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List of works by Mark Wheatley

A Gly/Ala switch contributes to high affinity binding of benzoxazinone-based non-peptide oxytocin receptor antagonists.

scientific article

A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors.

scientific article published in January 2005

A novel thromboxane A2 receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis

scientific article published on 14 October 2009

A selective biotinylated probe for V1a vasopressin receptors

scientific article published on May 1991

Agonist-specific requirement for a glutamate in transmembrane helix 1 of the oxytocin receptor ⬇️

scientific article published on December 3, 2010

An acid-compatible co-polymer for the solubilization of membranes and proteins into lipid bilayer-containing nanoparticles.

scientific article published in June 2018

An arginyl in the N-terminus of the V1a vasopressin receptor is part of the conformational switch controlling activation by agonist

scientific article (publication date: December 2003)

Binding and hydrodynamic properties of muscarinic receptor subtypes solubilized in 3-(3-cholamidopropyl)dimethylammonio-2-hydroxy-1-propanesulfonate

scientific article published on 01 September 1989

Biochemical mechanisms of calcium mobilisation induced by mastoparan and chimeric hormone-mastoparan constructs.

scientific article published in July 1998

Calcium-mobilizing actions of chimeric hormone-mastoparan peptides.

scientific article published in August 1997

Characterisation of brain D2 dopamine receptors solubilised by lysophosphatidylcholine

scientific article published on 01 January 1983

Characterization of G protein-coupled receptors expressed by ECV304 human endothelial cells.

scientific article published on January 1998

Characterization of an epitope-tagged vasopressin V1a receptor: a probe for receptor structure and function

scientific article published on 01 August 1997

Characterization of the human oxytocin receptor ligand binding site

scientific article published on 01 August 1997

Characterization of the structure of RAMP1 by mutagenesis and molecular modeling

scientific article published on 21 April 2006

Chimeric analogues of vasopressin and bradykinin

scientific article published on 01 August 1997

Chimeric hormones and neuropeptides

scientific article published on 01 December 1997

Chimeric strategies for the rational design of bioactive analogs of small peptide hormones ⬇️

scientific article published on June 1, 1997

Critical role of a subdomain of the N-terminus of the V1a vasopressin receptor for binding agonists but not antagonists; functional rescue by the oxytocin receptor N-terminus.

scientific article

Curcumin: a new cell-permeant inhibitor of the inositol 1,4,5-trisphosphate receptor.

scientific article

Defining the ligand-binding site for vasopressin receptors: a peptide mimetic approach.

scientific article published on February 1995

Design and synthesis of heterofunctional V1a-selective vasopressin receptor ligands with lysine at position 9

scientific article published on 01 October 1992

Diverse Functional Motifs within the Three Intracellular Loops of the CGRP1Receptor†

scientific article published in October 2006

Effects of vasopressin-mastoparan chimeric peptides on insulin release and G-protein activity

scientific article published on 01 June 1999

Extracellular loops and ligand binding to a subfamily of Family A G-protein-coupled receptors

scientific article published on August 2007

Family resemblances? Ligand binding and activation of family A and B G-protein-coupled receptors

scientific article published on August 2007

Fluorescent and biotinylated linear peptides as selective bifunctional ligands for the V1a vasopressin receptor.

scientific article published on April 1993

Functional and biophysical analysis of the C-terminus of the CGRP-receptor; a family B GPCR.

scientific article published on 18 July 2008

G Protein-Coupled Receptors

scientific article published on 22 January 2010

G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent.

scientific article published on 16 April 2015

G-protein-coupled receptor phosphorylation and palmitoylation.

scientific article published in January 2004

G-protein-coupled receptors: from structural insights to functional mechanisms

scientific article published on February 2013

GPCR-styrene maleic acid lipid particles (GPCR-SMALPs): their nature and potential.

scientific article published on April 2016

Glycosylation of G-protein-coupled receptors for hormones central to normal reproductive functioning: its occurrence and role.

scientific article

Hepatic vasopressin receptors (VPRs) exhibit species heterogeneity--absence of VPRs in sheep liver

scientific article published on 01 June 1993

Heterodimers and family-B GPCRs: RAMPs, CGRP and adrenomedullin

scientific article published in November 2004

Homology between neurohypophyseal hormone receptors.

scientific article published on December 1993

Human liver vasopressin receptors

scientific article published on 01 August 1991

Identification of an extracellular segment of the oxytocin receptor providing agonist-specific binding epitopes.

