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List of works by Michele Simonato

2017 WONOEP appraisal: Studying epilepsy as a network disease using systems biology approaches

scientific article published on 14 May 2019

5-Hydroxytryptamine-mediated effects of nicotine on endogenous GABA efflux from guinea-pig cortical slices

scientific article published in November 1995

A Matter of Genes: The Hurdles of Gene Therapy for Epilepsy

scientific article published on 01 January 2019

A pathogenetic hypothesis of Unverricht-Lundborg disease onset and progression.

scientific article published on 22 December 2006

A pathogenetic hypothesis of temporal lobe epilepsy.

scientific article published on April 1993

Absence of RNA-binding protein FXR2P prevents prolonged phase of kainate-induced seizures

scientific article published on 28 March 2021

Adenosine A1 receptors in the rat brain in the kindling model of epilepsy

scientific article published on 01 November 1994

Adenosine receptor antagonists alter the stability of human epileptic GABAA receptors.

scholarly article

Advances in the development of biomarkers for epilepsy.

scientific article

Advancing research toward faster diagnosis, better treatment, and end of stigma in epilepsy

scientific article published on 18 June 2019

Anaphylactic shock and acute pulmonary edema after a single oral dose of acetazolamide.

scientific article published in July 2002

Angels and demons: neurotrophic factors and epilepsy.

scientific article published on 19 October 2006

Are the neurotrophic factors a suitable therapeutic target for the prevention of epileptogenesis?

scientific article published on July 2010

Autoradiographic analysis of rat brain kinin B1 and B2 receptors: normal distribution and alterations induced by epilepsy

scientific article published in July 2003

BDNF mRNA splice variants display activity-dependent targeting to distinct hippocampal laminae.

scientific article

Blockade of nociceptin/orphanin FQ transmission attenuates symptoms and neurodegeneration associated with Parkinson's disease.

scientific article published in October 2005

Bradykinin B₂ receptors increase hippocampal excitability and susceptibility to seizures in mice.

scientific article

Brain-derived neurotrophic factor mRNA and protein are targeted to discrete dendritic laminas by events that trigger epileptogenesis.

scientific article

Cellular Antisilencing Elements Support Transgene Expression from Herpes Simplex Virus Vectors in the Absence of Immediate Early Gene Expression

article

Changes in NPY-mediated modulation of hippocampal [3H]D-aspartate outflow in the kindling model of epilepsy.

scientific article published in August 2003

Changes in [3H]-UK 14304 binding to alpha 2-adrenoceptors in morphine-dependent guinea-pigs.

scientific article published in December 1995

Changes in hippocampal and cortical B1 bradykinin receptor biological activity in two experimental models of epilepsy.

scientific article

Characterization of K(+)-evoked [3H]D-aspartate outflow in the rat hippocampus in vitro

scientific article published on 01 December 1993

Circadian differences in the individual sensitivity to opiate overdose.

scientific article

Common data elements and data management: Remedy to cure underpowered preclinical studies

scientific article

Decreased levels of neuropeptide Y(5) receptor binding sites in two experimental models of epilepsy

scientific article published on 01 January 2000

Deletion of the Virion Host Shut-off Gene Enhances Neuronal-Selective Transgene Expression from an HSV Vector Lacking Functional IE Genes

scientific article published on 16 June 2017

Differential expression of immediate early genes in the hippocampus in the kindling model of epilepsy ⬇️

scientific article published on September 1, 1991

Discovery and validation of blood microRNAs as molecular biomarkers of epilepsy: Ways to close current knowledge gaps

scientific article published on 30 October 2018

Dose- and time-dependent hippocampal cholinergic lesions induced by ethylcholine mustard aziridinium ion: effects of nerve growth factor, GM1 ganglioside, and vitamin E

scientific article published on 01 August 1988

Early changes in prodynorphin mRNA and ir-dynorphin A levels after kindled seizures in the rat

scientific article published on 01 September 1995

Effects of [Nphe1, Arg14, Lys15] N/OFQ-NH2 (UFP-101), a potent NOP receptor antagonist, on molecular, cellular and behavioural alterations associated with chronic mild stress.

scientific article published on January 2017

Effects of defective herpes simplex vectors expressing neurotrophic factors on the proliferation and differentiation of nervous cells in vivo.

scientific article

Engineered HSV vector achieves safe long-term transgene expression in the central nervous system

scientific article

Enhancement of GABA(A)-current run-down in the hippocampus occurs at the first spontaneous seizure in a model of temporal lobe epilepsy.

scientific article

Epilepsy an Update on Disease Mechanisms: The Potential Role of MicroRNAs.

scientific article published on 19 March 2018

Evaluation of cell damage in organotypic hippocampal slice culture from adult mouse: a potential model system to study neuroprotection

scientific article published on 01 April 2011

Fgf-2 overexpression increases excitability and seizure susceptibility but decreases seizure-induced cell loss.

scientific article published on December 2008

Finding a better drug for epilepsy: antiepileptogenesis targets.

scientific article published on 12 October 2012

Finding a better drug for epilepsy: preclinical screening strategies and experimental trial design.

scientific article

Fourth conference on epileptogenesis, May 23-26, 2007, Pisa, Italy

scientific article published on 01 May 2008

From fix to fit into the autoptic human brains

scientific article published on 27 August 2018

Gene therapy for epilepsy.

scientific article

Gene transfer into neurones for the molecular analysis of behaviour: focus on herpes simplex vectors.

