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List of works by Simon J Dowell

Characterization of 16 human G protein-coupled receptors expressed in baculovirus-infected insect cells.

scientific article published on November 2005

DNA binding of CPF1 is required for optimal centromere function but not for maintaining methionine prototrophy in yeast.

scientific article

Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity.

scientific article

Discovery of Tetrahydropyrazolopyridine as Sphingosine 1-Phosphate Receptor 3 (S1P3)-Sparing S1P1 Agonists Active at Low Oral Doses

scientific article published on 11 January 2016

Discovery of a Brain-Penetrant S1P3-Sparing Direct Agonist of the S1P1 and S1P5 Receptors Efficacious at Low Oral Dose ⬇️

scientific article published on September 9, 2011

Discovery of a Selective S1P1 Receptor Agonist Efficacious at Low Oral Dose and Devoid of Effects on Heart Rate

scientific article

Functional coupling of mammalian receptors to the yeast mating pathway using novel yeast/mammalian G protein alpha-subunit chimeras

scientific article published on 01 January 2000

Heterologous expression of G-protein-coupled receptors in yeast

scientific article published on 20 March 2015

Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo.

scientific article

Investigating G protein signalling bias at the glucagon-like peptide-1 receptor in yeast

scientific article published on August 2014

Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2).

scientific article published on 21 July 2015

Molecular identification of high and low affinity receptors for nicotinic acid

scientific article (publication date: 14 March 2003)

Mutagenesis of human Mel1a melatonin receptor expressed in yeast reveals domains important for receptor function

scientific article published on 01 August 1998

Pharmacological properties of acid N-thiazolylamide FFA2 agonists.

scientific article published on 8 May 2015

Pharmacology of GPR55 in Yeast and Identification of GSK494581A as a Mixed-Activity Glycine Transporter Subtype 1 Inhibitor and GPR55 Agonist ⬇️

scientific article published on January 13, 2011

Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors

scientific article published on 14 October 2016

Receptor activity-modifying protein-directed G protein signaling specificity for the calcitonin gene-related peptide family of receptors

scientific article published on December 2016

Structure-Activity Relationship of the GPR55 Antagonist, CID16020046

scientific article published on 08 October 2018

The centromere and promoter factor 1 of yeast contains a dimerisation domain located carboxy-terminal to the bHLH domain ⬇️

scientific article published on August 25, 1992

The utility of pharmacokinetic-pharmacodynamic modeling in the discovery and optimization of selective S1P(1) agonists

scientific article published on 09 January 2012

Two steps in the assembly of complexes at yeast replication origins in vivo

scientific article (publication date: 29 July 1994)

Understanding GPCRs - from orphan receptors to novel drugs

scientific article published on 01 September 2001

Yeast Assays for G-Protein-Coupled Receptors ⬇️

scientific article published on January 1, 2002

Yeast assays for G protein-coupled receptors

scientific article published on 01 January 2009

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