List of works - Kiel Hards

A soil actinobacterium scavenges atmospheric H2 using two membrane-associated, oxygen-dependent [NiFe] hydrogenases

scientific article

Activation of type II NADH dehydrogenase by quinolinequinones mediates antitubercular cell death

scientific article published on 30 June 2016

Alternate quinone coupling in a new class of succinate dehydrogenase may potentiate mycobacterial respiratory control

scientific article published on 07 February 2019

Bactericidal mode of action of bedaquiline.

scientific article published on 8 March 2015

Chemical synthesis of a pore-forming antimicrobial protein, caenopore-5, by using native chemical ligation at a glu-cys site

scientific article published on 25 November 2014

Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesis

scientific article published on 14 November 2019

Energetics of Respiration and Oxidative Phosphorylation in Mycobacteria.

scientific article

Energetics of pathogenic bacteria and opportunities for drug development

scientific article

Essentiality of succinate dehydrogenase in Mycobacterium smegmatis and its role in the generation of the membrane potential under hypoxia

scientific article published on 12 August 2014

Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection.

scientific article

FAD-sequestering proteins protect mycobacteria against hypoxic and oxidative stress

scientific article published on 19 December 2018

Fundamental and applied investigations into mycobacterial bioenergetics

2017 doctoral thesis by Kiel Jason Hards at University of Otago

Ionophoric effects of the antitubercular drug bedaquiline

scientific article published on 25 June 2018

Mixotrophy drives niche expansion of verrucomicrobial methanotrophs.

scientific article published on 4 August 2017

Oxidative Phosphorylation as a Target Space for Tuberculosis: Success, Caution, and Future Directions

scientific article published on June 2017

Persistence of the dominant soil phylum Acidobacteria by trace gas scavenging

scientific article

Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering

scientific article published on 07 February 2020

Pyrazolo[1,5- a]pyridine Inhibitor of the Respiratory Cytochrome bcc Complex for the Treatment of Drug-Resistant Tuberculosis

scientific article published on 11 December 2018

Synthesis and Investigation of Phthalazinones as Antitubercular Agents

scientific article published on 13 February 2019

Targeting bacterial energetics to produce new antimicrobials.

scientific article published on 11 November 2017

The succinate dehydrogenase assembly factor, SdhE, is required for the flavinylation and activation of fumarate reductase in bacteria.

scientific article published on 25 December 2013

Three different [NiFe] hydrogenases confer metabolic flexibility in the obligate aerobe Mycobacterium smegmatis

scientific article published in January 2014

Two uptake hydrogenases differentially interact with the aerobic respiratory chain during mycobacterial growth and persistence

scientific article published on 17 October 2019

List of works by Kiel Hards

A soil actinobacterium scavenges atmospheric H2 using two membrane-associated, oxygen-dependent [NiFe] hydrogenases

Activation of type II NADH dehydrogenase by quinolinequinones mediates antitubercular cell death

Alternate quinone coupling in a new class of succinate dehydrogenase may potentiate mycobacterial respiratory control

Bactericidal mode of action of bedaquiline.

Chemical synthesis of a pore-forming antimicrobial protein, caenopore-5, by using native chemical ligation at a glu-cys site

Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesis

Energetics of Respiration and Oxidative Phosphorylation in Mycobacteria.

Energetics of pathogenic bacteria and opportunities for drug development

Essentiality of succinate dehydrogenase in Mycobacterium smegmatis and its role in the generation of the membrane potential under hypoxia

Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection.

FAD-sequestering proteins protect mycobacteria against hypoxic and oxidative stress

Fundamental and applied investigations into mycobacterial bioenergetics

Ionophoric effects of the antitubercular drug bedaquiline

Mixotrophy drives niche expansion of verrucomicrobial methanotrophs.

Oxidative Phosphorylation as a Target Space for Tuberculosis: Success, Caution, and Future Directions

Persistence of the dominant soil phylum Acidobacteria by trace gas scavenging

Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering

Pyrazolo[1,5- a]pyridine Inhibitor of the Respiratory Cytochrome bcc Complex for the Treatment of Drug-Resistant Tuberculosis

Synthesis and Investigation of Phthalazinones as Antitubercular Agents

Targeting bacterial energetics to produce new antimicrobials.

The succinate dehydrogenase assembly factor, SdhE, is required for the flavinylation and activation of fumarate reductase in bacteria.

Three different [NiFe] hydrogenases confer metabolic flexibility in the obligate aerobe Mycobacterium smegmatis

Two uptake hydrogenases differentially interact with the aerobic respiratory chain during mycobacterial growth and persistence