scientific article

Harmonization in preclinical epilepsy research: A joint AES/ILAE translational initiative

scientific article published in November 2017

Hippocampal FGF-2 and BDNF overexpression attenuates epileptogenesis-associated neuroinflammation and reduces spontaneous recurrent seizures.

scientific article

Identification and characterization of outcome measures reported in animal models of epilepsy: Protocol for a systematic review of the literature-A TASK2 report of the AES/ILAE Translational Task Force of the ILAE.

scientific article published in November 2017

Identification of miRNAs differentially expressed in human epilepsy with or without granule cell pathology

scientific article

Identification of new epilepsy treatments: Issues in preclinical methodology ⬇️

scientific article published on January 31, 2012

Impairment of GABA release in the hippocampus at the time of the first spontaneous seizure in the pilocarpine model of temporal lobe epilepsy.

scientific article published on 21 April 2014

Implication of fibroblast growth factors in epileptogenesis-associated circuit rearrangements

scientific article published on 13 September 2013

Increased extracellular levels of glutamate in the hippocampus of chronically epileptic rats.

scientific article

Issues for new antiepilepsy drug development

scientific article published on April 2013

Joint AES/ILAE translational workshop to optimize preclinical epilepsy research.

scientific article published in August 2013

Kainate seizures increase nociceptin/orphanin FQ release in the rat hippocampus and thalamus: a microdialysis study.

scientific article published in October 2004

Kindled seizure-induced c-fos and prodynorphin mRNA expressions are unrelated in the rat brain.

scientific article published in October 1996

Localized overexpression of FGF-2 and BDNF in hippocampus reduces mossy fiber sprouting and spontaneous seizures up to 4 weeks after pilocarpine-induced status epilepticus.

scientific article published on 26 January 2011

Long-Term, Targeted Delivery of GDNF from Encapsulated Cells Is Neuroprotective and Reduces Seizures in the Pilocarpine Model of Epilepsy

scientific article published on 21 January 2019

Meta-Analysis of MicroRNAs Dysregulated in the Hippocampal Dentate Gyrus of Animal Models of Epilepsy.

scientific article published in November 2017

MicroRNA profiles in hippocampal granule cells and plasma of rats with pilocarpine-induced epilepsy--comparison with human epileptic samples.

scientific article

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats

scientific article published on 08 November 2018

Molecular analysis of behavior by gene transfer into neurons with herpes simplex vectors.

scientific article

Neuroprotective activity of CHF3381, a putative N-methyl-D-aspartate receptor antagonist

scientific article published in November 2002

Neurotrophic factors and status epilepticus

scientific article published on 29 August 2018

New Tools for Epilepsy Therapy.

scientific article

Nociceptin/Orphanin FQ Receptor Agonists Attenuate L-DOPA-Induced Dyskinesias

scientific article published on 01 November 2012

Noradrenergic modulation of gamma-aminobutyric acid outflow from the human cerebral cortex.

scientific article

On the Role of Somatostatin in Seizure Control: Clues from the Hippocampus ⬇️

scientific article published on January 1, 2003

Opportunities for improving animal welfare in rodent models of epilepsy and seizures

scientific article

Personalized Needles for Microinjections in the Rodent Brain

scientific article published on 24 January 2018

Preclinical evaluation of CHF3381 as a novel antiepileptic agent.

scientific article published in June 2001

Pro-nociceptin/orphanin FQ and NOP receptor mRNA levels in the forebrain of food deprived rats.

scientific article published in December 2002

Progress in gene therapy for neurological disorders.

scientific article published on 23 April 2013

Proposal for a "phase II" multicenter trial model for preclinical new antiepilepsy therapy development.

scientific article published on August 2013

Risk of hospitalization for upper gastrointestinal tract bleeding

scientific article (publication date: 2004)

SREBP2 gene therapy targeting striatal astrocytes ameliorates Huntington’s disease phenotypes

scientific article published on 07 May 2021

Seizure-Suppressant and Neuroprotective Effects of Encapsulated BDNF-Producing Cells in a Rat Model of Temporal Lobe Epilepsy.

scientific article published on 9 March 2018

Silencing Status Epilepticus-Induced BDNF Expression with Herpes Simplex Virus Type-1 Based Amplicon Vectors

scientific article

Somatostatin release in the hippocampus in the kindling model of epilepsy: a microdialysis study

scientific article published on 01 June 2000

Standardization procedure for plasma biomarker analysis in rat models of epileptogenesis: Focus on circulating microRNAs.

scientific article

Synthesis and anticonvulsant activity of a class of 2-amino 3-hydroxypropanamide and 2-aminoacetamide derivatives.

scientific article published on 3 February 2006

Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus

scientific article

Targeting kinin receptors for the treatment of neurological diseases.

scientific article

The challenge and promise of anti-epileptic therapy development in animal models

scientific article published on 10 August 2014

The neurochemistry of morphine addiction in the neocortex.

scientific article

Third conference on epileptogenesis. S Servolo Island, Venice, Italy, July 27-30, 2005

scientific article published on 01 July 2006

Unilateral ex vivo gene therapy by GDNF in epileptic rats

scientific article published on 21 November 2018

Unverricht-Lundborg disease

scientific article published on September 2016

WONOEP appraisal: Development of epilepsy biomarkers-What we can learn from our patients?

scientific article

WONOEP appraisal: new genetic approaches to study epilepsy

scientific article

eIF4B phosphorylation at Ser504 links synaptic activity with protein translation in physiology and pathology.

scientific article

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