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List of works by Dorothy Hudig

A serine proteinase as a "trigger" for human natural killer lymphocyte-mediated cytolysis

scientific article published on 01 January 1985

Activation of recombinant murine cytotoxic cell proteinase-1 requires deletion of an amino-terminal dipeptide

scientific article published on 01 August 1993

Active tumor cell resistance to human natural killer lymphocyte attack

scientific article published on 01 July 1981

An improved method to quantify human NK cell-mediated antibody-dependent cell-mediated cytotoxicity (ADCC) per IgG FcR-positive NK cell without purification of NK cells

scientific article published on 4 November 2017

Assessment of a role for phospholipase A2 and arachidonic acid metabolism in human lymphocyte natural cytotoxicity

scientific article published in August 1984

Binding of granzyme B in the nucleus of target cells. Recognition of an 80-kilodalton protein

scientific article published on April 1996

Biotinylated isocoumarins, new inhibitors and reagents for detection, localization, and isolation of serine proteases

scientific article published on 01 November 1993

Calreticulin, a component of the endoplasmic reticulum and of cytotoxic lymphocyte granules, regulates perforin-mediated lysis in the hemolytic model system.

scientific article

Cell surface thiols, methylation, and complement-like components are involved in the early events of CML whereas proteases participate in the later, Ca++-dependent events

scientific article published on 01 January 1985

Characterization, application and potential uses of biotin-tagged inhibitors for lymphocyte serine proteases (granzymes)

scientific article published on 01 May 1996

Chymase-directed serine protease inhibitor that reacts with a single 30-kDa granzyme and blocks NK-mediated cytotoxicity

scientific article published on 01 December 1994

Conversion of the substrate specificity of mouse proteinase granzyme B ⬇️

scientific article published on June 1, 1994

DNA synthesis and proliferation of human lymphocytes in vitro: III. Fate of cycling cells in aging cultures of phytohemagglutinin stimulated human lymphocytes

scientific article published on 01 January 1981

Definition and Redesign of the Extended Substrate Specificity of Granzyme B ⬇️

scientific article published on October 16, 1998

Design and evaluation of inhibitors for dipeptidyl peptidase I (Cathepsin C).

scientific article published on July 2004

Determination of activable proacrosin/acrosin in bovine sperm using an irreversible isocoumarin serine protease inhibitor

scientific article published on 01 September 1996

Dipeptide vinyl sulfones suitable for intracellular inhibition of dipeptidyl peptidase I

scientific journal article

Dipeptidyl peptidase I: importance of progranzyme activation sequences, other dipeptide sequences, and the N-terminal amino group of synthetic substrates for enzyme activity

scientific article

Effect of unsaturated fatty acids on human lymphocytes: disparate influences of oleic and linolenic acids on natural cytotoxicity

scientific article published on 01 September 1981

Ethanol activation of human natural cytotoxicity ⬇️

scientific article published on 01 December 1983

Fluorescent derivatives of diphenyl [1-(N-peptidylamino)alkyl]phosphonate esters: synthesis and use in the inhibition and cellular localization of serine proteases

scientific article published on September 1994

Fractionation of perforin and granzymes by immobilized metal affinity chromatography (IMAC)

scientific article published on 01 May 1996

Granzyme B induces endothelial cell apoptosis and contributes to the development of transplant vascular disease

scientific article published in March 2005

Granzymes (lymphocyte serine proteases): characterization with natural and synthetic substrates and inhibitors

scientific article

Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes

scientific article published on 01 December 1993

Hydrolysis of tumor cell lipids after CTL-mediated death

scientific article published on 26 March 2009

IL-15-mediated induction of LFA-1 is a late step required for cytotoxic differentiation of human NK cells from CD34+Lin- bone marrow cells

scientific article published in July 2003

Inclusion of family members without ME/CFS in research studies promotes discovery of biomarkers specific for ME/CFS

scientific article published on 16 June 2020

Induction of granzyme B and T cell cytotoxic capacity by IL-2 or IL-15 without antigens: multiclonal responses that are extremely lytic if triggered and short-lived after cytokine withdrawal

scientific article published on November 2006

Inhibition of human lymphocyte natural cytotoxicity and antibody-dependent cell-mediated cytotoxicity by K-76 COONa, a reagent that blocks complement activity

scientific article published on 01 July 1984

Inhibition of human natural cytotoxicity by macromolecular antiproteases

scientific article published on 01 April 1981

Interaction between a Ca2+-Binding Protein Calreticulin and Perforin, a Component of the Cytotoxic T-Cell Granules ⬇️

scientific article published on July 21, 1998

Interactions between human natural killer (NK) lymphocytes and yeast cells: human NK cells do not kill Candida albicans, although C. albicans blocks NK lysis of K562 cells

scientific article published on March 1988

Lipid-dependent cytotoxicity by the lipase PLRP2 and by PLRP2-positive cytotoxic T lymphocytes (CTLs).

