List of works by Scott B Rothbart

A DNA methylation reader complex that enhances gene transcription

scientific article published on 01 December 2018

A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin

scientific article

A fast, open source implementation of adaptive biasing potentials uncovers a ligand design strategy for the chromatin regulator BRD4. ⬇️

scientific article published on October 2016

A functional proteomics platform to reveal the sequence determinants of lysine methyltransferase substrate selectivity

scientific article published on 28 November 2018

A histone methylation network regulates transgenerational epigenetic memory in C. elegans

scientific article

A physical basis for quantitative ChIP-sequencing

scientific article published on 29 September 2020

AMP-activated Protein Kinase (AMPK) Control of mTORC1 Is p53- and TSC2-independent in Pemetrexed-treated Carcinoma Cells

scientific article

An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1.

scientific article

An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting

scientific article

An Interactive Database for the Assessment of Histone Antibody Specificity

scientific article

An acetyl-methyl switch drives a conformational change in p53.

scientific article

Analysis of Histone Antibody Specificity with Peptide Microarrays

scientific article published on August 2017

Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation

scientific article

Chromatin biochemistry enters the next generation of code 'seq-ing'.

scientific article published on August 2014

Chromatin structure and its chemical modifications regulate the ubiquitin ligase substrate selectivity of UHRF1

article published in the Proceedings of the National Academy of Sciences of the United States of America

Comparative biochemical analysis of UHRF proteins reveals molecular mechanisms that uncouple UHRF2 from DNA methylation maintenance.

scientific article published on 28 February 2018

Dido3 PHD Modulates Cell Differentiation and Division

scientific article

From histones to ribosomes: a chromatin regulator tangoes with translation

scientific article

Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1

scientific article

Histone H3.3 phosphorylation amplifies stimulation-induced transcription

scientific article published on 22 July 2020

Histone peptide microarray screen of chromo and Tudor domains defines new histone lysine methylation interactions

scientific article published on 14 March 2017

Identification of a BET family bromodomain/casein kinase II/TAF-containing complex as a regulator of mitotic condensin function

scientific article published on 22 February 2014

Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1.

scientific article

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators

scientific article published on 11 December 2020

Interpreting the language of histone and DNA modifications

scientific article published on 12 March 2014

Molecular Insights into Inhibition of the Methylated Histone-Plant Homeodomain Complexes by Calixarenes

scientific article

Molecular basis for chromatin binding and regulation of MLL5

scientific article

Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation

scientific article published on June 2013

Neuronal Stress Pathway Mediating a Histone Methyl/Phospho Switch Is Required for Herpes Simplex Virus Reactivation

scientific article

Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas

scientific article

Peptide microarrays to interrogate the "histone code".

scientific article

Poly-acetylated chromatin signatures are preferred epitopes for site-specific histone H4 acetyl antibodies

scientific article

Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a

scientific article published on 17 October 2016

Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF

scientific article published on 24 May 2019

Structural basis for DNMT3A-mediated de novo DNA methylation

scientific article published on 7 February 2018

Structural plasticity of methyllysine recognition by the tandem tudor domain of 53BP1

scientific article

Structures of RNA polymerase II complexes with Bye1, a chromatin-binding PHF3/DIDO homologue

scientific article

Systematic comparison of monoclonal versus polyclonal antibodies for mapping histone modifications by ChIP-seq

scientific article

Tandem PHD fingers of MORF/MOZ acetyltransferases display selectivity for acetylated histone H3 and are required for the association with chromatin

scientific article

The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer

scientific article published in December 2017

The finger loop of the SRA domain in the E3 ligase UHRF1 is a regulator of ubiquitin targeting and is required for the maintenance of DNA methylation

scientific article published on 03 September 2019

The histone and non-histone methyllysine reader activities of the UHRF1 tandem Tudor domain are dispensable for the propagation of aberrant DNA methylation patterning in cancer cells

scientific article published on 23 October 2020

Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation, and mammalian target of rapamycin inhibition

scientific article published on 23 June 2009

Trabectedin Inhibits EWS-FLI1 and Evicts SWI/SNF from Chromatin in a Schedule-dependent Manner

scientific article published on 05 February 2019

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