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List of works by Irina Bruck

A Positive Amplification Mechanism Involving a Kinase and Replication Initiation Factor Helps Assemble the Replication Fork Helicase

scientific article

An intact Mcm10 coiled-coil interaction surface is important for origin melting, helicase assembly and the recruitment of Pol-α to Mcm2-7

scientific article

Analysis of a multicomponent thermostable DNA polymerase III replicase from an extreme thermophile.

scientific article

Cdc45 protein-single-stranded DNA interaction is important for stalling the helicase during replication stress

scientific article

Conserved interactions in the Staphylococcus aureus DNA PolC chromosome replication machine

scientific article published on 12 January 2005

Conserved mechanism for coordinating replication fork helicase assembly with phosphorylation of the helicase

scientific article published on 24 August 2015

Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacterium

scientific article

Dbf4-Cdc7 phosphorylation of Mcm2 is required for cell growth

scientific article

DnaB helicase activity is modulated by DNA geometry and force

scientific article

Dpb11 may function with RPA and DNA to initiate DNA replication

scientific article

Dpb11 protein helps control assembly of the Cdc45·Mcm2-7·GINS replication fork helicase

scientific article

Enabling association of the GINS protein tetramer with the mini chromosome maintenance (Mcm)2-7 protein complex by phosphorylated Sld2 protein and single-stranded origin DNA.

scientific article

Eukaryotic Replicative Helicase Subunit Interaction with DNA and Its Role in DNA Replication

scientific article

GINS and Sld3 compete with one another for Mcm2-7 and Cdc45 binding

scientific article published on March 2011

Insights into the Initiation of Eukaryotic DNA Replication

scientific article published on 28 December 2015

Mcm subunits can assemble into two different active unwinding complexes

scientific article published on 17 September 2008

Mcm10 coordinates the timely assembly and activation of the replication fork helicase

scientific article published on 17 November 2015

Methods to study how replication fork helicases unwind DNA.

scientific article

Methods to study kinase regulation of the replication fork helicase

scientific article

Origin DNA Melting-An Essential Process with Divergent Mechanisms

scientific article

Origin single-stranded DNA releases Sld3 protein from the Mcm2-7 complex, allowing the GINS tetramer to bind the Mcm2-7 complex

scientific article published on June 2017

Origin single-stranded DNA releases Sld3 protein from the Mcm2-7 complex, allowing the GINS tetramer to bind the Mcm2-7 complex

scientific article published on April 2011

Synthesis of Extended Single-Molecule Optical Encoders

The Dbf4-Cdc7 kinase promotes Mcm2-7 ring opening to allow for single-stranded DNA extrusion and helicase assembly

scientific article

The Dbf4-Cdc7 kinase promotes Mcm2-7 ring opening to allow for single-stranded DNA extrusion and helicase assembly

scientific article published in Journal of Biological Chemistry

The Replication Initiation Protein Sld3/Treslin Orchestrates the Assembly of the Replication Fork Helicase during S Phase

scientific article published on 24 September 2015

The essential C family DnaE polymerase is error-prone and efficient at lesion bypass

scientific article published on 29 August 2003

The replication initiation protein Sld2 regulates helicase assembly

scientific article

The replication initiation protein Sld3/Treslin orchestrates the assembly of the replication fork helicase during S phase

scientific article published on June 2017

Tracking a molecular motor with a nanoscale optical encoder

scientific article

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