scientific article

Localization, implications for function, and gene expression of chymotrypsin-like proteinases of cytotoxic RNK-16 lymphocytes

scientific article published on December 1988

Low dose IL-15 induces snap arming of CD44(low) T lymphocytes in the absence of antigen

scientific article published on February 2008

Lymphocyte granule-mediated cytolysis requires serine protease activity

scientific article published on 01 December 1987

Lysis by RNK-16 cytotoxic lymphocyte granules. Rate assays and conditions to study control of cytolysis

scientific article published on December 1988

NK cells in gamma-interferon-deficient mice suppress lung innate immunity against Mycoplasma spp

scientific article

Natural Killer (NK) Cell Expression of CD2 as a Predictor of Serial Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC)

scientific article published on 16 October 2020

P-4 and RNKP-7, new granzyme-like serine proteases expressed in activated rat lymphocytes

scientific article published on 01 May 1997

Pancreatic lipase-related protein 2 (PLRP2) induction by IL-4 in cytotoxic T lymphocytes (CTLs) and reevaluation of the negative effects of its gene ablation on cytotoxicity

scientific article published on 18 May 2009

Perforin lytic activity is controlled by calreticulin

scientific article published on 01 April 2000

Perforin-Enhancing Protein, a Low Molecular Weight Protein of Cytotoxic Lymphocyte Granules, Enhances Perforin Lysis ⬇️

scientific article published on July 9, 1997

Properties of human blood monocytes. I. CD91 expression and log orthogonal light scatter provide a robust method to identify monocytes that is more accurate than CD14 expression

scientific article published on 8 October 2013

Properties of human blood monocytes. II. Monocytes from healthy adults are highly heterogeneous within and among individuals

scientific article published on 10 December 2013

Proteases and lymphocyte cytotoxic killing mechanisms

scientific article

Purification and characterization of lymphocyte chymase I, a granzyme implicated in perforin-mediated lysis ⬇️

scientific article published on May 15, 1998

RNKP-1, a novel natural killer-associated serine protease gene cloned from RNK-16 cytotoxic lymphocytes.

scientific article

Rapid purification of cationic granule proteases: application to human granzymes

scientific article published on 01 October 1993

Regulation of perforin lysis: implications for protein disulfide isomerase proteins

scientific article published on 14 January 2009

Selective isocoumarin serine protease inhibitors block RNK-16 lymphocyte granule-mediated cytolysis

scientific article published in August 1989

Sensitization of tumor cells to NK cell-mediated killing by proteasome inhibition

scientific article

Sulfonyl fluoride serine protease inhibitors inactivate RNK-16 lymphocyte granule proteases and reduce lysis by granule extracts and perforin ⬇️

scientific article published on June 1, 1992

Synthesis and Evaluation of Diphenyl Phosphonate Esters as Inhibitors of the Trypsin-like Granzymes A and K and Mast Cell Tryptase ⬇️

scientific article published on June 18, 1998

Synthesis and Kinetic Studies of Diphenyl 1-(N-Peptidylamino)alkanephosphonate Esters and Their Biotinylated Derivatives as Inhibitors of Serine Proteases and Probes for Lymphocyte Granzymes ⬇️

scientific article published on August 15, 1997

Synthetic substrates and inhibitors for serine proteases from lymphocytes, mast cells, semen, and blood

scientific article published on 01 January 1992

The function of lymphocyte proteases. Inhibition and restoration of granule-mediated lysis with isocoumarin serine protease inhibitors

scientific article published on 01 August 1991

The mechanism of cell-mediated cytotoxicity. I. Killing by murine cytotoxic T lymphocytes requires cell surface thiols and activated proteases

scientific article published on 01 February 1980

The mechanism of cell-mediated cytotoxicity. III. Protease-specific inhibitors preferentially block later events in cytotoxic T lymphocyte-mediated lysis than do inhibitors of methylation or thiol-reactive agents

scientific article published on 01 October 1983

The mechanism of cell-mediated cytotoxicity. IV. K-76 COONa, which inhibits the activity of Factor I and of C5, inhibits early events in cytotoxic T-lymphocyte-mediated cytolysis and in T-lymphocyte activation

scientific article published on 01 October 1984

The requirement for proteinase activity for human lymphocyte-mediated natural cytotoxicity (NK): evidence that the proteinase is serine dependent and has aromatic amino acid specificity of cleavage

scientific article published on 01 November 1984

cDNA cloning of granzyme J.

scientific article published in January 1997

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