scientific article published on March 2001

Interaction of calcitonin-gene-related peptide with its receptors

scientific article

Interactions between RAMP2 and CRF receptors: The effect of receptor subtypes, splice variants and cell context

scientific article published in May 2019

Intramedullary blood vessels of the spinal cord express V1a vasopressin receptors: visualization by a biotinylated ligand

scientific article published on 01 December 1995

Lifting the lid on GPCRs: the role of extracellular loops

scientific article published on March 2012

Ligand Binding and Activation of the CGRP Receptor

scientific article published on 4 September 2009

Ligand binding and activation of the CGRP receptor.

scientific article

Ligand-induced conformational changes in a SMALP-encapsulated GPCR

scientific article published on 29 February 2020

Localisation of arginine vasopressin V1a receptors on sympatho-adrenal preganglionic neurones.

scientific article published in March 1998

Molecular pharmacology of V1a vasopressin receptors.

scientific article

Muscarinic receptor subtypes and the selectivity of agonists and antagonists

scientific article published on January 1988

Novel strategies for the design of receptor-selective vasopressin analogues: Aib-substitution and retro-inverso transformation.

scientific article published on October 1999

Novel vasopressin receptor ligands ⬇️

scientific article published on April 1, 1991

Palmitoylation of the vasopressin V1a receptor reveals different conformational requirements for signaling, agonist-induced receptor phosphorylation, and sequestration.

scientific article published on 20 July 2001

Pharmacological characterization of linear analogues of vasopressin generated by the systematic substitution of positions 1 and 6 by L-amino acids

scientific article published on 01 April 1994

Preparation of a membrane fraction for receptor studies and solubilization of receptor proteins with retention of biological activity

scientific article published on 01 January 1997

Probing the V1a vasopressin receptor binding site with pyroglutamate-substituted linear antagonists

scientific article published on 01 February 1996

Propylbenzilylcholine mustard labels an acidic residue in transmembrane helix 3 of the muscarinic receptor

scientific article published on 5 January 1989

Reconstitution of solubilised brain D2 dopamine receptors into phospholipid vesicles

scientific article published on 01 January 1984

Renal bradykinin and vasopressin receptors: ligand selectivity and classification

scientific article published on 01 August 1996

Single molecule binding of a ligand to a G-protein-coupled receptor in real time using fluorescence correlation spectroscopy, rendered possible by nano-encapsulation in styrene maleic acid lipid particles

scientific article published on 19 May 2020

Soluble and membrane-bound muscarinic acetylcholine receptors

scientific article published on 01 January 1986

Structural analysis of a nanoparticle containing a lipid bilayer used for detergent-free extraction of membrane proteins

scientific article published on 23 October 2014

Structure and function of neurohypophysial hormone receptors.

scientific article published on August 1997

Structure-function analysis of RAMP1 by alanine mutagenesis

scientific article published in January 2009

Structure-function analysis of RAMP1-RAMP3 chimeras.

scientific article published in January 2010

Structure/function studies on receptors for vasopressin and oxytocin

scientific article published on 01 January 1998

Surfactant-free purification of membrane proteins with intact native membrane environment

scientific article published on June 2011

Synthesis and characterization of tagged human oxytocin receptors (hOTRs) ⬇️

scientific article published on May 1, 1998

Systematic analysis of the entire second extracellular loop of the V(1a) vasopressin receptor: key residues, conserved throughout a G-protein-coupled receptor family, identified.

scientific article published on 2 April 2007

Targeting V1A-vasopressin receptors with [Arg6, D-Trp7,9, NmePhe8]-substance P (6-11) identifies a strategy to develop novel anti-cancer therapies.

scientific article published on January 2009

The Effect on CGRP-Binding of Mutations to the Hydrophilic Residues within the First Transmembrane Region of Human Calcitonin Receptor-Like Receptor (CRLR)

The activation of the CGRP receptor

scientific article published on February 2013

The expression, activity and localisation of the secretory pathway Ca2+ -ATPase (SPCA1) in different mammalian tissues

scientific journal article

The importance of acidic amino acid residues in the binding of ligands to the V1a vasopressin receptor

scientific article published on 01 February 1995

The role of putative glycosylation sites in the extracellular loops of the vasopressin V1a receptor ⬇️

scientific article published on August 1, 1997

The role of the extracellular loops of the CGRP receptor, a family B GPCR.

scientific article published on April 2012

The second intracellular loop of the calcitonin gene-related peptide receptor provides molecular determinants for signal transduction and cell surface expression

scientific article published on 17 November 2005

The structure and properties of the purified muscarinic acetylcholine receptor from rat forebrain

scientific article published on 01 February 1987

The study of neurohypophyseal hormone receptors by ligand binding.

scientific article

The third extracellular loop of G-protein-coupled receptors: more than just a linker between two important transmembrane helices.

scientific article published in December 2004

The use of site-directed mutagenesis to study GPCRs

scientific article

Visualization of oxytocin receptors using selective biotinylated probes

scientific article published on 01 August 1997

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