures

scientific article published on 09 October 2007

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